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A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00193A, Paper
Yinsong Wu, Guanghao Shi, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Xiaobing Wu, Yongjia Shang, Xinwei He
We have developed a cascade annulation strategy triggered by rhodium(III)-catalyzed C–H activation for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines from free NH-sulfoximines with maleimides under mild conditions.
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1

Correction: Recent progress of core-substituted naphthalenediimides: highlights from 2010

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB90045F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sheshanath V. Bhosale, Sidhanath V. Bhosale, Suresh K. Bhargava
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1

Rh(III)-catalysed C-H annulation of cis-stilbene acids with 2-diazo-1,3-diketones: A facile access to 6,7-dihydrobenzofuran-4(5H)-one and α-pyrone scaffolds

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00151F, Paper
Shankaraiah Nagula, Mary Sravani Galla, Nandini B. Kale, Akshay Kumawat, Darshana Bora
An efficient Rh(III)-catalysed C-H functionalization, tandem annulation of cis-stilbene acids using 2-diazo-1,3-diketones was devised. The protocol has solely afforded 6,7-dihydrobenzofuran-4(5H)-ones using alicyclic diazocarbonyls via decarbonylation and α-pyrones with aliphatic diazo...
The content of this RSS Feed (c) The Royal Society of Chemistry




1

2-Azabicyclo[3.2.1]octane scaffold: synthesis and applications

Org. Biomol. Chem., 2024, 22,2902-2915
DOI: 10.1039/D4OB00199K, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mariana Crespo Monteiro, João Rafael Vale, Filipa Siopa
This review focuses on the preparation and applications in total synthesis of 2-azabicyclo[3.2.1]octane structures, a class of natural and synthetic compounds with a range of biological activities.
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1

Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum

Org. Biomol. Chem., 2024, 22,3019-3024
DOI: 10.1039/D4OB00334A, Paper
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
Six unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.
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1

Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics

Org. Biomol. Chem., 2024, 22,2974-2977
DOI: 10.1039/D4OB00278D, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Matthew Nutter, Henry Stone, Michael Shipman, Stefan Roesner
Stereoselective synthesis of both enantiomers of orthogonally protected 1,2-diazetidine-3-carboxylic acid (aAze) from homochiral glycidol and its application in peptidomimetics.
The content of this RSS Feed (c) The Royal Society of Chemistry




1

3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00391H, Communication
Alexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov
3-Halo-1,2-oxazine N-oxide derivatives act as surrogates of vinyl nitrile oxides in tandem [3 + 2]-cycloaddition/[3 + 2]-cyclofragmentation with arynes leading to benzisoxazoles.
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1

Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
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1

An FeCl3-catalyzed three-component reaction for the synthesis of β-(1,2,3-triazolyl)-ketones using DMF as a one-carbon source

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00207E, Communication
Ruilin Fang, Lei Zheng, Xuyang Chen, Can Wang, Yunfeng Chen
FeCl3-catalyzed oxidative condensation of NH-1,2,3-triazoles and aryl methyl ketones and DMF has been reported.
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1

Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00140K, Communication
R. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah Nagarajan
The use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.
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1

K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00488D, Paper
Meng-Yang Chang, Chin-Huey Ho, Hsing-Yin Chen
The K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....
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1

The Hobbit Experience 2014: Adding WebRTC gameplay to the Hobbit Experience

Learn how North Kingdom built an immersive multimedia experience optimized for modern mobile browsers using Web RTC




1

Electric aircraft set to transform urban mobility 

Investors are pouring in billions of dollars into eVTOL project (electric vertical take offs and landing aircraft) to ferry passengers




1

Cabin crew with an invisible cape 

Being a cabin crew member is not a mere job, but an ineffable life experience




1

Blockchain: Piloting the future of aviation

Enables effective solutions that positively impact industry players and end consumers




1

Mission to Net Zero: Aviation’s focus on making sustainable connections 

Flying the cleanest, greenest, youngest fleet possible can be a way towards the goal 




1

Why has private capital not been taken to Indian aviation 

With banks becoming increasingly cautious and credit flows tightening, private capital must be explored and enticed




1

Sarvam AI launches Sarvam 1 for Indic languages

The custom training corpus, Sarvam-2T comprised of 20 percent datasets in Hindi as well as English and programming languages so the AI model can perform multilingual tasks




1

 Instagram downgrades quality of less popular videos

Last year, Meta had admitted in a blog to having separate encoding configurations for different videos based on how popular they were




1

Google expands AI Overviews in Search to more than 100 countries

Earlier this month, the search giant rolled out ads in AI Overviews on mobile but only in the U.S.




1

Indonesia bans sales of Google phones days after blocking Apple's iPhone 16

Indonesia said it has banned sales of smartphones made by Alphabet's Google due to rules requiring the use of locally manufactured components




1

HTML5 Boilerplate 9.0.1 Released

See it on GitHub! View it on npm! This release was kicked off because of Gulp 5. Gulp 5 has breaking changes so we had to work through the upgrade manually. In the process of doing that upgrade we discovered a couple of bugs. Christian Oliff noticed that tests were failing on Windows I noticed […]




1

Karnataka government plans to start 11 medical colleges under contentious PPP model

As of now, the State has 22 government medical colleges in 22 districts while 11 others have no government medical colleges; the PPP model however has been criticised by some experts




1

WHO to evacuate 1,000 Gazan women, children for urgent medical care

Last week, U.N. investigators said Israel was deliberately targeting health facilities in Gaza, and killing and torturing medical personnel there, accusing the country of "crimes against humanity".




1

Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained

India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy




1

COVID-19 resulted in nearly half a million excess deaths, WHO’s global TB report states

Thirty high TB burden countries accounted for 87% of the world’s TB cases in 2022 and two-thirds of the global total was in eight countries including India




1

Wellness retreat that King Charles and Queen Camilla visited in Bengaluru to soon expand to Portugal 

King Charles III and Queen Camilla, who left the retreat after a three-day rejuvenation session, are happy with the expansion plans as this would be closer to the UK, says holistic health practitioner Issac Mathai, who runs the facility




1

Following WHO guidelines for sodium content in packaged food could prevent 3 lakh deaths in India in 10 years: study

Additionally, about 1.7 million new cardiovascular disease cases and 7,00,000 new chronic kidney disease cases could be prevented compared to current practices, the study said




1

Stop abuse of patent monopolies in rare diseases, say patient representatives and treatment activists 

They seek urgent intervention by government, courts, and lawmakers into the issue  




1

Lassa fever: Understanding the risk, response and global threat

The Lassa virus causes Lassa fever, a zoonotic disease; humans usually contract the virus through contact with food or items contaminated by the the Mastomys rat’s urine or faeces.




1

WHO identifies 17 pathogens in urgent need of vaccines

The list reconfirms longstanding priorities for vaccine research and development: HIV, malaria, and tuberculosis -- three diseases that collectively kill nearly 2.5 million people each year




1

'India Is No.1 Country Outside The US...'

'India has the largest slate of local original content outside the US.'




1

'I Didn't Expect To Be Away For 12 Years'

'Personal reasons required me to take some time off.'




1

'Ananya Gives It Her 100%'

'In anything in life, privilege helps.''Privilege means access. Access means connections.''Does it help? Of course, it does. In whatever you do.'




1

Stop iOS10 browser auto-locking

I had twitter open the other day and I had to put my phone down and attend to something else, the timeline happened to be on a looping gif video and I noticed when I came back that my phone was still awake and unlocked the fact that video was in view kept the phone … Continue reading "Stop iOS10 browser auto-locking"




1

Apple iPhone 16 is now banned in THIS country due to...

The ban on the iPhone 16 in Indonesia comes after Apple CEO Tim Cook's visit to Jakarta in April, where he spoke with President Joko Widodo about potential manufacturing plans.




1

Flipkart Big Diwali Sale 2024: Best deals on iPhone 16 Pro Max, others; buy Apple iPad 9th Gen for just Rs...

The iPhone 16 series made its debut in India in September, with the flagship iPhone 16 Pro Max starting at Rs. 1,44,900 for the 256GB variant.




1

OnePlus 13 launched with Snapdragon 8 Gen 4 SoC: Price details, battery and other specifications

While the OnePlus 13 has only been revealed in China so far, speculations are that it will arrive on the global market in the coming months. In India, the phone is expected to be launched in January 2025.




1

25 Billion Kilometers and Broken Voice: The Voyager 1 Saga

NASA's Voyager 1 Faces Technical Glitch in Deep Space, says Girish Linganna




1

21-Day Mars, Moon simulation in Ladakh

The main aim or the analog mission in Ladakh is to explore new possibilities by mimicking the harsh conditions that are found on Mars and the Moon.




1

Is arangetram losing its real purpose?

Despite a deluge of debut performances across the globe, very few young dancers seem to make it to the professional stage




1

How engaged is the 21st century workplace?

A culture of merit, a flexible environment and empowering technology are key to engaging the workforce of today




1

Coping and decision making in the time of Covid-19




1

Leadership in the time of Covid-19 for Family businesses




1

As farm labour diminishes, mechanisation is key for India’s agri-sector growth, says Mahindra & Mahindra’s Sikka 

Hemant Sikka says the farm machinery industry is expected to grow from ₹9,200 crores in financial year 2022 to ₹15,000 crores in financial year 2026.




1

Farmers from flood-ravaged northern States to gather in Chandigarh to press for special package, compensation from Centre 

Farmers associated with as many as 16 farmer outfits from the States Punjab, Haryana, Himachal Pradesh, Rajasthan, Uttar Pradesh, and Uttarakhand would be participating




1

Explained | Why was a 40% duty imposed on onion exports? 

Is there a demand-supply mismatch? Why is the government planning to offload buffer stocks? 




1

Manipur to compensate farmers hit by ethnic violence with ₹38-crore package 

Farmers are afraid to go to the fields because of sporadic firing by armed miscreants from higher grounds 




1

Govt hikes wheat MSP by ₹150 per quintal to ₹2,275/quintal for 2024-25: I&B minister

Currently, the MSP on wheat stands at ₹2,125 per quintal for the 2023-24 marketing season (April-March).




1

Pulses a worry even as kharif grain output may rise 1.5-4%

Production of pulses, some coarse cereals and groundnut seen likely hitting a 3-year low as per initial independent crop estimates; rice, cereals seen buoying overall output this season