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Fans can attend the red carpet for The Lord of the Rings: The War of the Rohirrim World Premiere in London on Dec 3

On Tuesday December 3, London's iconic Leicester Square will host the World Premiere of the feature-length anime The Lord of the Rings: The War of the Rohirrim ahead of the general film's release on December 13 (note: some locations, such as Japan, are actually getting it a little later).

There will be a slew of cast and crew from the film in attendance: Brian Cox, Gaia Wise, and Laurence Ubong Williams, as well as director Kenji Kamiyama, producers Philippa Boyens, Jason DeMarco, and Joseph Chou, and singer Paris Paloma. Carlos Laloli, Peter Jackson, Ken Kamis, Sam Register, Phoebe Gittins and Arty Papageorgiou will also be there.

Warner Bros. says it will be setting setting up a an area for a "limited number of fans to watch the red carpet arrivals". Warner Bros. also say they are setting up a ballot, and are taking applications for double passes.

Applications will close at 23:59 GMT Wednesday 20th November and winners will be drawn at random.

  • Click here to apply for access to the GENERAL ACCESS FAN AREA
  • Click here to apply for access to the ACCESSIBLE FAN AREA

In addition, there will be a live stream of the red carpet with details to be announced soon. Stay tuned, I guess!

Source: Warner Bros.





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Can't Tell if Epileptic, or Awesome Dancer




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Over half of general election candidates faced abuse

The Electoral Commission has called for action to tackle abuse of candidates during elections.




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Charity wants testing of prostate cancer high risk

Prostate Cancer Research acknowledges more accurate tests would be needed to justify screening all men.




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Mexican city's security chief held over mayor's beheading

The mayor of Chilpancingo, Alejandro Arcos, was murdered just days after taking office last month.




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Can GABA and L-Theanine Supplements Together Help With Stress and Anxiety?

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AI-Driven Liquid Biopsy Enhances Early Detection of Ovarian Cancer

Highlights: AI-powered liquid biopsy detects ovarian cancer early Combines DNA fragment analysis and biomarkers




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Rucking: The Ultimate Full-Body Workout You Can Start Today

Highlights: Rucking is a full-body workout that originated in the military, involving walking with a weighted b




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Want to Prevent Prostate Cancer Naturally? Try Button Mushroom Supplement

An investigational white button mushroom supplement shows promise in slowing and even preventing the spread of prostate cancer among men participating




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Can GABA and L-Theanine Supplements Together Help With Stress and Anxiety?

GABA and L-theanine are often used to reduce stress. While promising, there's limited research on their combined use, making healthcare consultation essential.




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AI-Driven Liquid Biopsy Enhances Early Detection of Ovarian Cancer

A breakthrough AI-powered liquid biopsy combining cell-free DNA and protein biomarkers improves early detection of ovarian cancer, aiding in accurate screening.




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Want to Prevent Prostate Cancer Naturally? Try Button Mushroom Supplement

Food as Medicine to Fight Prostate Cancer: White button mushroom supplement can keep prostate cancer at bay.




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Rucking: The Ultimate Full-Body Workout You Can Start Today

What is rucking? Discover how this military-inspired workout can boost your fitness, strengthen your core, and improve your overall health.




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Booking.com’s DMA deadline is approaching — what can hoteliers expect?

On May 13th 2024, Booking.com was the only Online Travel Agency (OTA) to be designated as a “gatekeeper” under the EU’s new Digital Markets Act, meaning they had six months to comply with the law’s stringent regulations.




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Delhi HC orders cancellation of LOC issued against Ashneer Grover and his wife

The Delhi High Court has ordered the Bureau of Immigration to cancel a Look Out Circular (LOC) issued against BharatPe's former Managing Director Ashneer Grover and his wife Madhuri Jain Grover.




can

India hosts senior cancer physicians, policymakers from Bay of Bengal countries

India hosted senior cancer physicians and policymakers from BIMSTEC countries during the annual meeting of National Cancer Grid (NCG) held at Mumbai's Tata Memorial Hospital.




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Bad Hires Can Cost You Thousands to Replace — and AI May Be to Blame. Try These 3 Ways to Ensure You Don't Fall Into Its Trap.

Over-relying on AI-driven hiring tools means taking human intuition out of the hiring process. The result? You miss out on top talent and risk stifling long-term growth.




can

Dejo Kappan vs Deccan Herald on 7 November, 2024

Dr. A.K.Jayasankaran Nambiar, J.

These writ petitions raise an interesting question as regards the scope, content and extent of the right to freedom of speech and expression enuring to the media when they report facts about ongoing criminal investigations or the proceedings in cases pending adjudication before the various adjudicatory forums in the country. The writ petitions were initially considered by a Full Bench of this Court. However, by an order dated 24.05.2018, the Full Bench took the view that in the light of an earlier decision of another Full Bench of this Court in S. Sudin v. Union of India and Others - [2015 (2) KLT 296 (FB)], these matters needed to be referred to a Larger Bench of five Judges for consideration. It is thus, and pursuant to an order dated 02.09.2024 of the Hon'ble the Acting Chief Justice, that these matters are now before us.




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Servicii AI pentru Bazilica Sf. Petru lansate de Vatican înainte de anul jubiliar

Vatican a lansat o serie de servicii noi bazate pe inteligență artificială pentru Bazilica Sf. Petru, permițând acces virtual la comorile arhitecturale din perioada Renașterii și tururi îmbunătățite pentru vizitatori – zilnic aproximativ 40.000-50.000 de oameni. Noile experiențe au fost prezentate în pregătirea pentru Anul Sfânt sau Jubileul Bisericii Catolice din 2025, care are loc ...

The post Servicii AI pentru Bazilica Sf. Petru lansate de Vatican înainte de anul jubiliar appeared first on Forbes Romania.




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A formal (3 + 2) annulation–Cannizzaro cascade of bifunctional peroxides for the synthesis of dihydrofurans

Org. Chem. Front., 2024, 11,2215-2219
DOI: 10.1039/D4QO00215F, Research Article
Yiwei Chen, Min Gao, Qianlan Xu, Jiumeng Zhang, Lin Hu
Tunable tandem processes of bifunctional peroxides allow the divergent construction of functionalized dihydrofurans and epoxides by simply changing the basic conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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New treatment option for young women with hormone-sensitive breast cancer

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.




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Waqf Board can initiate criminal proceedings in post-2013 Waqf land encroachment cases

A Single Judge of the Kerala High Court quashed the proceedings against two people in an alleged pre-2013 land encroachment case on Tuesday by noting that such acts were made punishable only through an amendment to the Waqf Act in 2013, the accused were in possession of the property even before the introduction of the amendment, and no penal acts could be given retrospective operation




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Canada: Peel Police requests temple body to postpone event amid 'threats'




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Gujarat: Consumers can lodge electricity-related complaints online at any time




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‘Unfortunate that Congress failed to rein in its rebel candidates…effect could be felt in 7-8 seats’: NCP leader Jayant Patil




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[LINK] Mark Boulton on “A Richer Canvas”

I won’t lie to you: I might’ve pounded the table emphatically a few times while reading Mark Boulton’s latest entry:

We can now design effective adaptive layouts that respond to their environment. If these layouts are based on a system that defines its ratios from the content, then there is connectedness on two levels: connectedness to the device, and connectedness to the content.

Mark’s thinking about flexible, content-driven grids has me damned excited about his upcoming talk at AEA Boston, and you know I’ll be flinging fistfuls of lucre at my laptop screen whenever his new book’s available to preorder.

The web really feels fun again.




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Oxygen vacancy-induced efficient hydrogen spillover in Ni17W3/WO3−x/MoO3−x for a superior pH-universal hydrogen evolution reaction

J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D4TA00729H, Paper
Open Access
Yiqing Sun, Yiwei Bao, Di Yin, Xiuming Bu, Yuxuan Zhang, Kaihang Yue, Xiaoshuang Qi, Ziyan Cai, Yongqiang Li, Xiulan Hu, Johnny C. Ho, Xianying Wang
By regulating the oxygen vacancy in the WO3−x/MoO3−x support synergistically, the active phase transition can be accomplished at low voltage, resulting in fast intermediate hydrogen uptake/transfer/desorption kinetics on the prepared catalyst surface and interface.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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In situ analysis of the oxygen evolution reaction on the CuO film in alkaline solution by surface interrogation scanning electrochemical microscopy: investigating active sites (CuIII) and kinetics

J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D4TA00628C, Paper
Seokjun Han, Jinoh Yoo, Won Tae Choi
Surface interrogation scanning electrochemical microscopy was employed to assess the electrocatalytic activity of CuO films for the oxygen evolution reaction in an alkaline solution.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Constructing vacancy-rich metal phosphates by the spatial effect of ionic oligomers for enhanced OER activity

J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D4TA01706D, Paper
Yida Zhao, Xinyu He, Xiaoming Ma, Zhengxi Guo, Menghui Qi, Zhaoming Liu, Ruikang Tang
By rationally selecting ionic oligomers as building blocks, sub-nano-sized gaps can be constructed in the solid structure of catalysts. This can overcome the inherent limitations associated with vacancy formation of the traditional nucleation pathway.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A New 3D Scan, Created from 25,000 High-Resolution Images, Reveals the Remarkably Well-Preserved Wreck of Shackleton’s Endurance

Photos on this page courtesy of the Falklands Maritime Heritage  Few who hear the story of the Endurance could avoid reflecting on the aptness of the ship’s name. A year after setting out on the Imperial Trans-Antarctic Expedition in 1914, it got stuck in a mass of drifting ice off Antarctica. There it remained for ten months, […]




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Farmers want baby canal alongside Kalingarayan Canal to be developed

A proposal to set up an effluent treatment plant and to carry out concrete lining of the baby canal, submitted in 2021-22, is under government’s consideration, says a senior official in the Water Resources Department




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IndiGo, Air India cancel flights to Bali following volcanic eruption

The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds




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Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics

RSC Med. Chem., 2024, 15,3639-3651
DOI: 10.1039/D4MD00183D, Review Article
Abdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke Hisamatsu
TRAIL induced apoptosis signalling by death receptors (DR4/DR5).
The content of this RSS Feed (c) The Royal Society of Chemistry




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Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Peddapalli goods train derailment: Several trains cancelled or diverted

Three railway lines were affected in the derailment. Some trains skipped stoppages.




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Only education can empower women: Siddaramaiah




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Delhi HC sets aside Centre’s order cancelling U.S.-based professor’s OCI card

On the govt.’s allegation of his being involved in “anti-India activities”, the court says the notice lacks specific details or evidence supporting these claims




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The globally-acclaimed Candlelight Concert is now in Chennai. Listen to classical and contemporary music at Museum Theatre, amidst thousands of candles

The first concert on November 15 will feature tunes from Tamil and Hindi films, followed by tributes to Coldplay, Mozart, Queen, and Abba in the upcoming months



  • Life & Style

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Watch: Can Trump’s win make it worse for Indian economy? | Business Matters

Private investment hasn’t really taken off as expected and industry watchers ascribed that to lack of adequate demand. With Trump slated to be next in the White House, how dark do things really look for India?




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African swine fever: culling of pigs complete at Kottiyur in Kannur

A 48-member rapid response team led by District Animal Husbandry Officer Dr. V. Prasanth and Chief Veterinary Officer Dr. P. Biju oversaw the culling of 193 pigs across three farms




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Republicans complete power takeover with House majority

After more than a week of vote counting Republicans party had reached the 218 seats needed to retain their majority in the 435-seat lower chamber, having already seized the Senate from the Democrats.




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In Beed, Independent candidates on strong footing against party nominees

Candidates who rebelled against party diktat stand out with strong support at the ground level and also have high chances of winning the seat




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Andhra Pradesh Government will fill all vacant teacher posts next year: Minister Nara Lokesh 

Nara Lokesh said that of the 22,542 posts notified in 1998 DSC, 18,008 candidates were given appointment in 1999




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Visakhapatnam-Gunupur express to be cancelled on some days from November 13 owing to traffic blocks

The cancellation is owing to traffic blocks in the Naupada-Gunupur section of Waltair Division