Omadacycline, a novel aminomethylcycline antibiotic with activity against Gram-positive and -negative organisms, including tetracycline-resistant pathogens, received FDA approval in October, 2018 for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). A previously-developed population pharmacokinetic (PK) model based on Phase 1 intravenous and oral PK data was refined using data from infected patients. Data from 10 Phase 1 studies used to develop the previous model were pooled with data from three additional Phase 1 studies, a Phase 1b uncomplicated urinary tract infection study, one Phase 3 CABP study, and two Phase 3 ABSSSI studies. The final population PK model was a three-compartment model with first-order absorption using transit compartments to account for absorption delay following oral dosing and first-order elimination. Epithelial lining fluid (ELF) concentrations were modeled as a sub-compartment of the first peripheral compartment. A food effect on oral bioavailability was included in the model. Sex was the only significant covariate identified, with 15.6% lower clearance for females relative to males. Goodness-of-fit diagnostics indicated a precise and unbiased fit to the data. The final model, which was robust in its ability to predict plasma and ELF exposures following omadacycline administration, was also able to predict the central tendency and variability in concentration-time profiles using an external Phase 3 ABSSSI dataset. A population PK model, which described omadacycline PK in healthy subjects and infected patients, was developed and subsequently used to support pharmacokinetic-pharmacodynamic (PK-PD) and PK-PD target attainment assessments.

The FBI seizes the internet domain to WeLeakInfo.com, a site that was cataloging billions of records, such as email addresses and passwords, from more than 10,300 data breaches at various companies and service providers.

On Tuesday, Avast responded to a PCMag-Motherboard investigation into the company's browser history collection practices, saying it was entirely legal. Avast users should expect to see a prompt from the antivirus products, asking them to consent to the data harvesting.

'As CEO of Avast, I feel personally responsible and I would like to apologize to all concerned,' wrote Ondrej Vlcek following a PCMag-Motherboard investigation into the privacy risks around the data harvesting.

Malware on an air-gapped computer can transmit data like Morse code by changing screen brightness in a way that's invisible to the naked eye but easily recorded with a camera.

Stock markets plunged on Thursday after economic growth data confirmed fears of Covid-19's bruising impact on the world economy.

For the first time, guest bloggers share analysis from 20 years of math and science international assessment data.

With the best scanning and OCR apps, you can save whiteboard text, business cards, and important documents so that you can not only read them, but also edit them.

Nearly every state in the nation has experienced enrollment declines, with some states seeing steep declines of more than 50 percent.

A recent school tour of three Bay Area schools with some blended learning experts helped provide answers to some of the common questions we hear about how to implement blended learning.

The first in a three post series on challenges and opportunities with blended learning, starting with getting to actionable data.

As a student in Penn State's College of Information Sciences and Technology, Steve Ney learned critical skills, from coding to data design and architecture. Today, he applies that foundation in his "dream job" as a healthcare data analyst for Geisinger Health, where he uses those skills to help produce visual outputs for doctors and staff to utilize in caring for patients.

The Brooklyn District Attorney released data to show the disparities in arrests. The NYPD released data to show the demographics of summonses.

Nebraska's education department released an interactive instructional materials map last week, showing what curricula districts have adopted for English-language arts, math, and K-8 science.

The Institute for Computational and Data Sciences, in conjunction with several Penn State colleges, awarded more than $725,000 in seed grants to fund 32 new computational and data sciences projects. The 57 researchers involved in the awards represent 12 Penn State colleges and 31 academic departments.

The bill would mandate local bullying policies and require data collection and reporting at the local, state, and federal level.

Single women dominated property sales in 2017, 2018 and 2019, compared to single men and even married couples, according to data analytics firm Lightstone.

The Naples processor is designed to compete with Intel's Xeon offerings for the data center.

An Epyc server can contain up to 4TB of memory and 128 lanes of PCIe, making it a worthy Intel Xeon competitor.

The deal will help Marvell generate $3.4 billion in annual revenue, Marvell says.

Originally announced in February 2015, Apple is giving up on trying to build the new facility.

Microsoft realizes you can use the sea as a giant heatsink and save a small fortune in cooling costs.

While it won't be ready until 2022, it will create hundreds of jobs, run on 100 percent renewable energy, and be the first data center to take advantage of a new StatePoint Liquid Cooling system that promises a 50 percent reduction in water use.

The old NATO bunker in Germany was acquired in 2013 and then turned into a heavily-secured data processing center for illegal activities linked to organized crime and the dark web.

Through a city-school partnership in Nashville, Tenn., after-school programs are using data to tailor lessons to students' learning needs.

As we continue to process and understand the ongoing effects of the novel coronavirus, many of us have grown used to viewing COVID-19 dashboards and visualizations, including this popular coronavirus dashboard from SAS. If you are more accustomed to building graphs and visualizations using the SGPLOT and SGPANEL procedures, this [...]

The post Visualizing COVID-19 data using SGPLOT and SGPANEL appeared first on Graphically Speaking.

Here are five takeaways on the teaching profession from the newly released 2017-18 National Teacher and Principal Survey.

In a national survey, we dug into how teachers use language to make sense of disparities in student outcomes by race and income level.

$600 million settlement over 2017 Equifax data breach includes up to $425 million in consumer restitution Attorney General Kathy Jennings Monday announced a settlement with Equifax as the result of an investigation into the largest-ever breach of consumer data. Under the terms of the settlement, Equifax agreed to provide a single Consumer Restitution Fund of […]

June 26, 2019 DOVER, DE – The Delaware Department of Insurance recently received notice of a data security breach suffered by Dominion National, an insurer and administrator of dental and vision benefits. On April 24, 2019, through its investigation of an internal alert, Dominion National discovered that servers containing enrollment data, demographic details, and personal […]

On Wednesday, July 31, 2019, Governor John C. Carney, Jr., signed House Bill 174 (“HB 174”) into law. Titled the Delaware Insurance Data Security Act, this law is based on an NAIC Model Act, which establishes a comprehensive regulatory framework requiring insurers licensed to do business in Delaware to implement information security programs, report instances […]

Executive Order 18 expands the Council to include all Executive Branch agencies   WILMINGTON, Del. – Governor John Carney on Monday signed Executive Order 18, expanding the Delaware Open Data Council to include members from all Executive Branch agencies to promote data sharing. The Governor was joined by members of his Cabinet, technology entrepreneurs and […]

Citizen coders and civic technologists from across Delaware are set to take on the state’s second annual Open Data Challenge, harnessing the power of public datasets to come up with new solutions to big statewide problems.

As the 2018 growing season officially comes to an end, the U.S. Department of Agriculture’s National Agricultural Statistics Service (NASS) will contact producers in Delaware to gather final year-end crop production numbers and the amount of grain and oilseeds they store on their farms. At the same time, NASS will survey grain facility operators to determine year-end grain and oilseed stocks.

The U.S. Department of Agriculture (USDA) National Agricultural Statistics Service (NASS) Delaware office today announced the results of the 2017 Census of Agriculture with new information about 2,302 Delaware farms and ranches and those who operate them, including first-time data about on-farm decision making, down to the county level.

Here Mudassar Ahmed Khan has explained with an example, how to read Excel File (xls & xlsx) data in ASP.Net using C# and VB.Net. When the Excel file is uploaded, the Excel File data is available in the InputStream property of the FileUpload control. Using ClosedXml library, the Excel file data can be easily read from the InputStream property and displayed on Web Page using GridView in ASP.Net using C# and VB.Net.

As a long-time SAS 9 programmer, I typically accomplish my data preparation tasks through some combination of the DATA Step, Proc SQL, Proc Transpose and some housekeeping procs like Proc Contents and Proc Datasets. With the introduction of SAS Viya, SAS released a new scripting language called CASL – a [...]

Challenge accepted: Learning data prep in CASL was published on SAS Users.

WILMINGTON, Del. – In support of a movement to transform how health care is delivered and paid for in the state, Delaware was one of eight states chosen to participate in a National Governors Association initiative to harness data systems to inform health policymaking. Joining Arkansas, Colorado, Indiana, Iowa, Minnesota, Vermont and Washington, Delaware’s team […]

The Division of Public Health announced updates to its My Healthy Community data portal. DPH launched My Healthy Community earlier this year to allow Delawareans to access information about the overall health of their communities.

By using data provided by a Game of Thrones fan, we use SAS to look at screen time for scene locations and characters in this crazy popular show.

The post Deeper enjoyment of your favorite shows -- through data appeared first on The SAS Dummy.

As a long-time SAS 9 programmer, I typically accomplish my data preparation tasks through some combination of the DATA Step, Proc SQL, Proc Transpose and some housekeeping procs like Proc Contents and Proc Datasets. With the introduction of SAS Viya, SAS released a new scripting language called CASL – a [...]

Challenge accepted: Learning data prep in CASL was published on SAS Users.

For beginners, how marketers can learn to create advanced data models from time series data

Advanced analytics programs can incorporate geospatial data. Learn how such data can be used to augment local marketing plans

Cyber security firm Cyble has revealed that the database of education technology firm Unacademy has been breached and details of various account holders, including those registered with corporate e-mail accounts, are on sale in the dark web.

Excitement levels are high for the March 2020 release of SAS Customer Intelligence 360, which includes multiple years of research and development culminating in enhancements to the platform's underlying data model. The changes will introduce the unification of a comprehensive data model recording both: Customer behavior -- what users are [...]

SAS Customer Intelligence 360: Unified data model, marketing attribution and AutoML was published on Customer Intelligence Blog.