Hong-Kong-based conglomerate Tencent has rolled out Xiao’e Pinpin, a mini program for...

Source: Streetwise Reports   04/28/2020

SmileDirectClub Inc. (SDC:NASDAQ) today announced "it has been issued a patent for its SmileShop intellectual property from the U.S. Patent & Trademark Office which further strengthens the telehealth dentistry pioneer's efforts to bring affordable, accessible oral care to more people through its unique and innovative teledentistry platform and direct-to-consumer business model." The firm claimed that the patent will prevent other clear aligner competitors from duplicating its business model for the next 18 years.

The company's CEO David Katzman commented, "This patent designation is a significant validation of our unique customer-oriented care model, and expands our category ownership, including the manufacturing and retail experience...As the industry pioneer and inventor of the SmileShop concept, this patent is recognition that SmileDirectClub offers an innovative way for consumers to access oral care that is safe, doctor-directed and convenient. We look forward to welcoming customers back to our SmileShops at the earliest and safest possible time."

"We are focused on the entire teeth straightening and care process, and we now own the manufacturing process of our clear aligner products, the customer experience via our teledentistry platform, as well as the retail experience for clear aligner therapy. This patent is another step in our process as we continue to grow and protect our business," Katzman added.

The firm advised that "the patent encompasses the unique SmileShop concept and process" which includes appointment scheduling, conducting an intraoral scan, generating an approved treatment plan by a licensed dentist or orthodontist and then creating and shipping the aligners to the customer. The company noted that so far more than one million customers have used its clear aligner therapy platform.

The company stated that it is planning to slowly reopen its SmileShops in the U.S. and other markets starting in May as local governments begin to lift business restrictions. The firm indicated that it will be supplying all of its SmileShop team members with face shields and other PPE and will institute staggered appointment times, temperature scans and other social distancing and sanitary measures to provide a safe experience for all staff and customers.

SmileDirectClub is an oral care company headquartered in Nashville, Tenn. The firm stated that it is the creator of the first direct-to-consumer medtech platform for teeth straightening. The company has since expanded its business and now offers its products directly through dentist and orthodontists' offices. Some of the products offered by the company include aligners, impression kits, retainers and whitening gel. In addition to the U.S., the company also operates in Australia, Canada, Germany, Hong Kong, Ireland, New Zealand and the U.K.

SmileDirectClub began the day with a market capitalization of around $2.1 billion with approximately 385 million shares outstanding and a short interest of about 10.4%. SDC shares opened more than 26% higher today at $6.76 (+$1.37, +26.42%) over yesterday's $5.39 closing price. The stock has traded today between $6.13 to $6.80 per share and is currently trading at $6.64 (+$1.25, +23.14%).

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

( Companies Mentioned: SDC:NASDAQ, )

Source: Streetwise Reports   05/04/2020

Stemline Therapeutics Inc. (STML:NASDAQ), which is focused on developing and commercializing novel oncology therapeutics, today announced that it has entered into a definitive agreement to be acquired by private Italian pharmaceutical and diagnostics company Menarini Group in a transaction valued up to $677 million.

The companies advised that the transaction has already been unanimously approved by both companies' Boards of Directors and that the transaction is expected to close in Q2/20 subject to customary closing conditions, regulatory approvals and a tender of at least 50% of the outstanding Stemline shares by shareholders. Menarini stated that it plans to fund the purchase by using existing cash resources.

The firms outlined that purchase details and advised that "under the terms of the agreement, a wholly owned subsidiary of the Menarini Group will commence a tender offer for all outstanding shares of Stemline, whereby Stemline shareholders will be offered a total potential consideration of $12.50 per share, consisting of an upfront payment of $11.50 in cash and one non-tradeable Contingent Value Right (CVR) that will entitle each holder to an additional $1.00 in cash per share upon completion of the first sale of ELZONRIS in any EU5 country after European Commission approval."

The report explained that ELZONRIS is a novel targeted therapy directed to the interleukin-3 (IL-3) receptor-α (CD123) and was developed by Stemline for treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and pediatric patients. The firm stated that the U.S. Food and Drug Administration (FDA) approved that drug in the U.S. in December 2018. A marketing authorization application (MAA) has already been submitted and is presently under review by the European Medicines Agency. Post acquisition, Menarini expects to obtain approvals and expand distribution of ELZONRIS to Europe and emerging markets.

Stemline Therapeutics' Chairman, CEO and Founder Ivan Bergstein, M.D., commented, "Joining Menarini represents a unique opportunity for Stemline to advance the commercialization of ELZONRIS across the globe and to accelerate the development of our pipeline of oncology assets. ...We are excited to be combining with a like-minded organization in Menarini, in a transaction that will deliver immediate and significant cash value to our shareholders, while also allowing our shareholders to participate in the future upside of ELZONRIS's European launch."

Elcin Barker Ergun, CEO of Menarini Group, remarked, "Stemline is an excellent fit for Menarini, enabling us to expand our presence in the U.S. with an established biopharmaceutical company focused on developing oncology therapeutics. Through this acquisition, we will continue to strengthen our portfolio and pipeline of oncology assets and deliver novel therapies around the world."

The company described BPDCN, formerly blastic NK-cell lymphoma, as "an aggressive hematologic malignancy, often with cutaneous manifestations, with historically poor outcomes which typically presents in the bone marrow and/or skin and may also involve lymph nodes and viscera."

Stemline Therapeutics is a commercial-stage biopharmaceutical company headquartered in New York that develops and markets oncology therapeutics. The firm stated that its "ELZONRIS^® (tagraxofusp) is a targeted therapy directed to CD123 and is FDA-approved and commercially available in the U.S. for the treatment of adult and pediatric patients, two years and older, with BPDCN." Stemline noted that ELZONRIS is also being currently being evaluated in clinical studies for other indications including chronic myelomonocytic leukemia, myelofibrosis and acute myeloid leukemia.

The Menarini Group is an international pharmaceutical company based in Italy which operates and sells its products in more than 100 countries. The company stated that it has $4.2 billion in sales annually. The company's medicines address many areas of illnesses including cardiovascular, gastroenterology, metabolic, infectious diseases and anti-inflammatory/analgesic therapeutic areas and oncology.

Stemline Therapeutics began the day with a market capitalization of around $249.2 million with approximately 54.27 million shares outstanding and a short interest of about 11.3%. STML shares opened nearly 150% higher today at $11.81 (+$7.06, +148.63%) over Friday's closing price of $4.75. The stock has traded today between $1.81 and $12.35 per share and is currently trading at $12.10 (+$7.35, +154.74%).

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

( Companies Mentioned: STML:NASDAQ, )

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American Express has

Payment service provider and direct card acquirer ECOMMPAY have...

Adopting the Green Economy approach will reap greater environmental, social and economic benefits, compared with a society that focuses on economic growth as the measure for future development, according to a recent UN report. Using two per cent of global GDP to ???green??? key sectors could be enough to trigger the transition towards a green economy.

Cities are key players in global greenhouse gas (GHG) emissions. A new World Bank study has proposed a three-stage plan for mitigating climate change at a local level. Its recommendations include improving urban infrastructure and encouraging lifestyle change, but most importantly, clarity in the way urban GHG inventories are calculated.

Science for Environment Policy are very pleased to announce the launch of a new series of policy briefs. Entitled 'Future Briefs', these will explore emerging areas of research with implications for environmental policy.'Plastic Waste: redesign and biodegradability' is the first Future Brief, which will be published week commencing 27 June. Future Briefs will be available to download free from our website: http://ec.europa.eu/environment/integration/research/newsalert/index_en.htm

Municipal solid waste (MSW) landfills, which consist of everyday consumer items, are potential long-term sources of emissions that could threaten the environment and human health if they are not managed carefully after closure. New research has presented a methodology to estimate future emission levels for closed MSW landfills and the impact of different aftercare strategies.

By ranking the ???hazard potential??? of a wide range of chemicals used to make common plastics, Swedish researchers have highlighted which plastic polymers are made from the most hazardous chemicals. These should be prioritised for assessing the risk of causing human or environmental harm.

Hypoxia (low levels of oxygen) is widespread in the coastal waters of the Baltic Sea, according to recently published research. The trend of increasing hypoxia since the 1950 is alarming, although improvements can be seen in some areas as a result of measures to reduce inputs of organic material.

City dwellers who grow their own fruit and vegetables may be consuming high levels of pollutants. In a recent study, researchers found that vegetables grown on plots in Berlin, Germany, often contained higher concentrations of some heavy metals than shop-bought vegetables, with those grown close to busy roads containing the greatest quantities.

The last two decades have seen a series of new construction waste policies management in Hong Kong. One of the most significant is an offsite construction waste sorting (CWS) programme which, since its implementation in 2006, has separated 5.11 million tonnes of construction waste into different materials. The researchers suggest that the study provides an important reference for other countries working to minimise construction waste.

To date, it has been difficult to collect data that are robust enough to demonstrate specific effects of chemical pollution in rivers on aquatic wildlife. However, a recent study combining detailed chemical, toxicological and ecological data in three European river basins now provides evidence linking cause and effect by revealing significant differences in the effects of differently polluted sediments on the organisms living in the river basins and the riverbed biodiversity.

A standardised method to help choose the most cost-effective measures to remediate contaminated sites has been developed by Austrian researchers. The method takes into account a wide range of factors, including the principles of sustainability.

Current knowledge on the availability of mineral resources is explored in a recent study, which focuses on phosphorus as a key example. Static measures of availability, such as the consumption-to-production ratio, are useful as early warning signals, the researchers suggest, but more dynamic indicators that consider technological development and population change are needed to better inform policy.

Researchers have discovered high levels of plastic particles and fibres, as well as black carbon (BC), which is formed by the incomplete burning of fossil fuels, in the waters of the Jade Bay, an inshore basin off the coast of Germany in the Southern North Sea. The concentration of suspended particles are of concern because they have the potential to be ingested by fish and other marine life, and enter the food chain.

A recent study has revealed how water use has changed across the world over the last 60 years. Growing populations and economic development, particularly in newly-emerging countries, have increased water demand, but technological developments have led to water efficiencies and savings, which moderate these demands.

Two tagged Cuvier's beaked whales have shown intense and lasting avoidance behaviours in response to military sonar. In the first study of this kind, the whales showed significant responses to sonar at volumes that are currently assumed in the US to have no effect on behaviour.

Urban water use increases with a population’s average income, finds a study of a stressed river basin in Spain. Consumption also increases with population age, but falls as education levels rise. Such information could help municipal water providers predict future water trends and to develop appropriate measures by which to manage demand. There is huge interest in mining polymetallic nodules in deep-sea environments. These bumpy rocks on the seafloor contain highly valuable materials including manganese, iron, cobalt, nickel and copper.

In 1989, researchers dragged a plough harrow across the seafloor of the Peru Basin to recreate some of the effects of deep-sea mining. Twenty-six years later, a new team of researchers returned to the site to assess whether there were any long-term ecological effects. They found that the seabed ecosystem remained disrupted, with significantly fewer suspension feeder species, such as anemones and sea sponges, than in undisturbed areas of seafloor. This suggests that deep-sea mining could cause irreversible changes to marine food webs in highly disturbed areas.

A circular economy, in which waste is minimised and resources are kept within the system, relies upon inventive ways of turning waste into a resource. A new study explored the possibility of using the microalga Scenedesmus obliquus to refine and process brewery wastewater. The alga efficiently removed pollutants from the effluent, produced biomass and biofuels in a range of different forms — and with different bioactive compounds — and encouraged waste barley and wheat to germinate at increased rates. This is especially important for breweries, as barley seeds are one of the main feedstocks for the industry — and thus are key to increasing its sustainability and circularity.

Current knowledge on the availability of mineral resources is explored in a recent study, which focuses on phosphorus as a key example. Static measures of availability, such as the consumption-to-production ratio, are useful as early warning signals, the researchers suggest, but more dynamic indicators that consider technological development and population change are needed to better inform policy.

Fish farming in the Mediterranean has increasingly shifted from producing fish such as grey mullet, which are herbivores near the bottom of the food chain, to species such as sea bass, which are predators. This ‘farming up’ the food chain requires wild fish to be caught to provide feed. A return to farming fish lower in the food chain would use marine resources more efficiently, a new study says.

New research suggests that the main driver for industrial ecology initiatives is financial gain, whilst regulation plays a smaller role. Policy does influence their development but this tends to be indirectly through initiatives such as pollution control and waste reduction targets, rather than through direct regulation to enforce or encourage industrial ecology.

A recent study has concluded that the green infrastructure concept has been successful in integrating green space policy with economic development policies in the north-west region of the UK, by emphasising the links between the economic benefits of green spaces and growth policies.

There is a need to broaden the debate on sustainable food security from a straight comparison between organic and conventional farming to a consideration of a variety of farming techniques. This is the conclusion of a new review of research that indicates, for some crop types, organic yields can nearly match conventional yields under good management practices and growing conditions.

Fish farms, and other forms of aquaculture, are seen as a potential solution to meeting increasing global demand for seafood. However, according to recent research, they must reduce their reliance on wild fish for animal feed if current production levels from both aquaculture and wild fisheries are to be maintained.

A new study indicates that ‘commitment’ interventions are effective in encouraging environmentally-friendly behaviour, both in the short- and long-term. However, to increase the effectiveness of such interventions, whereby people promise or pledge to perform certain behaviours, more research is needed on the psychological processes behind their effects.

Misreported fishing catches in the Baltic Sea have probably led to incorrect fishing quotas, new research suggests. The study found that total catches between 1996 and 2009 have been underestimated for a significant period, skewing quota calculations.

A bug is making it so users are unable to enable HDR video streaming after upgrading to Windows 10 1903 or later if they previously disabled the setting. [...]

DEF CON and Black Hat announced today that their upcoming security conferences in Las Vegas this summer will no longer be in-person and are instead moving to an all-virtual event. [...]

Microsoft Edge is now giving users the ability to hide those pesky browser notification dialog boxes that are commonly used by web sites to push their content, or even spam, on visitors. [...]

Hackers have hidden malware in a legitimate two-factor authentication (2FA) app for macOS to distribute Dacls, a remote access trojan associated with the North Korean Lazarus group. [...]

Researchers have used the psychological concept of ‘commitment’, normally used to understand relationships between people, to investigate our relationship with the environment. The results indicate that an individual’s commitment to the environment is important in their ecological behaviour, for example, their willingness to use public transport and make sacrifices for the environment.

A new study from Denmark has indicated that a substantial proportion of farmers may place professional values above cost savings when making decisions about how much pesticide to use. This implies that agricultural policy should consider a broad array of policy instruments to reduce pesticide usage.

A new study indicates that ‘commitment’ interventions are effective in encouraging environmentally-friendly behaviour, both in the short- and long-term. However, to increase the effectiveness of such interventions, whereby people promise or pledge to perform certain behaviours, more research is needed on the psychological processes behind their effects.

The views of organisations and industries affected by marine protected areas (MPAs) have been gathered by a new survey. 36 organisations from the UK and France responded to the survey, which asked about the perceived socio-economic and environmental impacts of multiple-use MPAs. Environmental NGOs, managing agencies and research centres gave a largely positive response, while fishers’, shipping, and other industrial organisations perceived an overall negative impact on them. Gathering stakeholders’ views on MPAs may help improve socioeconomic outcomes through informing the planning and management of these marine areas, the researchers say.

A fossil that has been in the collection of the Smithsonian's National Museum of Natural History since it was discovered in 1951 is today helping scientists piece together the evolutionary history of whales and dolphins, including the origins of the endangered South Asian river dolphin.

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When most people hear the word "pollinator," they think of bees and butterflies. However, certain beetles are known to pollinate plants as well, and new fossil evidence indicates that they were doing so 20 million years ago.

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An international team of scientists has described a rare fossil site that is believed to be among the earliest evidence of different fish species using a common nursery -- much like ones utilized by some fish today.

read more

An extinct reptile related to crocodiles that lived 212 million years ago in present day New Mexico has been named as a new species, Vivaron haydeni, in a paper published this week by Virginia Tech's Department of Geosciences researchers.

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There is a growing demand for new settlements in and around urban areas due to social, economic and population factors. However, this can lead to the loss of agricultural land and green spaces that provide essential ecosystem services and contribute to the wellbeing of local people. Several countries, such as the UK and Germany, have attempted to limit the growth of urban areas by encouraging the redevelopment of brownfield sites.

A recent study has revealed that grassland plots planted with a mixture of several agricultural plant species produced a greater yield than plots planted with a single species. The findings provide valuable evidence for scientists, farmers and policymakers who strive to increase the productivity of grassland, while reducing input of nitrogen fertilisers.