Covid-19 is straining supply chains around the world, most notably those of pharmaceutical companies. Scarcity of raw materials upstream and overheated demand downstream cause disruptions. Control over their supply chain is a major challenge for all pharma companies today.

With Covid-19 vaccine delivery highlighting the need for resilience in pharma and biotech supply chains, Karl H. Lauri, managing team member at MRPeasy.com, explains that ERP/MRP gives smaller suppliers the backbone required to take part.

The current crisis in Europe has led to increasing energy insecurity and shortages of raw materials, which are creating severe pharmaceutical manufacturing supply line disruptions. In some cases, supplier lead times have doubled, prices are no longer certain, and orders are subject to cancellations or delays.  

Cost reduction is a focus for many at the moment and understandably so. Multinational pharmaceutical company, Glenmark, is just one of those businesses looking at how it can optimise its costs globally.

By Rudrendu Kumar Paul and Bidyut Sarkar

Embracing the Future of Supply Chain Management: An Exploration of AI's Transformative Impact on Demand Forecasting and its Potential to Navigate Global Uncertainties.

The Threat Intelligence and Incident Response Team at Context Information Security has identified a new threat group behind a series of incidents targeted at the aerospace and defence industries in the UK and Europe.

ON-DEMAND WEBINAR: Responding to aerospace OEM demands with flexible product development.

A variety of pressures are driving change in aerospace and defense supply chains, including less funding and increasing complexity. Aerospace suppliers globally are dealing with product development challenges unlike anything they have seen before, including increasing cost pressures from OEMs, decreasing project timelines, and demanding industry regulations.

Manufacturers now expect logistics suppliers to further integrate with their operating systems DANX Carousel Chief Information Officer, Mohan Palaniandy, has told delegates at a recent supply chain transparency conference.

DHS's new Supply Chain Resilience Center will aim to marshal stakeholders to help avoid the type of shortages and bottlenecks that roiled the country during COVID-19.

The post New DHS supply chain center aims to head off future crises first appeared on Federal News Network.

By Mary Heiser, Director, Industry & Product Marketing, FourKites.

In today’s intricate food and beverage supply chains, ensuring product quality from farm to fork is paramount. One of the most crucial factors determining the integrity of perishable products is temperature. As any supply chain professional knows, even a slight temperature deviation can mean the difference between delivering a delicious ice cream cone or a disappointing puddle.

LGCF, the French wine exporting company, relies on Körber’s Warehouse Management System, Warehouse Control System, voice and gamification solutions to accelerate the performance at 14 logistics sites.

During this exclusive webinar, moderator Jason Miller and agency leaders will explore how organizations are approaching supply chain risk management and the data strategy behind this management.

The post How to develop actionable information to protect federal supply chains first appeared on Federal News Network.

As the world races towards digital transformation, the technologies we choose will have a lasting impact on our planet. Blockchain, NFTs, and other crypto assets have garnered much attention for their ability to securely and immutably store records. However, the environmental cost of maintaining these technologies is often overlooked. The energy consumption required to sustain blockchains, particularly those using Proof of Work (PoW), is enormous...

Location: Electronic Resource- 

Sm Supplier Management Job At Boeing Director Planning & Supply Chain

 As part of its ongoing partnership with DHL Supply Chain, Tesco Ireland has taken delivery of 50 state-of-the-art biomethane fuelled trucks which will operate across its country-wide distribution network.  

 New research from Wincanton reveals that two thirds (66%) of UK organisations say they are under pressure to hit their net-zero targets, with logistics seen as key to achieving their goals in this area, according to 83%.  

Researchers confirm the terror bird fossil 20 years after its South American discovery, comparing the creature to a massive, carnivorous-like ostrich.

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The benefits of short food chains and local produce were the focus of an event on Wednesday 3 July organised by Coventry University’s Centre for Agroecology and Food Security

http://www.musicxray.com/xrays/2672473 Carolyn202 - Breakin' The Chain

72% of FTSE 100 companies list threats to their supply chains amongst their principal risks, shows new research by supply chain management consultancy INVERTO, part of Boston Consulting Group.

When he first heard 8Ball and MJG.

The nucleus of Atlanta rap music.

The Royal Bermuda Regiment is hosting an ongoing Chainsaw Courses, in collaboration with Kingswood Training and Lantra. A spokesperson said, “Led by a team of experienced UK instructors comprising of Mr. Graham Dawdry, Mr. Matt Moss, and Mr. Steve Cackett, this comprehensive course aims to equip soldiers with essential skills in chainsaw maintenance and operation. […]

REVIEW – I’ve been updating my EDC and talking about it on my YouTube channel for the past few months. My next category to discuss is flashlights and it turned out to be a good choice because I was recently offered the chance to review the SPERAS ARC Ti Titanium USB-C keychain flashlight. Let’s check […]

Chipotle’s new chief executive is Scott Boatwright, a familiar face and name, given that he’s served as the interim CEO since August following former CEO Brian Niccol’s surprise decision to lead a turnaround at Starbucks. And while Boatwright, 52, will get a significant pay boost in his new…

Customize a beaded keychain Keep track of your keys (or your prox!). Attach it to a bag, your water bottle, or wear it as a bracelet. All supplies will be provided. Drop-ins welcome! Come for the entire time or only part of the session. Registration is optional, but if you know you’ll be attending please register so we can anticipate the number of people to expect.

Showing off the best parts of the Swiss riding scene, both on small and on big bikes.
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1. iPhone SE 4 expected to launch in March 2025, supply chain data suggests  Business Standard
2. iPhone SE4 is likely to launch soon and here are 5 big upgrades we are expecting  India Today
3. Apple iPhone SE 4 to launch next year, likely to become the cheapest iPhone to support Apple Intelligence...  Moneycontrol
4. iPhone SE 4 may spell trouble for iPhone 16 and premium Android phones, here’s why  Hindustan Times
5. iPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report  Gadgets 360

Continuing to set records, Pepe Unchained recently achieved a new milestone after reaching $26 million. The project’s presale has now… Continue reading As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU

The post As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU appeared first on ReadWrite.

November has turned into a remarkable month for cryptocurrency, with Bitcoin and meme coins like Dogecoin, Shiba Inu, and Pepe… Continue reading Meme Coins Are Soaring as Pepe Unchained Layer 2 ICO Raises $27.5 Million

The post Meme Coins Are Soaring as Pepe Unchained Layer 2 ICO Raises $27.5 Million appeared first on ReadWrite.

Chinese supply chains could tip the balance in Ukraine Expert comment NCapeling 29 March 2023

Disrupting supply chains of critical minerals to those supporting Ukraine could give China a key advantage in its wider international trade competition.

Direct military intervention from China into the war on Ukraine, with Chinese troops and airmen appearing at the front line, would be highly escalatory and highly unlikely.

Equipping Russia with weapons and equipment is much more likely – if indeed it hasn’t already happened – and considering the West is supplying armaments to Ukraine, a joust with western technologies would be an interesting development to follow.

But if Chinese weapons underperform in the heat of battle, this may have implications for the current situation with Taiwan and the US, as a poor outcome on the Ukraine front could give the West more confidence over the tensions in the South China Sea. And the use of Chinese weapons in Ukraine would also be a feast for Western technical intelligence to capture.

Creating economic disruption

A much more likely development for China is to put in place export controls on critical minerals for Western powers supplying arms to Ukraine. This is a significant lever which China has used before during its fishing dispute with Japan in 2010 when hi-tech industrial production in Japan was affected by shortages of China-sourced critical minerals. Once normal supplies were resumed, Japan started to stockpile critical mineral reserves.

In October 2020, the Chinese Communist Party (CCP) passed a new statute enabling – when necessary – restriction of critical mineral supplies to third party nations intending to use them for defence and security applications, adding a ‘versatile weapon to Beijing’s arsenal’ in its trade competition with the US.

That legal control has been applied to Lockheed Martin production of Taiwan-bound F-35s and it applies not only to critical minerals mined on the Chinese mainland, but also to Chinese-controlled enterprises within international supply chains, of which there are many.

Responding to any such restrictions by opening up new mines and setting up new supply chains can take more than a decade, so the countries involved may need to start stockpiling critical materials as Japan has been doing since 2010.

Commodity markets also need to be ready for some interesting price wobbles – a persistent problem in critical minerals extractives investment as is overcoming environmental, social, and governance (ESG) challenges in this new game of global supplies.

In addition, those markets include the London Metal Exchange, now owned by Hong Kong Exchanges & Clearing whose biggest shareholder is the Hong Kong government which is struggling to operate with complete independence from Beijing.

Splitting the West’s consensus

By extending the thinking on China’s potential to throttle global critical mineral supply chains and the ensuing latency of extraction from new mining resources, progress to the Paris Agreement 2050 goals on climate change will inevitably be affected.

Given there are no supply chain assurance mechanisms, such as distributed ledger technologies, in place within global mining supply chains, a key issue to overcome would be how the West assures China that critical mineral supplies are not destined for military applications.

But if China’s default position becomes a total refusal to supply client nations unless end-to-end assurances can be achieved to prove non-military use, the West’s aspirations regarding the Paris 2050 goals will certainly be put in jeopardy, or even made unachievable.

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

Implications of post-COVID-19 Restructuring of Supply Chains for Global Investment Governance 14 July 2020 — 9:00AM TO 10:30AM Anonymous (not verified) 9 February 2021 Online

As companies rethink and diversify their supply chains in order to enhance resilience, what will this mean for current and future global investment governance?

What are the risks of negative effects on inclusivity and transparency? Does this shift create an opportunity to advance good governance of cross-border investment practices?

This event is part of the Inclusive Governance Initiative, which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world.

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we studied the fibril structure of a recombinant light chain fragment corresponding to the fibril protein from patient FOR005, together with fibrils formed by protein sequence variants that are derived from the closest germline (GL) sequence. Both analyzed fibril structures were seeded with ex-vivo amyloid fibrils purified from the explanted heart of this patient. We find that residues 11-42 and 69-102 adopt β-sheet conformation in patient protein fibrils. We identify arginine-49 as a key residue that forms a salt bridge to aspartate-25 in the patient protein fibril structure. In the germline sequence, this residue is replaced by a glycine. Fibrils from the GL protein and from the patient protein harboring the single point mutation R49G can be both heterologously seeded using patient ex-vivo fibrils. Seeded R49G fibrils show an increased heterogeneity in the C-terminal residues 80-102, which is reflected by the disappearance of all resonances of these residues. By contrast, residues 11-42 and 69-77, which are visible in the MAS solid-state NMR spectra, show 13Cα chemical shifts that are highly like patient fibrils. The mutation R49G thus induces a conformational heterogeneity at the C terminus in the fibril state, whereas the overall fibril topology is retained. These findings imply that patient mutations in FOR005 can stabilize the fibril structure.

Africa Aware: Supply chains, land contestation, conflict Audio NCapeling 30 March 2023

This episode examines relations between Ethiopia and Sudan as part of an XCEPT project mini-series.

The war in northern Ethiopia since November 2020, and subsequent conquest of disputed farmlands in Al-Fashaga by the Sudanese army on the Ethiopia-Sudan border, has brought into focus the importance of agricultural commodities such as sesame as a potential driver of land contestation and conflict. 

The panel discusses the interrelation of commodity and conflict supply chains, land contestation, and boundary disputes in the Horn of Africa, with a particular focus on the regions of Wolkait/Western Tigray in northwest Ethiopia and Al Fashaga in eastern Sudan.

This podcast was produced with support from the Cross-Border Conflict Evidence, Policy and Trends (XCEPT) project, funded by UK Aid from the UK government.

Hideaki Kuge
Dec 1, 2020; 61:1747-1763
Research Articles

Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of proteolysis are debated. Identification of the N and C termini of LC fragments is instrumental to understanding involved processes and enzymes. We investigated the N and C terminome of the LC proteoforms in fibrils extracted from the hearts of two AL cardiomyopathy patients, using a proteomic approach based on derivatization of N- and C-terminal residues, followed by mapping of fragmentation sites on the structures of native and fibrillar relevant LCs. We provide the first high-specificity map of proteolytic cleavages in natural AL amyloid. Proteolysis occurs both on the LC variable and constant domains, generating a complex fragmentation pattern. The structural analysis indicates extensive remodeling by multiple proteases, largely taking place on poorly folded regions of the fibril surfaces. This study adds novel important knowledge on amyloid LC processing: although our data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils.

The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has implicated ceramides with different LCBs and N-acyl chains in distinct biological processes; moreover, they may play different roles in disease states and possibly even act as prognostic markers. We now demonstrate that the half-life, or turnover rate, of ceramides containing diverse N-acyl chains is different. By means of a pulse-labeling protocol using stable-isotope, deuterated free fatty acids, and following their incorporation into ceramide and downstream SLs, we show that very-long-chain (VLC) ceramides containing C24:0 or C24:1 fatty acids turn over much more rapidly than long-chain (LC) ceramides containing C16:0 or C18:0 fatty acids due to the more rapid metabolism of the former into VLC sphingomyelin and VLC hexosylceramide. In contrast, d16:1 and d18:1 ceramides show similar rates of turnover, indicating that the length of the sphingoid LCB does not influence the flux of ceramides through the biosynthetic pathway. Together, these data demonstrate that the N-acyl chain length of SLs may not only affect membrane biophysical properties but also influence the rate of metabolism of SLs so as to regulate their levels and perhaps their biological functions.

The plasma membrane of neurons consists of distinct domains, each of which carries specialized functions and a characteristic set of membrane proteins. While this compartmentalized membrane organization is essential for neuronal functions, it remains controversial how neurons establish these domains on the laterally fluid membrane. Here, using immunostaining, lipid-MS analysis and gene ablation with the CRISPR/Cas9 system, we report that the pancreatic lipase-related protein 2 (PLRP2), a phospholipase A1 (PLA1), is a key organizer of membrane protein localization at the neurite tips of PC12 cells. PLRP2 produced local distribution of 1-oleoyl-2-palmitoyl-PC at these sites through acyl-chain remodeling of membrane phospholipids. The resulting lipid domain assembled the syntaxin 4 (Stx4) protein within itself by selectively interacting with the transmembrane domain of Stx4. The localized Stx4, in turn, facilitated the fusion of transport vesicles that contained the dopamine transporter with the domain of the plasma membrane, which led to the localized distribution of the transporter to that domain. These results revealed the pivotal roles of PLA1, specifically PLRP2, in the formation of functional domains in the plasma membrane of neurons. In addition, our results suggest a mode of membrane organization in which the local acyl-chain remodeling of membrane phospholipids controls the selective localization of membrane proteins by regulating both lipid-protein interactions and the fusion of transport vesicles to the lipid domain.

Planet Fitness is seeking to further grow its number of locations in a second bid for the Blink Fitness chain of workout facilities, according to new reports.

Some 250 volunteers transported more than 2,000 books

An Apple supplier may have been tapped to build an Apple-designed smart home camera and future health-focused AirPods, according to analyst Ming-Chi Kuo.

Flathead catfish — native to the Mississippi River basin — were first detected in the Susquehanna River in Pennsylvania in 2002, according to the U.S. Geological Survey. In the two decades since then, the invasive species has spread throughout the river basin. The impact of the large predator on the waterway’s food webs and ecology was unknown, but now a team including researchers from Penn State is beginning to understand what Susquehanna flatheads are eating and how their presence is affecting native aquatic species in the river.

Donna Palumbo-Miele, executive director of the Center for Supply Chain Research at the Penn State Smeal College of Business, has been awarded the 2024 Women in Supply Chain award by Food Logistics and Supply & Demand Chain Executive.

ENS Labs will be launching its own layer-2 blockchain network, called Namechain by the end of 2025. The network is being built atop the Ethereum blockchain and will use scaling technology called zero-knowledge rollups to make transactions more cost and time efficient.