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Caffeine quantification in dietary supplements using high-throughput on-line solid phase extraction coupled to Venturi easy ambient sonic-spray ionization mass spectrometry

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00333K, Paper
David Ulisses Tega, Luan Felipe Campos Oliveira, Patrick Cesar Ferreira, Bruna Beatriz Soldera, Heliara Dalva Lopes Nascimento, Marcos Nogueira Eberlin, Alessandra Sussulini
Optimization of a LC-V-EASI-MS system. Employment of LC-V-EASI-MS and online SPE to enhance analytical performance for caffeine determination reaching 90 s per sample.
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Resolving phytosterols in microalgae using offline two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry

Anal. Methods, 2024, 16,2278-2285
DOI: 10.1039/D3AY02261G, Paper
Magali Batteau, Elodie Bouju, Adriana Ramirez-Romero, Sylvie Nuccio, René De Vaumas, Florian Delrue, Karine Faure
Development of an off-line LC-SFc-MS method, separation of sterol isomers in algal unsaponifiable fractions, elution pattern helping in the reduction of structural candidates.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol

Anal. Methods, 2024, 16,2267-2277
DOI: 10.1039/D4AY00032C, Paper
Yang He, Yangjie Li, Han Wang, Site Luo, Haihu Yu
Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol via a mechanism integrating photoinduced electron transfer.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Online quantification of nicotine in e-cigarette aerosols by vacuum ultraviolet photoionization mass spectrometry

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00279B, Paper
Shaoxin Ye, Zuoying Wen, Kai Xie, Xuejun Gu, Jian Wang, Xiaofeng Tang, Weijun Zhang
A new method for quantifying nicotine in e-cigarette aerosols within a few seconds using a homemade VUV-AMS.
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It is an offence: On Supreme Court clarification on online content on child sex abuse

Court has done well to clarify law on online content showing child sex abuse




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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00614C, Research Article
Vijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip Banerji
The development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.
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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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Nagapattinam MP presses for new express trains, railway line extensions




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The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports




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Stick to the left lane when making a turn, even in smaller lanes




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Senior feline resident: Defib stays at his ambulance station 

Online petition halts re-homing of 16-year-old cat in London




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Diagnosed with stage 4 non-Hodgkin’s lymphoma in 2021, IPS officer Nidhin Valsan resurrected himself by competing the Ironman triathlon and writing his memoir because he hopes to be a good influence on other cancer patients




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ARRL Members Raise $47,000 for STEM Education in Online Auction

ARRL® The National Association for Amateur Radio® is pleased to announce that the 19th annual ARRL Online Auction, sponsored by RT Systems Inc, raised $47,000 for amateur radio STEM education. 

The event was held from October 18- 24, 2024. In addition to hundreds of views, the auction saw 329 individual bidders vying for equipment, vintage books, “mystery junk boxes” from the ARRL Lab, and more....




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The BSE Sensex tumbled 426.85 points or 0.53% to settle at 79,942.18. The NSE Nifty dropped 126 points or 0.51% to 24,340.85




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Falling for the second day in a row, the BSE Sensex tumbled 553.12 points or 0.69% to settle at 79,389.06. During the day, it slumped 654.25 points or 0.81% to 79,287.93




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Dynamics of phase-separated microdroplets near the contact line of evaporating all-aqueous drops

Soft Matter, 2024, 20,8260-8266
DOI: 10.1039/D4SM01056F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rahul Rai, Maheshwar Gopu, Senthan Pugalneelam Parameswaran, Tapan Chandra Adhyapak, Dileep Mampallil
Evaporation of multicomponent drops can induce liquid–liquid phase separation and spatial reconfiguration of phases through complex dynamics near the contact line.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Liquid crystalline collagen assemblies as substrates for directed alignment of human Schwann cells

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00534A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Homa Ghaiedi, Luis Carlos Pinzon Herrera, Saja Alshafeay, Leonard Harris, Jorge Almodovar, Karthik Nayani
Collagen is a key component of the extracellular matrix (ECM) and well-oriented domains of collagen are important for mimicking the local cell environment in vitro. Here, we demonstrate macroscopic alignment on collagen in 2-D substrates and 3-D hydrogels.
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Morphology and line tension of twist disclinations in a nematic liquid crystal

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01076K, Paper
Open Access
Yihao Chen, Mina Mandić, Charlotte G. Slaughter, Michio Tanaka, James M. Kikkawa, Peter J. Collings, A. G. Yodh
This work characterizes twist disclinations in nematic liquid crystals, using confocal microscopy to measure their 3D profile and test theoretical predictions, and using magnetic fields to deform the disclinations and measure their line tension.
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Tribocharging of granular materials flowing in grounded inclined tubes

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01082E, Paper
Nicolas Preud’homme, Julien Schockmel, Eric Opsomer, Geoffroy Lumay
Numerical simulations using the patch model and the method of image charges, validated against experiments, show that tribocharging in granular materials within inclined grounded tubes depends on the tube's tilt angle and length.
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Effects of Hydration Water on Bioresponsiveness of Polymer Interfaces Revealed by Analysis of Linear and Cyclic Polymer–Grafted Substrates

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00977K, Paper
Open Access
Shin-nosuke Nishimura, Naoya Kurahashi, Shohei Shiomoto, Yoshihisa Harada, Masaru Tanaka
Given that the hydration water of polymer matrices may differ from that of outermost polymer surfaces, processes at biomaterial–biofluid interfaces and role of hydration water therein cannot be adequately examined...
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Future Accessibility Guidelines—for People Who Can’t Wait to Read Them

Alan Dalton uses this, the International Day of Persons with Disabilities, to look back at where we’ve come from, to evaluate where we are, and to look forward to what’s coming next in the future of accessibility guidelines.


Happy United Nations International Day of Persons with Disabilities! The United Nations have chosen “Promoting the participation of persons with disabilities and their leadership: taking action on the 2030 Development Agenda” for this year’s observance. Let’s see how the World Wide Web Consortium (W3C)’s Web Accessibility Initiative (WAI) guidelines of accessibility past, present, and yet-to-come can help us to follow that goal, and make sure that the websites—and everything else!—that we create can include as many potential users as possible.

Guidelines of Accessibility Past

The W3C published the Web Content Accessibility Guidelines (WCAG) 1.0 on 5th May 1999, when most of us were playing Snake on our Nokia 3210s’ 1.5” monochrome screens…a very long time ago in technology terms. From the start, those guidelines proved enlightening for designers and developers who wanted to avoid excluding users from their websites. For example, we learned how to provide alternatives to audio and images, how to structure information, and how to help users to find the information they needed. However, those guidelines were specific to the web technologies of the time, resulting in limitations such as requiring developers to “use W3C technologies when they are available […]”. Also, those guidelines became outdated; I doubt that you, gentle reader, consult their technical documentation about “directly accessible applets” or “Writing for browsers that do not support FRAME” in your day-to-day work.

Guidelines of Accessibility Present

The W3C published the Web Content Accessibility Guidelines (WCAG) 2.0 on 11th December 2008, when most of us were admiring the iPhone 3G’s innovative “iPhone OS 2.0” software…a long time ago in technology terms. Unlike WCAG 1, these guidelines also applied to non-W3C technologies, such as PDF and Flash. These guidelines used legalese and future-proofed language, with terms such as “time-based media” and “programmatically determined”, and testable success criteria. This made these guidelines more difficult for designers and developers to grasp, but also enabled the guidelines to make their way into international standards (see EN 301 549 — Accessibility requirements suitable for public procurement of ICT products and services in Europe and ISO/IEC 40500:2012 Information technology — W3C Web Content Accessibility Guidelines (WCAG) 2.0) and even international law (see EU Directive 2016/2102 … on the accessibility of the websites and mobile applications of public sector bodies).

More importantly, these guidelines enabled designers and developers to create inclusive websites, at scale. For example, in the past 18 months:

The updated Web Content Accessibility Guidelines (WCAG) 2.1 arrived on 5th June last year—almost a 10-year wait for a “.1” update!—and added 17 new success criteria to help bring the guidelines up to date. Those new criteria focused on people using mobile devices and touchscreens, people with low vision, and people with cognitive and learning disabilities.

(If you need to get up to speed with these guidelines, take 36 minutes to read “Web Content Accessibility Guidelines—for People Who Haven’t Read Them” and Web Content Accessibility Guidelines 2.1—for People Who Haven’t Read the Update.)

Guidelines of Accessibility Yet to Come

So, what’s next? Well, the W3C hope to release another minor update (WCAG 2.2) in November 2020. However, they also have a Task Force working on produce major new guidelines with wider scope (more people, more technologies) and fewer limitations (easier to understand, easier to use) in November 2022. These next guidelines will have a different name, because they will cover more than “Web” and “Content”. Andrew Kirkpatrick (Adobe’s Head of Accessibility) named the Task Force “Silver” (because the initials of “Accessibility Guidelines” form the symbol of the silver element).

The Silver Task Force want the next major accessibility guidelines to:

  • take account of more disabilities;
  • apply to more technologies than just the web, including virtual reality, augmented reality, voice assistants, and more;
  • consider all the technologies that people use, including authoring tools, browsers, media players, assistive technologies (including screen readers and screen magnifiers), application software, and operating systems.

That’s quite a challenge, and so the more people who can help, the better. The Silver Task Force wanted an alternative to W3C’s Working Groups, which are made up of employees of organisations who are members of the W3C, and invited experts. So, they created a Silver Community Group to allow everyone to contribute towards this crucial work. If you want to join right now, for free, just create a W3C account.

Like all good designers, the Silver Task Force and Silver Community Group began by researching. They examined the problems that people have had when using, conforming to, and maintaining the existing accessibility guidelines, and then summarised that research. From there, the Silver Community Group drafted ambitious design principles and requirements. You can read about what the Silver Community Group are currently working on, and decide whether you would like to get involved now, or at a later stage.

Emphasise expertise over empathy

Remember that today’s theme is “Promoting the participation of persons with disabilities and their leadership: taking action on the 2030 Development Agenda”. (The United Nations’ 2030 Development Agenda is outside the scope of this article, but if you’re looking to be inspired, read Alessia Aquaro’s article on Public Digital’s blog about how digital government can contribute to the UN’s Sustainable Development Goals.) In line with this theme, if you don’t have a disability and you want to contribute to the Silver Community Group, resist the temptation to try to empathise with people with disabilities. Instead, take 21 minutes during this festive season to enjoy the brilliant Liz Jackson explaining how empathy reifies disability stigmas, and follow her advice.

Choose the right route

I think we can expect the next Accessibility Guidelines to make their way into international standards and international law, just like their predecessors. We can also expect successful companies to apply them at scale. If you contribute to developing those guidelines, you can help to make sure that as many people as possible will be able to access digital information and services, in an era when that access will be crucial to every aspect of people’s lives. As Cennydd Bowles explained in “Building Better Worlds”, “There is no such thing as the future. There are instead a near-infinity of potential futures. The road as-yet-untravelled stretches before us in abundant directions. We get to choose the route. There is no fate but what we make.”


About the author

Alan Dalton worked for Ireland’s National Disability Authority for 9½ years, mostly as Accessibility Development Advisor. That involved working closely with public sector bodies to make websites, services, and information more accessible to all users, including users with disabilities. Before that, he was a consultant and trainer for Software Paths Ltd. in Dublin. In his spare time, he maintains StrongPasswordGenerator.com to help people stay safe online, tweets, and takes photos.

More articles by Alan




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Indian Overseas Bank launches online Re-KYC service for hassle-free updates

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Use-case approach to drive digital payments, says Worldline India CEO

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2,500 online courses in two years, a record feat by 51-year-old Srikakulam man

He wanted to highlight the need for students to acquire more knowledge and the availability of abundant free resources, says M.V.V.S. Sastry




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Naidu sets June deadline for completion of new terminal building at Vijayawada airport

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Uniform output regulation of nonlinear systems [electronic resource] : a convergent dynamics approach / Alexey Pavlov, Nathan van de Wouw, Henk Nijmeijer

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Representations of linear groups [electronic resource] : an introduction based on examples from physics and number theory / Rolf Berndt

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History of Banach spaces and linear operators [electronic resource] / Albrecht Pietsch

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Deepavali: KSRTC sets record with ₹5 crore in online ticket sales; 85,462 bookings in a day, highest since 2006 launch

According to KSRTC officials, major routes that saw high demand included popular destinations from Bengaluru such as Davangere, Mysuru, Hubballi, Tirupathi, Shivamogga, and Kalaburagi 




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Farmers urge MPs to consider alternative route for laying Udupi-Kasaragod Power Transmission line




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Passenger train rakes to stop moving to Bunder Yard once additional stabling line comes up at Central Railway Station in Mangaluru

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Online education: How Gen Z and millennials can leverage it for career growth

Transformative online education in India for Gen Z and millennials, driving growth and innovation, faces challenges of inclusivity and credibility.




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JEE Mains 2025: 45-day free online crash course by IIT-Kanpur




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Jet Airways stock falls 5%, SBI to stay away from funding airlines