The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

An aqueous delivery system is described including at least one surfactant and at least one water insoluble wetting agent. Further described are low surface energy substrates, such as microporous polytetrafluoroethylene, coated with such an aqueous solution so as to impart a change in at least one surface characteristic compared to the surface characteristics of the uncoated low surface energy substrate.

A substrate such as a fabric may be provided with a fragrance during washing or rinsing process by the addition to the wash water of a free-flowing solid fragrance-providing composition that comprises a fragrance deposited on a particulate carrier along with a water soluble salt of an alkali metal or an alkaline earth metal.

Long-lasting fragrance delivery systems and uses of the systems to provide fragrance-emitting articles with a long-lasting fragrance are disclosed herein. The long-lasting fragrance delivery systems include an emulsion of silicone-based polyurethane, fragrance, and a carrier.

An approach is disclosed that facilitates context delivery during communication sessions. The approach may be implemented in a computer infrastructure having computer executable code tangibly embodied on a computer readable storage medium having programming instructions operable to: render at least one service to a user device through a communication session; collect information of the communication session; and send the information of the communication session to a service provider when a call is setup between the user device and the service provider. The service provider renders the information of the communication session for viewing by the service provider.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

Disclosed herein are mesocapsules that include agriculturally active ingredients. These mesocapsules are comprised of a polyurea shell and include hydrophilic groups on their surfaces and have a volume-average diameter of about 500 nm or less and some of them have a volume-average diameter on the order of about 300 nm or less. These mesocapsules are suited for delivering active ingredients that are not very soluble in water. Methods for making these mesocapsules include interfacial polycondensation reactions carried out in the presence of surfactants and other methods in which all or most of the surfactant is replaced by adding amino acids to the aqueous phase of the interfacial reaction mixture before forming the final emulsion.

A method of managing content format conversion for transmission of converted content to a mobile device includes retrieving initial content, which includes video content, having a first format over a data communications network. The retrieved initial content is analyzed based on an identification of data delivery parameters relating to potential delivery of converted content and a determination is made as to whether or not the data delivery parameters meet predetermined criteria. The format of the initial content is converted to a second format only in response to a determination that the data delivery parameters meet the predetermined criteria. The converted content forms a message body of a message. A conversion management system configured to manage content format conversion for transmission of converted content to a mobile device, and a computer program for performing the method, are also provided.

A toolholder assembly includes a toolholder body having a coolant passage and a cutting insert seated within a recess of the body. The cutting insert includes an insert orifice extending between a top face and a bottom face that aligns with the coolant passage. A lock pin includes a lock pin orifice that aligns with and is in fluid communication with the coolant passage of the body. The lock pin orifice has an outlet port to allow the fluid to flow through the lock pin orifice and exit through the outlet port. A lock pin ring includes a coolant port in fluid communication with the outlet port of the lock pin to effectively discharge cooling fluid in the direction of a cutting area of the cutting insert.

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

A control system for controlling movement of a medical device delivery system, a stent delivery system and a method for controlling movement of a medical device delivery system are provided. The control system includes a rotatable gear operably connected to a first movable member and a second movable member movable by the rotatable gear. The first movable member is operably connected to the first shaft and the second movable member operably connected to the second shaft. The first movable member moves the first shaft and the second movable member moves the second shaft to change a position of the first shaft relative to the second shaft and to change a configuration of a medical device operably connected to the first shaft and the second shaft.

Endoprothesis delivery systems and methods for making an using the same. An example medical endoprosthesis delivery system may include an inner member. An outer member may at least partially surround the inner member. The inner member and the outer member may be configured so that an implantable medical endoprosthesis can be disposed therebetween. A coupling device may be coupled to a portion of the outer member so that, when there is substantially no slack in the coupling device, as the coupling device moves in a proximal direction the portion of the outer member moves in the proximal direction. An adjustable stop may be coupled to the coupling device so that, when there is slack in the coupling device, as the adjustable stop is moved in the proximal direction, the amount of slack in the coupling device can be reduced.

Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A cap is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.

A pusher assembly for a stent delivery device includes a distal end of an elongate member and a stent-engaging member having proximal and distal ends. The proximal end of the stent-engaging member is mechanically coupled to the distal end of the inner member by a connector, or the proximal end of the stent-engaging member is at least partially inside the distal end of the elongate inner member. The stent-engaging member includes a portion that radially outwardly extends towards the distal end of the stent-engaging member, or the stent-engaging member includes a portion that radially outwardly extends towards the distal end of the stent-engaging member. The stent-engaging member is configured to move a stent when distally advanced and configured to not move a stent when proximally retracted. A stent delivery device includes an elongate outer member, an elongate inner member coaxially positioned within the outer member, and the pusher assembly.

A method includes receiving first information identifying profile information associated with a customer, habit information associated with the customer's television viewing habits, or Internet usage information associated with the customer. The method also includes receiving preference information from the customer, wherein the preference information identifies advertisements or types of advertisements that the customer would like to view or would not like to view. The method further includes identifying advertisements based on the received first information and the received preference information, inserting, by a service provider, the identified advertisements in a television programming data stream and providing the identified advertisements to the customer.

A system and method may provide sets or packets of playing cards for forming part or all of a hand of playing cards. Each set or packet may be formed before starting to form another set or packet. Sets or packets may be formed in respective playing card receiving compartments. The playing cards may be withdrawn from a plurality of playing card receiving compartments of an intermediary playing card receiver in random or pseudo-random fashion, which may, or may not, be based at least in part on the selected payout or house odds and/or house advantage.

A fluid dispensing toothbrush (100). In one aspect, the toothbrush comprises a body (105) having a reservoir (135) containing an oral care fluid (136) therein, the oral care fluid being delivered to an applicator (132) via capillary action. The toothbrush comprises an actuator (130) for moving either the applicator and/or the reservoir between different positions.

In a wireless base station, a specific information receiver receives specific information delivered from a higher-level device to a wireless terminal. A specific information deliverer delivers the specific information to the wireless terminal via multiple physical channels activated in a wireless base station. Where a common channel via which information is periodically broadcast to multiple wireless terminals and a shared channel of which available radio resources are allocated to wireless terminals to transmit voice data and the like to the terminals are activated in the wireless base station, for example, the specific information deliverer can deliver the specific information using the common channel if the wireless terminal is in a standby state, and can deliver the specific information using the shared channel if the wireless terminal is in a communicating state.

A device for deploying a tissue fixation apparatus of the type including first and second tissue anchors coupled together by an adjustable suture assembly. The device comprises a handle mechanism and a needle cartridge assembly releasably coupled to the handle mechanism. The needle cartridge assembly includes a needle cannula with a side opening through which a tissue anchor can be loaded into an internal chamber of the needle cannula. A push rod is disposed in the needle cannula and is operable between an extended position in which the push rod prevents the tissue anchor from entering the chamber through the side opening, and a retracted configuration in which the tissue anchor can be pushed into the chamber under the action of a resilient band positioned over the side opening.

A device for delivering a percutaneous nephrostomy plug is provided. The device comprises a tubular member configured for insertion into a biological body. The device further comprises a handle coupled to a proximal end of the tubular member. The handle comprises a pusher element, an actuation element, and a transmission. The pusher element is disposed within the tubular member, and is configured to deliver a plug through a distal end of the tubular member. The transmission is coupled to the tubular member and the actuation element, and the transmission is configured to cause a retraction of the tubular member relative to the pusher element in response to a depression of the actuation element. A first depression of the actuation element toward the tubular member urges a partial exposure of the plug. A second depression of the actuation element urges a further exposure of the plug.

Devices for attaching a sheet-like implant to a target tissue include a sheath and a staple push rod. The sheath has a distal end configured to be pressed against the target tissue. The staple push rod is disposed within at least a portion of the sheath and is slidable relative thereto. The staple push rod includes a pair of stakes. Each stake is dimensioned to abut a surface of a staple to apply pushing forces thereto. The stakes are biased to assume a bow-like shape such that an intermediate portion of a staple extends tautly between the first stake and the second stake when the stakes are extending beyond the distal end of the tubular member. Methods for attaching a sheet-like implant to a target tissue are also disclosed.

Devices capable of deterring or preventing bulk extraction of drugs from, for example, drug-delivery systems are exemplarily disclosed. In one embodiment, such a device may include a package releasably retaining a drug and an agent. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The cell package is configured such that an amount of the drug is selectively releasable with respect to the agent when the package is operably proximate to an encoded key. The package, however, may be configured to impose a relatively high likelihood that either the drug will not be accessed or the drug will be contaminated by the agent if access to the contents of the package is sought without the use of an encoded key.

A method of enabling administration of a drug includes determining, within a drug-transfer device including cells, a location of at least one cell and generating information identifying the determined location. A user may be provided with the drug-transfer device. The drug is retained within the at least one cell when the user is provided with the drug-transfer device. The method also includes encoding a key with the information and providing the user with the key before, after or when the user is provided with the drug-transfer device. Drug retained within the at least one cell is selectively releasable when the key is operably proximate to the drug-transfer device and is encoded with the information. The key can be encoded with the information before and/or after being provided to the user. In some embodiments, the key is encoded based on instructions transmitted over a network.

A cloud computing system for object location, object identification, object picking, object picking by line, object loading onto one or more transport devices, or object delivery that can include using a cloud based server comprising a cloud based processor in communication with a cloud based data storage. The cloud based server can be in communication with at least one mobile processor in communication with a mobile data storage and a display. The method can also include sending instructions to an operator from the cloud based computer to a mobile processor associated with an operator to instruct the operator to perform a logistics operation. The logistic operation can include one or more of object location, object identification, object picking, object picking by line, object loading onto one or more transport devices, and object delivery.

A system and method for digital management and control of power conversion from battery cells. The system utilizes a power management and conversion module that uses a CPU to maintain a high power conversion efficiency over a wide range of loads and to manage charge and discharge operation of the battery cells. The power management and conversion module includes the CPU, a current sense unit, a charge/discharge unit, a DC-to-DC conversion unit, a battery protection unit, a fuel gauge and an internal DC regulation unit. Through intelligent power conversion and charge/discharge operations, a given battery type is given the ability to emulate other battery types by conversion of the output voltage of the battery and adaptation of the charging scheme to suit the battery.

A water delivery system is provided, comprising at least one faucet device with a cold water faucet part and a hot water faucet part, a cold water line to the at least one faucet device, a tankless heater device for heating water, a hot water line having a first portion running from an outlet of the tankless heater device to the at least one faucet device and having a second portion running from the at least one faucet device to an inlet of the tankless heater device, and a circulatory pump arranged in the second portion of the hot water line, wherein the circulatory pump has a prefixed first performance level and a prefixed second performance level, wherein the first performance level causes a finite water flow in the hot water line which is below an operation threshold value of the tankless heater device.

An automated lumber handling system laser-scans the top profile of multiple stacks of lumber, each of which contain boards of a unique size. Based on the scanned profiles, the system determines the order in which individual boards from a chosen stack should be transferred to a numerically controlled saw. The saw cuts the boards to proper size, and in the proper sequence to facilitate orderly assembly of a roof truss or prefabricated wall. In some examples, the system lifts individual boards by driving two retractable screws, or some other piercing tool, down into the upward facing surface of the board. A track mounted cantilever, holding the screws and a laser unit, translates over the lumber stacks to retrieve and deliver individual boards and, while doing so, the laser repeatedly scans the stacked lumber profiles on-the-fly to continuously update the profiles. The open cantilever design facilitates replenishing the stacks of lumber.

An agricultural implement system that includes a control system configured to receive a first signal to initiate seeding operations, to transition a ground engaging tool toward a working position at a first time after receiving the first signal, and to activate a product delivery system at a second time, different from the first time, after receiving the first signal.

A stack-fold implement having a central bulk fill hopper assembly is provided. The bulk fill hopper assembly is mounted to the center frame section of the stack-told implement and does not affect the narrowness of the stack-fold implement when it's in a stacked, transport position, The hopper assembly includes a pair of bulk fill hoppers or tanks supported by cradle that is in turn supported by a pair of wheels. The cradle is removably coupled to the center frame section by a plurality of rigid frame members.

A seed metering assembly for a farm implement has a meter roller that can be accessed and removed in a relatively quick manner. The seed metering assembly includes a fluted meter roller that is segmented into a number of discrete fluted sections. Each fluted section has an associated flow control member that is selectively operable to impede the flow of granular material from a seed hopper to its corresponding section of the fluted meter roller.

Referring to the drawings, wherein like reference numerals designate identical or corresponding parts throughout the several views, FIG. 1 illustrates a side elevation view of a single row unit (10) of a conventional row crop planter such as the type disclosed in U.S. Pat. No. 7,438,006, the disclosure of which is hereby incorporated herein in its entirety by reference. As is well known in the art, the row units (10) are mounted in spaced relation along the length of a transverse toolbar (12) by a parallel linkage (14), comprised of upper and lower parallel arms (16, 18) pivotally mounted at their forward ends to the transverse toolbar (12) and at their rearward end to the row unit frame (20).

An agricultural implement is provided that includes a first tool bar and a second tool bar each supporting respective ground engaging tools and fluid dispersal components. The second tool bar is pivotally coupled to the first tool bar. The agricultural implement further includes fluid conduits coupled to respective tool bars for conveying fluid to the respective fluid dispersal components. Additionally, each of the conduits has a flexible end adjacent to the other tool bar. Furthermore, the agricultural implement includes a fluid joint coupled between the first and second flexible ends and configured to provide a sealed connection between the first and second flexible ends during relative pivotal movement of the first and second tool bars in operation but to allow for uncoupling of the first and second flexible ends for servicing of the implement.

In a reciprocating piston compressor with delivery rate control, the electromagnetic actuating device (3) of the valve lifter (2) has a separate positioning drive (10) for adjusting the working stroke range of the magnetic actuator (5) used, whereby this can be chosen to be small and highly dynamic and only low power losses occur.

A piston ring has a body member for sitting in a ring groove of a piston. The body member has an inner periphery, upper wall, lower wall and an outer periphery. The outer periphery has a concavity therein for storing lubricant therein. The upper wall has an outer section proximate to the outer periphery is constructed to be resiliently flexible between a flexed and unflexed position such during a portion of a power stroke, the volume of the concavity to store the lubricant is decreased by the flexing of the upper wall to the flexed position for expelling lubricant therefrom to a wall of the cylinder. The wall resiliently returns to the unflexed position during other times to allow excess lubricant from the wall of the cylinder to pass into the concavity.

Embodiments of chemical delivery systems disclosed herein may include an enclosure; a first compartment disposed within the enclosure and having a plurality of first conduits to carry a first set of chemical species, the first compartment further having a first draw opening and a first exhaust opening to facilitate flow of a purge gas through the first compartment; and a second compartment disposed within the enclosure and having a plurality of second conduits to carry a second set of chemical species, the second compartment further having a second draw opening and a second exhaust opening to facilitate flow of the purge gas through the second compartment, wherein the first set of chemical species is different than the second set of chemical species, and wherein a draw velocity of the purge gas through the second compartment is higher than the draw velocity of the purge gas through the first compartment.

The present invention relates to a device for delivering targets (2) comprising at least one column (4) for storing targets (2) capable of receiving a first target (11) at the lowest point of the column (4) and at least a second target (12) stacked on the first target (11), means for delivering the first target (11), and retention means for retaining the second target (12) in the column (4), characterized in that the retention means for retaining comprise a ramp (21) configured to exert a bearing force on the lower face of the second target (12) during the delivery of the first target (11). This invention also relates to a machine for launching targets (2) equipped with a device and a method for distributing the targets (2).

A method of controlling a fluid delivery machine configured to deliver fluid on a worksite is disclosed. In the method, operation of a power source of the fluid delivery machine is controlled with a control module. Fluid delivery on the worksite is also controlled by the control module.

A reductant delivery unit (10) includes a fluid injector (12) and a flange (20) coupled with the fluid injector. An exhaust boss (28) has a surface (39) defining a through-hole (40) that communicates with a vehicle's exhaust flow path. The flange is coupled to a mounting surface such that the outlet of the fluid injector communicates with the exhaust flow path so as to control injection of urea solution into the exhaust gas flow path. A gasket (32) is sandwiched between the flange and the mounting surface. The gasket has a surface (37) defining a through-hole (38) therein that communicates with the through-hole in the exhaust boss to permit the urea solution to pass from the fluid outlet to the exhaust flow path. Gasket shielding structure (44) covers the surface defining the through-hole in the gasket to prevent the urea solution from contacting the gasket.

An approach that analyzes and manages unresolved (i.e., pending, outgoing) change-sets is provided. Specifically, this approach parses the change-set into a plurality (i.e., one or more) of changes having interdependencies within a java class file to determine the impact each change may have. More specifically, a change-set management tool provides this capability. The change-set management tool includes a parsing module configured to receive an outgoing change-set and to parse the change-set into a plurality of changes having interdependencies within a java class file. The change-set management tool further comprises an evaluation module configured to evaluate an impact that each of the plurality of changes within the change-set has on source code external to the change-set in the java class file based on the interdependencies.

A system for development, deliver, deployment and operation of an application includes at least one memory including instructions on a computing device and at least one processor on the computing device. The processor is operably coupled to the at least one memory and is arranged and configured to execute the instructions that, when executed, cause the processor to implement an application within a platform associated with a namespace for the platform, where the platform is one platform of a plurality of platforms. The processor implements a descriptor having an identifier that uniquely associates the descriptor with the application, where the descriptor comprises a single file that is platform independent and that includes a plurality of namespaces and application-specific attributes for each of the namespaces to enable the application to operate on multiple different platforms using the same descriptor.

An exemplary system for delivering a turbomachine fluid to a supplied area is a pump configured to draw fluid from both a first container and a second container when operating in both a positive g-force environment and a negative g-force environment. The fluid from the first container in a positive g-force environment is a mixture of air and oil, and the fluid from the first container in a negative g-force environment is primarily oil.

A USB interface to provide power delivery negotiated through a dedicated transmission channel includes a transmitter circuit including a digital-to-analog converter having an output coupled with an input of a transmission filter, a receiver circuit including an analog-to-digital converter having an input coupled with an output of a receiving filter, and a switching circuit configured in an operating mode of the USB interface to connect an output of the transmission filter and an input of the receiving filter to a connection node of the dedicated transmission channel.

A precision coaxial water jet disruption explosive device system that holds a blasting cap precisely to the surface of a cylindrically cut positioned plastic explosive that couples a detonation shock wave into water surrounding a hollow forming cavity. A pressure relief vent enables the water filled system to be assembled without deforming the thin walled hollow jet forming cavity, enabling forming repeatable supersonic jets on centerline axis. This system is positioned with two triangular pivot legs and aligned with two fan light beams or a line sight to define a projected jet route to deliver a water jet that can cut through over 1 inch of steel and disrupt target objects more than 9 feet away. This system is used to disable improvised explosive devices, and other dangerous objects, without detonating the targeted explosives and electronic devices such that the contents are destroyed without explosion sequences occurring.

The present invention is directed to a mobile platform for the delivery of bulk explosives to a blast hole. One embodiment of the platform provides the ability to obtain weight information relating to the contents of a tank that is associated with the platform and that, in operation, contains either the bulk explosive or a constituent of the explosive. The platform comprises a vehicle with a frame, a tank, a load cell structure for connecting the frame and the tank and providing weight data relating to the contents of the tank, and a suspension system that prevents relative movement of the frame and the tank that could compromise the load cell structure. Another embodiment of the platform provides a tank for holding an explosive composition and a rotary shaft that supports a mixing blade that mixes the explosive composition within the tank. The platform further comprises bearing structure for supporting the rotary shaft that is located to deter any of the explosive composition from entering the bearing. A further embodiment of the platform comprises a conduit structure for discharging a bulk explosive into a blast hole that includes a substantially rigid tube with an outlet port for discharging a bulk explosive into the blast hole. The tube is adapted to rotate about a vertical axis such that the outlet port can be moved towards and away from the vehicle along an arc of less than 180°. In one embodiment, the outlet port can be positioned substantially adjacent to an operator's station to allow an operator to readily view the loading of the explosive into the blast hole.

A beverage flavoring apparatus comprising of an elongated tubular body, having at least three elongated hollow sections and a container for holding liquid flavor. The top hollow section is for suction and at least one of the hollow sections is adapted to receive liquid flavor and it has a smaller cross sectional area and shorter length which enables the flavoring liquid to be introduced into the beverage stream in minute quantity. The other hollow section is adapted to receive beverage. The container is mounted or loaded on the elongated tubular body so that the section adapted to receive liquid flavor is immersed in the liquid flavor while the other hollow section is dipped in a beverage. As oral suction is being applied, both the liquid flavor and the beverage are drawn up the tubular body and mixes at the hollow suction end before ingestion.

The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.

A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents; and related methods.

Disclosed herein is a nutrient delivery system that provides a nutritional formula for consumption. The nutrient delivery system includes a pod and a nutritional powder comprising at least one phospholipid. The nutritional formula has improved characteristics, such as decreased foaming.

A device is provided for collapsing a stented bioprosthetic valve, including first section and second sections, each spanning between first and second ends of the device. The second section of the device is associated with the first section to at least partially enclose an internal cavity formed by the first and second sections, the internal cavity tapering from an open insertion portion at a first end of the device to an open exit portion at a second end of the device. The insertion portion has a larger dimension than the exit portion. When the first section and second section are substantially enclosing the internal cavity, a stented bioprosthetic valve may be inserted into the insertion portion and collapsed as it is moved toward and through the exit portion. The valve may then be loaded on an apparatus for insertion into the body.