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Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank




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Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma




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Does multiparametric imaging with <sup>18</sup>F-FDG-PET/MRI capture spatial variation in immunohistochemical cancer biomarkers in head and neck squamous cell carcinoma?




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The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer




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NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial




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Nature Reviews Endocrinology




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Noncanonical amino acids on display




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Evaluation of an AI system for the detection of diabetic retinopathy from images captured with a handheld portable fundus camera: the MAILOR AI study




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Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH)




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El aspecto social de la biblioteca pública y la inclusión social de las minorías

Saurin-Parra, Julia . El aspecto social de la biblioteca pública y la inclusión social de las minorías., 2019 In: El libro y la lectura en recintos penitenciarios. Gráfica Nacional, pp. 73-81. [Book chapter]




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Extinction Watch: How African Black Rhino came back from extinction

Between 2012 and 2018, the Black Rhino (Diceros bicornis) population across Africa has grown at a modest annual rate of 2.5% from an estimated 4,845 to 5,630 animals in the wild, respectively. Population models predict a further slow increase over the next five years, according to IUCN’s March 2020 update.







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Sino-EU relations, a post-Brexit jump into the unknown?

Outgoing British Prime Minister David Cameron once proudly stated that "there is no country in the Western world more open to Chinese investment than Britain." What will happen to the Sino-British relationship now that the U.K. will almost certainly leave the EU?

      
 
 




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America’s youthful minority population


The “diversity explosion,” described in my recent book, is altering all parts of American life but particularly the lives of our younger population. As the white population ages and whites continue to decline in numbers among our under-30 population, as recent Census tabulations project, a growing portion of America’s children are racial minorities from a kaleidoscope of backgrounds in terms of their parents’ or grandparents’ place of birth. Origin countries include Mexico, China, the Philippines, India, Vietnam, El Salvador, Korea, the Dominican Republic, Guatemala, Jamaica, Colombia, Haiti, Honduras, Ecuador, Peru, Taiwan, Brazil, and others. 

A dramatic remaking of the nation’s child population is under way; in growing parts of the country growth of the child population is synonymous with the growth of minority children. More than one-third of the 100 largest metropolitan areas now have minority-white child populations. California and Texas house the largest number of these metropolitan areas, and Hispanics constitute the largest minorities. Florida, Georgia, and Arizona each contain more than one of these metro areas; the newest include Atlanta, Orlando, and Phoenix. And in many other “whiter” areas, such as Allentown, Pa. on the periphery of the New York megalopolis, the share of minorities among children is increasing. 

Of course, metro areas such as Los Angeles, Miami, and New York are used to accommodating large numbers of young children from dozens of foreign countries. Yet the first-generation immigrant children in large sections of the Southeast and Mountain West and scattered parts of “middle America” represent the front lines of the country’s diversity explosion. For an overview of U.S. county profiles by race and age, see the U.S. interactive map.

Material adapted from Diversity Explosion: How New Racial Demographics Are Remaking America by William H. Frey, 2014.

Authors

      
 
 




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Sino-EU relations, a post-Brexit jump into the unknown?


Editors’ Note: Outgoing British Prime Minister David Cameron once proudly stated that "there is no country in the Western world more open to Chinese investment than Britain." What will happen to the Sino-British relationship now that the U.K. will almost certainly leave the EU? This post originally appeared in the Nikkei Asia Review.

One of the many side effects of the June 23 British referendum on the European Union is that it will put an end to a honeymoon that had barely started less than a year ago, when George Osborne, the U.K.'s chancellor of the exchequer, declared on the eve of Chinese President Xi Jinping's state visit to Britain: "Let's stick together and make a golden decade for both our countries." Much has happened since the visit, during which Xi was feted as a guest of honor by Queen Elizabeth II at Buckingham Palace and at the British Parliament.

Over the past three years, British Prime Minister David Cameron and Osborne, (the man in effect running the country's China policy), seem to have partly anticipated the referendum's outcome by partnering with a few Asian countries outside the European Union—China especially—that would help finance some of the major infrastructure projects needed by the U.K., including nuclear plants, high-speed railways and airport infrastructure.

Now, in the turmoil following the referendum, Cameron is on the way out and Osborne's future remains uncertain. What will happen to the Sino-British relationship now that the U.K. will almost certainly leave the EU? Initial signals from China have been subdued. Foreign Ministry spokeswoman Hua Chunying recently said she believed that the impact of Brexit will be at all levels—not only in relations between China and Britain.

"China supports the European integration process and would like to see Europe playing a proactive role in international affairs. We have full confidence in the outlook for the development of China-EU ties," she said. This is a far cry from the enthusiastic comments in Chinese media on the Sino-British relationship in 2015, when Britain decided—much to the chagrin of Washington, Tokyo, Berlin and Paris—to be the first Western country to join the China-backed Asian Infrastructure Investment Bank (AIIB) and when it hosted Xi, hoping to attract massive Chinese foreign direct investment.

Cameron had proudly stated that "there is no country in the Western world more open to Chinese investment than Britain." The U.K. is currently Europe's top destination for Chinese FDI with a cumulative investment of $16.6 billion in the country since 2000 (including $3.3 billion in 2015 alone), and many memoranda of understanding signed during Xi's visit last fall. Will these be completed now that the British people have voted to leave the EU? A few months ago, Wang Jianlin, the head of China's Dalian Wanda Group—a commercial property and cinema chain operator—and a major investor in Europe warned: "Should Britain exit the EU, many Chinese companies would consider moving their European headquarters to other countries," adding that "Brexit would not be a smart choice for the U.K., as it would create more obstacles and challenges for investors and visa problems."

The Global Times, an English-language publication that is part of the Chinese Communist Party's People's Daily, was even less sympathetic to the British situation, writing in an editorial after the referendum, that the vote would "probably be a landmark event that proves Britain is heading in the direction of being a small country with few people, writing itself off as hopeless and acting recklessly."

The Beijing leadership—which uniquely went out of its way to support the Remain camp on several occasions—is puzzled by the referendum's result, which has not only created some disorder (an unbearable word in official party language) but also led to the resignation of the country's prime minister and the risk of further pro-autonomy referenda (namely, in Scotland). In the eyes of a communist party fully focused on retaining all its powers, Cameron made a serious mistake as the leader of a major country.

After all, China has no soft intentions toward the U.K. The two countries have had a complicated history. The Chinese still call the period starting in the mid-1800s— which included the British-led Opium Wars—the "century of humiliation." And it has only been 19 years since Hong Kong was returned to the motherland as a Chinese "special administrative region (SAR)." Not that the Cameron government has done very much to support its former territory: As the "golden decade" was unfolding, Hong Kong faced one of its most difficult times, with arrests of dissidents and the disappearance of some booksellers—including Lee Bo, who holds dual Sino-British citizenship and had published controversial books about Chinese leaders.

Now that British voters have spoken, chances of a backlash are running high. For a start, China is keen on keeping close involvement with the EU—its second-largest trading partner after the U.S., a source of technology transfers, and an ally in Beijing's "One Belt, One Road" projects in Europe and Asia, or in initiatives such as the AIIB and the country' Silk Road fund. In this respect China will almost certainly want to continue its close partnership with both EU institutions and individual countries, especially in Eastern and Central Europe where "One Belt, One Road" has been warmly welcomed. (Two countries recently visited by Xi, Poland and the Czech Republic, received substantial financial commitments from the Chinese president.)

London will, of course, continue to play a key role in finance as one of the world's top international trading platforms with Chinese treasury bonds issued in renminbi. Chinese visitors (including property buyers looking for fresh opportunities) will continue to flock to the city. But when it comes to being China's bridge to the EU, it is clear that Beijing will look for alternatives, particularly Germany, which is China's top economic partner in Europe. German Chancellor Angela Merkel recently made her ninth visit to China and managed to address a long list of key issues, including trade, investment and reciprocity, as well as human rights, new laws regulating nongovernment organizations and territorial claims in the South China Sea. In a powerful speech to Nanjing University students in Beijing on June 12, she stressed that the trust of the citizens can only be achieved by the rule of law, "rather than rule by law." It has been many years since British leaders have used this language in China. Even though some British politicians are now calling for a reassessment of the country's China policy, it is unlikely that the U.K. will do anything but accommodate China in order to preserve trade and investment in the post-Brexit uncertainty.

For all its openness, the "new U.K." will become less attractive market-wise. After Brexit, China will also lose a proponent of free trade within the EU—that is bad news as the 28-nation block is pondering the decision to grant market economy status to China, in accordance with an agreement under the World Trade Organization. Market economy status affects the way anti-dumping duties are used. Job-wise, the European steel industry is vulnerable. Since the adoption by the European Parliament of a nonbinding resolution against granting market economy status to China on May 12, many European politicians fear that more Chinese economic involvement in their home countries would lead to more cheap goods competing with European-made products and fewer jobs at home—hence a less favorable context for China. The chances of an EU-China free-trade agreement are becoming more remote now as the EU is more focused on finalizing a comprehensive agreement on investment with China. European companies have been lobbying for such a pact.

Although it will almost certainly make the most of an autonomous U.K. after conducting its own assessment, China does not like uncertainty—especially in turbulent times both at home and abroad. It worries about challenges against ruling parties, as well as an anti-globalization attitude that could affect its own image as a beneficiary of globalization. As for Europe, both Germany and France have strong relations with China. With their backing, the European Commission has just published an ambitious new strategy on China. It looks like the U.K. will not be part of it.

      
 
 




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Largest Minority Shareholder in Global Order LLC: The Changing Balance of Influence and U.S. Strategy

Bruce Jones explores the prospects for cooperation on global finance and transnational threats, the need for new investments in global economic and energy diplomacy, and the case for new crisis management tools to help de-escalate inevitable tensions among emerging powers across the globe.

      
 
 




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Businesses owned by women and minorities have grown. Will COVID-19 undo that?

There are two small business crises in the United States. The first—the sudden shock to small businesses induced by COVID-19—is acute and immediate. Our recent analysis indicates that over 50% of small businesses with employees (an astounding 4 million establishments) face immediate or near-term risks due to the pandemic. The second crisis—the structural racial and…

       




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Businesses owned by women and minorities have grown. Will COVID-19 undo that?

There are two small business crises in the United States. The first—the sudden shock to small businesses induced by COVID-19—is acute and immediate. Our recent analysis indicates that over 50% of small businesses with employees (an astounding 4 million establishments) face immediate or near-term risks due to the pandemic. The second crisis—the structural racial and…

       




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On April 8, 2020, Tanvi Madan discussed the implications of the coronavirus pandemic for the Sino-Indo bilateral relations with ORF

On April 8, 2020, Tanvi Madan discussed the implications of the coronavirus pandemic for the Sino-Indo bilateral relations via teleconference with Observer Research Foundation.

       




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Shifting Balance of Power: Has the U.S. Become the Largest Minority Shareholder in the Global Order?


Event Information

March 15, 2011
2:00 PM - 3:30 PM EDT

Falk Auditorium
The Brookings Institution
1775 Massachusetts Ave., NW
Washington, DC

Register for the Event

While the future impact of rising powers such as Brazil, Russia, India and China is uncertain and the shifting political landscape in the Arab world is still playing out, the influence of these emerging nations is a central fact of geopolitics.

Already the global financial crisis, the Copenhagen climate negotiations, and the debate over Iran sanctions have illustrated the potential, the pitfalls, and above all the centrality of the relationship between American power and the influence of these rising actors and developing democracies.

In a new paper, Senior Fellow Bruce Jones, director of the Managing Global Order Project at Brookings, argues the greatest risk lies not in a single peer competitor but in the erosion of cooperation on issues vital to U.S. interests and a stable world order. U.S. power is indispensible for that purpose but not sufficient. No longer the CEO of Free World Inc., the United States is now the largest minority shareholder in Global Order LLC.

On March 15, the Brookings Institution and Foreign Policy magazine hosted the launch of Bruce Jones’s paper "Largest Minority Shareholder in Global Order LLC: The Changing Balance of Influence and U.S. Strategy." Panelists explored the prospects for cooperation on global finance and transnational threats; the need for new investments in global economic and energy diplomacy; and the case for new crisis management tools to help de-escalate inevitable tensions with emerging powers.

Susan Glasser, editor in chief of Foreign Policy, moderated the discussion. After the presentations, panelists took audience questions.

Video

Audio

Transcript

Event Materials

     
 
 




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Kobe Bryant and his enduring impact on the Sino-American friendship

The tragic loss of Kobe Bryant on January 26, 2020 came as a devastating shock to sports fans around the world, including millions of people in China who awoke to this terrible news. Two circumstantial factors made the emotional reaction by the Chinese people­­––and their heartfelt affection and admiration for this legendary basketball player and…

       




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Opponents of Smart Meters Fall Short on Effort to Ban Installations In Illinois Town

A judge rules against smart meter opponents in Naperville, Illinois who wanted to hold a vote on whether the devices should be installed in their city.




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Eco Wine Review: Cline Cellars 2010 Cool Climate Pinot Noir

This eco-wine is bursting with red fruit aromas and vanilla. And it's minty finish is subtle yet clean so you won't mind a second glass. Which isn't a bad thing as this Pinot comes in under the $15 mark. And the winery is 100-percent solar-powered.




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Eco Wine Review: Lynmar Estate 2008 Russian River Valley Pinot Noir

A delicate balance of dark fruit, cocoa, pepper and mushroom from a sustainable vineyard that donates to AIDS and cancer patients.




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Eco Wine Review: Hahn SLH Estate 2010 Santa Lucia Highlands Pinot Noir

This wine is brimming with bright fruit, dark undertones and those farmyard aromas common to most Pinots. With notes of pepper, strawberry and dried mint on the palette, this wine is as food-friendly as it is drinkable.




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Eco Wine Review: Wrath 2010 Ex Vite Pinot Noir

Wrath's 2010 Ex Vite Pinot Noir is complete, with lots of black cherry and red raspberry. A bit fuller than your typical Pinot, this wine is as drinkable as it is food friendly.




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Luminous Fish Bikes Light Up Sydney Festival

A trio of awesome fish bikes made a rousing debut at this arts festival in Australia.




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Ultra-Rare, Perhaps the Last Remaining, Javan Rhino Found Killed in Vietnam

The total estimated population of the Javan rhinoceros in Vietnam was perhaps eight individuals just three years ago. Now WWF reports that there is one less of the beyond critically endangered rhinos in the Cat Tien




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The Week in Animal News: Miracle Pando Poo Tea, Another Rhino Species Officially Extinct, and More

Can panda poo prevent cancer? We also have sad rhino news, fish lawnmowers, and more.




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Modern classic jewelry made with recycled domino & Scrabble pieces

'Slow' games make a comeback, as stylish jewelry with a twist.




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Giant 5-foot tall penguins roamed New Zealand with the dinosaurs

The discovery of one of the oldest penguin fossils in the world reveals higher diversity of early penguins than previously assumed.




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Bubble cars are back with the electric Microlino

The tiny Italian car is now available in Europe.




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Will Alberta's tar sands create a Canadian "cancer alley"? Study finds high levels of carcinogens in air.

A new study has found that the air pollution from Alberta's massive tar sands operations is putting the health of downwind residents at risk by releasing unsafe levels of carcinogenic and toxic chemicals into the air.




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Luminous lunar pavilion blends tradition with digital design (Video)

This stunning temporary pavilion utilizes Hong Kong's time-honored bamboo construction methods in conjunction with cutting-edge computational design.




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Six more weeks of winter, says Canada's famous albino groundhog

Wiarton Willie saw his shadow this morning, which means the cold weather will stick around.




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Quinoa, Commodities, and the Gentrification of the Food System

Demand for quinoa in developed countries means agrarian people in Bolivia and Peru can't afford the one-time staple crop. Is that entirely bad news? The answer is complicated.




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Hurricane Michael as seen from space is an ominous thing (video)

See the view captured by the International Space Station as the category 4 hurricane makes landfall over Florida.




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The peaceful farm I stayed on in northern Illinois

I picked a lot of squash.




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Los Vecinos: First Platinum LEED-Certified, 100% Solar Powered, Affordable Housing in San Diego

Image via: Wakeland Housing & Development Corporation Los Vecinos, the first LEED-Certified Platinum, 100% solar-powered affordable housing in San Diego, offer 42-units of state of the art in green housing. The $17.6 million USD project opened its doors




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Illinois Spending $2M to Ship Asian Carp Back to China

If you can't beat 'em, ship 'em. The state of Illinois is spending $2 million to ship invasive Asian carp back to China, where they're considered a delicacy. In Illinois, and the Great Lakes region, they're




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Illinois passes first microbead ban in the world

Finally one state is putting a stop to the "exfoliocean." Hopefully others will follow its lead, forcing companies to adopt eco-friendly alternatives.




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The last male northern white rhino in the world has died

WIth the death of Sudan, the world's last male northern white rhinoceros, the species is one step closer to complete extinction.




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Luminous Laser-Cut Lamps Made Out of Kelp

Kelp isn't just for eating; this designer is experimenting with the fast-growing, large algae for lighting.




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Dinosaur 7x bigger than T-Rex discovered

Paleontologists in Argentina have uncovered a supermassive dinosaur