The Alcohol and Other Drugs Committee's Centennial Paper to review what it has accomplished since its inception in the early 1970s, how it has evolved along with the field, and what challenges and opportunities it confronts going forward. To learn more about the history of impaired driving and the Standing Technical Committee on Alcohol, Other Drugs, and Transportation (ANB50), check out the Committee's Centennial Paper. As part of TRB's Centennial Celebration, the Technical Activities Council invited al...

Coincidental to TRB's 1982 promotion to a stand-alone unit within the NRC and its acceptance of the responsibility to oversee consensus studies, Congress was working on an update to surface transportation legislation. The timing meant that TRB was not going to be able to ease into its new responsibilities. To learn the whole story, check out the latest release in the TRB History Highlights series. As part of the Centennial Celebration, TRB has initiated the History Highlights series that will regularly r...

TRB's “Tell Us ‘Our’ Story" challenge is now looking into the future. What impact do you hope to have on the world and how is the Transportation Research Board helping you make that impact? What is your vision for the Transportation Research Board 100 years from now? What are solutions that you have identified as a result of research you learned about through TRB? TRB welcomes all stories: small or large, profound or light-hearted, sobering or humorous. In addition to posting responses to these questions...

According to Ken Murray, Sr. Landscape Architect, California Department of Transportation "TRB allows for expanding your influence and connections throughout the transportation world nationally. You're able to connect with fellow peers from different states and share experiences, discuss strategies for difficult situations, and solutions to issues that others may have already handled that you personally are dealing with. It expands your network that allows for more diverse information for other areas tha...

Oscar Daniel Galvis Arce, University of Texas at Austin said that "during my teenager years, I always loved to play games where you can build cities. It was fascinating. Then, during my undergrad in Civil Engineering I discovered that designing transportation systems was a real career. I felt motivated by the idea of contributing on people's life because everyone, every day, needs to rely on transportation systems. A portion of our lives goes by on a bus, train, airplane, bike, walking… So, is it possibl...

According to Antoine Gergess, Professor of Civil Engineering, University of Balamand, Labanon "What drew my attention to the transportation community is the urgent need for reconstruction and rehabilitation of transportation systems in the world and specifically in my homeland of Lebanon." Antoine continues to participate in TRB "due to the professional and constructive spirit of people involved, the exposure it gives me and the rich data available for educational, design, and construction purposes." Tha...

They met in June 1975 in Boise, Idaho, for a workshop organized by the Transportation Research Board’s (TRB’s) Special Task Force on Low-Volume Roads. Although the field trip took them over humble forest roads, workshop participants had global ambitions. Among the workshop’s sponsors were the U.S. Agency for International Development (USAID) and the International Bank for Reconstruction and Development, which today is part of the World Bank. To learn the whole story, check out the latest release in the T...

Susan Heap, the Director of Operations at Ferrovial Services says that "Transportation is meaningful across all societies, for many different reasons. I chose a career that connected me to things that matter to all of us. I stay in this industry because of the variety of people and projects that I get to work with every day. There is always a new challenge to overcome or skill-set to learn." Thank you Susan for participating in TRB's Centennial Celebration. To read the more than 60 responses to April's q...

TRB's “Tell Us ‘Our’ Story" challenge is now looking into the future. What impact do you hope to have on the world and how is the Transportation Research Board helping you make that impact? What is your vision for the Transportation Research Board 100 years from now? What are solutions that you have identified as a result of research you learned about through TRB? TRB welcomes all stories: small or large, profound or light-hearted, sobering or humorous. In addition to posting responses to these questions...

According to Ken Murray, Sr. Landscape Architect, California Department of Transportation "TRB allows for expanding your influence and connections throughout the transportation world nationally. You're able to connect with fellow peers from different states and share experiences, discuss strategies for difficult situations, and solutions to issues that others may have already handled that you personally are dealing with. It expands your network that allows for more diverse information for other areas tha...

Upcoming History/Royalty There are no applications to process at this time. Finished History/Royalty There are no finished forms to process at this time. Moved History/Royalty Pirates (People: Groups) Closed History/Royalty (Open for application) There are no closed forms to process at this time. Troubled History/Royalty(Not open for application) The following fanlisting is scheduled for removal […]

The first time we saw Buddy he was walking across the grave of one of our beloved cats, Harley, who had just passed away while we were on vacation. This

Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycoside antibiotics or platinum-containing chemotherapy agents. In animal models, induction of heat shock confers substantial otoprotection against aminoglycoside- and cisplatin-induced hair cell death. In this issue of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock protein 70 (HSP70) in response to heat stress. HSP70 acted by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death. Exosomes and the HSP70/TLR4 pathway could thus provide treatment targets for the protection of hair cells from chemically induced death or from other insults, such as noise.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Real heroes deserve their own comics/Los héroes reales merecen sus propios comics

The post Heroes always come home in David Rubín’s free COVID-19 SUPERMAN story (version en español incluída) appeared first on The Beat.

IBM today announced plans to acquire Promontory Financial Group, a global market-leading risk management and regulatory compliance consulting firm. Upon close, the capabilities of Promontory combined with IBM's deep industry expertise and Watson’s cognitive capabilities will directly address the massive operational effort and manual cost of escalating regulation and risk management requirements.

In the chilling series finale, Ahsoka and Rex try to survive Order 66 and plot one final escape.

• 1 orange, peeled and chopped ($.70)
• 1 teaspoon powdered tumeric ($.10)
• 1 teaspoon caraway seeds($10)
• a few black peppercorns, or pinch of black pepper
• stevia or sweetener, if desired ($.10)

1. Place the orange, turmeric, and caraway seeds in a large saucepan with four cups water. 
2. Bring to a boil over high heat and continue to boil for about five minutes. This will reduce any bitterness in the turmeric.
3. Add the peppercorns or pinch of pepper and steep for a minute or two. 
4. Strain through a fine mesh strainer into mugs and and the sweetener of your choice, if desired. 

History of Lisp (The history of LISP according to McCarthy's memory in 1978, presented at the ACM SIGPLAN History of Programming Languages Conference.)

This is such a fun paper which I couldn't find on LtU. It's about the very early history of programming (1950s and '60s), back when things we take for granted today didn't exist yet.

On taking apart complex data structures with functions like CAR and CDR:

It was immediately apparent that arbitrary subexpressions of symbolic expressions could be obtained by composing the functions that extract immediate subexpressions, and this seemed reason enough to go to an algebraic language.

On creating new data, i.e. CONS:

At some point a cons(a,d,p,t) was defined, but it was regarded as a subroutine and not as a function with a value. ... Gelernter and Gerberich noticed that cons should be a function, not just a subroutine, and that its value should be the location of the word that had been taken from the free storage list. This permitted new expressions to be constructed out of subsubexpressions by composing occurrences of cons

On inventing IF:

This led to the invention of the true conditional expression which evaluates only one of N1 and N2 according to whether M is true or false and to a desire for a programming language that would allow its use.

On how supreme laziness led to the invention of garbage collection:

Once we decided on garbage collection, its actual implementation could be postponed, because only toy examples were being done.

You might have heard this before:

S.R. Russell noticed that eval could serve as an interpreter for LISP, promptly hand coded it, and we now had a programming language with an interpreter.

And the rest is history...

Becky Lynch has become the Superstar with the most total days as Raw Women’s Champion, surpassing Alexa Bliss.

NIH clinical trial testing antiviral remdesivir plus anti-inflammatory drug baricitinib for COVID-19 begins  National Institutes of HealthView Full coverage on Google News

1. Laid bare: How the Dean Laidley story reveals cultural change  Sydney Morning Herald
2. Dean Laidley police photo leak: Fourth officer suspended  NEWS.com.au
3. 'Gross stupidity': Fresh investigation into Dean Laidley photo leak  Yahoo Sport Australia
4. Vic watchdog to probe leaked Laidley pics  AFL
5. IBAC to investigate leaked Laidley photos  Yass Tribune
6. View Full coverage on Google News

VICTORY is a turn-on

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This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and IRISS that was about health and social care in Scotland. This paper was written by iain Houston from Alzeimer Scotland who participated in the PROP2 programme. What this research paper explores: An explorative case study investigating how completing a life story project affected a person with dementia.

News article

Мацуно сейчас продолжает работать с ЁСидой над фф14: в конце сюжетки Return to Ivalice была зацепка на будущее: там появлялся имперский командир Габрант. Сейчас это ружьё выстрелило: сюжетку релик-оружия из Shadowbringers пишет Мацуно, и она про Ноа Башевича Габранта. Я сам не возвращался ещё в фф14 после того, как этот патч вышел, так что ничего сказать не могу - но там явно лучше дождаться выхода всей сюжетки, чтобы оценивать. Арка Return to Ivalice была крутой.

Тем интереснее, что Мацуно пытался вернуться в Ивалис до того, как в 17-м году его взял к себе Ёсида. Решив узнать в твиттере, как западная аудитория относится к Save the Queen, его новой сюжетной арке из фф14, Мацуно разоткровенничался.

По его словам, использованная в этой арке концепция "разум обманывает себя, чтобы справляться с травмой" изначально предлагалась для продолжения Vagrant Story, которое Мацуно придумал в 2002-м и предложил Скваре в 2013-м.

Ten years ago, April 20, 11 men on the Deepwater Horizon were incinerated when the BP/Transocean oil rig blew out and exploded. Just 17 months before the Deepwater Horizon destroyed 600 miles of Gulf Coast, BP covered up a

The post Deepwater Horizon: BP’s SECOND Blowout<div id='sec-title'>The Secret History - 10 Year Anniversary</div> appeared first on Greg Palast.

Microsoft Xbox One X 1 TB Console - Black - $229.99 - Free shipping for Prime members https://electronics.woot.com/offers/microsoft-xbox-one-x-1-tb-console-black-1?utm_medium=share&utm_source=app

On February 20, 1792, President Washington formally created the U.S. Postal Service with the signing of the Postal Service Act, which outlined in detail Congressional power to establish official mail routes. The act allowed for newspapers to be included in mail deliveries and made it illegal for postal officials to open anyone's mail.

There’s a very definite Tokyo-area bias in this survey from goo Ranking into which factory tours people would want to go on; the pictured food sample factory is not one of them, though. The only factory tours I’ve been on in Japan were three times to the Yamazaki distillery tour and tasting and once to […]

Princeton historian Rhae Lynn Barnes reflects on teaching and service during the coronavirus outbreak and the history website she launched for educators.

In his book "The Torture Letters," Princeton anthropologist Laurence Ralph examines the torture of people of color at the hands of police from the mid-1970s to the early 2000s in Chicago.

Her résumé also includes "Brave," "The Book of Life," "Elf," and an eight-year stint as a layout artist during the Disney Renaissance.

The post RIP Denise Blakely Fuller, Matte Painter On ‘Toy Story 3,’ ‘The Book Of Life,’ ‘Hotel Transylvania’ appeared first on Cartoon Brew.

A visitor asked me if there was a way to stop her web server from showing a directory listing of the folders on her site, without having to create a .htaccess file. This article gives 2 alternative solutions.

Tuesday 7 April DetentionWe touch down in Melbourne and there is applause from the cabin. Dwayne and I refrain. We are know what is coming with the Federal and Victorian Governments. Within 10 seconds of exiting the plane police and Fe