Welcome to the Resistance, Mooch. Better late than never.

Mandeep Bajaj
Nov 1, 2005; 54:3148-3153
Metabolism

JAMAICA OLYMPIC Association (JOA) President Christopher Samuda believes that his sports administration experience will aid him in helping to finally shape a professional football league in the Caribbean. Concacaf announced Samuda’s appointment to...

Delicious fish dish for a summer night.

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by John Susman.

Berolini : Typis Augusti Petschii, 1828.

Oxford : printed by W. Baxter, 1843.

London : Chapman & Hall, 1908.

The next Egor Zamula? A package of size and skill could be there for the Flyers in the 2020 NHL draft with William Wallinder. By Jordan Hall

Mathieu Wolff
Jan 2, 2019; 39:3-14
Viewpoints

The tuberal hypothalamus is comprised of the dorsomedial, ventromedial, and arcuate nuclei, as well as parts of the lateral hypothalamic area, and it governs a wide range of physiologies. During neurogenesis, tuberal hypothalamic neurons are thought to be born in a dorsal-to-ventral and outside-in pattern, although the accuracy of this description has been questioned over the years. Moreover, the intrinsic factors that control the timing of neurogenesis in this region are poorly characterized. Proneural genes, including Achate-scute-like 1 (Ascl1) and Neurogenin 3 (Neurog3) are widely expressed in hypothalamic progenitors and contribute to lineage commitment and subtype-specific neuronal identifies, but the potential role of Neurogenin 2 (Neurog2) remains unexplored. Birthdating in male and female mice showed that tuberal hypothalamic neurogenesis begins as early as E9.5 in the lateral hypothalamic and arcuate and rapidly expands to dorsomedial and ventromedial neurons by E10.5, peaking throughout the region by E11.5. We confirmed an outside-in trend, except for neurons born at E9.5, and uncovered a rostrocaudal progression but did not confirm a dorsal-ventral patterning to tuberal hypothalamic neuronal birth. In the absence of Neurog2, neurogenesis stalls, with a significant reduction in early-born BrdU⁺ cells but no change at later time points. Further, the loss of Ascl1 yielded a similar delay in neuronal birth, suggesting that Ascl1 cannot rescue the loss of Neurog2 and that these proneural genes act independently in the tuberal hypothalamus. Together, our findings show that Neurog2 functions as a classical proneural gene to regulate the temporal progression of tuberal hypothalamic neurogenesis.

SIGNIFICANCE STATEMENT Here, we investigated the general timing and pattern of neurogenesis within the tuberal hypothalamus. Our results confirmed an outside-in trend of neurogenesis and uncovered a rostrocaudal progression. We also showed that Neurog2 acts as a classical proneural gene and is responsible for regulating the birth of early-born neurons within the ventromedial hypothalamus, acting independently of Ascl1. In addition, we revealed a role for Neurog2 in cell fate specification and differentiation of ventromedial -specific neurons. Last, Neurog2 does not have cross-inhibitory effects on Neurog1, Neurog3, and Ascl1. These findings are the first to reveal a role for Neurog2 in hypothalamic development.

Perhaps the cigar-shaped object is a shard from a shredded planetary body, a computer simulation suggests

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">Squeekville, model train amusement park, on display at Children's ...: Squeekville, model train amusement park, ... http://bit.ly/9x4oFS</span></span>

Report from the Salamu Aleikum outreach among Arabs in Zel am See in Austria.

Crisis Group mourns the passing today of Sandy Berger, a tremendous friend and colleague who worked tirelessly to promote greater peace and security in a troubled world. He died of cancer at the age of 70.

For Immediate Release  SAMUEL MCGARVEY TO REPRESENT DELAWARE IN 2018 POETRY OUT LOUD NATIONAL FINALS IN WASHINGTON Dover, Del. (February 28, 2018) – From a competitive field of 12 Delaware high school students, Samuel McGarvey, a sophomore from Tall Oaks Classical School, earned the title of 2018 Poetry Out Loud Delaware State Champion at the […]

According to officials who traced the movement of the group, the entire group travelled in a second class coach (S9) of AP Sampark Kranti Express. They first got down on March 13 at Ramagundam in Peddapalli district of Telangana.

Around 2,000 Indians will be evacuated from the island nation. And for this purpose two Ships of the navy – INS Jalshwa and INS Magar are being used.

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$73.8m mega-project will be the first of its kind in the city.

France defender Samuel Umtiti has picked up a calf injury in just the second session since Barcelona returned to training from the coronavirus quarantine, the Spanish champions announced on Saturday. Barca said that Umiti picked up an injury to his right calf during Saturday’s training session at the club’s Joan Gamper facility, but did not
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The post Barca’s Samuel Umtiti suffers calf knock in second training session appeared first on Vanguard News.

Quantum computing could change the face of many international development programs, including those involving transport, financial services and health care.

Investors in SkyBridge Capital asked for hundreds of millions of dollars back after the fund suffered a 23% loss in March when investments made by its debt-focused hedge fund managers soured, Anthony...

Boredom can be unpleasant, but we can learn from some of the world's dullest people how to keep ourselves amused, says boredom researcher James Danckert

Title: More Than 4,000 U.S. Kids Hurt Each Year on Amusement Rides
Category: Health News
Created: 5/1/2013 10:35:00 AM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: Make Your Amusement Park Visits Safe
Category: Health News
Created: 5/4/2018 12:00:00 AM
Last Editorial Review: 5/4/2018 12:00:00 AM

We describe an atypical pediatric case of immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, in which formation of spontaneous hematoma of the paraspinal muscles developed. Spontaneous or unprovoked hematomas rarely occur in IgAV. These manifestations have not been described specifically in the pediatric literature as coinciding with IgAV. These findings are alarming for nonaccidental trauma, particularly in a patient without underlying blood dyscrasia. Our objective for this report is to highlight the possible association of muscular hematoma formation with IgAV and to help providers consider this association when trauma and hemophilia has been ruled out.

Virus-like-particle (VLP) influenza vaccines can be given intramuscularly (i.m.) or intranasally (i.n.) and may have advantages over split-virion formulations in the elderly. We tested a plant-made VLP vaccine candidate bearing the viral hemagglutinin (HA) delivered either i.m. or i.n. in young and aged mice. Young adult (5- to 8-week-old) and aged (16- to 20-month-old) female BALB/c mice received a single 3-μg dose based on the HA (A/California/07/2009 H1N1) content of a plant-made H1-VLP (i.m. or i.n.) split-virion vaccine (i.m.) or were left naive. After vaccination, humoral and splenocyte responses were assessed, and some mice were challenged. Both VLP and split vaccines given i.m. protected 100% of the young animals, but the VLP group lost the least weight and had stronger humoral and cellular responses. Compared to split-vaccine recipients, aged animals vaccinated i.m. with VLP were more likely to survive challenge (80% versus 60%). The lung viral load postchallenge was lowest in the VLP i.m. groups. Mice vaccinated with VLP i.n. had little detectable immune response, but survival was significantly increased. In both age groups, i.m. administration of the H1-VLP vaccine elicited more balanced humoral and cellular responses and provided better protection from homologous challenge than the split-virion vaccine.

Balamuthia mandrillaris is an under-reported, pathogenic free-living amoeba that causes Balamuthia amoebic encephalitis (BAE) and cutaneous skin infections. Although cutaneous infections are not typically lethal, BAE with or without cutaneous involvement is usually fatal. This is due to the lack of drugs that are both efficacious and can cross the blood-brain barrier. We aimed to discover new leads for drug discovery by screening the open-source Medicines for Malaria Venture (MMV) Malaria Box and MMV Pathogen Box, with 800 compounds total. From an initial single point screen at 1 and 10 μM, we identified 54 hits that significantly inhibited the growth of B. mandrillaris in vitro. Hits were reconfirmed in quantitative dose-response assays and 23 compounds (42.6%) were confirmed with activity greater than miltefosine, the current standard of care.

Gastric cancer (GC) is the fifth-ranked cancer type by associated mortality. The proportion of early diagnosis is low, and most patients are diagnosed at the advanced stages. First-line therapy standardly includes fluoropyrimidines and platinum compounds with trastuzumab for HER2-positive cases. For recurrent disease, there are several alternative options including ramucirumab, a monoclonal therapeutic antibody that inhibits VEGF-mediated tumor angiogenesis by binding with VEGFR2, alone or in combination with other cancer drugs. However, overall response rate following ramucirumab or its combinations is 30%–80% of the patients, suggesting that personalization of drug prescription is needed to increase efficacy of treatment. We report here original tumor RNA sequencing profiles for 15 advanced GC patients linked with data on clinical response to ramucirumab or its combinations. Three genes showed differential expression in the tumors for responders versus nonresponders: CHRM3, LRFN1, and TEX15. Of them, CHRM3 was up-regulated in the responders. Using the bioinformatic platform Oncobox we simulated ramucirumab efficiency and compared output model results with actual tumor response data. An agreement was observed between predicted and real clinical outcomes (AUC ≥ 0.7). These results suggest that RNA sequencing may be used to personalize the prescription of ramucirumab for GC and indicate potential molecular mechanisms underlying ramucirumab resistance. The RNA sequencing profiles obtained here are fully compatible with the previously published Oncobox Atlas of Normal Tissue Expression (ANTE) data.

We cut our way to the main news…oh look another trading card. I mean…wow that’s a good price for that game…er…excuse me. We do a...

Despite having made 130 more films – including six Tarantinos – Jackson trails king of the curse word Hill. But then he wasn’t in The Wolf of Wall Street …

With the movie industry shut down due to coronavirus, now is a valuable time for us to look back and properly examine the attraction that we have to certain figures. Are we drawn to Tom Hanks because he exudes a sense of benevolent paternalism that we tend to find subconsciously appealing? Do we flock to Marvel films because we seek the clarity of a good-v-evil dynamic in a world where those are becoming increasingly opaque?

And why do people go and see Jonah Hill films? Seriously, why?

Actor took part in the latest episode of Krasinski's YouTube show

Tanguy Ndombele's time at Tottenham could be over after just one year as Barcelona are reportedly ready to offer Samuel Umtiti and Nelson Semedo in exchange for the midfielder.

In that time, Messi has gone from a shy, talented teenager to a six-time Ballon d'Or winner and the world's highest-paid player, but Eto'o said: "He hasn't changed at all. He's still the good person that I knew back then, and that I still know.

Samuel Piette est plus ou moins chaud à l’idée de revenir à Montréal pour reprendre l'entraînement avec ses coéquipiers dans le contexte actuel.

Samuel Clarke knows withdrawing his retirement savings early is not ideal, but he says the coronavirus pandemic and subsequent loss of business has left him no option.

Patients were used as guinea pigs but denied access to resulting therapies. This time, Big Pharma must be held to account

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The year I turned 11, my uncle Josiah Ssesanga was admitted to a hospital in Uganda with meningitis. It was 1994, and he was HIV positive. Between him and death stood a tattered post-civil war health system.

Treatments for HIV and Aids existed in other parts of the world, but in Uganda they were mostly limited to those used in clinical trials. For my uncle’s particular infection – cryptococcal meningitis – there was a drug called Fluconazole. But he didn’t know it existed; regardless, he wouldn’t have been able to afford it. and even among patients who took it, only 12% survived beyond six months.

Related: Macron calls for clinical trials of controversial coronavirus 'cure'

Related: Fear, bigotry and misinformation – this reminds me of the 1980s Aids pandemic | Edmund White

"The Civil Rights Division enforces the Americans with Disabilities Act (“ADA”) and Section 504 of the Rehabilitation Act, and we have a substantial role in implementing Section 508 of the Rehabilitation Act."