Nathan MacKinnon had his most productive night of the season to pull the Colorado Avalanche out of a funk, but the club's extraordinary injury crisis may have somehow reached a new level.

Dancing across tables with turkey.

The military veteran uses a trash can.

Awareness is just the first step.

Niecy is not having it.

Thanks to a partnership between the Bermuda Zoological Society and the I Am Water Conservation Trust, which is sponsored by XL Catlin, Bermuda’s students are being exposed to our underwater frontiers through a unique programme called Kids on the Reef. A spokesperson said, “Since Bermuda’s formation, the ocean has run through its veins and served […]

“Despite living walking distance to the shoreline, many Bermudian young people have never seen the world just beneath the waves. With no exposure to the wonder and excitement of the ocean, how would Bermuda’s future generations appreciate their own big blue backyard?” – I Am Water Foundation. The Bermuda Zoological Society, and lead sponsor XL […]

The XL Catlin Kids on the Reef programme, a partnership between the Bermuda Zoological Society [BZS] and the I Am Water Foundation, sponsored by XL Catlin has now completed its fifth successful year. The programme brings together world-class free-diving conservationists and local marine ecology educators to take local public middle school students beyond the classroom […]

The Bermuda Underwater Exploration Institute [BUEI] announced that the topic for this month’s ‘Kids Hour Saturdays’ on June 18th is coral reefs. A spokesperson said, “Kids Hours Saturdays’ takes place every third Saturday of the month at 11am and 2pm respectively. Each hour features the screening of short films followed by a book reading for […]

The Clarien Iron Kids Triathlon took place at Clearwater Beach this weekend, with some of the island’s budding athletes in action. The junior triathlon competition offers a chance to win a $1,000 Clarien Iron Kids Bank account, and the event also has a Tiny Tots Race where little ones aged 3 to 6-years-old can take part, […]

The Bermuda Underwater Exploration Institute [BUEI] announced that the topic for this month’s ‘Kids Hour Saturdays’ on March 19 is turtles. A spokesperson said, “Kids Hours Saturdays’ takes place every third Saturday of the month at 11am and 2pm respectively. Each hour will feature the screening of short films followed by a book reading for […]

The Bermuda Underwater Exploration Institute [BUEI] iannounced that the topic for this month’s ‘Kids Hour Saturdays’ is Sea Turtles. A spokesperson said, “On Saturday, June 17th, at both 11am and 2pm, ‘Kids Hour’ will screen an episode of the TV series ‘Ocean Vet’ all about Bermuda’s Green Sea Turtles. This will be followed by a […]

Every year I try to keep an eye out for any children's book that gives ample attention to photographs in some way. Thanks to advances in technology and printing, it's never been easier to make books with photographic images. Yet despite this, few come out. Today's list is a small one, but I'm grateful that each and every single one of these books exists.

This year, ALA established the first Graphic Novels & Comics Round Table (GNCRT). Long gone are the days when we would pooh-pooh anything with a panel or a little sequential art. And so, in celebration of their status, I cast aside the "graphic novel" moniker. Long live, comics! Long live, panels! And long live speech balloons!

So this week, we decided to make a pretty Valentine's canvas for their playroom, that can stay up all year. My kids really love looking at art that they've created and declaring, "I'm the artist! I made that!"

The post Valentine Canvas – Easy Art Project for Kids appeared first on Joyful Abode.

Here's your ultimate guide to declutter kids' clothes and keep the clutter from coming back! A whole new way of thinking about kids' wardrobes.

The post How to Declutter and Simplify Kids’ Clothes – The Ultimate Guide appeared first on Joyful Abode.

I couldn’t believe my eyes as I wandered through IKEA’s soft toy section. There, perched among the bins was Hedwig from Harry Potter. It was then I realized I was staring at IKEA’s new SKOGSDUVA snowy owl hand puppet. The resemblance to Harry’s faithful feathered companion was uncanny. While it might not deliver Hogwarts acceptance letters, it certainly brought a touch of magic to my shopping trip. With its fluffy white feathers and expressive eyes, this soft, cuddly version of […]

The post This Must-Have IKEA Item Completes Your Kid’s Harry Potter Costume appeared first on IKEA Hackers.

I'm dreading the day when I have to explain to my children what a LOLcat was.

In this episode I'm joined by Lewis Ambrose to chat about last night's 4-1 friendly win over Bayer Leverkusen. We analyse the very familiar looking team line-up in the context of Mikel Arteta's comments about needing more from the players we have, leading to discussion of Gabriel Jesus and Kai Havertz among others. There's also some focus on young players like Myles Lewis-Skelly and Ethan Nwaneri after they impress again, but how do you find the balance between their integration and further additions to the squad? There's some transfer discussion, Arteta's pickpocketing high jinx, and a goodbye from an old (angry) friend.

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In the last 48 hours many of Y’s friends have been arrested for being part of an anti-war encampment at their college. I am shocked by the large number of college encampments across the US, but I knew this was coming because Y (who goes by they) has been discussing it for months. We are […]

The post My Jewish college kid is protesting the war in Gaza. And I’m proud. appeared first on Penelope Trunk Careers.

Kids at a tribal school in Arizona are preparing for their own election to determine their favorite school lunch: pizza or chicken nuggets? And they're learning about democracy along the way.

Over the past year, Aya and Khalid have been filming their lives for a BBC documentary.

Shaolin Temple Cultural Centre has been able to expand classes thanks to BBC Children in Need.

This is how mentally deranged liberals are… a Democrat in Minnesota was so filled with rage that Donald Trump won the election last week that he murdered his own wife and kids and then committed suicide to prevent them all from having to live during the next Trump presidency. Notice how you never heard any […]

The post Lunatic Democrat Murders His Wife and Kids Over His Hate for Donald Trump appeared first on The Lid.

Philadelphia and other cities are quietly building installations like the “Urban Thinkscape” to layer on learning where families already spend time. On a tiny triangular lot in the city’s Belmont neighborhood, kids waiting with their parents for the No. 40 bus can also work on their executive functioning skills, playing a hopscotch variation designed to train their brains. In Chicago, a wooden game mounted on the wall of a laundromat teaches children, in two languages, how to find color patterns in a lineup of detergent bottle tops.

Informational text — resources whose purpose is to inform — is essential to daily life and fundamental to literacy. Unfortunately, young children typically have limited exposure to informational text. Two 9-week randomized controlled trials with 263 first-grade children from low-income communities examined whether free educational videos and digital games from the PBS KIDS show “Molly of Denali” supported children’s ability to use informational text to answer real-world questions. Study 1 found significant positive intervention impacts on child outcomes; Study 2 replicated these findings.

The following article, Lunatic Democrat Murders Wife and Kids, Commits Suicide Over His Hate for Donald Trump, was first published on Conservative Firing Line.

This is how mentally deranged liberals are… a Democrat in Minnesota was so filled with rage that Donald Trump won the election last week that he murdered his own wife and kids and then committed suicide to prevent them all from having to live during the next Trump presidency. Notice how you never heard any …

Continue reading Lunatic Democrat Murders Wife and Kids, Commits Suicide Over His Hate for Donald Trump ...

Yi-Han Lin
Dec 1, 2020; 19:2030-2046
Research

Ji Eun Kim
Dec 20, 2020; 0:RA120.002159v1-mcp.RA120.002159
Research

Chiara Pavanello
Dec 1, 2020; 61:1784-1788
Patient-Oriented and Epidemiological Research

Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents the leading cause of morbidity and mortality in FLD cases. However, the prognosis is not known and the rate of deterioration of kidney function is variable and unpredictable from patient to patient. In this article, we present data from a follow-up of the large Italian cohort of FLD patients, who have been followed for an average of 12 years. We show that renal failure occurs at the median age of 46 years, with a median time to a second recurrence of 10 years. Additionally, we identify high plasma unesterified cholesterol level as a predicting factor for rapid deterioration of kidney function. In conclusion, this study highlights the severe consequences of FLD, underlines the need of correct early diagnosis and referral of patients to specialized centers, and highlights the urgency for effective treatments to prevent or slow renal disease in patients with LCAT deficiency.

Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to kidney damage under immunocompromised conditions. However, although AKI has been recognized as a disease with long-term sequelae, partly because of the associated higher risk of chronic kidney disease (CKD), the understanding of kidney pathophysiology at the molecular level and the global view of dynamic regulations in situ after S-AKI, including the transition to CKD, remains limited. Existing studies of S-AKI mainly focus on deriving sepsis biomarkers from body fluids. In the present study, we constructed a mid-severity septic murine model using cecal ligation and puncture (CLP), and examined the temporal changes to the kidney proteome and phosphoproteome at day 2 and day 7 after CLP surgery, corresponding to S-AKI and the transition to CKD, respectively, by employing an ultrafast and economical filter-based sample processing method combined with the label-free quantitation approach. Collectively, we identified 2,119 proteins and 2950 phosphosites through multi-proteomics analyses. Among them, we identified an array of highly promising candidate marker proteins indicative of disease onset and progression accompanied by immunoblot validations, and further denoted the pathways that are specifically responsive to S-AKI and its transition to CKD, which include regulation of cell metabolism regulation, oxidative stress, and energy consumption in the diseased kidneys. Our data can serve as an enriched resource for the identification of mechanisms and biomarkers for sepsis-induced kidney diseases.

Urinary proteomics studies have primarily focused on identifying markers of chronic kidney disease (CKD) progression. Here, we aimed to determine urinary markers of CKD renal parenchymal injury through proteomics analysis in animal kidney tissues and cells and in the urine of patients with CKD. Label-free quantitative proteomics analysis based on liquid chromatography-tandem mass spectrometry was performed on urine samples obtained from 6 normal controls and 9, 11, and 10 patients with CKD stages 1, 3, and 5, respectively, and on kidney tissue samples from a rat CKD model by 5/6 nephrectomy. Tandem mass tag-based quantitative proteomics analysis was performed for primary cultured glomerular endothelial cells (GECs) and proximal tubular epithelial cells (PTECs) before and after inducing 24-h hypoxia injury. Upon hierarchical clustering, out of 858 differentially expressed proteins (DEPs) in the urine of CKD patients, the levels of 416 decreased and 403 increased sequentially according to the disease stage, respectively. Among 2965 DEPs across 5/6 nephrectomized and sham-operated rat kidney tissues, 86 DEPs showed same expression patterns in the urine and kidney tissue. After cross-validation with two external animal proteome datasets, 38 DEPs were organized; only 10 DEPs, including serotransferrin, gelsolin, poly ADP-ribose polymerase 1, neuroblast differentiation-associated protein AHNAK, microtubule-associated protein 4, galectin-1, protein S, thymosin beta-4, myristoylated alanine-rich C-kinase substrate, and vimentin were finalized by screening human GECs and PTECs data. Among these ten potential candidates for universal CKD marker, validation analyses for protein S and galectin-1 were conducted. Galectin-1 was observed to have a significant inverse correlation with renal function as well as higher expression in glomerulus with chronic injury than protein S. This constitutes the first multi-sample proteomics study for identifying key renal-expressed proteins associated with CKD progression. The discovered proteins represent potential markers of chronic renal cell and tissue damage and candidate contributors to CKD pathophysiology.

Linebacker Quinton Bell and Miami Dolphins defenders deleted drives and put the Los Angeles Rams offense in quicksand, holding them without a touchdown to propel a primetime victory and snap a three-game losing streak.

The allergy and asthma drug montelukast, also known as Singulair, can cause psychiatric side effects—and researchers aren’t sure why

Hulu released the trailer for "Nutcrackers" Tuesday. The Ben Stiller holiday comedy premieres Nov. 29.

K-pop group Stray Kids released the Japanese album "Giant" and a music video for its song of the same name.

TED Fellow and composer Sahba Aminikia brings the healing power of dance, storytelling, music and performance to some of the most dangerous places on Earth. By celebrating children and their communities with beauty and joy, he shows how to cultivate hope, connection and love — even in conflict zones. "The ultimate power is in unity," Aminikia says.

Schools are slowly figuring out how to balance thinking globally with acting locally, and recognizing that some key skills are valuable no matter where students end up living.

Two infectious disease experts weigh in on how a COVID-19 vaccine that’s 90 percent effective, as early results are showing, could change school health and safety protocols.

Math teachers share advice for making remote instruction work.

Previous studies can provide a window into why math learning is taking a big hit during the pandemic, and what educators can do about it.

Schools are slowly figuring out how to balance thinking globally with acting locally, and recognizing that some key skills are valuable no matter where students end up living.

Enrollment snags, head-count problems, and more home schooling could end up costing districts millions in funding based on the annual tally of how many students actually show up.

Indiana's magical season makes rare move into the College Football Playoff top five despite an embarrassingly easy schedule

These grounded planes in the Congo have captured the imagination of these children

Quebec provincial police have confirmed that the body found in a Montreal nature park on Oct. 30 was that of kidnapping victim and cryptocurrency influencer Kevin Mirshahi.

Volker (OM Montenegro) describes how their outdoor lessons for Roma kids were threatened by bad weather. Then God provided not only the solution - building a carport as a shelter - but also the funds and manpower needed to build it.