While President Donald Trump traveled to the battleground state of Arizona this week, his Democratic opponent for the White House, Joe Biden, campaigned from his basement as he has done throughout the coronavirus pandemic. The freeze on in-person campaigning during the outbreak has had an upside for Biden, giving the former vice president more time to court donors and shielding him from on-the-trail gaffes. "I personally would like to see him out more because he's in his element when he's meeting people," said Tom Sacks-Wilner, a fundraiser for Biden who is on the campaign's finance committee.

Cristiano Villa, Jeong Eun Lee.

Source: Bayesian Analysis, Volume 15, Number 2, 533--558.

Abstract:
In this work we propose a novel model prior for variable selection in linear regression. The idea is to determine the prior mass by considering the worth of each of the regression models, given the number of possible covariates under consideration. The worth of a model consists of the information loss and the loss due to model complexity. While the information loss is determined objectively, the loss expression due to model complexity is flexible and, the penalty on model size can be even customized to include some prior knowledge. Some versions of the loss-based prior are proposed and compared empirically. Through simulation studies and real data analyses, we compare the proposed prior to the Scott and Berger prior, for noninformative scenarios, and with the Beta-Binomial prior, for informative scenarios.

Brian Neelon.

Source: Bayesian Analysis, Volume 14, Number 3, 849--875.

Abstract:
Motivated by a study examining spatiotemporal patterns in inpatient hospitalizations, we propose an efficient Bayesian approach for fitting zero-inflated negative binomial models. To facilitate posterior sampling, we introduce a set of latent variables that are represented as scale mixtures of normals, where the precision terms follow independent Pólya-Gamma distributions. Conditional on the latent variables, inference proceeds via straightforward Gibbs sampling. For fixed-effects models, our approach is comparable to existing methods. However, our model can accommodate more complex data structures, including multivariate and spatiotemporal data, settings in which current approaches often fail due to computational challenges. Using simulation studies, we highlight key features of the method and compare its performance to other estimation procedures. We apply the approach to a spatiotemporal analysis examining the number of annual inpatient admissions among United States veterans with type 2 diabetes.

Ioannis Ntzoufras, Claudia Tarantola, Monia Lupparelli.

Source: Bayesian Analysis, Volume 14, Number 3, 797--823.

Abstract:
We introduce a novel Bayesian approach for quantitative learning for graphical log-linear marginal models. These models belong to curved exponential families that are difficult to handle from a Bayesian perspective. The likelihood cannot be analytically expressed as a function of the marginal log-linear interactions, but only in terms of cell counts or probabilities. Posterior distributions cannot be directly obtained, and Markov Chain Monte Carlo (MCMC) methods are needed. Finally, a well-defined model requires parameter values that lead to compatible marginal probabilities. Hence, any MCMC should account for this important restriction. We construct a fully automatic and efficient MCMC strategy for quantitative learning for such models that handles these problems. While the prior is expressed in terms of the marginal log-linear interactions, we build an MCMC algorithm that employs a proposal on the probability parameter space. The corresponding proposal on the marginal log-linear interactions is obtained via parameter transformation. We exploit a conditional conjugate setup to build an efficient proposal on probability parameters. The proposed methodology is illustrated by a simulation study and a real dataset.

Marko Järvenpää, Michael U. Gutmann, Arijus Pleska, Aki Vehtari, Pekka Marttinen.

Source: Bayesian Analysis, Volume 14, Number 2, 595--622.

Abstract:
Approximate Bayesian computation (ABC) is a method for Bayesian inference when the likelihood is unavailable but simulating from the model is possible. However, many ABC algorithms require a large number of simulations, which can be costly. To reduce the computational cost, Bayesian optimisation (BO) and surrogate models such as Gaussian processes have been proposed. Bayesian optimisation enables one to intelligently decide where to evaluate the model next but common BO strategies are not designed for the goal of estimating the posterior distribution. Our paper addresses this gap in the literature. We propose to compute the uncertainty in the ABC posterior density, which is due to a lack of simulations to estimate this quantity accurately, and define a loss function that measures this uncertainty. We then propose to select the next evaluation location to minimise the expected loss. Experiments show that the proposed method often produces the most accurate approximations as compared to common BO strategies.

Zhixiang Lin, Mahdi Zamanighomi, Timothy Daley, Shining Ma, Wing Hung Wong.

Source: Statistical Science, Volume 35, Number 1, 2--13.

Abstract:
Unsupervised methods, including clustering methods, are essential to the analysis of single-cell genomic data. Model-based clustering methods are under-explored in the area of single-cell genomics, and have the advantage of quantifying the uncertainty of the clustering result. Here we develop a model-based approach for the integrative analysis of single-cell chromatin accessibility and gene expression data. We show that combining these two types of data, we can achieve a better separation of the underlying cell types. An efficient Markov chain Monte Carlo algorithm is also developed.

John D. Cahoy
Jan 2, 2008; 28:264-278
Cellular

Ye Zhang
Sep 3, 2014; 34:11929-11947
Cellular

PR Montague
Mar 1, 1996; 16:1936-1947
Articles

John D. Cahoy
Jan 2, 2008; 28:264-278
Cellular

Ye Zhang
Sep 3, 2014; 34:11929-11947
Cellular

Microsoft has introduced a slew of new products, including the Surface Go 2, the Surface Book 3, Surface Headphones 2 and Surface Earbuds. Both the Surface Go 2 and the Surface Book 3 come in consumer and corporate versions. "The two products are very different," noted Rob Enderle, principal analyst at the Enderle Group. "The Go 2 is a high-value product -- the Surface Book 3 high innovation."

Speech by Mr Agustín Carstens, General Manager of the BIS, at the Fourteenth ASBA-BCBS-FSI High-level Meeting on Global and Regional Supervisory Priorities, Lima, 1 October 2019.

Reward has a remarkable ability to invigorate motor behavior, enabling individuals to select and execute actions with greater precision and speed. However, if reward is to be exploited in applied settings, such as rehabilitation, a thorough understanding of its underlying mechanisms is required. In a series of experiments, we first demonstrate that reward simultaneously improves the selection and execution components of a reaching movement. Specifically, reward promoted the selection of the correct action in the presence of distractors, while also improving execution through increased speed and maintenance of accuracy. These results led to a shift in the speed-accuracy functions for both selection and execution. In addition, punishment had a similar impact on action selection and execution, although it enhanced execution performance across all trials within a block, that is, its impact was noncontingent to trial value. Although the reward-driven enhancement of movement execution has been proposed to occur through enhanced feedback control, an untested possibility is that it is also driven by increased arm stiffness, an energy-consuming process that enhances limb stability. Computational analysis revealed that reward led to both an increase in feedback correction in the middle of the movement and a reduction in motor noise near the target. In line with our hypothesis, we provide novel evidence that this noise reduction is driven by a reward-dependent increase in arm stiffness. Therefore, reward drives multiple error-reduction mechanisms which enable individuals to invigorate motor performance without compromising accuracy.

SIGNIFICANCE STATEMENT While reward is well-known for enhancing motor performance, how the nervous system generates these improvements is unclear. Despite recent work indicating that reward leads to enhanced feedback control, an untested possibility is that it also increases arm stiffness. We demonstrate that reward simultaneously improves the selection and execution components of a reaching movement. Furthermore, we show that punishment has a similar positive impact on performance. Importantly, by combining computational and biomechanical approaches, we show that reward leads to both improved feedback correction and an increase in stiffness. Therefore, reward drives multiple error-reduction mechanisms which enable individuals to invigorate performance without compromising accuracy. This work suggests that stiffness control plays a vital, and underappreciated, role in the reward-based imporvemenets in motor control.

Nuclear bomb tests caused a spike in a radioactive form of carbon that accumulated in living things

Major League Baseball players and team employees to participate in 10,000-person COVID-19 study

During his 20-year professional career, his boisterous style endeared him to fans but rankled traditionalists

The Northwoods League announced Thursday that its 2020 season will not begin on May 26, as originally scheduled, due to the COVID-19 pandemic.

The following is a guest post by Hanna Soltys, Reference Librarian, Prints & Photographs Division. The post was written with the help of Sara W. Duke, Curator of Popular and Applied Graphic Art.   While professional baseball’s Opening Day will take place at a later date, the spirit and excitement of the day still live […]

Press release about the Basel Committee publishing consultation paper on revisions to the credit valuation adjustment risk framework, 28 November 2019.

Press release: Basel Committee invites comments on the design of a prudential treatment for crypto-assets, 12 December 2019.

Press release about the Basel Committee launching the consolidated Basel Framework, 16 December 2019.

Basel Committee Press release "Basel Committee meets to review vulnerabilities and emerging risks, advance supervisory initiatives and promote Basel III implementationl", 27 February 2020.

BIS statement, 16 March 2020.

Press release about Basel Committee assesses members' implementation of the Net Stable Funding Ratio and large exposures framework, 19 March 2020

Press release "Basel Committee coordinates policy and supervisory response to Covid-19", 20 March 2020

Press release "Governors and Heads of Supervision announce deferral of Basel III implementation to increase operational capacity of banks and supervisors to respond to Covid-19", 27 March 2020

BCBS Press release "Basel Committee sets out additional measures to alleviate the impact of Covid-19", 3 April 2020

BCBS Press release "Basel Committee and IOSCO announce deferral of final implementation phases of the margin requirements for non-centrally cleared derivatives", 3 April 2020

BCBS Press release "Basel III monitoring results based on end-June 2019 data published by the Basel Committee", 8 April 2020

BCBS Press release "Basel Committee issues progress report on banks' implementation of the 'Principles for effective risk data aggregation and reporting'", 29 April 2020

Rutgers' RUCDR Infinite Biologics received an amended emergency use authorization from the FDA late Thursday for the first SARS-CoV-2 coronavirus test that will allow people to collect their own saliva at home and send to a lab for results.

Live professional baseball games could be televised in the United States as early next week, with South Korea's Yonhap News Agency reporting Monday that ESPN and the Korea Baseball Organization are nearing an agreement.

Derek Jeter, Larry Walker and the rest of this year's Baseball Hall of Fame class will have to wait another year for their big moment at Cooperstown.

The Korean baseball league opens its delayed season Tuesday in empty stadiums across South Korea and Canada's Jamie Romak, along with the rest of the league's players, are getting used to a new baseball normal that includes rules against high fives and spitting, daily temperature checks and the absence of fans.

The new baseball season began in South Korea on Tuesday with the crack of the bat and the sound of the ball smacking into the catcher's mitt echoing around empty stadiums.

Everyone is rooting for Korean baseball to succeed right now because, if it fails, we're left with a pretty dark thought: If they can't pull this off, what hope do we have?

A sports writer covering the strange return of South Korea's baseball season says fans should brace for similarly odd experience in Toronto, if and when the 2020 season begins.

BCBS Press release "Basel Committee publishes stocktake report on climate-related financial risk initiatives'", 30 April 2020

We document that corporate pension contributions respond to tax-based incentives using the 2017 Tax Cut & Jobs Act (TCJA) as a natural experiment. The TCJA cut the U.S. federal corporate tax rate, temporarily increasing contribution incentives for sponsors of defined-benefit retirement plans. We exploit cross-sectional variation in ex-ante exposure to these incentives.

Stoking interest in an expected second season of Apple TV+ original "For All Mankind," Apple on Wednesday shared a virtual tour of the show's fictional Jamestown lunar base.

The impact of baseball as an outreach tool is growing far beyond the first teams that began nine years ago in Érd.

OM Hungary's Sports Team brings baseball and the Gospel to local schools in their now-annual visit to sports classes.

Sports ministry is having an impact on peoples' lives, both young and old. In Hungary its no different with their ever growing Baseball Ministry

The post Frequently Asked Questions about Cloud-based Abaqus Simulation for SOLIDWORKS appeared first on The SOLIDWORKS Blog.

Rome, Italy, May 8, 2020 / 10:00 am (CNA).- The U.S. Ambassador to the Holy See has called attention to the role of faith-based organizations in delivering U.S government relief funds to assist people who are suffering due to the coronavirus in Italy.

“The United States is funding NGOs and faith-based organizations that can effectively deliver critical assistance,” U.S. Ambassador Callista Gingrich told EWTN News May 6. 

“It’s important that American money be put to good use. Faith-based organizations are effective and trustworthy partners. They’re inspired by a sense of purpose and dedication to help those most in need,” the ambassador said.

The U.S. Agency for International Development (USAID) has committed $50 million to aid Italy as it responds to the outbreak, which includes $30 million in funding split between faith-based organizations, nongovernmental organizations, and public international organizations, an official from the embassy told CNA. 

This is part of the $900 million the U.S. government is contributing globally in response to the COVID-19 pandemic. On May 6, U.S. Secretary of State Mike Pompeo announced that $100 million will be used to support virus detection and control, and $28 million to support refugees and migrants.

While the U.S. government is still in the process of vetting which NGOs and faith-based organizations will be receiving funds in Italy, Ambassador Gingrich said that the assistance package includes funding for “some of our Vatican-affiliated partners here, in Italy.”

A USAID document published in April describes the work of Catholic Relief Services and Caritas in Bangladesh, Nepal, Lebanon, Liberia, Kenya, Guatemala, and Mexico in supporting health care among vulnerable populations. It also showcases the contributions of Islamic Relief USA, the Jewish Distribution Committee, World Vision, and Malteser International, the aid agency of the Order of Malta.

In Italy, Malteser International set up a hospital and donated 260 ventilators, and distributed food and medicine to elderly in isolation.

A symposium at the Vatican on government partnerships with faith-based organizations co-hosted by the U.S. Embassy to the Holy See in October also highlighted the work of Caritas Internationalis, the Community of Sant’Egidio, and Aid to the Church in Need in providing humanitarian assistance.

The U.S. government has previously partnered with faith-based groups to provide emergency relief, defend religious freedom, and combat human trafficking, stating that faith-based organizations provide “unparalleled access to local populations and a fierce dedication to human dignity.”

In April, the embassy publicized the work of the evangelical Christian organization Samaritan’s Purse in creating and staffing an emergency field hospital in Cremona, Italy, in an online video. 

“As the world continues to battle the COVID-19 pandemic, faith-based organizations are playing a vital role,” Gingrich said in the video. 

Nearly 30,000 people have died in Italy’s coronavirus outbreak, according to the Italian Ministry of Health’s statistics on May 7. At least 89,000 people remain infected with COVID-19 in Italy after a total of more than 215,000 cases were documented, mostly in the north of the country.

Due to Italy’s nationwide lockdown, the U.S. Embassy to the Holy See has had to cancel several events it had scheduled for the spring, including a symposium, “Confronting the global rise of anti-Semitism,” scheduled to coincide with the opening of the Vatican’s archives on Pope Pius XII. 

However, the ambassador said that she has continued to speak with members of the diplomatic community via weekly video conferences.

“This pandemic will greatly affect our priorities and activities going forward. However, through meetings, symposiums, and cultural diplomacy, the U.S. Embassy to the Holy See will continue our important work with the Vatican to advance peace, freedom, and human dignity around the world,” Gingrich said.

Rome, Italy, May 8, 2020 / 10:00 am (CNA).- The U.S. Ambassador to the Holy See has called attention to the role of faith-based organizations in delivering U.S government relief funds to assist people who are suffering due to the coronavirus in Italy.

“The United States is funding NGOs and faith-based organizations that can effectively deliver critical assistance,” U.S. Ambassador Callista Gingrich told EWTN News May 6. 

“It’s important that American money be put to good use. Faith-based organizations are effective and trustworthy partners. They’re inspired by a sense of purpose and dedication to help those most in need,” the ambassador said.

The U.S. Agency for International Development (USAID) has committed $50 million to aid Italy as it responds to the outbreak, which includes $30 million in funding split between faith-based organizations, nongovernmental organizations, and public international organizations, an official from the embassy told CNA. 

This is part of the $900 million the U.S. government is contributing globally in response to the COVID-19 pandemic. On May 6, U.S. Secretary of State Mike Pompeo announced that $100 million will be used to support virus detection and control, and $28 million to support refugees and migrants.

While the U.S. government is still in the process of vetting which NGOs and faith-based organizations will be receiving funds in Italy, Ambassador Gingrich said that the assistance package includes funding for “some of our Vatican-affiliated partners here, in Italy.”

A USAID document published in April describes the work of Catholic Relief Services and Caritas in Bangladesh, Nepal, Lebanon, Liberia, Kenya, Guatemala, and Mexico in supporting health care among vulnerable populations. It also showcases the contributions of Islamic Relief USA, the Jewish Distribution Committee, World Vision, and Malteser International, the aid agency of the Order of Malta.

In Italy, Malteser International set up a hospital and donated 260 ventilators, and distributed food and medicine to elderly in isolation.

A symposium at the Vatican on government partnerships with faith-based organizations co-hosted by the U.S. Embassy to the Holy See in October also highlighted the work of Caritas Internationalis, the Community of Sant’Egidio, and Aid to the Church in Need in providing humanitarian assistance.

The U.S. government has previously partnered with faith-based groups to provide emergency relief, defend religious freedom, and combat human trafficking, stating that faith-based organizations provide “unparalleled access to local populations and a fierce dedication to human dignity.”

In April, the embassy publicized the work of the evangelical Christian organization Samaritan’s Purse in creating and staffing an emergency field hospital in Cremona, Italy, in an online video. 

“As the world continues to battle the COVID-19 pandemic, faith-based organizations are playing a vital role,” Gingrich said in the video. 

Nearly 30,000 people have died in Italy’s coronavirus outbreak, according to the Italian Ministry of Health’s statistics on May 7. At least 89,000 people remain infected with COVID-19 in Italy after a total of more than 215,000 cases were documented, mostly in the north of the country.

Due to Italy’s nationwide lockdown, the U.S. Embassy to the Holy See has had to cancel several events it had scheduled for the spring, including a symposium, “Confronting the global rise of anti-Semitism,” scheduled to coincide with the opening of the Vatican’s archives on Pope Pius XII. 

However, the ambassador said that she has continued to speak with members of the diplomatic community via weekly video conferences.

“This pandemic will greatly affect our priorities and activities going forward. However, through meetings, symposiums, and cultural diplomacy, the U.S. Embassy to the Holy See will continue our important work with the Vatican to advance peace, freedom, and human dignity around the world,” Gingrich said.

BACKGROUND AND OBJECTIVES:

Systems of care emphasize parent-delivered intervention for children with autism spectrum disorder (ASD). Meanwhile, multiple studies document psychological distress within these parents. This pilot longitudinal randomized controlled trial compared the parent-implemented Early Start Denver Model (P-ESDM) to P-ESDM plus mindfulness-based stress reduction (MBSR) for parents. We evaluated changes in parent functioning during active treatment and at follow-up.

Almost 1 in 4 adolescents have a sexually transmitted infection (STI). These infections are preventable through safe sexual practices and routine screening. Pediatricians are the first line of clinical care for adolescents and are well positioned to offer sexual and reproductive health care counseling and services to their patients; yet, there is a paucity of sexual health screening provided at routine health supervision visits. This article addresses the epidemiology of STIs in adolescents, reviews the evidence of current clinical practice, presents recommended STI screening from government and medical agencies, and offers strategies to address barriers to providing care for adolescents and for sexual health screening in primary care.