A national fertility business attached to clinics in six Australian states and territories says its email system has been subjected to a "malicious cyber attack", with patients reporting receiving bogus messages that appear to be from the company.

One person is dead and another injured after a crash between a truck and a car, which will see the Monaro Highway closed for the rest of the day.

(United States First Circuit) - In a dispute between two monasteries for copyright infringement of a religious text, district court's judgment in favor of the plaintiff is affirmed, as the plaintiff has established both elements of an infringement claim of actual copying and actionable copying, and all of the defenses set forth by the defendant are without merit.

(California Court of Appeal) - In a class action against a Water District challenging the method used by District to calculate wastewater service 'fees or charges' between about 2012 and 2014, the trial court's judgment in favor of defendant, holding that plaintiffs failed to exhaust their administrative remedies under article XIII D of the California Constitution, is reversed where: 1) plaintiffs' class action is not barred by their failure to exhaust the administrative remedies set forth in section 6 because plaintiffs' substantive challenge involving the method used by District to calculate its wastewater service fees or charges is outside the scope of the administrative remedies; and 2) under the facts of this case, those remedies are, in any event, inadequate.

(California Court of Appeal) - Held that the City of Pomona violated the terms of a 1993 ballot initiative prohibiting the construction of additional billboards within city limits. A citizen group challenged the city council's decision to extend a pre-existing agreement with an outdoor advertising company when the arrangement expired in 2014. Affirmed the granting of a writ of mandate.

UK Band Unveils Music Video Ahead Of “Strangers” Album Release

UK Band Unveils Highly Anticipated Album And Partnership With Menswear Brand, By Robert James

(Supreme Court of California) - Clarified the procedure for challenging a local governmental agency's decision to impose or increase property-related fees. The question in this case involving a wastewater service charge had to do with whether the plaintiff must first raise the issue when the agency holds a public hearing on the matter.

The game will never, ever be the same.

The slayage is so real.

Join us in making lemonade cocktails in honor of Queen Bey.

Hint: She got it from her mama's mama.

The charismatic and familiar monarch butterfly serves as a flagship species for pollinator conservation, and gives rights-of-way entities opportunities to engage a diverse array of stakeholders who are invested in not only restoring monarch numbers to sustainable levels, but also mitigating many other environmental and economic issues. This pre-publication draft of the TRB National Cooperative Highway Research Program's NCHRP Research Report 942 Pre-Pub: Evaluating the Suitability of Roadway Corridors fo...

Bimonthly newsletter released by the Institute of Transport Studies at Monash University

By Leo Babauta My Zen teacher Susan recently told a group of her students at the end of a Zen meditation retreat, “We’re all monastics now.” In this global pandemic, we’re in an era of isolation, retreat. We’re also in an era of heightened uncertainty. This can be a terrible thing, and drive us to […]

A brilliant, mercurial and often rebellious poet and critic, would-be translator of Jorge Luis Borges and mentor to John Darnielle and many others.

QUEEN ELIZABETH II, 94, is the world's best-travelled monarch and has visited countries all over the world. Prince Philip, 98, often joins her on her many travels - but there's one thing he hates.

YOUNG Princess Elizabeth's night out celebrating VE Day on the streets of London helped turn her into a Queen like no other.

Janelle Monae brought a thinking-human's dance party to Indianapolis to promote standout album 'Dirty Computer.'

Janelle Monae brought a thinking-human's dance party to Indianapolis to promote standout album 'Dirty Computer.'

Watch highlights as Pascal Wehrlein takes a lights-to-flag win in the third Formula E Race At Home Challenge at Monaco which saw a "shunt that never ends" on the opening lap.

A chronology of key events

An overview of Monaco including key facts, political leaders and notes on the media

ADvTECH attributed the expected rise in earnings to one-off transactions including "bargain purchase gains" arising from the Monash SA acquisition, foreign exchange movements and insurance proceeds related to a previously reported fraud event.

The French Riviera (Nice, Cannes, Antibes) and Monaco

The Amateur Traveler talks to to Gary Arndt about the 4 micro-states in Europe: Andorra, Liechtenstein, Monaco, San Marino.  "They all have very unique histories and the one thing that they are all very small"

(Louisiana State University Health Sciences Center) A study conducted at LSU Health New Orleans has shown for the first time that chronic exposure to inhaled nicotine alone increases blood pressure in both the body's general circulation and in the lungs that can lead to pulmonary hypertension. The study also found that nicotine-induced pulmonary hypertension is accompanied by changes in the size, shape and function (remodeling) of the blood vessels in the lung and the right lower chamber of the heart.

Quentin Perraud
Apr 1, 2020; 19:589-607
Research

Prediction of post-operative pulmonary function in lung cancer patients before tumor resection is essential for patient selection for surgery and is conventionally done with a non-imaging segment counting method (SC) or a two-dimensional planar lung perfusion scintigraphy (PS). The purpose of this study was to compare quantitative analysis of PS to single photon emission computed tomography/computed tomography (SPECT/CT) and to estimate the accuracy of SC, PS and SPECT/CT in predicting post-operative pulmonary function in patients undergoing lobectomy. Methods: Seventy-five non-small cell lung cancer (NSCLC) patients planned for lobectomy were prospectively enrolled (68% males, average age 68.1±8 years ). All patients completed pre-operative forced expiratory volume capacity (FEV1), diffusing capacity of the lung for carbon monoxide (DLCO), Tc99m-MAA lung perfusion scintigraphy with PS and SPECT/CT quantification. A subgroup of 60 patients underwent video-assisted thoracoscopic (VATS) lobectomy and measurement of post-operative FEV1 and DLCO. Relative uptake of the lung lobes estimated by PS and SPECT/CT were compared. Predicted post-operative FEV1 and DLCO were derived from SC, PS and SPECT/CT. Prediction results were compared between the different methods and the true post-operative measurements in patients who underwent lobectomy. Results: Relative uptake measurements differed significantly between PS and SPECT/CT in right lung lobes, with a mean difference of -8.2±3.8, 18.0±5.0 and -11.5±6.1 for right upper, middle and lower lobes respectively (p<0.001). The differences between the methods in the left lung lobes were minor with a mean difference of -0.4±4.4 (p>0.05) and -2.0±4.0 (p<0.001) for left upper and lower lobes respectively. No significant difference and strong correlation (R=0.6-0.76, p<0.001) were found between predicted post-operative lung function values according to SC, PS, SPECT/CT and the actual post-operative FEV1 and DLCO. Conclusion: Although lobar quantification parameters differed significantly between PS and SPECT/CT, no significant differences were found between the predicted post-operative lung function results derived from these methods and the actual post-operative results. The additional time and effort of SPECT/CT quantification may not have an added value in patient selection for surgery. SPECT/CT may be advantageous in patients planned for right lobectomies but further research is warranted.

Objectives: The study compared the diagnostic performance of Planar Ventilation/perfusion (V/Q) and V/Q Single-photon computed tomography (SPECT), and determined whether combining perfusion scanning with low-dose computed tomography (Q-LDCT) may be equally effective in a prospective study of patients with chronic thromboembolic pulmonary hypertension (CTEPH) patients. Background: V/Q scanning is recommended for excluding CTEPH during the diagnosis of pulmonary hypertension (PH). However, Planar V/Q and V/Q SPECT techniques have yet to be compared in patients with CTEPH. Methods: Patients with suspected PH were eligible for the study. PH attributable to left heart disease or lung disease was excluded, and patients whose PH was confirmed by right heart catheterization and who completed Planar V/Q, V/Q-SPECT, Q-LDCT, and pulmonary angiography were included. V/Q images were interpreted and patients were diagnosed as instructed by the 2009 EANM guidelines, and pulmonary angiography analyses were used as a reference standard. Results: A total of 208 patients completed the study, including 69 with CTEPH confirmed by pulmonary angiography. Planar V/Q, V/Q-SPECT, and Q-LDCT were all highly effective for diagnosing CTEPH, with no significant differences in sensitivity or specificity observed among the three techniques (Planar V/Q [sensitivity/specificity]: 94.20%/92.81%; V/Q-SPECT: 97.10%/91.37%, Q-LCDT: 95.65%/90.65%). However, V/Q-SPECT was significantly more sensitive (V/Q-SPECT: 79.21%; Planar V/Q: 75.84%, P = 0.012; Q-LDCT: 74.91%, p<0.001), and Planar V/Q was significantly more specific (Planar V/Q: 54.14%; V/Q-SPECT 46.05%, p<0.001; Q-LDCT: 46.05%, P = 0.001) than the other two techniques for identifying perfusion defects in individual lung segments. Conclusion: Both Planar V/Q and V/Q-SPECT were highly effective for diagnosing CTEPH, and Q-LDCT may be a reliable alternative method for patients who are unsuitable for ventilation imaging.

Bacteria secrete siderophores to access iron, a key nutrient poorly bioavailable and the source of strong competition between microorganisms in most biotopes. Many bacteria also use siderophores produced by other microorganisms (exosiderophores) in a piracy strategy. Pseudomonas aeruginosa, an opportunistic pathogen, produces two siderophores, pyoverdine and pyochelin, and is also able to use a panel of exosiderophores. We first investigated expression of the various iron-uptake pathways of P. aeruginosa in three different growth media using proteomic and RT-qPCR approaches and observed three different phenotypic patterns, indicating complex phenotypic plasticity in the expression of the various iron-uptake pathways. We then investigated the phenotypic plasticity of iron-uptake pathway expression in the presence of various exosiderophores (present individually or as a mixture) under planktonic growth conditions, as well as in an epithelial cell infection assay. In all growth conditions tested, catechol-type exosiderophores were clearly more efficient in inducing the expression of their corresponding transporters than the others, showing that bacteria opt for the use of catechol siderophores to access iron when they are present in the environment. In parallel, expression of the proteins of the pyochelin pathway was significantly repressed under most conditions tested, as well as that of proteins of the pyoverdine pathway, but to a lesser extent. There was no effect on the expression of the heme and ferrous uptake pathways. Overall, these data provide precise insights on how P. aeruginosa adjusts the expression of its various iron-uptake pathways (phenotypic plasticity and switching) to match varying levels of iron and competition.

Monarch butterflies are dying at an alarming rate around the world -- a looming extinction that could also put human life at risk. But we have just the thing to help save these insects, says author Mary Ellen Hannibal: citizen scientists. Learn how these grassroots volunteers are playing a crucial role in measuring and rescuing the monarch's dwindling population -- and how you could join their ranks to help protect nature. (You'll be in good company: Charles Darwin was a citizen scientist!)

Concerned that schools don't notice or nurture business skills, nonprofits are using the humble lemonade stand to foster entrepreneurship.

Edinburgh : Young J. Pentland, 1894.

Philadelphia : Barrington and Haswell, 1850.

Glasgow : Alex MacDougall, 1881.

London : J. Churchill, 1867.

Strasbourg : G. Silbermann, 1865.

Paris : Rueff, 1896.

[between 1700 and 1799]

[between 1700 and 1799]

The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 21 November. Speaker: Professor Roberta Gilchrist (University of Reading), ‘The archaeology of monastic healing: spirit, mind and body’ This paper highlights the potential of archaeology to… Continue reading

At 5,000 years old, the weapon predates the era when humans first started using tin to make bronze

As monarchs leave their winter hideaways, conservationists are seeking assistance in studying their migration routes

In the wild, only about one in 20 caterpillars grows up to be a butterfly