Respiratory syncytial virus (RSV) infection is a common cause of pediatric hospitalizations. Mortality rates associated with RSV hospitalizations are based on estimates from studies conducted decades ago. Accurate understanding of mortality is required for identifying high-risk infants and children.

Mortality associated with RSV is uncommon in the 21st century, with annual deaths far lower than previous estimates. The majority of deaths occurred in infants with complex chronic conditions or in those with life-threatening conditions in addition to RSV infection. (Read the full article)

Myxovirus resistance protein A (MxA) is a protein induced during viral infections. A few small-scale studies have suggested that MxA could be used as a marker of viral infection in clinical routine practice.

This study involves the largest patient population thus far and confirms the usefulness of MxA for diagnosing viral infections in children consulting the emergency department in a clinical routine setting. (Read the full article)

Making a diagnosis of Kawasaki disease (KD) is often a diagnostic dilemma. This dilemma is confounded when children present with symptoms consistent with known, common respiratory viruses and/or with KD symptoms that could potentially be attributed to a respiratory virus.

Patients with KD commonly have a concurrent respiratory viral infection. Clinicians should not dismiss the diagnosis of KD based on the presence of respiratory symptoms. Furthermore, a positive respiratory virus test result should not be used to exclude the diagnosis of KD. (Read the full article)

Background: This study summarizes drug resistance analyses in 4 recent phase 2b trials of the respiratory syncytial virus (RSV) fusion inhibitor presatovir in naturally infected adults.

Methods: Adult hematopoietic cell transplant (HCT) recipients, lung transplant recipients, or hospitalized patients with naturally acquired, laboratory-confirmed RSV infection were enrolled in 4 randomized, double-blind, placebo-controlled studies with study-specific presatovir dosing. Full-length RSV F sequences amplified from nasal swabs obtained at baseline and postbaseline were analyzed by population sequencing. Substitutions at RSV fusion inhibitor resistance-associated positions are reported.

Results: Genotypic analyses were performed on 233 presatovir-treated and 149 placebo-treated subjects. RSV F variant V127A was present in 8 subjects at baseline. Population sequencing detected treatment-emergent substitutions in 10/89 (11.2%) HCT recipients with upper and 6/29 (20.7%) with lower respiratory tract infection, 1/35 (2.9%) lung transplant recipients, and 1/80 (1.3%) hospitalized patients treated with presatovir; placebo-treated subjects had no emergent resistance-associated substitutions. Subjects with substitutions at resistance-associated positions had smaller decreases in viral load during treatment relative to those without, but similar clinical outcomes.

Conclusions: Subject population type and dosing regimen may have influenced RSV resistance development during presatovir treatment. Subjects with vs without genotypic resistance development had decreased virologic responses but comparable clinical outcomes.

The quinoline MK-571 is the most commonly used inhibitor of multidrug resistance protein-1 (MRP-1) but was originally developed as a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist. While studying the modulatory effect of MRP-1 on anti-hepatitis C virus (HCV) direct acting-antivirals (DAA) efficiency, we observed an unexpected anti-HCV effect of compound MK-571 alone. This anti-HCV activity was characterized in Huh7.5 cells stably harboring a subgenomic genotype 1b replicon. A dose-dependent decrease of HCV RNA levels was observed upon MK-571 administration, with an EC₅₀ of 9±0.3 μM and a maximum HCV RNA level reduction of approximatively 1 Log₁₀. MK-571 also reduced the replication of the HCV full-length J6/JFH1 model in a dose-dependent manner. However, probenecid and apigenin homodimer (APN), two specific inhibitors of MRP-1, had no effect on HCV replication. In contrast, the CysLTR1 antagonists SR2640 increased HCV-SGR RNA levels in a dose-dependent manner, with a maximum increase of 10-fold. In addition, a combination of natural CysLTR1 agonist (LTD4) or antagonists (zafirlukast, cinalukast, and SR2640) with MK-571 completely reversed its antiviral effect, suggesting its anti-HCV activity is related to CysLTR1 rather to MRP-1 inhibition. In conclusion, we showed that MK-571 inhibits HCV replication in hepatoma cell cultures by acting as a CysLTR1 receptor antagonist, thus unraveling a new host-virus interaction in the HCV life cycle.

The biologic Griffithsin (GRFT) has recently emerged as a candidate to safely prevent sexually transmitted infections (STIs) including human immunodeficiency virus (HIV-1) and herpes simplex virus 2 (HSV-2). However, to date, there are few delivery platforms that are available to effectively deliver biologics to the female reproductive tract (FRT). The goal of this work was to evaluate rapid-release polyethylene oxide (PEO), polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) fibers, that incorporate GRFT, in in vitro (HIV-1 and HSV-2) and in vivo (HSV-2) infection models. GRFT loading was determined via ELISA, and the bioactivity of GRFT fibers was assessed using in vitro HIV-1 pseudovirus and HSV-2 plaque assays. Afterwards, the efficacy of GRFT fibers was assessed in a murine model of lethal HSV-2 infection. Finally, murine reproductive tracts and vaginal lavages were evaluated for histology and cytokine expression, 24 and 72 hr after fiber administration, to determine safety. All rapid-release formulations achieved high levels of GRFT incorporation and were completely efficacious against in vitro HIV-1 and HSV-2 infections. Importantly, all rapid-release GRFT fibers provided potent protection in a murine model of HSV-2 infection. Moreover, histology and cytokine levels, evaluated from collected murine reproductive tissues and vaginal lavages treated with blank fibers, showed no increased cytokine production or histological aberrations, demonstrating the preliminary safety of rapid-release GRFT fibers in vaginal tissue.

Bunyaviruses are significant human pathogens, causing diseases ranging from hemorrhagic fevers to encephalitis. Among these viruses, La Crosse virus (LACV), a member of the California serogroup, circulates in the eastern and midwestern United States. While LACV infection is often asymptomatic, dozens of cases of encephalitis are reported yearly. Unfortunately, no antivirals have been approved to treat LACV infection. Here, we developed a method to rapidly test potential antivirals against LACV infection. From this screen, we identified several potential antiviral molecules, including known antivirals. Additionally, we identified many novel antivirals that exhibited antiviral activity without affecting cellular viability. Valinomycin, a potassium ionophore, was among our top targets. We found that valinomycin exhibited potent anti-LACV activity in multiple cell types in a dose-dependent manner. Valinomycin did not affect particle stability or infectivity, suggesting that it may preclude virus replication by altering cellular potassium ions, a known determinant of LACV entry. We extended these results to other ionophores and found that the antiviral activity of valinomycin extended to other viral families including bunyaviruses (Rift Valley fever virus, Keystone virus), enteroviruses (Coxsackievirus, rhinovirus), flavirivuses (Zika), and coronaviruses (HCoV-229E and MERS-CoV). In all viral infections, we observed significant reductions in virus titer in valinomycin-treated cells. In sum, we demonstrate the importance of potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus replication.

Importance No antivirals are approved for the treatment of bunyavirus infection. The ability to rapidly screen compounds and identify novel antivirals is one means to accelerate drug discovery for viruses with no approved treatments. We used this approach to screen hundreds of compounds against La Crosse virus, an emerging bunyavirus that causes significant disease, including encephalitis. We identified several known and previously unidentified antivirals. We focused on a potassium ionophore, valinomycin, due to its promising in vitro antiviral activity. We demonstrate that valinomycin, as well as a selection of other ionophores, exhibits activity against La Crosse virus as well as several other distantly related bunyaviruses. We finally observe that valinomycin has activity against a wide array of human viral pathogens, suggesting that disrupting potassium ion homeostasis with valinomycin may be a potent host pathway to target to quell virus infection.

Attention has been paid to H5N6 highly pathogenic avian influenza virus (HPAIV) because of its heavy burden on the poultry industry and human mortality. Since an influenza A virus carrying N6 neuraminidase (NA) has never spread in humans, the potential for H5N6 HPAIV to cause disease in humans and the efficacy of antiviral drugs against the virus need to be urgently assessed. We used non-human primates to elucidate the pathogenesis of H5N6 HPAIV as well as to determine the efficacy of antiviral drugs against the virus. H5N6 HPAIV infection led to high fever in cynomolgus macaques. The lung injury caused by the virus was severe with diffuse alveolar damage and neutrophil infiltration. In addition, an increase in IFN-α showed an inverse correlation with virus titers during the infection process. Oseltamivir was effective for reducing H5N6 HPAIV propagation, and continuous treatment with peramivir reduced virus propagation and severity of symptoms in the early stage. This study also showed the pathologically severe lung injury states in the cynomolgus macaques infected with H5N6 HPAIV, even in those that received early antiviral drug treatments, indicating the need for close monitoring and the need for further studies on the virus pathogenicity and new antiviral therapies.

Seasonal and pandemic influenza causes 650,000 deaths annually in the world. The emergence of drug-resistance to specific anti-influenza drugs such as oseltamivir and baloxavir marboxil highlights the urgency of novel anti-influenza chemical entity discovery. In this study, we report a series of novel thiazolides derived from an FDA-approved drug nitazoxanide with antiviral activity against influenza and a broad range of viruses. The preferred candidates 4a and 4d showed significantly enhanced anti-influenza potentials with 10-fold improvement, compared with nitazoxanide, and were effective against a variety of influenza subtypes including oseltamivir-resistant strains. Notably, the combination using of compounds 4a/4d and oseltamivir carboxylate or zanamivir displayed synergistic antiviral effect against oseltamivir-resistant strain. Mode of action analysis demonstrated that compounds 4a/4d acted at the late phase of viral infection cycle through inhibiting viral RNA transcription and replication. Further experiments showed that treatment with compounds 4a/4d significantly inhibited influenza virus infection in human lung organoids, suggesting the druggability of the novel thiazolides. In-depth transcriptome analysis revealed a series of up-regulated cellular genes that may contribute to the antiviral activities of 4a/4d. Together, our study pointed the optimization direction of nitazoxanide as anti-influenza drug, and discovered two novel-structured candidates 4a/4d with relatively broad-spectrum antiviral potential.

Despite the worldwide re-emergence of the chikungunya virus (CHIKV) and the high morbidity associated with CHIKV infections, there is no approved vaccine or antiviral treatment available. We here aim to identify the target of a novel class of CHIKV inhibitors i.e. CHVB series. CHVB compounds inhibit the in vitro replication of CHIKV isolates with 50% effective concentrations in the low micromolar range. A CHVB-resistant variant (CHVB^res) was selected that carried two mutations in the gene encoding nsP1 (responsible for viral RNA capping), one mutation in nsP2 and one mutation in nsP3. Reverse genetics studies demonstrated that both nsP1 mutations were necessary and sufficient to achieve ~18-fold resistance, suggesting that CHVB targets viral mRNA capping. Interestingly, CHVB^res was cross-resistant to the previously described CHIKV capping inhibitors from the MADTP series, suggesting they share a similar mechanism of action. In enzymatic assays, CHVB inhibited the methyltransferase and guanylyltransferase activities of alphavirus nsP1 proteins. To conclude, we identified a class of CHIKV inhibitors that targets the viral capping machinery. The potent anti-CHIKV activity makes this chemical scaffold a potential candidate for CHIKV drug development.

Ebola Virus (EBOV) is among the most devastating pathogens causing fatal hemorrhagic fever in humans. The 2013–2016 epidemics resulted in over 11000 deaths, while another outbreak is currently ongoing. Since there is no FDA-approved drug so far to fight EBOV infection, there is an urgent need to focus on drug discovery. Considering the tight correlation between the high EBOV virulence and its ability to suppress the type-I Interferon (IFN-I) system, identifying molecules targeting viral protein VP24, one of the main virulence determinants blocking IFN response, is a promising novel anti-EBOV therapy approach. Hence, in the effort of finding novel EBOV inhibitors, a screening of a small set of flavonoids was performed, showing that Quercetin and Wogonin can suppress the VP24 effect on IFN-I signaling inhibition. The mechanism of action of the most active compound, Quercetin, showing an IC₅₀ value of 7.4 μM, was characterized to significantly restore the IFN-I signaling cascade, blocked by VP24, by directly interfering with the VP24 binding to karyopherin-α and thus restoring P-STAT1 nuclear transport and IFN genes transcription. Quercetin significantly blocked viral infection, specifically targeting EBOV VP24 anti-IFN-I function. Overall, Quercetin is the first identified inhibitor of the EBOV VP24 anti-IFN function, representing a molecule interacting with a viral binding site that is very promising for further drug development aiming to block EBOV infection at the early steps.

Drug repositioning is the only feasible option to address the COVID-19 global challenge immediately. We screened a panel of 48 FDA-approved drugs against SARS-CoV-2 which were pre-selected by an assay of SARS-CoV and identified 24 potential antiviral drug candidates against SARS-CoV-2 infection. Some drug candidates showed very low micromolar IC50s and in particular, two FDA-approved drugs - niclosamide and ciclesonide – were notable in some respects.

Cyclophilins play a key role in the lifecycle of coronaviruses. Alisporivir (Debio 025) is a non-immunosuppressive analogue of cyclosporin A with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in VeroE6 cell line, with an EC₅₀ of 0.46±0.04 μM. Alisporivir inhibited a post-entry step of the SARS-CoV-2 lifecycle. These results justify that a proof-of-concept Phase 2 trial be rapidly conducted with alisporivir in patients with SARS-CoV-2 infection.

Oil prices made a spectacular comeback Thursday as fresh US-Iran tensions erupted, also helping equities advance after US labour market figures provided a glimmer of hope for the world's top economy.

Stock markets struggled on Friday as hopes of quickly finding a treatment for coronavirus were dashed, analysts said, and more crushing economic data delivered a body blow to confidence.

Penn State Health Milton S. Hershey Medical Center has begun enrolling participants in an international clinical trial evaluating an investigational antiviral drug, remdesivir, for treatment of coronavirus disease 2019 (COVID-19).

A new protocol using aerosolized hydrogen peroxide to decontaminate N95 respirators could allow them to be safely reused in hospital settings. The protocol, optimized by a team of Penn State researchers, inactivates viruses without deforming or damaging the respirator and could help hospitals overcome the current respirator shortage due to the COVID-19 pandemic.

G. C. Liggins
Oct 1, 1972; 50:515-525
ARTICLES

The IMpact-RSV Study Group
Sep 1, 1998; 102:531-537
ARTICLES

When parents or guardians hope for a miracle for their child who is critically ill, ethical and professional challenges can arise. Often, although not always, the parent or guardian’s hope for a miracle entails a request for continued life-sustaining interventions. Striking a balance between the pediatrician’s conception of good medicine and the parent or guardian’s authority requires a response that is sensitive, practical, and ethically sound. In this article, we recommend 3 cumulative steps that promote such a response. First, we recommend ways of exploring essential issues through open inquiry, interdisciplinary dialogue, and self-reflection. As part of this exploration, pediatricians will discover that parents or guardians often have unique ideas about what a miracle might be for their child. The second step includes analyzing this diversity and seeking understanding. We classify the hope for a miracle into 3 distinct categories: integrated, seeking, and adaptive. After the pediatrician has categorized the parent or guardian’s hope, they can consider specific recommendations. We detail context-specific responses for each kind of hope. By attending to these nuances, not only will the parent or guardian’s perspective be heard but also the pediatrician’s recommendation can strike a balance between advocating for their conception of good medicine and respecting the parent or guardian’s beliefs.

CNA Staff, Mar 27, 2020 / 11:19 am (CNA).- Four men working in Iraq for the French humanitarian organization SOS Chrétiens d'Orient who went missing in Baghdad in January have been released by their kidnappers, the French president announced Thursday.

Emmanuel Macron announced March 26 that he “welcomes the release of our three nationals Antoine Brochon, Julien Dittmar, Alexandre Goodarzy and Iraqi Tariq Mattoka.”

The men disappeared Jan. 20 after they made a trip to an appointment by car. SOS Chrétiens d'Orient tried to contact them the following day, unsuccessfully.

The missing employees had gone to Baghdad “to renew their visas and the registration of association with the Iraqi authorities and to monitor the association's operations” in the country.

Macron's office said it had made “every effort” to secure their release, and he expressed “gratitude to the Iraqi authorities for their co-operation.”

SOS Chrétiens d'Orient said last week that they had received no ransom demand, and no group had claimed responsibility for the abduction.

The organization works to support Eastern Christians with humanitarian material aid; it has permanent missions in Syria, Iraq, Lebanon, and Egypt.

Christians in Iraq have suffered persecution in recent years, especially during the invasion of the Islamic State.

Prior to the United States invasion of Iraq in 2003, there were about 1.5 million Iraqi Christians. Today, that number is believed to be fewer than 500,000.

Rome Newsroom, Apr 22, 2020 / 12:00 pm (CNA).- For Iraqi Christian and Yazidi communities still recovering from the destruction wreaked by the Islamic State, the coronavirus poses significant risks, NGOs have said in a joint statement. 

“The public health system in Sinjar and the wider Nineveh Governorate was decimated by ISIS during its brutal occupation and genocidal campaign in Iraq, beginning in 2014,” the letter stated.

“An impending humanitarian and security disaster looms large in Iraq. … There is a significant attendant threat to global security if ISIS uses this opportunity to regroup and return, but it does not have to be this way. Iraqi authorities and the United Nations must act now,” it continued.

Twenty-five NGOs working in northern Iraq issued a joint statement April 16 calling on the World Health Organization to undertake an assessment mission in the area, where testing has been limited, and urging Iraqi authorities to prevent the Islamic State from regrouping.

Signed by the Iraqi Christian Relief Council, Free Yezidi Foundation, Genocide Alert, and the Religious Freedom Institute, the statement described how the pandemic is exacerbating existing security, humanitarian, and health risks among displaced and rebuilding Iraqi minority communities. It highlighted, in particular, the global risk of a potential resurgence of the Islamic State.

Security threat

“COVID-19 and the precipitous drop in oil prices have caused the Iraqi economy to collapse, leaving a dangerous security vacuum for ISIS to exploit. Indeed, the resultant political turmoil and social strife recall the very conditions that earlier incarnations of ISIS and its supporters capitalized on during its initial surge almost a decade ago,” it stated.

“According to International Crisis Group, ISIS in its weekly newsletter Al-Naba called on its fighters to attack and weaken its enemies while they are distracted by the pandemic,” it added.

U.S. military officials have expressed concern that the Islamic State could use adverse conditions to its advantage in it recruitment efforts.

“COVID-19 has also hastened the departure of some coalition forces from Iraq, weakening counter-terrorism operations, while some ISIS detainees have recently escaped prison in Syria,” the letter stated.

On March 30, Islamic State fighters imprisoned in northwestern Syria revolted. The rioting prisoners took over one wing of the prison before Kurdish forces intervened.

“There is an urgent need for reform in the civilian security sector, in order to integrate regional militias into a unified Federal Police that upholds the rule of law and protects all citizens, regardless of religion or clan affiliation,” the letter said.

Health infrastructure needs

The economic strain has also hindered Iraqi minorities’ efforts to rebuild their communities, including medical infrastructure needs.

“Many Yazidis (Ezidis/Yezidis) want to return to Sinjar, but security, reconstruction and basic services are still lacking to allow a dignified return. There are currently only two hospitals and just one ventilator to assist the current population of around 160,000 people in the region,” the NGOs’ statement explained.

Iraq’s healthcare system, which has suffered for decades from the effects of sanctions and war, currently faces a critical shortage of doctors and medicine, according to a Reuters investigation. Hospitals in Iraq are already overcrowded and doctors overworked, while the healthcare situation is slightly better in the semi-autonomous Kurdistan Region of Iraq, which has its own health ministry.

There have been at least 1,600 cases of COVID-19 documented in Iraq, which is under pressure to reopen its border with Iran, which has had more than 85,000 confirmed coronavirus cases, according to Johns Hopkins University Coronavirus Resource Center.

Humanitarian workers have also had trouble reaching those in need due to movement restrictions, and have raised concerns about the risk of an outbreak in internally displaced persons (IDP) camps.

Social distancing is very difficult in these high-density IDP camps in Iraq, where 1.8 million people remain displaced due to insecurity and reconstruction needs, according to the UN.

The 25 NGOs called for the government of Iraq and the United Nations to provide testing capacity in the IDP camps in Sinjar, Tel Afar and the Nineveh Plains.

“At present, it is impossible to apprehend the extent of the spread of the virus because no testing for the disease is taking place in the camps, while restrictions of movement impede the work of humanitarian actors who provide basic essentials such as food, water and medicine,” they stated.

Psychological risk for trauma survivors

Genocide survivors with trauma also face increased personal risk of psychological harm amid isolation imposed by coronavirus measures.

As in much of the world, authorities in Iraqi Kurdistan have ordered people to stay home, imposed a curfew, and have closed places of worship, schools, restaurants, and most businesses. 

“Another alarming corollary of the COVID-19 pandemic in Iraq is the psychological impact on at-risk communities, including Yazidis, Turkmen and Christians, such as Assyrians,” it said.

This is a particular concern for the Yazidi communities in which thousands of women were victims of sexual violence by the Islamic State.

“Prior to the outbreak, Médecins Sans Frontières reported on a debilitating mental health crisis among Yazidis in Iraq, including a rising number of suicides,” it stated.

Suicides in this community have already been reported since social distancing measures were put into place, the NGOs reported. They called on the World Health Organization to address this “acute mental health crisis.”

In their appeal to the WHO and Iraqi government, the NGOs insisted that the stakes were high: 

“COVID-19 is a pandemic the likes of which we have not seen before. Survivors of genocide and other mass atrocity crimes are now waiting for this silent death to pass through the camps and their homes, unable to fight back.”

Ukraine will take on holders Brazil while European champions Spain have again been matched with Iran in the draw for the 2016 FIFA Futsal World Cup final tournament.

Inter FS, Barça, Sporting CP and Kairat have reached April's finals after topping their groups.

Sporting CP beat hosts Kairat Almaty 2-1 to win the title, while Barça edged Inter FS for bronze.

This phase IIb randomized controlled trial demonstrates greater efficacy of phenobarbital than levetiracetam in the treatment of neonatal seizures; more adverse events occurred with phenobarbital.

Jessie Stein tells the story of God's faithfulness in the midst of learning a foreign language and the struggles of a broken family.

VFS Global has appointed L&K Saatchi & Saatchi as its global creative agency. The agency will manage VFS Global’s marketing and branding mandate for its operations worldwide.

The book also conveys an important message that misconceptions often lead to wrong judgment about people, and aims at making us better decision makers.

Elon Musk for his sheer audacity of dreaming unabashedly and then making those impossible dreams come true, says Ajit Andhare, COO, Viacom18 Studios.

The Messy Middle. The book talks about the middle stages of every start-up, the troubles it goes through, and how crossing that hurdle is important yet tricky

The Godfather, of course. It is a cult classic. Another movie that I would like to watch again is Andhadhun for its unpredictable storyline and performances.

"I find my job very exciting; every day is new, as we are creating a brand in the Indian market which is a challenge in itself," says Rahul Vira, CEO, Skechers, South Asia.

Virat Kohli feels that it would be difficult to create the magic of playing in front of thousands of fans if games are held behind closed doors.

Rohit Sharma shared a picture of daughter Samaira surrounded by her toys.

Virat Kohli and wife Anushka Sharma have donated Rs 5 lakh each for Mumbai police welfare amid the coronavirus outbreak.

Ira and Hazel have worked together in the former's directorial debut Medea

"Big love with my little love," wrote Mira

Venezuela has charged two former US soldiers with "terrorism" and "conspiracy" for allegedly taking part in a failed invasion bid to topple President Nicolas Maduro, the attorney general said on...

Researchers in Hong Kong have found that patients suffering milder illness caused by the new coronavirus recover more quickly if they are treated with a three-drug antiviral cocktail soon after...

A visit to any neighbourhood kirana shop will reveal piles of snacks, bakery goods, groceries, soaps and sanitisers that have been made in the immediate vicinity.

Our eyes have landed on two new videos and they loved them as Hyundai WRC driver Thierry Neuville gets behind the wheel of the i20 WRC, the RM19, and the i20 N prototype, putting them through their paces in a snowy landscape. The i20 N will be the most powerful Hyundai i20 there’s been and […]

A 5.1 magnitude earthquake has jolted an area in northern Iran, home to a sleeping volcano, forcing panicked residents in and around Tehran to rush onto the streets despite the Covid-19 lockdown.
Read Full Article at RT.com

House Intelligence Committee chair Adam Schiff has published all the transcripts of ‘Russiagate’ interviews he had kept secret, blaming President Donald Trump for the delay, but their content belied his conspiracy narrative.
Read Full Article at RT.com

Venezuela has charged two former US soldiers with terrorism and conspiracy offences for taking part in a botched bid to oust President Nicolas Maduro, the country’s top prosecutor said on Friday.
Read Full Article at RT.com