Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

Celebrated chef-restaurateur Kyle Itani, who helms both Itani Ramen and Hopscotch Restaurant & Bar in Uptown Oakland, has just launched a brand-new project: a takeout sushi spot.

Operating out of Itani Ramen and serving its fare via pickup and delivery, Nikkei Sushi will be open Wednesday through Sunday, 2 p.m. - 8 p.m. during its soft opening with hours extending in the future.…

Celebrated chef-restaurateur Kyle Itani, who helms Itani Ramen and Hopscotch Restaurant & Bar in Uptown Oakland, has just launched a brand-new project: a takeout sushi spot.

CHRISTINE Cassell (letters 28th April) asks a pertinent question when she enquires where the responsibility for the problem with PPEs for front line NHS workers lies.

I SHOULD like to pay tribute to Alan Wiltshire the Echo and Romsey Advertiser reporter whose death was sadly announced last week

Right now there’s a lot of uncertainty in the world – with lots of people within our industry struggling to figure out what they’re going to do next. So when Bandcamp announced their fee-free Fridays were happening again, we decided to lean in and help our own community be supported in something great: making music. […]

The post 80+ DJTT Artists You Should Support Today On Bandcamp appeared first on DJ TechTools.

The Children at Aurora Theatre Company makes us think deeply. Noble on its face for messages involving climate change and generational responsibility, excellent craft rises foremost as the walk-away reward of Aurora Theatre's new production. Written by Lucy Kirkwood and directed with signature, uncanny brilliance by Barbara Damashek, The Children employs a familiar theatrical construct to reveal the play's layered, complex story in 95 uninterrupted minutes.…

Now how can I be more of a “guy” for my boyfriend? My boyfriend and I were having relationship issues until we tried something new: pegging. He wanted to try it, but he was afraid and sometimes said the idea disgusted him.…

Oral sex, beards and other gross-outs. I'm a 31-year-old cis bisexual woman. I'm hetero-romantic and in a monogamish relationship with a man. We play with other people together.…

A charge-transporting varnish according to the present invention includes a charge-transporting substance, a dopant substance, and an organic solvent, wherein the charge-transporting substance contains at least one selected from N,N'-di(1-naphthyl)benzidine, N,N'-di(2-naphthyl)benzidine, and N-(1-naphthyl)-N'-(2-naphthyl)benzidine. The charge-transporting varnish allows formation of a charge-transporting thin film with which an organic EL element excellent in durability can be achieved when the charge-transporting thin film is applied to a hole injection layer.

A thin film that has high flatness and high charge transport properties and enables an organic EL element to achieve excellent luminance characteristics if applied thereto can be obtained by using a charge-transporting varnish which contains a charge-transporting substance, an organosilane compound that is composed of a polymer prepared in advance by subjecting an alkoxysilane compound to hydrolysis-condensation and having a weight average molecular weight of 500-10,000, and an organic solvent, said alkoxysilane compound containing at least one compound selected from among alkoxysilane compounds represented by formulae (1-1) and (1-2). SiR1(OR2)3 (1-1) SiR12(OR2)2 (1-2) (In the formulae, each R1 independently represents an alkyl group having 1-20 carbon atoms, which is substituted by Z1, or the like; each R2 independently represents an alkyl group having 1-20 carbon atoms, which may be substituted by Z3; and each of Z1 and Z3 represents a halogen atom or the like.)

The heat shield assembly includes an inner-most layer that is directly engagable with an exhaust component and is of a non-ceramic material with a first heat capacity and a first thermal conductivity. The heat shield assembly additionally includes an insulating layer that surrounds the inner-most layer and is of a material that has a second heat capacity which is lower than the first heat capacity and has a second thermal conductivity which is lower than the first thermal conductivity. The direct engagement of the inner-most layer with the exhaust component allows heat to be easily transferred between the exhaust component and the inner-most layer.

The modular platform for offshore constructions, composed of more than two separate buoyancy elements partially immersed in water, which move along with the water wave movement and which, in the part above the water level, are connected to the structural elements forming a rigid horizontal spatial structure, characterized in that the buoyancy element (1) is given the shape of a cuboid or cylinder having at least one vertical hollow (2) to accommodate the structural element, i.e. piston (3), which forms the axis along which the buoyancy element (1) moves, and which is connected to the horizontal structural element (4) fitted to take external loads.

Embodiments of showerheads having a detachable gas distribution plate are provided herein. In some embodiments, a showerhead for use in a substrate processing chamber includes a body having a first side and an opposing second side; a gas distribution plate disposed proximate the second side of the body; and a clamp disposed about a peripheral edge of the gas distribution plate to removably couple the gas distribution plate to the body, wherein the body is electrically coupled to the gas distribution plate through the clamp.

There are provided an adhesive for a solar-cell back sheet having an excellent curing rate and being capable of exhibiting excellent adhesive performance by short-term aging, and also a polyol composition used for the adhesive, a solar-cell back sheet using the adhesive, and a solar-cell module using the sheet. The adhesive for a solar-cell back sheet contains, as essential components, at least one hydroxyl group-containing resin (A) selected from a polyester polyurethane polyol (A1), a polyester polyol (A2), a hydroxyl group-containing (meth)acrylic resin (A3), and a hydroxyl group-containing fluorocarbon resin (A4), a polyisocyanate (B), and a cyclic amide compound (C).

A device for producing a strip-shaped composite sheet may comprise at least two outer metal cover sheets and at least one plastic layer disposed between the two outer metal cover sheets. The device may further comprise at least one first laminating device for laminating the metal cover sheets with the at least one plastic layer arranged between the metal cover sheets, with the first laminating device comprising at least two laminating rolls forming a laminating gap. One object of the present disclosure is to provide methods and devices for producing composite sheets, with which the economy, in particular the production speed, of the production method can be significantly increased and at the same time the risk of delamination of the composite sheets during the further processing can be reduced.”

There’s a lot to like in This Is My Family which is directed by Daniel Evans with a light comic touch.

THERE’S no doubt that the Prime Minister spoke from the heart when he addressed the Tory conference in Birmingham this week, speaking of the NHS.

Weddings and civil partnership ceremonies at Chewton Glen are something of a speciality.

Oakley Hall offers a spectacular backdrop to the most memorable day of your life.

News you don't want to miss for April 9:

1. Six residents at a nursing home in Hayward have died from covid-19, the East Bay Times reports.…

News you don't want to miss for April 13:

1. "If the country’s most popular coronavirus model proves accurate, California will reach the peak of its outbreak this Wednesday," the San Francisco Chronicle reports, when it will reach a predicted 66 deaths.…

News you don't want to miss for April 22:

1. Oakland is looking at a potentially historic $80 million budget shortfall over the next year, Bay City News reports.…

News you don't want to miss for April 23:

1. BART learned on Thursday that $250 million in recent federal relief funds will allow it to balance its budget for this fiscal year, with $78 million remaining, BART Board Director Rebecca Saltzman said.…

News you don't want to miss for April 24:

1. San Francisco Mayor London Breed provided a hint on Friday that the city's shelter in place order will be extended past May 4, possibly weeks or a month, KPIX reports.…

News you don't want to miss for April 27:

1. Alameda County, along with five other Bay Area counties, announced the shelter in place order will be extended through the end of May, the San Francisco Chronicle reports.…

Plus, the Alameda County Sheriff's Department updates it budget request. Body-camera video of the fatal shooting of Steven Taylor by San Leandro Police last Saturday shows the officer and the victim were face-to-face just moments before he was shot in the chest. The San Leandro Police Department released what they called a "critical incident video" last week.…

Coronavirus Journal: restrictions are easing across the region and state Bay Area health officials have eased some restrictions in the latest shelter-in-place order that's at curbing the coronavirus outbreak.…

You may not yet be able to bike to work, but that's all the more reason to embrace cycling Buying a bicycle has always been a life-changing experience for many, but during the Covid-19 pandemic, it can bring a heightened sense of freedom and control to one's life. Lydia Felt was previously too terrified to ride a bicycle on roadways.…

This April, whether we're in, out or, most likely, just shaken all about, one thing is certain... it’s the time of annual public service price rises. While you can't prevent the rises, there are often other ways to cut these bills. I want to show how you can steal a March (sorry) on April's hikes.

Are you ripping yourself off? At least 11m people in the UK are overpaying on their energy bills, usually by £100s a year. Sorting it is one of the biggest and easiest savings you can make – yet the majority still don’t do it. More so, even if you’re scared of switching firm, right now you may be able to save £100s and stick with your existing provider. So as we’re in the core of winter, carpe diem (translation: get off your bum and try to give it a go).

An outsole of a shoe includes: a plurality of ridges having a tread surface to be in contact with a road surface; and at least one longitudinal groove defined between the plurality of ridges. At least in a partial area of each of a forefoot portion and a rear foot portion on a medial side of a foot, the plurality of ridges and the longitudinal groove extend in a longitudinal direction or a diagonal longitudinal direction and are set so that an angle of the ridges and that of the longitudinal groove with respect to a long axis of the outsole are in a range of 0° to 35°. A ratio of a length of the tread surface of the ridges with respect to a width of the tread surface is set to be 1.8 to 200. The width of the tread surface of the ridges is set to be greater than a width of the longitudinal groove by a factor of 2 to 100.

A ventilated shoe, including a sole and an upper assembly associated therewith in an upward region, the upper assembly including: an external upper, with which an inner lining is associated which is constituted at least partly by a first element that defines at least one interspace that separates the foot of the user from the external upper and includes preferential passages for sweat that moves away from the foot of the user toward the upper external edge of the shoe; and a breathable insole, joined perimetrically at least to the inner lining.

Described are shoes, particularly a sports shoe, having an upper and at least one of an outer sole and a midsole connected to the upper. As examples, the outer sole is knitted in a unitary fashion with the upper. As further examples, an insert is positioned within the one-piece knitwear, wherein the insert comprises a profile that increases traction of the outer sole.