Where did Georgia land in the latest CFP bracket and rankings? Here’s the College Football Playoff picture for the Bulldogs and path to championship.

Georgia football tumbled nine spots in the College Football Playoff rankings Tuesday and fell out of the 12-team bracket. What committee chair said

Nov. 12—The Gonzaga women's basketball team has much to learn after a challenging loss at Stanford on Sunday. Losses have a way of exposing a team's shortcomings. And there is much to learn from the worst loss (89-58) in coach Lisa Fortier's 11 seasons. Stanford, unranked in the preseason poll for the first time since 1999-2000, is unranked no more. The Cardinal (3-0) entered at No. 24 in the ...

Evdokia Menelaou
Aug 8, 2012; 32:10925-10939
BehavioralSystemsCognitive

A slowed-down recording, made as part of a scientific study, shows one dog quickly mimicking another canine's expression during playtime in a park in Palermo. (Video courtesy Elisabetta Palagi)

After a dog digs up a rabbit's nest and leaves a litter exposed, the team at the Toronto Wildlife Center must rehabilitate the malnourished babies before they can be released back into the wild.

Sally, a Labrador retriever, sniffs sock samples and then pauses on the sample worn by a child with malaria. (Durham University/Medical Detection Dogs/London School of Hygiene & Tropical Medicine)

Read more at http://www.smithsonianmag.com/history-archaeology/The-Beer-Archaeologist.html One of the brains behind the famed Delaware brewery talks about what goes into producing one of their beers.

Lola, a Lagotto Romagnolo trained to sniff out and dig up black truffles in her native Washington, is ready for a challenge: to find truffles out of season on a hot day where their distinctive odor dissipates really quickly. Video courtesy of Smithsonian Channel.

Eric Schulze delves into little Rover's mind to see what all that racket is about

Amid rapid global advances and deployment of artificial intelligence technologies, the federal government has invested millions to combine the minds of three existing institutes into one that can keep an eye on potential dangers ahead.

In opening remarks at the Inuit-Crown partnership committee meeting in Ottawa on Friday, Crown-Indigenous Relations Minister Gary Anandasangaree said the government is preparing to deliver an apology in Nunavik — the Inuit region of northern Quebec.

Saskatchewan's Serious Incident Response Team (SIRT) is investigating the role the Moose Jaw Police Service played in a crash that killed a 31-year-old man.

A 43-year-old man is dead after being shot by police at a west-end Hamilton apartment building Saturday, in an incident which also sent an officer to hospital, Ontario's police watchdog says. 

Several firearms, body armour, diamonds and fentanyl shaped like dog treats were among the items seized in a recent bust, say Metro Vancouver Transit Police.

Some might say these feeding numbers are slightly skewed.

SA's financial regulator is investigating allegations that agents of online brokerage Banxso, whose licence has been suspended, contacted clients claiming it has been "cleared".

Elon Musk, alongside Indian-American entrepreneur Vivek Ramaswamy, will lead the 'Department of Government Efficiency' in the Donald Trump-led US government.

डोनाल्ड ट्रंप ने ऐतिहासिक जीत के बाद चुनाव के दौरान दिए 'सेव अमेरिका' के नारे में जमीन पर उतारने की तैयारी शुरू कर दी है. लगातार वह बाइडेन सरकार (Biden Government) पर फिजूलखर्ची के आरोप लगाते चले आ रहे थे. ट्रंप ने बाइडेन सरकार की कई नीतियों की आलोचना भी की थी. साथ ही अवैध इमीग्रेशन के विरोध में सख्त कदम उठाने का भी लोगों से वादा किया है. अब सरकार ने बनने वाली और डोनाल्ड ट्रंप सरकार गठन की प्रक्रिया पूरी कर रहे हैं. उन्होंने सबसे पहले यह बता दिया है कि उनकी सरकार के काम करने का थीम क्या होगा. 

***WARNING: GRAPHIC IMAGE BELOW. MAY TRIGGER.***       DOVER, DE (Aug. 5) – The Office of Animal Welfare’s (OAW) Delaware Animal Services (DAS) is seeking the public’s help with providing any information that may lead to identifying the person responsible for abandoning a dog that was found clinging to life earlier this week. The […]

DOVER, DE (Jan. 11, 2023) –   The Delaware Division of Public Health’s (DPH) Office of Animal Welfare (OAW) and the Delaware State Police (DSP) responded to a complaint of suspicious activity at a Seaford residence over the weekend resulting in charges related to dog fighting and the rescue of 14 dogs. One dog died from the […]

DOVER, DE (Jan. 20, 2023) –   The Delaware Division of Public Health’s (DPH) Office of Animal Welfare (OAW) announces the arrest of a sixth man involved in a Seaford dog fighting incident from January 8. OAW charged Laurel, DE, resident Ronnell Jacobs, age 45, with three felony counts related to dog fighting, and two misdemeanor counts […]

LEWES, Del. (March 29, 2023) – The Delaware Division of Public Health Office of Animal Welfare’s Delaware Animal Services (DAS) is seeking the public’s help with providing any information that may lead to an arrest in an act of animal cruelty. On the afternoon of Friday, March 24, DAS was contacted by Lewes Police who […]

Delaware Animal Services (DAS), the enforcement unit within the Office of Animal Welfare, announces the arrest of a man and a woman involved in an animal cruelty case.  On Aug. 25, 2023, Delaware State Police (DSP) Troop 7 received a tip from a concerned citizen that Dillon Hensey, age 32, and his wife, Chelsie Puckett, age 33, were seen […]

The Delaware Judiciary welcomed its first “facility” or comfort dog to the Leonard L. Williams Justice Center in partnership with the Delaware Capitol Police.

1. Elon Musk, Vivek Ramaswamy to lead DOGE to clean up US bureaucracy: Trump  India Today
2. Trump’s 'Manhattan Project' of government reform: Musk and Ramaswamy to lead efficiency crusade  The Times of India
3. Democrat Senator's 'efficient' dig at Elon Musk-Vivek Ramaswamy heading DOGE  India Today
4. Donald Trump picks Elon Musk, Vivek Ramaswamy to lead newly formed Department of Government Efficiency (DOGE)  The Hindu
5. A dope for DOGE (and Dogecoin): Trump taps Musk in efficiency team, crypto fans rejoice  The Economic Times

BAKU, Azerbaijan — The head of the United Nations' nuclear watchdog said Tuesday he's hopeful that meetings this week with Iranian officials, including the country's new president, can lead to a breakthrough in monitoring the country's nuclear program, a longstanding issue that has gained new urgency as Israel has twice struck Iran amid rising tensions in the Middle East. Rafael Mariano Grossi, director general of the International Atomic Energy Agency, will travel to Iran on Wednesday to meet for the first time with President Masoud Pezeshkian, who was elected in July. Grossi said he hopes to build on positive discussions he had with Iranian Foreign Minister Abbas Araghchi during the U.N. General Assembly in September. "We have a problem that we need to solve," Grossi said in an interview at the U.N. climate conference in Azerbaijan. "That is this gap, this lack of confidence, which we should not allow to grow into a self-fulfilling prophecy of using nuclear facilities as targets." He added: "There has been a bit of a dire straits dynamic with Iran that we want to go beyond." Iran is rapidly advancing its atomic program while increasing stockpiles of uranium enriched to near weapons-grade levels, all in defiance of international demands, according to the IAEA. Iran says its program is for energy purposes, not to build weapons. Grossi's visit comes as Israel and Iran have traded missile attacks in recent months after more than a year of war in Gaza, which is governed by Hamas, a group supported by Iran. Grossi noted that international law prohibits the attack of nuclear facilities and "it's obvious that is something that can have radiological consequences." The Biden administration said last month that it had won assurances from Israel that it would not attack nuclear or oil sites. A 2015 nuclear agreement between Iran and world powers put limits on Iran's nuclear program, which the West fears could be used to make nuclear weapons. The deal included the lifting of economic sanctions on Iran. But that deal collapsed after Donald Trump's administration in 2018 pulled the United States from it. That led Iran to abandon all limits put on its program and enrich uranium to up to 60% purity. When asked if the IAEA feared Iran may be developing a bomb, Grossi said he didn't "have any information that would sustain that." He added that inspectors' job was not to "judge intentions," but rather verify that what Iran says about its nuclear program was true. Trump's reelection last week raises questions about whether and how the incoming administration and Iran may engage. Grossi said he had worked with the first Trump administration, which he said engaged in "seamless, professional work," and looked forward to looking with Trump's second administration. "Circumstances have changed in that the problem has grown bigger than it was," said Grossi. "The problem of not finding a solution."

STOCKHOLM — Lower voter turnout and increasingly contested results globally are threatening the credibility of elections, an intergovernmental watchdog warned on Tuesday, as its sub-index for free and fair elections suffered its biggest decline on record in 2023. In its report, the Stockholm-based International Institute for Democracy and Electoral Assistance (IDEA) said 2023 was the eighth consecutive year with a net decline in overall democratic performance, the longest consecutive fall since records began in 1975. The watchdog bases its Global State of Democracy indexes on more than 100 variables and is using four main categories - representation, rights, rule of law and participation - to categorize performance. The category of democracy related to free and fair elections and parliamentary oversight, a sub-category of representation, suffered its worst year on record in 2023. "This report is a call for action to protect democratic elections," IDEA's Secretary-General Kevin Casas-Zamora said in the report. "The success of democracy depends on many things, but it becomes utterly impossible if elections fail." The think-tank said government intimidation and electoral process irregularities, such as fraudulent voter registration and vote-counting, were increasing. It also said that threats of foreign interference, disinformation and the use of artificial intelligence in campaigns added to challenges. It also said that global voter participation had fallen to 55.5% of eligible voters in 2023 from 65.2% in 2008. Globally, in almost 20% of elections between 2020 and 2024, one of the losing candidates or parties rejected the results. IDEA said that the democratic performance in the U.S., which holds a presidential election this year, had recovered somewhat in the past two years, but the assassination attempt on former President Donald Trump in July highlighted continued risks. "Less than half (47%) of the Americans said the 2020 election was 'free and fair' and the country remains deeply polarized," IDEA said.

Erdogan urged Muslim nations at an Arab League summit in Saudi Arabia to unite against Israel

What is it like to be a dog? And what can we learn from them? Mark Rowlands's take, in his book The Happiness of Dogs, is full of insights, finds Abigail Beall

Four-legged robot dogs learned to perform new tricks by practising in a virtual platform that mimics real-world obstacles – a possible shortcut for training robots faster and more accurately

A 2200-year-old burial ground in northern Italy includes people interred with dogs and horses, perhaps showing they had strong bonds with their animals

Title: Benji, Marley or Bo: Three Genes Dictate Dog's Coat
Category: Health News
Created: 8/27/2009 4:10:00 PM
Last Editorial Review: 8/28/2009 12:00:00 AM

Title: Dog Walking a Treat for Pet and Owner Alike
Category: Health News
Created: 9/1/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: Gene 'Editing' in Dog Study Shows Promise for Kids With Muscular Dystrophy
Category: Health News
Created: 8/30/2018 12:00:00 AM
Last Editorial Review: 8/31/2018 12:00:00 AM

Title: Brutus & Barnaby Pig Ear Treats For Dogs Recalled
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM

Title: Cooler Weather Could Mean More Diabetes in Dogs
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM

Title: Dogs Do Cry When Reunited With Owners
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM

Title: Michigan Officials Puzzled by Mysterious Deaths of 30 Dogs
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

Title: Dogs Get Healthier When People Get Fitter
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are important hepatic transporters. We previously identified OATP1B3 being critically implicated in the disposition of abiraterone. We aimed to further investigate the effects of abiraterone on the activities of OATP1B1 and OATP1B3 utilizing a validated endogenous biomarker coproporphyrin I (CP-I). We used OATP1B-transfected cells to characterize the inhibitory potential of abiraterone against OATP1B-mediated uptake of CP-I. Inhibition constant (K_i) was incorporated into our physiologically based pharmacokinetic (PBPK) modeling to simulate the systemic exposures of CP-I among cancer populations receiving either our model-informed 500 mg or clinically approved 1000 mg abiraterone acetate (AA) dosage. Simulated data were compared with clinical CP-I concentrations determined among our nine metastatic prostate cancer patients receiving 500 mg AA treatment. Abiraterone inhibited OATP1B3-mediated, but not OATP1B1-mediated, uptake of CP-I in vitro, with an estimated K_i of 3.93 μM. Baseline CP-I concentrations were simulated to be 0.81 ± 0.26 ng/ml and determined to be 0.72 ± 0.16 ng/ml among metastatic prostate cancer patients, both of which were higher than those observed for healthy subjects. PBPK simulations revealed an absence of OATP1B3-mediated interaction between abiraterone and CP-I. Our clinical observations confirmed that CP-I concentrations remained comparable to baseline levels up to 12 weeks post 500 mg AA treatment. Using CP-I as an endogenous biomarker, we identified the inhibition of abiraterone on OATP1B3 but not OATP1B1 in vitro, which was predicted and observed to be clinically insignificant. We concluded that the interaction risk between AA and substrates of OATP1Bs is low.

Cannabinoid and opioid receptor activities can be modulated by a variety of post-translational mechanisms including the formation of interacting complexes. This study examines the involvement of endogenous and exogenous chaperones in modulating the abundance and activity of cannabinoid CB₁ receptor (CB₁R), opioid receptor (DOR), and CB₁R-DOR interacting complexes. Focusing on endogenous protein chaperones, namely receptor transporter proteins (RTPs), we examined relative mRNA expression in the mouse spinal cord and found RTP4 to be expressed at higher levels compared with other RTPs. Next, we assessed the effect of RTP4 on receptor abundance by manipulating RTP4 expression in cell lines. Overexpression of RTP4 causes an increase and knock-down causes a decrease in the levels of CB₁R, DOR, and CB₁R-DOR interacting complexes; this is accompanied by parallel changes in signaling. The ability of small molecule lipophilic ligands to function as exogenous chaperones was examined using receptor-selective antagonists. Long-term treatment leads to increases in receptor abundance and activity with no changes in mRNA supporting a role as pharmacological chaperones. Finally, the effect of cannabidiol (CBD), a small molecule ligand and a major active component of cannabis, on receptor abundance and activity in mice was examined. We find that CBD administration leads to increases in receptor abundance and activity in mouse spinal cord. Together, these results highlight a role for chaperones (proteins and small molecules) in modulating levels and activity of CB₁R, DOR, and their interacting complexes potentially through mechanisms including receptor maturation and trafficking.

Putting aside my natural annoyance at Metal Gear Solid Delta: Snake Eater for almost beating out the Twarhammer series in the headline real estate wars, I am more than a little excited to play. Some days, you simply must feast on a tree frog, and while we still don’t have a solid release date, that day doesn’t feel too far away. Good news for stealth fans, and perhaps gooder news for a dozen strapline writers sweating profusely, soiling themselves in anticipation of using “kept you waiting, huh?”.

Until then, I at least have a steady drip feed of new information to keep me sated, the latest of which is the substantial hint that there'll be some new dialogue in the game, as per the video below. Alongside that, the previously pseudonymous Suzetta Miñet - who was credited with voicing EVA in MGS3 and Peace Walker - has revealed herself to be Jodi Benson, the voice of Ariel in Disney’s The Little Mermaid. Cheers for the spot, Automaton West.

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A Spot robot equipped with a blowtorch can locate weeds on farms and precisely heat them up to stop them growing, offering a possible alternative to herbicides

Four-legged robot dogs learned to perform new tricks by practising in a virtual platform that mimics real-world obstacles – a possible shortcut for training robots faster and more accurately

Tech expert Kurt “CyberGuy" Knutsson discusses how MAB Robotics' Honey Badger 4.0, a versatile robot, now walks underwater with amphibious skills.