Ceftobiprole is an advanced-generation broad-spectrum cephalosporin antibiotic with potent and rapid bactericidal activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, as well as susceptible Gram-negative pathogens, including Pseudomonas sp. pathogens. In the case of Pseudomonas aeruginosa, ceftobiprole acts by inhibiting P. aeruginosa penicillin-binding protein 3 (PBP3). Structural studies were pursued to elucidate the molecular details of this PBP inhibition. The crystal structure of the His-tagged PBP3-ceftobiprole complex revealed a covalent bond between the ligand and the catalytic residue S294. Ceftobiprole binding leads to large active site changes near binding sites for the pyrrolidinone and pyrrolidine rings. The S528 to L536 region adopts a conformation previously not observed in PBP3, including partial unwinding of the α11 helix. These molecular insights can lead to a deeper understanding of β-lactam-PBP interactions that result in major changes in protein structure, as well as suggesting how to fine-tune current inhibitors and to develop novel inhibitors of this PBP.

Based on evidence provided by customer receipts, the investigation confirmed that the pricing of several food items exceeded the 10-per cent increase allowed during a state of emergency, with some prices being as much as 200 per cent more.

An investigator went to CCA Logistics Ltd. (Newsway) on April 1, where they say they found several pieces of personal protective equipment (PPE) for sale at grossly inflated prices.

Manchester United are reportedly beaten their Premier League rivals to the signing of Sunderland teenager Joe Hugill after some impressive displays at youth level.

Manchester United are set to complete the signing of Sunderland prospect Joe Hugill as part of a major drive to secure the best emerging talent in the UK and abroad.

The current 5.25 per cent interest rate for reverse mortgages under the Government's Pension Loans Scheme has not fallen despite three official cash rate cuts this year.

EBay is refusing listings for N95 and N100 masks, hand sanitizer and disinfecting wipes and says it's working to remove listings with inflated prices.

While the price of petrol falls to the lowest point in a generation in Brisbane, service stations are charging 30 per cent more in north Queensland and 75 per cent more in Mt Isa, with a federal MP raising accusations of collusion.

After nearly 13 years as a fugitive, a former New Jersey resident has been returned to the United States, and pleaded guilty today to conspiring to committing one of the nation’s largest known motor fuel excise tax schemes. Aaron Misulovin a/k/a Albert Friedman, a/k/a Valery Vibornov, pleaded guilty before U.S. District Judge Joseph E. Irenas in Camden, N.J., to one count of conspiracy, three counts of wire fraud, three counts of money laundering and three counts of tax evasion.

Diego Montoya Sanchez, 48, one of the leaders of the Norte Valle Colombian drug cartel and a former FBI Top Ten Fugitive, pleaded guilty today in Miami to drug trafficking, murder and racketeering charges.

The defendants are accused of various crimes, including murder, sex offenses, drug trafficking and moneylaundering in Texas, Washington, Florida, Indiana, California and Maryland.

Jose Garcia, 55, who has been a fugitive since 2008, was taken into federal custody yesterday at Miami International Airport.

Former National Century Financial Enterprises (NCFE) executive Rebecca S. Parrett, 62, has been arrested in Mexico.

Caridad Guilarte, 54, and Clara Guilarte, 57, each pleaded guilty before U.S. District Judge Cecilia M. Altonaga to one count of conspiracy to commit health care fraud and one count of conspiracy to commit money laundering.

Roger Charles Day Jr., a former America’s Most Wanted fugitive, was sentenced today to 105 years in prison for his role in leading an international conspiracy to defraud the Department of Defense (DOD) of more than $11.2 million by supplying nonconforming and defective parts for military aircraft, vehicles and weapons systems.

A former Los Angeles resident, who fled to Canada and was a federal fugitive for 12 years, pleaded guilty today to aggravated identity theft and bankruptcy fraud in connection with leading a nearly 15-year foreclosure-rescue scam that fraudulently postponed foreclosure sales for more than 800 distressed homeowners.

Glen Alan Ward, 48, a former Los Angeles resident who fled to Canada and was a federal fugitive for 12 years, was sentenced today to serve 132 months in prison for aggravated identity theft and bankruptcy fraud in connection with his leading role in a nearly 15-year foreclosure-rescue scam that fraudulently postponed foreclosure sales for more than 800 distressed homeowners.

Earlier today, charges were unsealed against Romanian fugitive Nicolae Popescu, the leader of an international organized crime syndicate that ran a multimillion dollar cyber fraud scheme, and six other fugitives charged with participating in the same scheme. Interpol has issued red notices to foreign law enforcement partners seeking assistance in the apprehension of these fugitives, and the FBI has also released “Wanted” posters to facilitate their arrests.

A Las Vegas-based former Department of Defense contractor has been extradited from Iraq to the United States to face fraud and conspiracy charges for attempting to bribe U.S. officials in order to secure government contracts for his companies

By Karin F.R. Moore —

La crisis de refugiados venezolanos está a punto de superar la escala de la crisis siria. Para finales del 2019, 4 años después del comienzo de la crisis humanitaria venezolana, 4.6 millones de venezolanos han huido del país, alrededor del 16 por ciento de la población. La cifra es sumamente similar a los 4,8 millones…

Frank Lloyd Wright would probably have liked this little addition to his winter home.

This traditional Japanese method of finishing wood is having a dramatic resurgence.