A training session designed to improve players' ability in one-on-one and two-on-two situations.

The Russia and MFK Dinamo Moskva forward offers you a futsal masterclass.

A training routine focused on movement, passing and dribbling inspired by the winning France team at UEFA EURO 2000.

We present a practice exercise to improve your team's potency in attack from wide positions.

Catch your opponents cold by improving your team's counterattack with this training exercise.

Penn State Homecoming's Legacy Celebration, a Facebook Live event hosted by Centre County United Way and a new online exhibit by the University Libraries in conjunction with Earth Day are among the virtual highlights at Penn State this weekend and next week.

A virtual Senior Week, the first "We Are Penn State Virtual 5K" and the College of Engineering's Learning Factory Capstone Design Showcase are among the virtual highlights at Penn State this weekend and next week.

There is an urgent need for new, potent anti-tuberculosis (TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3, 4-dihydrocarbostyril derivatives and identified OPC-167832 as having potent anti-tuberculosis activity. The minimum inhibitory concentrations of the compound for Mycobacterium tuberculosis ranged from 0.00024 to 0.002 μg/mL. It had bactericidal activity against both growing and intracellular bacilli, and the frequency of spontaneous resistance for Mycobacterium tuberculosis H37Rv was less than 1.91 x 10^-7. It did not show antagonistic effects with other anti-TB agents in an in vitro checkerboard assay. Whole genome and targeted sequencing of resistant isolates to OPC-167832 identified the decaprenylphosphoryl-β-D-ribose 2'-oxidase (DprE1), an essential enzyme for cell wall biosynthesis, as the target of this compound, and further studies demonstrated inhibition of the DprE1 enzymatic activity by OPC-167832. In a mouse model of chronic TB, OPC-167832 showed potent bactericidal activities starting at a dose of 0.625 mg/kg. Further, it exhibited significant combination effects in 2-drug combinations with delamanid, bedaquiline, or levofloxacin. Finally, 3-4 drug regimens comprised of delamanid and OPC-167832 as the core along with bedaquiline, moxifloxacin, or linezolid showed superior efficacy in reducing bacterial burden and preventing relapse compared to the standard treatment regimen. In summary, these results suggest that OPC-167832 is a novel and potent anti-TB agent and regimens containing OPC-167832 and new or repurposed anti-TB drugs may have the potential to shorten the duration of treatment for TB.

Alejandro Hoberman
Jul 1, 1999; 104:79-86
ARTICLES

Paul L. Aronson
Oct 1, 2014; 134:667-677
ARTICLES

Julie A. Jaskiewicz
Sep 1, 1994; 94:390-396
COMMENTARY

The first defender to win the UEFA Women's Player of the Year award: we salute Lyon and England right-back Lucy Bronze.

The all-time top UEFA women's club scorer among many, many honours: we salute Ada Hegerberg.

The Centre County United Way will host #LIVEUNITEDLive, a Facebook Live concert featuring 25 performers with Centre County or Penn State connections, beginning at 6 p.m. April 24 as a fundraiser for 28 nonprofit human service organizations.

Giving users of smart assistants the option to adjust settings for privacy or content delivery, or both, doesn’t necessarily increase their trust in the platform, according to a team of Penn State researchers. In fact, for some users, it could have an unfavorable effect.

Penn State alumnus and author Paul Levine's latest novel, "Cheater's Game," focuses on the college admissions scandal.

The Sokolov-Miller Family Financial and Life Skills Center at Penn State has a slate of programming for Financial Literacy Month this April and is offering help to anyone in the University community who is anxious about their financial future.

It's not too late to register for Virtual Spring Open House at Penn State York. Discover what the campus has to offer and how to become a part of the blue and white.

Source: www.thestar.com - Friday, May 08, 2020
The unemployment rate jumped 5.2 points in April to 13 per cent in the first full month of economic restrictions.

Students, staff and faculty members from Penn State's College of Education share recent research and career achievements.

Keep up with information about various happenings at Penn State, including study volunteer requests, activities and other opportunities.

Holders Spain are among the 15 teams that came through the elite round to join hosts England in May's finals.

The first defender to win the UEFA Women's Player of the Year award: we salute Lyon and England right-back Lucy Bronze.

The all-time top UEFA women's club scorer among many, many honours: we salute Ada Hegerberg.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

The Chinese government is getting local ISPs and cloud service providers to practice taking websites offline quickly when they are deemed harmful.

Photos are available for media use on Flickr. WILMINGTON — Families and others who want to learn more about buying a home can get a wealth of information at the free Delaware Homebuyer Fair later this month. The April 22 event at the Chase Center on the Riverfront, running from 8 a.m. to 3 p.m., […]

WILMINGTON – Families and others who want to learn more about buying a home can get a wealth of information at the free Delaware Homebuyer Fair this weekend. The April 21 event at the Chase Center on the Riverfront, running from 8 a.m. to 3 p.m., offers educational seminars on every aspect of homebuying, as […]

WILMINGTON, DE – Families and individuals who want to learn more about buying a home can get a wealth of information at the free Delaware Homebuyer Fair scheduled for Saturday, April 13 at the Chase Center on the Riverfront in Wilmington. Running from 8 a.m. to 3 p.m., the fair offers educational seminars on every […]

The final phase of a $690,000 trail-improvement project will limit access to the Cooper Road trailhead for Wintergreen Gorge over the next two weeks. The 14-mile trail system will still be accessible from locations at Penn State Behrend.

Highlights include Buena Vista’s First Annual Spring Open House, The Old State House's Coffee-Hour Lecture Series and programs on Delaware's Dutch heritage.

Guests are encouraged to bring their cameras to capture the awakening of spring at one of Delaware’s most historic properties

(Dover, DE) – This week, Delaware joins libraries nationwide in celebrating the many ways libraries enrich their communities through the transformative services and expertise they offer. April 8-14, 2018 is National Library Week, the annual celebration of the life-changing work of libraries, librarians, and library workers. People of all ages can collaborate, try out new […]

Theatrical murder-mystery based on an actual incident that took place in 1916 in Lewes.

Fun and thought-provoking Constitutional programs to take place on April 4, 11, 18 and 25, 2019.

Highlights include programs on the artist who created "His Master's Voice," the bombardment of Lewes and a festival at Fort Christina.

One-day-only event showcases one of Delaware’s most historic homes.

India's fuel demand dipped 45.8% in April from a year earlier, as a nationwide lockdown and travel curbs to combat the spread of novel coronavirus eroded economic activity. Consumption of fuel, a...

Zoom has gained immense popularity in India despite the government warning against it, and advising users to opt for other alternatives. According to app intelligence firm Sensor Tower, India...

The May 5-7 poll median of more than 40 economists predicted India's annual consumer price inflation fell to 5.68% in April from March's 5.91%.

Non-food credit fell Rs 67,910 crore to Rs 102.17 lakh crore, while food credit fell Rs 1,430 crore to Rs 52,643 crore.

Net flows into mutual funds that invest in equity fell 47 per cent to Rs 6,212 crore in April from Rs 11,722 crore in March, AMFI data showed.

The Delaware Forest Service will hold its 19th annual Fire Camp at Redden State Forest near Georgetown on Saturday, April 26 from 7 a.m. to 6 p.m. The intensive one-day seminar provides hands-on training to volunteer wildland firefighters and, weather permitting, will feature a "live burn" exercise in which crew members battle an actual wildfire.

With a record season behind them, Delaware's farmers' markets are gearing up for another great year. Twenty-three community-run farmers' markets will be opening over the next three months, selling Delaware produce and other farm-fresh goods.

The Delaware Forest Service’s 21st Annual Fire Camp will be held on Saturday, April 23, 2016 at Redden State Forest from 6:45 a.m. to 5 p.m. The intensive, one-day seminar is the capstone of the agency's wildfire training program to certify its emergency firefighters to meet National Wildfire Coordinating Group standards. In addition to completing an arduous "work capacity test" - which involves carrying a 45-pound pack over a three-mile course in less than 45 minutes - crew members will receive hands-on instruction in several key areas: wildfire suppression techniques, how weather affects fire behavior, crew mobilization and teamwork, water pump and chainsaw usage, and culminating with a “live” controlled burn fire situation.

The Delaware Forestry Association (DFA) will present its 2018 “Tree Farmer of the Year” award on Thursday, March 22, at its annual banquet and meeting at the Bridgeville Fire Hall, 311 Market Street, Bridgeville, Delaware 19933, (302) 337-7272. Tickets are $27 for adults, $13.50 for children ages 6 to 12, and free for children 6 and under. Reservations are kindly requested by March 16. The Delaware Forestry Association is also offering its annual $1000 scholarship to a student who chooses forestry or a related major at a two-year or four-year accredited college or university. Applications are due by April 1 and the winner will be notified by May 1.

Volunteers are needed to plant 2,000 hardwood seedlings at Blackbird State Forest on Saturday and Sunday, April 13 and 14, from 9 a.m. to 4 p.m. each day. Two seniors from Middletown High School, Bryan Alberding and Nick Kupsick, are leading the project in cooperation with the Delaware Forest Service and the DNREC Nonpoint Source Program (NPS), which is funding the trees. The project will take place on Blackbird State Forest's Naudain Tract, 2076 Harvey Straughn Road, Townsend, Delaware 19734. The rain date is April 27 and 28, 2019.

 Amends Notification No. 41/1999 – Customs, dated the 28th April, 1999 - This notification exempts specified g

 Compliance with circular dated April 15, 2010

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