Washington, May 07: A Chinese medical researcher on the "verge of making very significant" coronavirus findings has been found shot dead in the US state of Pennsylvania, media reports said on Wednesday. University of Pittsburgh professor Bing Liu, 37, was found

Within days of receiving immense praise, love and appreciation for the second season, Amazon Prime Video has announced today (May 8, 2020) that fans can look forward to a third season of the Amazon Original Series, Four More Shots Please.Created by

The Coronavirus crisis has changed work spaces and dynamics for many around the world. The entertainment industry too is slowly adjusting to new realities, and figuring out innovative ways to shoot. One of India's most popular game shows, Kaun Banega Crorepati,

Amidst the lockdown, when the whole world has come to a halt, Eros Now has come up with a unique concept for a one of a kind web series that starts streaming today on the platform.   A Viral Wedding is

Amidst the lockdown, when the whole world has come to a halt, Eros Now has come up with a unique concept for a one of a kind web series that starts streaming today on the platform.   A Viral Wedding is

The transmembrane intracellular lectin ER–Golgi intermediate compartment protein 53 (ERGIC-53) and the soluble EF-hand multiple coagulation factor deficiency protein 2 (MCFD2) form a complex that functions as a cargo receptor, trafficking various glycoproteins between the endoplasmic reticulum (ER) and the Golgi apparatus. It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53CRD) interacts with N-linked glycans on cargo glycoproteins, whereas MCFD2 recognizes polypeptide segments of cargo glycoproteins. Crystal structures of ERGIC-53CRD complexed with MCFD2 and mannosyl oligosaccharides have revealed protein–protein and protein–sugar binding modes. In contrast, the polypeptide-recognition mechanism of MCFD2 remains largely unknown. Here, a 1.60 Å resolution crystal structure of the ERGIC-53CRD–MCFD2 complex is reported, along with three other crystal forms. Comparison of these structures with those previously reported reveal that MCFD2, but not ERGIC-53–CRD, exhibits significant conformational plasticity that may be relevant to its accommodation of various polypeptide ligands.

With the emergence of X-ray free-electron lasers, it is possible to investigate the structure of nanoscale samples by employing coherent diffractive imaging in the X-ray spectral regime. In this work, we developed a refinement method for structure reconstruction applicable to low-quality coherent diffraction data. The method is based on the gradient search method and considers the missing region of a diffraction pattern and the small number of detected photons. We introduced an initial estimate of the structure in the method to improve the convergence. The present method is applied to an experimental diffraction pattern of an Xe cluster obtained in an X-ray scattering experiment at the SPring-8 Angstrom Compact free-electron LAser (SACLA) facility. It is found that the electron density is successfully reconstructed from the diffraction pattern with a large missing region, with a good initial estimate of the structure. The diffraction pattern calculated from the reconstructed electron density reproduced the observed diffraction pattern well, including the characteristic intensity modulation in each ring. Our refinement method enables structure reconstruction from diffraction patterns under difficulties such as missing areas and low diffraction intensity, and it is potentially applicable to the structure determination of samples that have low scattering power.

Characterizing and controlling the uniformity of nanoparticles is crucial for their application in science and technology because crystalline defects in the nanoparticles strongly affect their unique properties. Recently, ultra-short and ultra-bright X-ray pulses provided by X-ray free-electron lasers (XFELs) opened up the possibility of structure determination of nanometre-scale matter with Å spatial resolution. However, it is often difficult to reconstruct the 3D structural information from single-shot X-ray diffraction patterns owing to the random orientation of the particles. This report proposes an analysis approach for characterizing defects in nanoparticles using wide-angle X-ray scattering (WAXS) data from free-flying single nanoparticles. The analysis method is based on the concept of correlated X-ray scattering, in which correlations of scattered X-ray are used to recover detailed structural information. WAXS experiments of xenon nanoparticles, or clusters, were conducted at an XFEL facility in Japan by using the SPring-8 Ångstrom compact free-electron laser (SACLA). Bragg spots in the recorded single-shot X-ray diffraction patterns showed clear angular correlations, which offered significant structural information on the nanoparticles. The experimental angular correlations were reproduced by numerical simulation in which kinematical theory of diffraction was combined with geometric calculations. We also explain the diffuse scattering intensity as being due to the stacking faults in the xenon clusters.

This article reports conformational polymorphisms of the EF-hand protein MCFD2 which is involved in glycoprotein transport..

A crystallographic indexing algorithm, pinkIndexer, is presented for the analysis of snapshot diffraction patterns. It can be used in a variety of contexts including measurements made with a monochromatic radiation source, a polychromatic source or with radiation of very short wavelength. As such, the algorithm is particularly suited to automated data processing for two emerging measurement techniques for macromolecular structure determination: serial pink-beam X-ray crystallography and serial electron crystallography, which until now lacked reliable programs for analyzing many individual diffraction patterns from crystals of uncorrelated orientation. The algorithm requires approximate knowledge of the unit-cell parameters of the crystal, but not the wavelengths associated with each Bragg spot. The use of pinkIndexer is demonstrated by obtaining 1005 lattices from a published pink-beam serial crystallography data set that had previously yielded 140 indexed lattices. Additionally, in tests on experimental serial crystallography diffraction data recorded with quasi-monochromatic X-rays and with electrons the algorithm indexed more patterns than other programs tested.

Just like humans, great apes can catch the flu. That’s why the Smithsonian’s National Zoo’s primate keepers train our gorillas and orangutans—like Iris, featured here—to […]

The post Get a flu shot? These orangutans did…. appeared first on Smithsonian Insider.

Myke discovered his ranking, Grey will not switch, and they both answer #askcortex questions before the Cortexmas season begins.

Biologists use weapons to harass Oregon sea lions into leaving an area populated by endangered salmon and other fish.

Antwon Lee tells his little man "it's OK to cry" and to "stay strong" during the ordeal.

Despite the HPV vaccine being effective at preventing infections and cancers down the line, just one-third of teen girls complete the injection series.

Misinformation and 'vaccine fears' are causing parents to forgo a safe solution to a dangerous newborn vitamin deficiency.

Top polluters would pay $20 per ton of carbon emissions under the carbon tax plan, with 60 percent of the revenue returned to each U.S. resident.

A new study suggests people who deliver bad news are never seen as innocent.

Breakthrough vaccine technique makes you immune to all forms of the flu virus.

A dozen senators are asking the Departments of Interior and Energy to get the event back on the mall.

West Virginia U.S. Senate race brings out the guns, not to mention a former president and a former vice presidential candidate.

Scientists say C/2019 Q4 is a comet from another galaxy.

All Americans over 6 months old should get their flu shot this year, health officials urged today. While last year's flu season was relatively mild, the illness

From flu shots to full-service health care, on-the-job clinics can boost worker productivity. On-the-job flu shot clinics are promoted by the Centers for Diseas

Actor's comments during the Golden Globes did not sit well with the Centers for Disease Control and Prevention.

More adults have gotten the flu shot this year, but there's still plenty of room for improvement, says the CDC.

The CDC issued a warning that a mutated flu strain might make this year's vaccine less effective.

Lots of research goes into the annual vaccine, but that doesn't mean we always get it right.

If you're getting the vaccine this year, here are four things you should know about side effects, effectiveness and risks.

Drug stores start offering flu shots in early summer, but the CDC recommends getting a shot by the end of October.

The Royal Meteorological Society, in association with WeatherPro, announces the winners of the 2019 Weather Photographer of the Year competition.

The Sip of Hope coffeehouse in Chicago's Logan Square supports mental health initiatives, including suicide prevention.

Two new studies map out the potential revival of Earth's lost forests.

It is time for you to get your flu shot 2005 and you had better not waste any time in getting to your doctors office, if you do you could find yourself without any protection for the coming flu season.

The Dark Side is a docufiction film shot during and after Hurricane Sandy that mixes together the unlikely pair of a Romantic Comedy and a documentary. NY writer/director Richard Ledes is releasing The Dark Side on Youtube.

The holiday trappings can elicit a number of allergic reactions, but sublingual immunotherapy drops provide a simple alternative to allergy shots.

Snyder's book has received 29 industry awards. His father, pilot of the 'Susan Ruth', was shot down over Europe during WWII. 'Shot Down' is a dramatic retelling of the stories surrounding that event.

Snyder's book has received 29 industry awards. His father, pilot of the 'Susan Ruth', was shot down over Europe during WWII. 'Shot Down' is a dramatic retelling of the stories surrounding that event.

StoneShot's 2019 Event Marketing Report offers in-depth analysis on email campaigns for marketers looking to boost specific event registration, attendance, and leads.