amu

Boney Kapoor's Birthday Celebration Featured Cheesecake, Gulab Jamun And More

Anshula shared a heartwarming video from the intimate gathering on Instagram, where Boney Kapoor can be seen feeding cake to everyone.




amu

Kyiv seeks amusement park investors

$73.8m mega-project will be the first of its kind in the city.




amu

President Mohamud Congratulates Trump On Election Victory

[Radio Dalsan] Somali President Hassan Sheikh Mohamud has extended his congratulations to Donald Trump following provisional results indicating his victory in the U.S. presidential election.




amu

President Mohamud Vows to Reintegrate Somali Nationals As Germany Agrees On Deportation Plan

[Radio Dalsan] Somalia is prepared to welcome back its nationals from Germany, particularly those without legal residency, following a meeting between Somali President Hassan Sheikh Mohamud and German Chancellor Olaf Scholz on Wednesday.




amu

Resilient Amu Darya River Basin Sector Development Program

The proposed project will undertake a long-term and strategic approach to deliver climate adaptive solutions for water resources management in the Amu Darya River Basins in Uzbekistan. Predicted climate change impacts include increased temperatures, increased frequency and severity of extreme events such as floods and droughts, and a reduction of water availability and increased variability of water flows in the major river basins. Decreasing availability and increased water requirements by different sectors are leading to a growing seasonal and absolute supply-demand gap.




amu

Why the amazing Altamura Man fossil remains a mystery

A Neanderthal skeleton was discovered encased in rock in an Italian cave 30 years ago, but it hasn’t been studied much due to a long-running impasse about how to safely excavate it




amu

Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5 [Articles]

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC50 and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC50 values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

SIGNIFICANCE STATEMENT

These findings provide valuable insight regarding in vitro testing conditions to investigate the metabolism of new drug candidates and help determine drug safety in neonates. The results presented here also clearly demonstrate the effect that probe selection may have on CYP3A cytochrome P450 inhibition studies.





amu

Hiro Murai to make feature film debut with samurai epic, ‘Bushido’ for A24

The film looks to deliver an exploration of samurai culture in a tumultuous era that aligns with a renewed global interest in samurai narratives, spurred by FX’s ‘Shōgun’




amu

Musou Games on Steam Deck – Samurai Warriors, Dynasty Warriors, Warriors Orochi, Empires, and Much More Tested on Steam Deck OLED

One of the biggest advantages to PC gaming is having access to multiple generations of game releases. We’ve seen entire …




amu

SwitchArcade Round-Up: ‘Umamusume: Pretty Derby’, ‘Super Dark Deception’, Plus Today’s Other Releases and Sales

Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 30th, 2024. In today’s article, we have a handful …




amu

ICMR announces call for CAR proposals under extramural research programme

The Indian Council of Medical Research (ICMR) has issued a call for proposals for its Centre for Advanced Research (CAR) initiative under the Extramural Research Programme, inviting experienced research teams to




amu

Power couple: Anushka Sharma and Virat Kohli enjoy dosa date in Mumbai; fans amused with photoshop pictures

The edited image humorously captioned with "Pov: the one day you miss school," touched fans empathised with Dinesh's plight. Many of them hoped for Virat and Anushka's visit just for Dinesh.




amu

Amul's tribute to The Buckingham Murders: "You made my year," says Kareena Kapoor Khan

Amul has shared a tribute for Kareena Kapoor's role in The Buckingham Murders with a cute picture. Take a look.




amu

FTX bankruptcy estate sues Anthony Scaramucci, FWD.us, others

Bankrupt cryptocurrency company FTX filed 23 lawsuits Friday against Anthony Scaramucci (pictured above), his hedge fund SkyBridge Capital, and other organizations, including Crypto.com and the Mark Zuckerberg-backed lobbying group Fwd.us. These lawsuits are an attempt to claw back money for FTX’s creditors following the company’s collapse. FTX claims that the money targeted in these suits […]

© 2024 TechCrunch. All rights reserved. For personal use only.




amu

K.Sundaramoorthy vs R.S.Amuthan on 24 January, 2019

R.SAKTHIVEL, J.

This Common Judgment will govern the following Civil Miscellaneous Appeals filed assailing the ‘Award dated January 24, 2019, passed in M.C.O.P.No.140 of 2016’ [henceforth ‘impugned Award’], by the ‘Motor Accident Claims Tribunal at Ariyalur (Chief Judicial Magistrate)’ [henceforth ‘Tribunal’]:

(i) C.M.A.No.3927 of 2019 filed by the petitioner seeking enhancement of compensation,

(ii) C.M.A.No.3204 of 2019 filed by the first respondent praying to set aside the impugned Award,




amu

K.Sundaramoorthy vs R.S.Amuthan on 24 January, 2019

R.SAKTHIVEL, J.

This Common Judgment will govern the following Civil Miscellaneous Appeals filed assailing the ‘Award dated January 24, 2019, passed in M.C.O.P.No.140 of 2016’ [henceforth ‘impugned Award’], by the ‘Motor Accident Claims Tribunal at Ariyalur (Chief Judicial Magistrate)’ [henceforth ‘Tribunal’]:

(i) C.M.A.No.3927 of 2019 filed by the petitioner seeking enhancement of compensation,

(ii) C.M.A.No.3204 of 2019 filed by the first respondent praying to set aside the impugned Award,




amu

Ramu vs The Appellate Authority Of on 12 August, 2024

This writ petition has been filed challenging the orders passed by the respondents 1 & 2, thereby rejecting the claim made by the petitioner under Section 23(1) of the Maintenance and Welfare of Parents and Senior Citizens Act, 2007 (hereinafter referred to as “the Act”) and ordered for maintenance of Rs.2,500/- per month, payable by the third respondent to the petitioner.

2. The petitioner is the father and the third respondent is his daughter. The petitioner has one daughter and one son. The petitioner had purchased a house plot comprised in S.F.No.144/2 at Koranampatti, Edappadi Taluk, Salem district, to an extent of 3744½ sq.ft., in which the petitioner also constructed a small hut and living there. It was purchased by him through registered sale deed dated 24.11.2010 vide document No.4313 of 2010. After marriage of the third respondent, due to love and https://www.mhc.tn.gov.in/judis affection, the petitioner had executed settlement deed in respect of the subject property in favour of the third respondent on 13.12.2019 vide registered document No.5380 of 2019. However, the third respondent failed to maintain the petitioner and also threatened the petitioner to vacate the hut which is put up in the settled property.




amu

Reinventing Restaurants: Covid-Era Ideas From Chef Marcus Samuelsson

As restaurants struggle to survive during the Covid-19 pandemic, the Chef-Owner of Red Rooster, Marcus Samuelsson spoke with WSJ’s Lorie Hirose about change, history and hope. Photo: Lev Radin/Zuma Press




amu

Brahmamudi November 12th episode : ఆస్తి కోసం రుద్రాణి కొత్త ప్లాన్ .. ఆఫీసులో రాజ్ టైంపాస్ , కావ్యకి షాక్

భార్యను తన కళ్ల ముందే అవమానించడంతో జీవితంలో ఇంటికి రానని చెప్పి వెళ్లిపోతాడు కళ్యాణ్. కోట్లకు వారసుడైన నా బిడ్డ పేదరికంలో మగ్గిపోకూడదని ఆస్తిని ముక్కలు చేయమని అడుగుతుంది ధాన్యలక్ష్మీ. పనిలో పనిగా రాహుల్‌కు కూడా ఆస్తిలో వాటా ఇవ్వమని రుద్రాణి అడగటంతో ఇందిర, ప్రకాశంలు చీవాట్లు పెడతారు. తాను కోరినట్లు ఆస్తిని పంచకుంటే ఇంట్లో నుంచి




amu

Brahmamudi November 13th episode : రాజ్- కావ్యలకి టెస్ట్ పెట్టిన సీతారామయ్య .. గెలిస్తే కళావతి‌కి జాక్‌పాటే!

ఆస్తి ముక్కలు కాకుండా కావ్య అడ్డుపడుతుందని జాగ్రత్తగా ఉండమని ధాన్యలక్ష్మీని హెచ్చరిస్తుంది రుద్రాణి. ఆస్తిని పంచుతారా? లేదా? అని సీతారామయ్యని ధాన్యలక్ష్మీ నిలదీయడంతో ఇందిర కోప్పడుతుంది. కోడలి మీద చేయి చేసుకునే పరిస్ధితి తీసుకురావొద్దని హెచ్చరిస్తుంది. అప్పూని పిన్ని కోడలిగా అంగీకరిస్తే అందరం కలిసి ఉండొచ్చని అంటాడు రాజ్. ముందు నీ పెళ్లాన్ని నువ్వు ఇంటికి తీసుకురమ్మని




amu

“King Khan Ko Haarana Mushkil Hi Nahi, Namumkin Hai” – Why Shah Rukh Khan Remains Unstoppable!

A 5ft 8 inch guy captured hearts worldwide with his iconic pose-the hand stretch that began in Dilwale Dulhania Le Jayenge and still makes fans want to run into his embrace. Known as the undisputed 'King Khan' of Bollywood, Shah Rukh




amu

Meet Dr Priti Challa, Kangana Ranaut film director Krish Jagarlamudi's second wife, she leads...

The 47-year-old is one of the most renowned gynaecologists and obstetricians in Hyderabad.




amu

State and Business in Tanzania's Development : The Institutional Diagnostic Project [Electronic book] / edited by François Bourguignon, Samuel Mwita Wangwe.

Cambridge : Cambridge University Press, 2023.




amu

1 and 2 Samuel [Electronic book] / V. Philips Long.

Nottingham, England : Inter-Varsity Press ; Downers Grove, Illinois : Intervarsity Press, 2020.




amu

Anna Samuel’s hyper reality cakes come in the form of biryanis and kappa-meen curry

Anna’s cakes are customised to suit client’s tastes and each is a piece of edible art




amu

Poornima Indrajith is a revelation in the Malayalam film ‘Thuramukham’

Poornima Indrajith effortlessly transforms for the role of a lifetime in Rajeev Ravi’s opus Thuramukham




amu

Malayalam scenarist and theatre practitioner Gopan Chidambaram on writing ‘Thuramukham’ and ‘Iyobinte Pusthakam’

TheWriter of two of the best period dramas in the recent history of Malayalam cinema, Gopan Chidambaram talks speaks about how Thuramukham, a play written by his father in 1968, was adapted to the screen and why he often gravitates towards historical tales




amu

Nandini Reddy on ‘Anni Manchi Sakunamule’: I remembered the warmth of my grandmother’s palm

B V Nandini Reddy, director of the Telugu film ‘Anni Manchi sakunamule’, talks about understanding relationships across age groups and what she learnt from Sooraj Barjatya films




amu

Legendary Indian classical dancer Yamini Krishnamurti passes away at 84

Yamini was a celebrated exponent of Bharatanatyam and Kuchipudi, receiving numerous accolades throughout her illustrious career.




amu

‘Bedurulanka 2012’ movie review: A quirky social satire that’s partly amusing, partly patience testing

Written and directed by first-timer Clax, the Telugu dramedy ‘Bedurulanka 2012,’ starring Kartikeya Gummakonda and Neha Shetty, is an indie-spirited narrative that’s delightful in parts 




amu

Pluie noire (1989) / written and directed by Shōhei Imamura [DVD].

[France] : Films sans frontières (FSF), [2005]




amu

La colmena (1982) / directed by Mario Camus [DVD].

[Spain] : Suevia Films, [2001]




amu

The Heterogeneous Effects of Trade across Occupations: A Test of the Stolper-Samuelson Theorem [electronic journal].




amu

Donor-modified asymmetric N/B/O multi-resonance TADF emitters for high-performance deep-blue OLEDs with the BT.2020 color gamut

Chem. Sci., 2024, 15,18135-18145
DOI: 10.1039/D4SC04896B, Edge Article
Open Access
Jing Jin, Zhaolong He, Di Liu, Yongqiang Mei, Jiahui Wang, Huihui Wan, Jiuyan Li
Spiro-acridine modified N/B/O type MR-TADF emitters realized deep blue fluorescence with an EQEmax of 20.5% and CIE (0.147, 0.048), which is state-of-the-art efficiency for N/B/O type deep-blue MR emitters with CIEy approaching the BT.2020 standard.
The content of this RSS Feed (c) The Royal Society of Chemistry




amu

Gukesh the overwhelming favourite in World title match: Nakamura

The American GM believes the Indian has an 80:20 chance of beating Ding; feels no player is going to be super dominant the way Carlsen has been; emphasises the importance of Global Chess League going forward




amu

Chhath Puja: Devotees take dip in Yamuna even as toxic foam floats over river  




amu

Yamuna highly toxic, says Delhi HC, bins plea to allow Chhath Puja rituals on riverbanks

Court dismisses petition against order prohibiting Chhath Puja rituals on Yamuna’s banks, says it can’t let devotees fall sick; have made ample arrangements at 1,000 ghats: Delhi govt. counsel; 4-day festival dedicated to Sun God began on Tuesday




amu

SC verdict on AMU minority status: University’s teachers’ body welcomes judgment

Describing the decision as historic, AMUTA looks forward to the speedy resolution of the minority character case as directed by the norms of the Constitutional Bench




amu

Centre will firmly put forth its stand before Supreme Court on question of AMU's minority status: BJP

BJP to strongly defend Aligarh Muslim University’s minority status in Supreme Court, overruling 1967 judgement




amu

‘Vinaro Bhagyamu Vishnu Katha’ movie review: A concoction of absurd ideas

The twists and turns notwithstanding, it’s tough to sit through the Telugu film ‘Vinaro Bhagyamu Vishnu Katha’




amu

Owaisi hails Supreme Court ruling on AMU’s minority status

The Modi government should take this judgement in its stride, says Asad




amu

CM Revanth Reddy announces resolve to complete pending projects of Palamuru district

Criticises opposition parties for trying to create obstacles in district development  




amu

Amul to enter Europe by end of this month: MD

The company will launch the products in Spain first and then look at expanding to other countries in Europe




amu

Mass fish kill in Ashtamudi triggers panic

Residents started noticing dead fish from Saturday evening and by Sunday morning fish were washed ashore in large numbers. They say leachate released into the lake, resulting in contamination, caused the fish kill. Experts call for a detailed study




amu

Supreme Court clarifies AMU’s minority status, rejects ‘safe haven’ argument for minorities

As part of a seven-judge Constitution bench, Justice Sharma, along with a majority, overruled a 1967 verdict that denied Aligarh Muslim University’s minority institution status.




amu

Kudamurutti riverbank along Konakarai Road raises a stench




amu

Minority tag of AMU: Govt to withdraw plea against HC verdict




amu

Samudrayaan Mission will establish India as a significant contributor to deep-sea research, says scientist




amu

Why Nivin Pauly Is Full Of Rage In Thuramukham

'The audience's ability to connect with the character is what truly matters. For example, in my previous film Kanakam Kamini Kalaham, I played a husband with deep-seated feelings of inferiority. I would take up any role that offers me the scope to perform.'