This little snippet can come in handy when you need to serve a different header on a per page basis. All you need to do is create a new header file – header-yourfilename.php and then put in some logic in your desired template file. In my case I have a header file called header-home.php and in my homepage template I ... Read more

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New findings could help researchers and governments decide which trees to prioritise for protection

How is enterprise education different from entrepreneurship education? Why do students need both?

Recent work might have implications for drug development

Smooth engine, plush interiors, great suspension that handle dodgy roads with ease, futuristic design elements that have little by way of competition in the market -- it's all there, says Pavan Lall.

Two shows launched by Vijay TV and Zee Tamil feature actors performing daredevil stunts

This tough, no-frills SUV sure has an air of indestructibility about it thanks to the body-on-frame chassis

You may have form the idea that celebrities are the trendiest person ever, no matter their dressing-up or making-up. Thus keep an eye on what they look is a wise means to keep pace with trend. How to make themselves different from other...

Robert Jenrick says trial in Isle of Wight will inform decision making on technology

Wood Ants Store Short- And Long-Term Memories on Different Sides of Their Brains  ScienceAlert

Since the Middle Ages, alchemists have sought to transmute elements, the most famous example being the long quest to turn lead into gold. Now, Princeton University theorists have proposed a different approach to this ancient ambition — just make one material behave like another. The researchers demonstrate that any two systems can be made to look alike, even if just for the smallest fraction of a second.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Six young people joined STEP OUT 2014 and an outreach in the Philippines to challenge their comfort zones, and they were not disappointed.

The power of unity and the diversity of the body of Christ was enjoyed during an outreach in El Salvador.

Mi 10 5G by Xiaomi has finally made its debut in India. The Xiaomi Mi 10 5G comes in two storage models and is offered in two colour options. Additionally, the phone packs the Qualcomm Snapdragon 865...

Idealist notions of the State overtaking the Market as the one in charge are unfounded.

With more than 49,000 positive Coronavirus cases in India, rolling out a vaccine has become a key focus for Indian scientists and researchers.

From Shoppers Stop to Fujifilm and Nivea, brands take to social media to celebrate Mother’s Day

The possibility of producing shale gas in some European countries has triggered a very heated debate about the environmental and social impacts of the technique used to extract gas from shale rocks (today only in the US and Canada); this technique is widely known as hydraulic fracturing or fracking.

Many families have had to adjust to new routines with the extension of the lockdown. Nathan Adams writes about life in Cape homes in a time of crisis

A new study of London's Bangladeshi community finds that cultural assimilation changes how people engage with the world

Company owners and executives top donors to Republican billionaire

Nov. 15 - Professor Ashutosh Varshney discusses the difference between authoritarian political dispensation and messy democracies.

My firm is registered with my permanent address (say "X") for getting GST & MSME- Udyog Aadhaar Registration Certificate is also done using address "X" & no other additional address was entered during registration.I reside in

Displaying wine is important and how you display matters a lot. There are many different ways to display wines. In this article, we are going to learn some common and useful wine display ideas.

Wine Cooler...

The current humanitarian crisis is unprecedented with an appalling and unacceptable human cost. This issue of Migration Policy Debates looks at the most recent developments in the humanitarian migration crisis and what makes this crisis different from previous ones.

When it comes to labour and migration, global governance of almost any kind is missing. When it comes to labour, the International Labour Organization, which is the oldest among the institutions mentioned here, has little power and deals mostly with national labour rules.

This paper assesses the effect of environmental regulations on plant survival and emissions using data on the extent of vintage differentiation of regulations (VDR5) regarding air pollution emission limit values for existing and new coal-fired power plants. Focussing on NOx and SOx emissions, the paper applies survival analysis techniques on a sample of generating units across 31 OECD and non-member countries between 1962 and 2012.