Company: P & I Management Consultants
Experience: 7 to 10
location: India
Ref: 24341094
Summary: Job Description: MBA Marketing ,7-10 yr experience in selling Garments for Kids,Gents and Ladies in North India Markets thru Distributor network. Job Description Appoint & Manage Dealer/Distributors. Identifying potential areas in....

The Matthew Hedges case highlights curbs on academic freedom that extend beyond the Gulf

A rock-and-roll artist who overcame misfortune and became a key US cultural figure

A trailblazing satirist who battled racial injustice in America

A specific type of small startup has a window to raise crowdfunding in a somewhat less regulated way than normally required in the US based on a temporary set of rule changes by the SEC announced this week. Excited yet?

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

Deepika Padukone is not only a prolific actress, who has been upping her acting game but she is also a saree connoisseur. With her resplendent sarees, the actress has inspired the young ladies of today to drape sarees. In

The Kansas City Chiefs will look to repeat as Super Bowl champions in 2020, but their regular season schedule won't offer any concessions.

In many species, mating comes at the steep price of an organism's life, an evolutionary process intended to regulate reproductive competition. But Princeton University researchers report that males of the roundworm species Caenorhabditis elegans have doubled down with two methods of checking out after reproducing — a lethal gene activated after mating, and pheromones released by other males. The findings provide insight into how aging, longevity and population are naturally regulated for different species and sexes.

PHILADELPHIA (April 29, 2020) — The U.S. Environmental Protection Agency announced today that Lea Wang, a sophomore at Council Rock High School in Holland, Pennsylvania, is the 2019 winner of a President’s Environmental Youth Award (PEYA) for EPA’s Mid-Atlantic Region.

PHILADELPHIA (April 29, 2020) – The U.S. Environmental Protection Agency announced today that science teacher Ann Strozyk from the Howard County Public School District in Maryland is a 2019 winner of a Presidential Innovation Award for Environmental Educators (PIAEE).

Environmental News FOR IMMEDIATE RELEASE

Environmental News FOR IMMEDIATE RELEASE

DENVER (April 23, 2020)) - Today, the U.S. Environmental Protection Agency (EPA) recognized Sprouts Farmers Market Store #305 in Aurora, CO and Sprouts Farmers Market Store #325 in Englewood, CO, with 2019 Food Recovery Challenge Regional Awards.

Environmental News FOR IMMEDIATE RELEASE

(PHILADELPHIA, April 28, 2020) – The U.S. Environmental Protection Agency (EPA) recognized Towson University in Maryland today with a 2019 Food Recovery Challenge Regional Award.

WASHINGTON (April 28, 2020) —  Today, the U.S. Environmental Protection Agency’s (EPA) Science Advisory Board (SAB) transmitted its official advice and comments to EPA Administrator Wheeler on the Strengthening Transparency in Regulatory Science proposed rule.

U.S. VIRGIN ISLANDS – Recently, U.S. Environmental Protection Agency (EPA) Regional Administrator Pete Lopez met with Gov. Albert Bryan Jr. of the U.S.

SAN JUAN, PUERTO RICO – Recently, U.S.

Pasquale "Patrick" Amore, 88, had an infectious laugh and a zest for life. He died of COVID-19 at the age of 88.

Reggie Brooks bullish on Notre Dame RB Chris Tyree and the Holtz's Heroes Foundation

Residents of Quebec’s regions want Montrealers to stay away, considering the city has the highest concentration of COVID-19 infections in Canada.

A Welsh MP claims cases include workers with the NHS and in care homes.

She created Mother's Day out of love for her own mother but was shocked by how it became commercialised.

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.