Inspired by Bengaluru’s AsTraM app, Kozhikode police plan an exclusive app with real-time traffic updates, SOS alerts, and easy fine payments for improved traffic management

[Place of publication not identified] : Filmhub, [2023]

Minister, ADC Chairman, CSOs mourn RK Peter's demise

In the crystal structure of the isostructural title compounds, namely {2,6-bis­[(di-tert-butyl­phosphan­yl)­oxy]-4-hy­droxy­phen­yl}chlorido­palladium(II), [Pd(C22H39O3P2)Cl], 1, and {2,6-bis­[(di-tert-butyl­phosphan­yl)­oxy]-4-hy­droxy­phen­yl}chlorido­platinum(II), [Pt(C22H39O3P2)Cl], 2, the metal centres are coordinated in a distorted square-planar fashion by the POCOP pincer fragment and the chloride ligand. Both complexes form strong hydrogen-bonded chain structures through an inter­action of the OH group in the 4-position of the aromatic POCOP backbone with the halide ligand.

Two new chalcones containing both pyrazole and thio­phene substituents have been prepared and structurally characterized. 3-(3-Methyl-5-phen­oxy-1-phenyl-1H-pyrazol-4-yl)-1-(thio­phen-2-yl)prop-2-en-1-one, C23H18N2O2S (I), and 3-[3-methyl-5-(2-methyl­phen­oxy)-1-phenyl-1H-pyrazol-4-yl]-1-(thio­phen-2-yl)prop-2-en-1-one, C24H20N2O2S (II), are isomorphous as well as isostructural, and in each the thio­phene substituent is disordered over two sets of atomic sites having occupancies 0.844 (3) and 0.156 (3) in (I), and 0.883 (2) and 0.117 (2) in (II). In each structure, the mol­ecules are linked into sheets by a combination of C—H⋯N and C—H⋯O hydrogen bonds. Comparisons are made with some related compounds.

The stressosome transduces environmental stress signals to SigB to upregulate SigB-dependent transcription, which is required for bacterial viability. The stressosome core is composed of RsbS and at least one of the RsbR paralogs. A previous cryo-electron microscopy (cryo-EM) structure of the RsbRA–RsbS complex determined under a D2 symmetry restraint showed that the stressosome core forms a pseudo-icosahedron consisting of 60 STAS domains of RsbRA and RsbS. However, it is still unclear how RsbS and one of the RsbR paralogs assemble into the stressosome. Here, an assembly model of the stressosome is presented based on the crystal structure of the RsbS icosahedron and cryo-EM structures of the RsbRA–RsbS complex determined under diverse symmetry restraints (nonsymmetric C1, dihedral D2 and icosahedral I envelopes). 60 monomers of the crystal structure of RsbS fitted well into the I-restrained cryo-EM structure determined at 4.1 Å resolution, even though the STAS domains in the I envelope were averaged. This indicates that RsbS and RsbRA share a highly conserved STAS fold. 22 protrusions observed in the C1 envelope, corresponding to dimers of the RsbRA N-domain, allowed the STAS domains of RsbRA and RsbS to be distinguished in the stressosome core. Based on these, the model of the stressosome core was reconstructed. The mutation of RsbRA residues at the binding interface in the model (R189A/Q191A) significantly reduced the interaction between RsbRA and RsbS. These results suggest that nonconserved residues in the conserved STAS folds between RsbS and RsbR paralogs determine stressosome assembly.

Kristina Drizyte-Miller, Jing Chen, Hong Cao, Micah B. Schott, and Mark A. McNiven

Epithelial cells such as liver-resident hepatocytes rely heavily on the Rab family of small GTPases to perform membrane trafficking events that dictate cell physiology and metabolism. Not surprisingly, disruption of several Rabs can manifest in metabolic diseases or cancer. Rab32 is expressed in many secretory epithelial cells but its role in cellular metabolism is virtually unknown. In this study, we find that Rab32 associates with lysosomes and regulates proliferation and cell size of Hep3B hepatoma and HeLa cells. Specifically, we identify that Rab32 supports mTORC1 signaling under basal and amino acid stimulated conditions. Consistent with inhibited mTORC1, an increase in nuclear TFEB localization and lysosome biogenesis is also observed in Rab32-depleted cells. Finally, we find that Rab32 interacts with mTOR kinase and that loss of Rab32 reduces the association of mTOR and mTORC1 pathway proteins with lysosomes, suggesting that Rab32 regulates lysosomal mTOR trafficking. In summary, these findings suggest that Rab32 functions as a novel regulator of cellular metabolism through supporting mTORC1 signaling.

Kristina Drizyte-Miller
Apr 15, 2020; 0:jcs.236661v1-jcs.236661
Articles

The Alang-Sosiya shipbreaking yard in India is highly polluted with heavy metals, a study concludes. The researchers studied heavy metal contamination in sediments taken from the intertidal zone of the shipbreaking yard and compared them to a control site. The area was found to be ‘strongly polluted’ with copper, cobalt, manganese, lead and zinc.

Covid-19 crisis has seen a surge in demand for the roles of CISOs and CDOs, while the CIO role seems to be headed for an on-demand model among the small and medium enterprises.

Covid-19 crisis has seen a surge in demand for the roles of CISOs and CDOs, while the CIO role seems to be headed for an on-demand model among the small and medium enterprises.

The Alang-Sosiya shipbreaking yards in India highlight the inequalities and opportunities of global waste management. The yards, which recycle retired ships from more economically developed countries, have dramatically altered the ecosystems and social structures of the local area. A study looking at stakeholder perceptions analyses different positions on the social and environmental impacts of the yards.

The Colorado-based school wants to buy itself from a cash-strapped parent organization, but it may have to close if it can't raise $2.5 million by Jan. 31.

Thinking of Your OT Network as an Extension of Your IT Network Will Give You a Consolidated Picture of Your Technology Infrastructure

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Puntos destacados de la investigación: Los adultos de mediana edad que caminaron una mayor cantidad de pasos al día mostraron un 43% menos de riesgo de padecer diabetes y un 31% menos de riesgo de hipertensión arterial, en comparación con personas de...

DALLAS, 3 de abril del 2020 – Debido al esfuerzo de médicos, científicos e investigadores de todo el mundo por comprender la pandemia del coronavirus (COVID-19), la American Heart Association está desarrollando un nuevo registro para agregar datos y...

Rescue vessels are the main actors in maritime safety and rescue operations. At the same time, aerial drones bring a significant advantage into this scenario. This paper presents the research directions of the AutoSOS project, where we work in the development of an autonomous multi-robot search and rescue assistance platform capable of sensor fusion and object detection in embedded devices using novel lightweight AI models. The platform is meant to perform reconnaissance missions for initial assessment of the environment using novel adaptive deep learning algorithms that efficiently use the available sensors and computational resources on drones and rescue vessel. When drones find potential objects, they will send their sensor data to the vessel to verity the findings with increased accuracy. The actual rescue and treatment operation are left as the responsibility of the rescue personnel. The drones will autonomously reconfigure their spatial distribution to enable multi-hop communication, when a direct connection between a drone transmitting information and the vessel is unavailable.

Formulations comprising an isosorbide-modified unsaturated polyester comprising maleic acid, fumaric acid, itaconic acid or maleic anhydride and isosorbide and one or more low profile additives. The formulations exhibit better shrink control in molding compound formulations with standard low profile additives than their non-isosorbide-modified analogues. These isosorbide-modified unsaturated polyester resins may be applied in molding compounds like sheet molding compounds or bulk molding compounds and may be components of fiber reinforced composites or other composite materials.

A method of forming a component (30) by isostatic pressing, the method comprising: providing a canister (4) suitable for isostatic pressing, the canister comprising first and second membranes (14, 16) which, in use, are disposed within the canister (4); the first and second membranes (14, 16) defining a component cavity (24) disposed between the first and second membranes (14, 16), a first tool cavity (26) disposed between the first membrane (14) and an adjacent wall (10) of the canister (4), and a second tool cavity (28) disposed between the second membrane (16) and another adjacent wall (12) of the canister (4); filling the component cavity (24) with the component powder for forming the component (30); filling the first and second tool cavities (26, 28) with a second tool powder; and isostatically pressing the canister (4) to form the component (30).

For the past decade 96-year-old Betty Reid Soskin has served as the nation’s oldest Park Ranger

Hay medidas buenas y no tan buenas, pero el punto de fondo es que todos pongan para superar el Covid19

(United States Ninth Circuit) - Denied petition for review of Board of Immigration Appeals (BIA) decision to remove Plaintiff from the United States. The appeals court held that Plaintiff's conviction for indecent exposure was a crime involving moral turpitude and held that the BIA decision in Matter of Cortes Medina applied retroactively to Plaintiff making him ineligible for cancellation of removal.

(United States First Circuit) - Affirmed a drug-trafficking sentence despite the defendant's argument that he was given an unwarranted Guidelines enhancement for obstruction of justice. The defendant, who pleaded guilty, also argued that he should be given a credit for acceptance of responsibility. However, the First Circuit found that he had maintained a false identity (i.e., used an assumed name) throughout his criminal proceedings, and thus affirmed the sentence.

(United States First Circuit) - Affirmed the sentence of a defendant who pleaded guilty to one count of being a felon in possession of a firearm and to one count of possession of a machine gun. The defendant challenged his sentence on procedural and substantive reasonableness grounds. Finding no error, the First Circuit affirmed.

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IBM y PAPALOTE MUSEO DEL NIÑO, anunciaron hoy su alianza para desarrollar y ofrecer dos cursos de formación para profesores de la Ciudad de México. El taller estará basado en el portal web teacherstryscience.org de IBM y representa el compromiso de ambas instituciones por contribuir a la enseñanza de la ciencia y en particular de la astronomía, a través de dispositivos en línea.

IBM y VON DER HEIDE, compañía especializada en servicios de consultoría de Recursos Humanos, informan que han firmado una importante alianza para expandir su oferta de servicios de Employee Engagement y HR Analytics en toda América Latina. Por medio de las tecnologías de IBM, esta alianza le permitirá a VON DER HEIDE brindar a sus clientes una oferta de consultoría única en el mercado, para transformar estrategias de talento en resultados de negocio.

The Coronavirus crisis introduces critical operational challenges to business continuity, placing high stress on organizations' management. As a result, CIOs and CISOs face a double challenge on the cyber risk front – apart from the new risks that the mass transfer of employees working remotely brings, capturing the management mindshare for further investments in security becomes harder than

Milo & Olive gives us the recipe for their giant garlic knots, which the restaurant now also offers as a take-and-bake item

Ex-juiz da Lava Jato, Moro anunciou sua demissão do governo e acusou o presidente Bolsonaro de tentar interferir em investigações.

Buscador interativo permite consultar dados oficiais de todos os municípios afetados pelo vírus até o momento no Brasil.

Hear about travel to Namibia as the Amateur Traveler talks to Karthik Iyer about his most recent trip to this desert country.

Gernot F. Grabner
Apr 29, 2020; 0:jlr.RA119000516v1-jlr.RA119000516
Research Articles

Bis(monoacylglycero)phosphate (BMP), also known as lysobisphosphatidic acid (LBPA), is a phospholipid that promotes lipid sorting in late endosomes/lysosomes by activating lipid hydrolases and lipid transfer proteins. Changes in the cellular BMP content therefore reflect an altered metabolic activity of the endo-lysosomal system. Surprisingly, little is known about the physiological regulation of BMP. In this study, we investigated the effects of nutritional and metabolic factors on BMP profiles of whole tissues and  parenchymal and non-parenchymal cells. Tissue samples were obtained from fed, fasted, two-hours refed, and insulin-treated mice, as well as from mice housed at  5°C, 22°C, or 30°C. These tissues exhibited distinct BMP profiles, which were regulated by the nutritional state in a tissue-specific manner. Insulin treatment was not sufficient to mimic refeeding-induced changes in tissue BMP levels indicating that BMP metabolism is regulated by other hormonal or nutritional factors. Tissue fractionation experiments revealed that fasting drastically elevates BMP levels in hepatocytes and pancreatic cells. Furthermore, we observed that the BMP content in brown adipose tissue strongly depends on housing temperatures. In conclusion, our observations suggest that BMP concentrations adapt to the metabolic state in a tissue-and cell type-specific manner in mice. Drastic changes observed in hepatocytes, pancreatic cells, and brown adipocytes suggest that BMP possesses a role in the functional adaption to nutrient starvation and ambient temperature.

Niemann-Pick disease type C (NPC) disease is a lipid-storage disorder that is caused by mutations in the genes encoding NPC proteins and results in lysosomal cholesterol accumulation. 2-Hydroxypropyl-β-cyclodextrin (CD) has been shown to reduce lysosomal cholesterol levels and enhance sterol homeostatic responses, but CD’s mechanism of action remains unknown. Recent work provides evidence that CD stimulates lysosomal exocytosis, raising the possibility that lysosomal cholesterol is released in exosomes. However, therapeutic concentrations of CD do not alter total cellular cholesterol, and cholesterol homeostatic responses at the ER are most consistent with increased ER membrane cholesterol. To address these disparate findings, here we used stable isotope labeling to track the movement of lipoprotein cholesterol cargo in response to CD in NPC1-deficient U2OS cells. Although released cholesterol was detectable, it was not associated with extracellular vesicles. Rather, we demonstrate that lysosomal cholesterol trafficks to the plasma membrane (PM), where it exchanges with lipoprotein-bound cholesterol in a CD-dependent manner. We found that in the absence of suitable extracellular cholesterol acceptors, cholesterol exchange is abrogated, cholesterol accumulates in the PM, and reesterification at the ER is increased. These results support a model in which CD promotes intracellular redistribution of lysosomal cholesterol, but not cholesterol exocytosis or efflux, during the restoration of cholesterol homeostatic responses.

  Stationery & Office Supplies Limited, SOS, has implemented work rotation schedules, which sees only 50 per cent of its staff working from the office on a daily basis, as it tries to balance the needs of the business and the...

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Presentación del reporte que refleja el contenido de encuentros del grupo de estudio sobre la migración México-Estados Unidos convocado por El Colegio de México y el Migration Policy Institute (MPI).

La migración entre México y Estados Unidos ha cambiado dramáticamente en los últimos años, pero las políticas y la retórica política en ambos países no se han actualizado a este contexto a la misma velocidad. Este reporte explora esta nueva realidad migratoria y cómo los dos gobiernos podrían trabajar juntos para abordar los desafíos de políticas públicas que tienen en común.

Benjamin Meyer
Jul 3, 2019; 39:5326-5335
Systems/Circuits

Italian translation of the BIS press release on the presentation of the Annual Economic Report 2018, 24 June 2018. Le autorità possono fare in modo che l'attuale ripresa economica si mantenga oltre il breve termine avviando riforme strutturali, ridando margine di manovra alle politiche monetarie e di bilancio per affrontare eventuali future minacce, e incoraggiando la pronta attuazione delle riforme regolamentari, scrive la Banca dei Regolamenti Internazionali (BRI) nella sua Relazione economica annuale. ...

Spanish translation of the BIS press release on the presentation of the Annual Economic Report 2018, 24 June 2018. Las autoridades pueden prolongar el actual repunte económico más allá del corto plazo aplicando reformas estructurales, reconstruyendo el espacio de las políticas monetaria y fiscal para afrontar futuras amenazas y fomentando una pronta implementación de las reformas reguladoras, sostiene el Banco de Pagos Internacionales (BPI) en su Informe Económico Anual. ...

DOVER – La División de Salud Pública de Delaware (DPH, por sus siglas en inglés) ha confirmado once casos de paperas asociados a un brote entre las personas que asistieron a dos diferentes bailes mexicanos en el condado de New Castle. Siete de los casos confirmados asistieron, o viven con personas que asistieron, al evento […]

La División de Salud Pública de Delaware (DPH por sus siglas en inglés) anunció hoy que hay 26 casos confirmados de Salmonella en niños y niñas de edad escolar en el condado de New Castle. Estos casos forman parte de un brote multiestatal de Salmonella Javiana vinculado a frutas cortadas que fueron retiradas del mercado.