More than 280 state employees and their family members have registered to show artwork at Delaware State University Art Center/Gallery Dover, Del. (February 17, 2020) – The free exhibition will be open to the public from February 24 to March 25, 2020 at the Art Center/Gallery at Delaware State University, Dover. CANCELED AS OF 3/12/2020 […]

The Delaware Department of Justice’s Office of Civil Rights & Public Trust announced Monday that a grand jury has indicted a Pennsylvania man on two counts of the crime of Abusing a Corpse. In two separate incidents, James T. Schaeffer-Patton, 39, of Pennsylvania is accused of having improperly moved decedents’ bodies during his employment as […]

STANTON (March 2, 2020) – Delaware Division of Public Health (DPH) Director Dr. Karyl Rattay announced at a press conference today that DPH has two Patients Under Investigation (PUIs) for coronavirus disease in Kent County, who had traveled to a country under a travel alert. Three previous PUIs were tested and all came back negative. […]

Division of Historical and Cultural Affairs museums will be closed beginning on March 24, 2020 and their programs postponed until further notice.

Delawareans should wear cloth face coverings in public settings where maintaining social distancing is difficult WILMINGTON, Del. – Consistent with guidance from the Centers for Disease Control Prevention (CDC), the Division of Public Health (DPH) recommended on Wednesday that Delawareans should wear cloth face coverings in public settings where social distancing measures are difficult to […]

Carney signs legislation permanently elevating former Office of Civil Rights & Public Trust Attorney General Kathy Jennings announced Monday that Deputy Attorney General Mark Denney will be tapped to lead the Department of Justice’s new Division of Civil Rights & Public Trust. “The DOJ is the people’s law firm, and the Division of Civil Rights […]

SMYRNA (April 25, 2020) – The Delaware Division of Public Health (DPH) is announcing 12 additional fatalities related to coronavirus disease 2019 (COVID-19) and is providing an update on the number of positive cases and recovered individuals. All data reported through the daily updates are based on data received as of 6 p.m. the previous […]

SMYRNA (April 26, 2020) – The Delaware Division of Public Health (DPH) is announcing 8 additional fatalities related to coronavirus disease 2019 (COVID-19) and is providing an update on the number of positive cases and recovered individuals. All data reported through the daily updates are based on data received as of 6 p.m. the previous […]

Eligible applicants include those that received General Operating Support from FY 18/19/20 or Project Support from FY20 Wilmington, DE (April 30, 2020) – The Delaware Division of the Arts, with support from the National Endowment for the Arts through the Coronavirus Aid, Relief, and Economic Security (CARES) Act, has developed a program to help secure […]

Social distancing recommended in response to state of emergency.

The post Division offices open but electronic interaction urged appeared first on Division of Historical and Cultural Affairs - State of Delaware.

Curator of collections made a lasting impact in presenting and Saving Delaware History.

The post Ann Baker Horsey to retire from the division after 44 years of service appeared first on Division of Historical and Cultural Affairs - State of Delaware.

Former historic-site interpreter served at The Old State House for nearly 10 years.

The post Division mourns passing of Latecia Prophet appeared first on Division of Historical and Cultural Affairs - State of Delaware.

NEW CASTLE (March 9, 2020) – The Delaware Division of Public Health (DPH) advises older Delawareans and people with severe chronic health conditions to follow guidance issued by the Centers for Disease Control and Prevention (CDC) encouraging them to “avoid crowds as much as possible” as a way to reduce their risk of contracting coronavirus […]

DOVER (March 12, 2020) – The Delaware Division of Public Health (DPH) is providing an update on the number of individuals currently being tested for coronavirus disease 2019 (COVID-19). In Delaware, DPH is currently monitoring 35 individuals. A total of 44 individuals have been tested for COVID-19, including the 4 individuals who tested positive for […]

Our next EV will be developed on the dedicated Electric-Global Modular Platform (E-GMP), and that car will be launched globally in early 2021. That platform will be used for Hyundai, Kia and Genesis EVs.

ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

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ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ADB has a vacancy for the position of Intern - Urban Development and Water Division, SERD - 2008 in the Southeast Asia Department. The deadline for submitting applications is on 15 September 2019.

ADB has a vacancy for the position of Intern - Solutions Delivery Division, OIST - 2012 in the Office of Information Systems and Technology. The deadline for submitting applications is on 15 September 2019.

Dentons has advised TSXV listed Bragg Gaming Group Inc., a next generation gaming group, on the sale of its online media division to SN&CK Media Limited. The sale follows a strategic review initiated by CEO, Dominic Mansour, and will allow Bragg to focus its efforts and resources on Oryx,  the group's rapidly growing B2B online gaming business.

ABSTRACT

Transporters belonging to the chromosomally encoded resistance-nodulation-division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria. However, the cotransfer of large gene clusters encoding RND-type pumps from the chromosome to a plasmid appears infrequent, and no plasmid-mediated RND efflux pump gene cluster has yet been found to confer resistance to tigecycline. Here, we identified a novel RND efflux pump gene cluster, designated tmexCD1-toprJ1, on plasmids from five pandrug-resistant Klebsiella pneumoniae isolates of animal origin. TMexCD1-TOprJ1 increased (by 4- to 32-fold) the MICs of tetracyclines (including tigecycline and eravacycline), quinolones, cephalosporins, and aminoglycosides for K. pneumoniae, Escherichia coli, and Salmonella. TMexCD1-TOprJ1 is closely related (64.5% to 77.8% amino acid identity) to the MexCD-OprJ efflux pump encoded on the chromosome of Pseudomonas aeruginosa. In an IncFIA plasmid, pHNAH8I, the tmexCD1-toprJ1 gene cluster lies adjacent to two genes encoding site-specific integrases, which may have been responsible for its acquisition. Expression of TMexCD1-TOprJ1 in E. coli resulted in increased tigecycline efflux and in K. pneumoniae negated the efficacy of tigecycline in an in vivo infection model. Expression of TMexCD1-TOprJ1 reduced the growth of E. coli and Salmonella but not K. pneumoniae. tmexCD1-toprJ1-positive Enterobacteriaceae isolates were rare in humans (0.08%) but more common in chicken fecal (14.3%) and retail meat (3.4%) samples. Plasmid-borne tmexCD1-toprJ1-like gene clusters were identified in sequences in GenBank from Enterobacteriaceae and Pseudomonas strains from multiple continents. The possibility of further global dissemination of the tmexCD1-toprJ1 gene cluster and its analogues in Enterobacteriaceae via plasmids may be an important consideration for public health planning.

IMPORTANCE In an era of increasing concerns about antimicrobial resistance, tigecycline is likely to have a critically important role in the treatment of carbapenem-resistant Enterobacteriaceae, the most problematic pathogens in human clinical settings—especially carbapenem-resistant K. pneumoniae. Here, we identified a new plasmid-borne RND-type tigecycline resistance determinant, TMexCD1-TOprJ1, which is widespread among K. pneumoniae isolates from food animals. tmexCD1-toprJ1 appears to have originated from the chromosome of a Pseudomonas species and may have been transferred onto plasmids by adjacent site-specific integrases. Although tmexCD1-toprJ1 still appears to be rare in human clinical isolates, considering the transferability of the tmexCD1-toprJ1 gene cluster and the broad substrate spectrum of TMexCD1-TOprJ1, further dissemination of this mobile tigecycline resistance determinant is possible. Therefore, from a "One Health" perspective, measures are urgently needed to monitor and control its further spread. The current low prevalence in human clinical isolates provides a precious time window to design and implement measures to tackle this.

Symmetric division of stem cells positive for gastrin receptor CCK2R is linked to gastric cancer.

The Department’s Antitrust Division today announced the appointment of its new leadership team including the Chief of Staff, four Deputy Assistant Attorneys General, and a Special Counsel for Competition Policy. Two Deputies will oversee civil matters, one Deputy will oversee economic analysis and one Deputy will oversee international, policy and appellate issues.