Archives, Room Use Only - UG582.S4 S96 1914

Archives, Room Use Only - TK5627.J46 1862

Archives, Room Use Only - UG573.U78 1901

Archives, Room Use Only - TK5627.U55 1946

Archives, Room Use Only - UG607.U55 1905

Archives, Room Use Only - UG603.A76 1912

Archives, Room Use Only - TK5741.T74 1902

Archives, Room Use Only - TF615.B38 1913

Archives, Room Use Only - D570.346 406th.S33 1921

Archives, Room Use Only - UG580.S65 1916

Archives, Room Use Only - UG573.G53 1917

Archives, Room Use Only - UG575.G7 G74 1915

Archives, Room Use Only - V285.G7 S54 1937

Archives, Room Use Only - VK381.B76 1917

Archives, Room Use Only - UG573.U56 1916

Archives, Room Use Only - TK5262.B79 1876

Words to tattoo on your knuckles:

Over the past couple of years, my blog hasn’t felt my own, to a degree. It’s felt like I’ve been writ­ing for an audi­ence, post­ing stuff for oth­ers rather than myself. That’s arse-backwards. A blog should be about per­sonal expres­sion. The moment you start think­ing, and writ­ing, to please oth­ers then it’s a bind; it feels less like a per­sonal exer­cise and more of a job.

A beautiful, thoughtful redesign from Mark Boulton (and a responsive one at that). Go go, read read.

The Congress requested the President to remind the central government of its 'raj dharma', Singh said.

Nearly 7,000 paramilitary forces have been deployed in the affected areas of the northeast district since Monday.

The Congress and other opposition parties have accused the police of bias and inaction in the Delhi violence.

Startup designs foldable japi

September 23, 2015

As an industry, we’ve worked to established many new practices and tools for nimble design teams, from A/B testing to measuring bounce rates and CTR performance. But a lot of these methods require engineers or some amount of technical know-how to execute, and they take place only after something has been launched.

The judicious application of “dumb data” can streamline your workflow and improve your designs

What many people don’t know is that there are some unexpected applications of data to consider earlier in the design process, which you, the designer, can do yourself. They’re not fancy, and you don’t need to know how to write SQL queries. The judicious application of just-enough “dumb data” can streamline your workflow and improve your designs in surprisingly useful ways.

Here are...read more
By Jocelyn Lin

September 28, 2015

Good design in any discipline usually carries a structure of order and harmony. Since the Renaissance, artists and architects have used a strong understanding of proportions to create aesthetically pleasing architecture. Many of these classical design principles have followed us into modern times and can be found today in effective web design.

Take an A4 piece of paper for example. If you take it and halve it, the resulting size is A5 with the same exact proportions. No other proportion has the same properties. 16th century architect, Andrea Palladio knew this well. It is believed that because, fundamentally, most architects—like Palladio—use a similar system of proportions to plan and design spaces, buildings can look very different while remaining similar at their cores.

Structure and Beauty

It’s in human nature to...read more
By Ling Lim

September 30, 2015

By their very nature, heuristics offer a hands-on approach to discovery, where knowledge is culled through trial and error. They are rules of thumb that give us a framework as we move through the research and design process.

In service design, this kind of framework is also valuable for assessing completed projects to find the weak links. A heuristic can apply to a single interaction as well as to the overall service eco-system. Heuristics can be applied to a single moment in time or to a user’s entire long-term relationship with a service.

This conceptual approach to design recognizes that experiences are coproduced, and that human interaction is a key component of many, if not all, services. As systems grow ever more sophisticated and interconnected, designers will continue to face new challenges. Service design heuristics can help us to frame and think about...read more
By Usability Matters

October 5, 2015

You may have recently seen an abundance of bug-eyed people puking rainbows on Snapchat. Thank Looksery for that. Launched last year as an entertainment app based on face recognition technology and special effects, Looksery was acquired by Snapchat last month.

Looksery technology propels Snapchat’s new special effects

Founded in 2013, Looksery launched in October 2014 after...read more
By Jordan Crone

October 6, 2015

Many important considerations impact software design. Business goals, user goals, user context, cultural considerations, platform paradigms, branding requirements, devices … the list goes on and on. While a primary focus for any software design effort should be the data or other content that’s being displayed, this keystone element is often given short shrift. This is unfortunate and shortsighted. Given the focus it your content will receive, it should be a primary consideration during the design process.

It is a common practice to represent data and content as “Lorem ipsum,” repeating data, or simply using “best case scenario” data. In reality, this isn’t what will be experienced in the final product. The data you have to work with can drastically affect the final design, and the design will influence the type, format, and presentation of data.

Infusing Real Content into Your Designs

Whether you’re using...read more
By Juan Sanchez

No-touch systems, infrastructure to work from home are some of the changes

If you are wondering when to apply which design methods, this mind map may help you.

O’REILLY DESIGN CONFERENCE - get the skills and insights you need to design the products of the future. Save 20% with code ALIST

Fracking: UK shale gas reserves 'significantly lower than previous estimates'  Energy Live News - Energy Made Easy

Fracking firm Cuadrilla signs secret deal with geological agency to 'destroy confidential documents'  iNews

The present work reports on the charge and spin density modelling of YTiO3 in its ferromagnetic state (TC = 27 K). Accurate polarized neutron diffraction and high-resolution X-ray diffraction (XRD) experiments were carried out on a single crystal at the ORPHÉE reactor (LLB) and SPRING8 synchrotron source. The experimental data are modelled by the spin resolved pseudo-atomic multipolar model (Deutsch et al., 2012). The refinement strategy is discussed and the result of this electron density modelling is compared with that from XRD measured at 100 K and with density functional theory calculations. The results show that the spin and charge densities around the Ti atom have lobes directed away from the O atoms, confirming the filling of the t2g orbitals of the Ti atom. The dxy orbital is less populated than dxz and dyz, which is a sign of a partial lift of degeneracy of the t2g orbitals. This study confirms the orbital ordering at low temperature (20 K), which is already present in the paramagnetic state above the ferromagnetic transition (100 K).

Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process. While SBDD has proven successful for many drug-discovery projects, its application to G protein-coupled receptors (GPCRs) has been limited owing to extreme difficulties with their crystallization. Here, a method is presented for the rapid determination of multiple co-crystal structures for a target GPCR in complex with various ligands, taking advantage of the serial femtosecond crystallography approach, which obviates the need for large crystals and requires only submilligram quantities of purified protein. The method was applied to the human β2-adrenergic receptor, resulting in eight room-temperature co-crystal structures with six different ligands, including previously unreported structures with carvedilol and propranolol. The generality of the proposed method was tested with three other receptors. This approach has the potential to enable SBDD for GPCRs and other difficult-to-crystallize membrane proteins.

The performance of automated model building in crystal structure determination usually decreases with the resolution of the experimental data, and may result in fragmented models and incorrect side-chain assignment. Presented here are new methods for machine-learning-based docking of main-chain fragments to the sequence and for their sequence-independent connection using a dedicated library of protein fragments. The combined use of these new methods noticeably increases sequence coverage and reduces fragmentation of the protein models automatically built with ARP/wARP.

A versatile, compact heater designed at National Synchrotron Light Source-II for in situ X-ray nano-imaging in a full-field transmission X-ray microscope is presented. Heater design for nano-imaging is challenging, combining tight spatial constraints with stringent design requirements for the temperature range and stability. Finite-element modeling and analytical calculations were used to determine the heater design parameters. Performance tests demonstrated reliable and stable performance, including maintaining the exterior casing close to room temperature while the heater is operating at above 1100°C, a homogenous heating zone and small temperature fluctuations. Two scientific experiments are presented to demonstrate the heater capabilities: (i) in situ 3D nano-tomography including a study of metal dealloying in a liquid molten salt extreme environment, and (ii) a study of pore formation in icosahedral quasicrystals. The progression of structural changes in both studies were clearly resolved in 3D, showing that the new heater enables powerful capabilities to directly visualize and quantify 3D morphological evolution of materials under real conditions by X-ray nano-imaging at elevated temperature during synthesis, fabrication and operation processes. This heater design concept can be applied to other applications where a precise, compact heater design is required.

The optical design of a Hettrick–Underwood-style soft X-ray spectrometer with Wolter type 1 mirrors is presented. The spectrometer with a nominal length of 3.1 m can achieve a high resolving power (resolving power higher than 10000) in the soft X-ray regime when a small source beam (<3 µm in the grating dispersion direction) and small pixel detector (5 µm effective pixel size) are used. Adding Wolter mirrors to the spectrometer before its dispersive elements can realize the spatial imaging capability, which finds applications in the spectroscopic studies of spatially dependent electronic structures in tandem catalysts, heterostructures, etc. In the pump–probe experiments where the pump beam perturbs the materials followed by the time-delayed probe beam to reveal the transient evolution of electronic structures, the imaging capability of the Wolter mirrors can offer the pixel-equivalent femtosecond time delay between the pump and probe beams when their wavefronts are not collinear. In combination with some special sample handing systems, such as liquid jets and droplets, the imaging capability can also be used to study the time-dependent electronic structure of chemical transformation spanning multiple time domains from microseconds to nanoseconds. The proposed Wolter mirrors can also be adopted to the existing soft X-ray spectrometers that use the Hettrick–Underwood optical scheme, expanding their capabilities in materials research.

Elucidating the structural dynamics of small molecules and proteins in the liquid solution phase is essential to ensure a fundamental understanding of their reaction mechanisms. In this regard, time-resolved X-ray solution scattering (TRXSS), also known as time-resolved X-ray liquidography (TRXL), has been established as a powerful technique for obtaining the structural information of reaction intermediates and products in the liquid solution phase and is expected to be applied to a wider range of molecules in the future. A TRXL experiment is generally performed at the beamline of a synchrotron or an X-ray free-electron laser (XFEL) to provide intense and short X-ray pulses. Considering the limited opportunities to use these facilities, it is necessary to verify the plausibility of a target experiment prior to the actual experiment. For this purpose, a program has been developed, referred to as S-cube, which is short for a Solution Scattering Simulator. This code allows the routine estimation of the shape and signal-to-noise ratio (SNR) of TRXL data from known experimental parameters. Specifically, S-cube calculates the difference scattering curve and the associated quantum noise on the basis of the molecular structure of the target reactant and product, the target solvent, the energy of the pump laser pulse and the specifications of the beamline to be used. Employing a simplified form for the pair-distribution function required to calculate the solute–solvent cross term greatly increases the calculation speed as compared with a typical TRXL data analysis. Demonstrative applications of S-cube are presented, including the estimation of the expected TRXL data and SNR level for the future LCLS-II HE beamlines.

The program Mercury, developed at the Cambridge Crystallographic Data Centre, was originally designed primarily as a crystal structure visualization tool. Over the years the fields and scientific communities of chemical crystallography and crystal engineering have developed to require more advanced structural analysis software. Mercury has evolved alongside these scientific communities and is now a powerful analysis, design and prediction platform which goes a lot further than simple structure visualization.

Single-crystalline-like thin films composed of crystallographically aligned grains are a new prototype of 2D materials developed recently for low-cost and high-performance flexible electronics as well as second-generation high-temperature superconductors. In this work, significant texture improvement in single-crystalline-like materials is achieved through growth of a 330 nm-thick silver layer.

The new agreement, effective immediately through Dec. 5, 2015, stipulates that the Smithsonian's National Zoological Park will conduct research in the areas of giant panda breeding and cub behavior.

The post Smithsonian signs new giant panda agreement with China appeared first on Smithsonian Insider.

The male’s fluke design helps it overcome the drag caused by their long tusks, the scientists determined. The female’s fluke design gives them increased speed for diving while foraging.

The post Narwhal fluke design helps compensate for drag caused by tusk appeared first on Smithsonian Insider.