Story: Several apostles affiliated with the movement helped organize or spoke at Rick Perry's recent prayer rally. A leading apostle, C. Peter Wagner, talks about the movement and its missions, which include acquiring leadership positions in government, the media, and arts and entertainment.

Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized as a key pathophysiological process underlying clinical manifestations in Alzheimer's disease and related neurodegenerative tauopathies. Here, we conducted PET along with postmortem assays to investigate time course changes of excitatory and inhibitory synaptic constituents in an rTg4510 mouse model of tauopathy, which develops tau pathologies leading to noticeable brain atrophy at 5-6 months of age. Both male and female mice were analyzed in this study. We observed that radiosignals derived from [¹¹C]flumazenil, a tracer for benzodiazepine receptor, in rTg4510 mice were significantly lower than the levels in nontransgenic littermates at 2-3 months of age. In contrast, retentions of (E)-[¹¹C]ABP688, a tracer for mGluR5, were unaltered relative to controls at 2 months of age but then gradually declined with aging in parallel with progressive brain atrophy. Biochemical and immunohistochemical assessment of postmortem brain tissues demonstrated that inhibitory, but not excitatory, synaptic constituents selectively diminished without overt loss of somas of GABAergic interneurons in the neocortex and hippocampus of rTg4510 mice at 2 months of age, which was concurrent with enhanced immunoreactivity of cFos, a well-characterized immediate early gene, suggesting that impaired inhibitory neurotransmission may cause hyperexcitability of cortical circuits. Our findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegenerative tauopathies.

SIGNIFICANCE STATEMENT In this study, we examined the in vivo status of excitatory and inhibitory synapses in the brain of the rTg4510 tauopathy mouse model by PET imaging with (E)-[¹¹C]ABP688 and [¹¹C]flumazenil, respectively. We identified inhibitory synapse as being significantly dysregulated before brain atrophy at 2 months of age, while excitatory synapse stayed relatively intact at this stage. In line with this observation, postmortem assessment of brain tissues demonstrated selective attenuation of inhibitory synaptic constituents accompanied by the upregulation of cFos before the formation of tau pathology in the forebrain at young ages. Our findings indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy.

The liquid inside is 3 percent alcohol by volume—and contains 0.13 milligrams of lead per liter

A 19-year-old man was flown back to Ontario after he pleaded guilty to violating New Brunswick’s emergency measures order prohibiting visitors from entering the province.

The current deconfinement plan in the Montreal area could lead to a rapid increase in deaths in the city, according to findings by Quebec's public health institute. 

A $28.8 million spending bill nearing legislative approval would allocate funding to combat lead in Michigan drinking water systems and investigate sexual assaults by clergy.

1. Bharat Biotech to lead human monoclonal antibodies project  The Hindu
2. Bharat Biotech leads CSIR project to develop antibodies against Covid-19  Times of India
3. Bharat Biotech To Lead CSIR’s Project To Develop Human Monoclonal Antibodies For Covid-19 Therapy  Swarajya
4. Bharat Biotech to develop human antibodies for COVID-19 therapy  Telangana Today
5. Bharat Biotech vows human monoclonal antibodies to neutralise COVID-19 in 6 months  Mumbai Mirror
6. View Full coverage on Google News

"We don't have the big hospitals and specialized care. Should COVID-19 spread, we don't have the capacity or the resources to deal with it," said Cree Grand Chief Abel Bosum.

Lambton County resident Joeleen DeGurse-MacDonald still has memories of the fatal vehicle collisions she's witnessed at the intersection of Kimball Road and Petrolia Line. Now in her 50s, DeGurse-MacDonald said she vividly remembers an accident that took place when she was only five-years-old, eating a pear picked from an orchard on her family's farm at the northest intersection of Kimball and Petrolia. 

Just when you thought you watched the best shot of the Brier, another best shot of the Brier appears at the 2020 Canadian men's curling championship being held in Kingston, Ont.

Team Homan, Canada’s 2018 Olympic women’s curling team and the 2017 World Women’s Curling Champions have announced that the team has parted ways with lead Lisa Weagle. 

Let go last week after a decade-long run with skip Rachel Homan's Ottawa-based rink, lead Lisa Weagle has joined Team Jennifer Jones, which will operate with five members.

Apple Watch extended its lead over smartwatch market competitors during the first quarter of 2020, according to new statistics from research firm Strategy Analytics, with Apple's wearable now accounting for more than 55% of the whole.

An OM worker rediscovers how God can use a difficult situation to accomplish His purposes.

A group of people open to the Holy Spirit's leading find an open door for ministry in Nazareth.

A short-termer engages people in spiritual conversation while on tour of Israel.

These times are testing leaders from the schoolhouse to the White House, from city halls to corporate suites.

Lincoln and Manna from Hong Kong are two of the four candidates to participate in OM EAP’s first Timothy Trek training programme this year.

As OM Hong Kong celebrates 25 years, leader Cheuk-chung Lau reflects on the past 19 years and wonders who the next “Joshua” will be.

Marco Salas and his wife SeRah Kim have taken on the leadership of OM Mexico. They were encouraged by many fellow OM workers.

Extreme Leadership Training camps create unity in Ukraine.

During the summer months, OM Ukraine in Odessa facilitated a camp, during which the Lord touched the hearts of many children.

When Berlin Brandenburg Airport is put into operation at the end of October 2020, Schönefeld Airport will become Terminal 5 (T5) of BER. In order to avoid duplicate names of terminal sections, gates and car parks at BER, the building and car park infras...

Olger Morales shares his testimony of how he came to work in OM full-time after participating in numerous short-term outreaches.

OM is known for action, not reflection; for pioneering, not reminiscing. Still, we are wise to celebrate milestones and learn from our past, whatever will serve us well for today and tomorrow.

Mercy Teams International (MTI) strives to see local workers in each ministry field trained and equipped as leaders. MTI Cambodia is one example.

A BIOTECH veteran has hailed a Glasgow firm that claims to have discovered two separate potential treatments for Covid-19 patients for use before they are put on ventilators.

British Olympic Association chairman Sir Hugh Robertson has been selected to lead an independent governance review of World Rugby.

The American politician John Nance Garner is better remembered for something he said rather than anything he did as Franklin Roosevelt’s vice-president.

The top technology official for Virginia's Fairfax County schools resigned after the district struggled to handle some major technical glitches in its e-learning platforms.

Education Week's Andrew Ujifusa hashes out the details of the education budget with Prince George's County, Md., Schools CEO Kevin Maxwell.

A group of Texas high school cheerleaders filed a petition with the state Supreme Court over an ongoing dispute about the display of banners with religious messages at high school football games.

The battle stems from Varsity Brands' efforts to gain copyright protection for the design of stripes, chevrons, zigzags, and color blocks that are on its uniforms.

The annual issue, now in its eighth year, highlights the work of district leaders who are deploying new ideas to make a difference for their staff and students.

Talk to school and district leaders and you’ll hear worries about the next recession, spending restrictions, and a public that knows little about worries that lawmakers and elected officials who know little about their funding needs.

As superintendents, we must make the system work for all students—however socially, politically, and professionally dangerous it may be, writes Demond A. Means.

Race, education disparities, school-leader standards, and criminal proceedings (in Atlanta and Chicago) were among the top stories on the District Dossier blog.

The coronavirus crisis has made staffing and hiring decisions more uncertain, but planning needs to start now, writes Terry B. Grier.

Effective management approaches are not skills principals typically learn through the traditional pathways of education. To fill the gap, they are turning to business programs and publications.

When it comes to school technology, Superintendent Doug Brubaker emphasizes robust infrastructure, regular refresh cycles, and training. Taxpayers and teachers are buying into the practical approach.

Less than 20 percent of respondents to a new CoSN survey marked any items on a list of cybersecurity threats as "high-risk" from their perspective.

WE should be wary of comparing the crisis of war with the crisis of coronavirus, but the 75th anniversary of VE Day is a reminder of what a national emergency can do to a leader. It can reveal their weaknesses and end their career, or it can highlight the qualities and skills that are needed in a time of trouble.

The Center for American Progress has released a set of recommendations for governors in 2019 that includes things such as full-day universal preschool and the study of pre-term births, which can cause learning difficulties.

Research shows demands put on school principals are increasing when it comes to instructional leadership. Greater demands bring out increasing gaps, and a need for better leadership development.

Being a school leader is difficult. They are meant to focus on improvement while also negotiating their way through adult behavior. Can leadership coaching help them focus on what truly matters?