In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, andat least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

A scraper that has a frame that supports wheels. The scraper includes a blade and a blade height and tilt assembly that are connected to the frame in order to both adjust the height of the blade and the angle at which the blade cuts soil.

A scraper assembly for removing mud and moist soil from the gauge wheels of an agricultural planter includes a support rod attached to a hub of a gauge wheel arm, a clamp structure attached to an end portion of the support rod, and a scraper blade attached to the clamp structure. An axis of the end portion of the support rod is approximately perpendicular to and intersects with an axis of rotation of the gauge wheel. The scraper blade is mounted approximately perpendicular to the outer surface of the gauge wheel and is angled approximately 45 degrees from the sides of the gauge wheel. The scraper blade has a curved profile along its length that substantially matches an outer profile of the outer surface of the gauge wheel when the scraper blade is properly adjusted.

A device and methods for bilateral or unilateral physical therapy of lower limbs are disclosed. The device comprises a curved rail mounted on a base and a pair of support members configured to accommodate a portion of a leg of a person, and to slide along the curved rail. The curved rail allows lateral movements of the lower limbs with the support members, the movements being driven by a force of the lower limbs. The methods of the invention allow physical unilateral or bilateral therapy of lower limbs of a person. The initial reinforcement of the lower limbs of a person is improved by the use of this device, which reduces the friction or the resistance caused by the device during the prescribed movements. The invention provides to patients with severe lower limb disability, a physical therapy device that is easy to use with minimum supervision by a physical therapist.

An interior sock is fabricated of a flexible elastic polymer. The interior sock has a cylindrical closed toe section, a cylindrical open ankle section and an intermediate heel section. The heel section is provided between the toe and ankle sections. An exterior sock is fabricated of a knitted blend of cotton and a minor portion of an elastic. The exterior sock has a cylindrical closed toe section, a cylindrical open ankle section and an intermediate heel section. The heel section is provided between the toe and ankle sections. A quantity of therapeutic fluid is located within the interior sock. The therapeutic fluid is in contact with a foot of a user. The interior sock provides support for the therapeutic fluid. The exterior sock provides pressure and warmth to the interior sock and the therapeutic fluid.

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

The Grapes is one the nearest pubs to the Eastern Docks in Southampton, and as such was always popular with dock workers and seamen alike.

The #MeToo movement has swept from Hollywood to Capitol Hill. The careers of powerful men ended as women spoke out against workplace harassment and assault.

On this episode of Reveal, we look at what happens when the people involved aren’t celebrities or powerful. We team up with KQED, the UC Berkeley Investigative Reporting Program, FRONTLINE and Univision to investigate sexual violence against female janitors.

They usually work alone at night and that isolation can leave them vulnerable. A lot of them are immigrants, some living in the country illegally.

Plus, we talk with an investigative editor for The New York Times who helped steer the coverage that toppled Hollywood mogul Harvey Weinstein.

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Head over to revealnews.org for more of our reporting.

Follow us on Facebook at fb.com/ThisIsReveal and on Twitter @reveal.

And to see some of what you’re hearing, we’re also on Instagram @revealnews.

Shares of Pluristem Therapeutics Inc. (PSTI) are rising over 16% in pre-market today, after the company announced that the European Investment Bank has approved a ?50 million non-dilutive financing for the company.

Shares of TherapeuticsMD Inc. (TXMD) are soaring over 17% in pre-market today, after the company announced that the United States Patent and Trademark Office has issued a patent that covers the labeled indication for ANNOVERA, the first and only long-lasting, patient-controlled, procedure-free, reversible prescription contraceptive option for women.

Shares of Akebia Therapeutics, Inc. (AKBA) are gaining over 25% on Tuesday morning after the drug maker reported positive topline results from a late stage study on patients with chronic kidney disease.

Shares of Horizon Therapeutics plc (HZNP) are rising almost 9 percent or $3.29 in Wednesday's morning trade at $40.67 on better-than-expected first-quarter results and upbeat sales outlook for the full year.

A deeply affecting experience that ought to win the opera many new admirers.

The man accused of the Claremont serial killings, Bradley Edwards, has pleaded guilty to attacks on two women in the years leading up to the disappearance of Sarah Spiers.

Detective Senior Sergeant Daren Edwards

An example of a hidden camera, placed inside a smoke alarm and discovered by police

A Sunshine Coast man has been charged with rape and secretly recording a number of his female flatmates using hidden cameras, over the course of five years.

Lawyers for a former senior NT police officer facing rape allegations can access the identity of a whistleblower who complained about him, an NT Supreme Court judge rules.

Two men have been charged with raping an Albany woman while she was asleep.

Courts of law exist for good reason, but the judicial process can also retraumatize, rather than heal, victims and witnesses who are exposed to it. Therapeutic jurisprudence offers a different approach

An ACCC report highlights transparency and objectiveness as issues that need to be addressed in the wine grape industry.

A man appears in a Melbourne court charged with raping a 32-year-old woman who was walking a dog in Thornbury on Saturday night.

One of three peregrine falcon chicks that hatched, in front of thousands of online fans, has died in a nest perched high on a Melbourne skyscraper, marking the third year in a row the nest has suffered such a loss.

A judge describes the attack on 21-year-old Aiia Maasarwe as "unsophisticated and opportunistic" in sentencing her killer to 36 years' prison, with a non-parole period of 30, as the victim's father and sister watch on in court.

The Australian Competition and Consumer Commission's final report into the wine grape sector makes 10 recommendations to improve the efficiency and fairness of Australia's wine grape markets.

A central Victorian woman is one of only three accredited teachers of a Japanese form of freestyle weaving that is beginning to grow in popularity.

Police announce a $500,000 reward for information about the rape of an 18-year-old woman in Melbourne's CBD last year, as the victim speaks about the "traumatic" attack for the first time.

Kelly says the way police handled the investigation into her alleged assault "has been the most devastating part of it" after she was told her rape kit was destroyed and then never existed at all.

It has been six years since Samira Elagoz was raped by her ex-boyfriend. So she decided to own the narrative and write a performance about what had happened to her.

A man who raped a woman in his Melbourne apartment, which he described as "the perfect location", has been jailed for eight years for the "violent act" he inflicted on his victim.

The former rugby league star pleads not guilty to two counts of aggravated sexual assault against a 26-year-old woman in the NSW Hunter Valley and tells reporters outside court it's been "a very hard time" for his family.

A man who previously admitted to the kidnap and sexual abuse of an 11-year-old girl in Newcastle has pleaded guilty to three further offences.

The NSW Education Department investigates after a video emerges online of a teacher telling her class that if a woman is raped, her clothing should be held partly accountable.

Members of a NSW rugby league club who were photographed at an airport wearing offensive t-shirts emblazoned with a topless mermaid look set to face the wrath of the sport's officials.

Hot temperatures and low rainfall take their toll on South Australian wine grape growers, but many are happy with the quality of the wines in spite of, or perhaps even because of, the tough conditions.

A Melbourne doctor is banned from practising after sparking outrage with online chat room posts, including one that said "some women deserve to be raped" and another that said his marriage "would end in murder" if it fell apart.

One of Australia's biggest table grape companies is threatening to rip up vines and scrap its million-dollar plan to expand in the Northern Territory.

The 41-year-old man from a remote Central Australian community was found guilty of two counts of "sexual intercourse without consent" for a sustained assault in which he raped and punched his aunt and then brandished a shovel at her as she tried to flee.

The wrongful arrest of a man who spent 103 days in custody over an alleged rape, while awaiting DNA results, prompts a review into the NT Police forensics branch.

A former Canberra law lecturer serving time for sexual offences against several students loses his battle with prison authorities, who want him to undertake a course for sex offenders.

A woman was allegedly raped so violently by a man she met in a shared laundry that she was lucky to survive, the ACT Supreme Court has heard. WARNING: This story contains graphic content.

The sexual assault, and her future brother-in-law's warning that she not tell anyone, left her with an eating disorder and post traumatic stress disorder.

Rape victims are being made to wait for hours in the clothes they were assaulted in before being examined, or sometimes not examined at all, a damning auditor-general report reveals, highlighting the lack of qualified staff.

Draper Tools, the hand and power tool distributor, is a family-run company that has been in business for just over a century and has more than 5,000 UK and overseas customers. Historically its customers have been mostly business-to-business (B2B) retailers and distributors but more recently Draper has also begun using its logistics platform to ship to consumers directly on behalf of its customers.

Taking the waters of a mineral pool is a long, human tradition, and today it is often grey nomads seeking out their reputed healing and bubbling waters.