Stone is a leading engineering scholar and pioneer in fluid dynamics research. University Professor is Princeton’s highest honor for faculty.

tataata has added a photo to the pool:

McLaren’s Lando Norris explains why he wants to win the British Grand Prix more than any other race in Formula 1.

Paramount Plus, Peacock, and the Paramount Network all have a hand in the Yellowstone franchise, but it can be tricky to stream episodes.

Yue Chen
May 1, 2007; 6:812-819
Research

Linda J. Pike
Jul 1, 2006; 47:1597-1598
Report

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA.

Histone recognition by “reader” modules serves as a fundamental mechanism in epigenetic regulation. Previous studies have shown that Spindlin1 is a reader of histone H3K4me3 as well as “K4me3-R8me2a” and promotes transcription of rDNA or Wnt/TCF4 target genes. Here we show that Spindlin1 also acts as a potent reader of histone H3 “K4me3-K9me3/2” bivalent methylation pattern. Calorimetric titration revealed a binding affinity of 16 nm between Spindlin1 and H3 “K4me3-K9me3” peptide, which is one to three orders of magnitude stronger than most other histone readout events at peptide level. Structural studies revealed concurrent recognition of H3K4me3 and H3K9me3/2 by aromatic pockets 2 and 1 of Spindlin1, respectively. Epigenomic profiling studies showed that Spindlin1 colocalizes with both H3K4me3 and H3K9me3 peaks in a subset of genes enriched in biological processes of transcription and its regulation. Moreover, the distribution of Spindlin1 peaks is primarily associated with H3K4me3 but not H3K9me3, which suggests that Spindlin1 is a downstream effector of H3K4me3 generated in heterochromatic regions. Collectively, our work calls attention to an intriguing function of Spindlin1 as a potent H3 “K4me3-K9me3/2” bivalent mark reader, thereby balancing gene expression and silencing in H3K9me3/2-enriched regions.

Congcong Lu
Nov 17, 2020; 0:R120.002257v1-mcp.R120.002257
Review

Histone post-translational modifications (PTMs) are one of the main mechanisms of epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such as cancer. Due to its high-throughput, accuracy, and flexibility, mass spectrometry (MS) has emerged as a powerful tool in the epigenetic histone modification field, allowing the comprehensive and unbiased analysis of histone PTMs and chromatin-associated factors. Coupled with various techniques from molecular biology, biochemistry, chemical biology and biophysics, MS has been employed to characterize distinct aspects of histone PTMs in the epigenetic regulation of chromatin functions. In this review we will describe advancements in the field of MS that have facilitated the analysis of histone PTMs and chromatin biology.  

Citizen mathematicians are using GPUs to find the highest prime numbers based on specific computing formulas. As it turns out, it is also a good way to stress test GPUs […]

The post GPUs Help Establish New Milestone in Mathematics appeared first on HPCwire.

The fate of fictional Montana Gov. John Dutton -- played by Kevin Costner -- has finally been disclosed in the Season 5B premiere of "Yellowstone" that aired on Paramount Sunday night.

Kevin Costner says he didn't know about his "Yellowstone" character John Dutton's death until after the episode aired on Sunday.

86 Sergei Bobrovsky, 85 Cole Perfetti, and 85 Alexandar Goergiev among new cards

Prepare to be amazed.

Have you ever wondered why Yellowstone is full of hot springs, bubbling mudpots and geysers like Old Faithful? In this one-minute video, Ask Smithsonian host Eric Schulze explains the supervolcano that lies beneath this national park and answers the life-or-death question: Will it erupt in a fiery inferno anytime soon?

The Orkneys, an archipelago of islands off the northern coast of Scotland, are home to some of the greatest neolithic treasures in western Europe: from the settlement of Skara Brae to the Ness of Brodgar.

Researchers analyzed tiny fossils embedded in the limestone to determine the age and origins of the grave maker, which marked the final resting place of a prominent Jamestown colonist

Thousands of years ago, our ancestors used symbols to track the sale of textile and agricultural products. New research suggests that these markings informed the development of writing

The Sacro Bosco's meaning is the subject of debate, with scholars alternatively describing the sprawling complex as a memorial, an allegorical site or a tribute to ancient civilizations

In honour of Remembrance Day, Students from St. Paul School visited St Andrew's Catholic Cemetery to clean headstones of veterans, a partnership with the No Stone Left Behind project.

Former Logos Hope port volunteer Swens Wong discovers God’s creativity in his cake-baking business and uses his creations, and story, to bring God glory.

Federal judge ensures mifepristone access in Delaware Attorney General Kathy Jennings announced Friday that Judge Thomas O. Rice of the U.S. District Court for the Eastern District of Washington has issued an order reiterating that his injunction protecting access to mifepristone in 17 states — including Delaware — and the District of Columbia remains in […]

The legal debacle over mifepristone underscores how easily a small group of extremist plaintiffs can abuse the judicial system to force draconian, unscientific, and undemocratic laws on the nation. These questions should not even be up for debate: mifepristone has a safer track record than Viagra. But we live in an era where women once […]

With the announcement of the 27th round of easement selections by the Delaware Agricultural Lands Preservation Foundation, Delaware has reached a new milestone, permanently preserving 151,257 acres of farmland.

NEW CASTLE (Jan. 4, 2022) – The Department of Health and Social Services’ (DHSS) Division of Substance Use and Mental Health (DSAMH) has surpassed a milestone of 100,000 referrals through its Delaware Treatment and Referral Network (DTRN), a system for Delawareans seeking substance use and mental health services. Delaware is the first state to make […]

A State of Delaware program that helps small businesses start or grow during the first few years of operation hit a major milestone Thursday. The Delaware Division of Small Business announced the most recent grant awards for the Encouraging Development, Growth and Expansion (EDGE) competition on May 23rd in Dover. The awards given to 10 Delaware small businesses for the spring 2024 round, bring the total number of businesses awarded funds under the EDGE program to 100.

On November 5, 2024, the Cadence Bangalore Toastmasters Club celebrated a significant milestone by hosting its 50th meeting. Established in December 2020, the club was created to provide a supportive environment for individuals looking to improve their communication and leadership skills. Over the years, the club has evolved into a vibrant community filled with success stories of personal development and newfound confidence. A testament to the club's dedication is its achievement of the "Select Distinguished Club" status during the 2023-2024 program year. By fulfilling 7 out of 10 distinguished goals, the club highlighted its commitment to excellence—a success driven by its vibrant members' relentless focus and perseverance. The strategic insight gained from regular Toastmasters committee meetings and the influential "Moments of Truth" sessions held in 2023 and 2024 are key to this success. Our club members have consistently demonstrated strong performance in various speech contests, with notable achievements across multiple levels. In 2023, members excelled in Evaluation and Table Topics contests, reaching the district level while advancing to the Division Level in the International Speech Contest. Continuing their success into 2024, members again qualified for area-level contests, securing third-place positions in the Evaluation and Table Topics categories, highlighting the club's dedication and competitive spirit. The 50th meeting was based on the theme of serendipity. It was not only a milestone celebration but also a vibrant festival of achievements and growth. The day buzzed with energy as activities like a spirited Treasure Hunt injected enthusiasm and camaraderie among attendees. Distinguished guests, including Kripa Venkitachalam and Madhavi Rao, enriched the occasion with inspiring speeches. Madhavi reignited the club's spirit, while Kripa's discourse on the Growth Mindset and the "Power of Yet" encouraged members to pursue continuous self-improvement. The Cadence Bangalore Toastmasters Club is enthusiastic about its promising future and is committed to creating an environment that promotes personal and professional growth. Many members are close to completing their Toastmasters levels and pathways, and this term, a new group of approximately 30 individuals has joined, bringing the total membership to 52. This vibrant community is just beginning its journey and is eager to reach new milestones together through mutual support and a shared commitment to excellence. The transformations experienced by many club members are truly compelling. They often share how the club has significantly improved their communication skills and boosted their confidence. One member recalls, "Before joining, I found public speaking intimidating. Now, I embrace every opportunity to share my ideas." Another member highlights how the club's supportive environment helped him overcome his fear of public speaking, propelling his career to new heights. This culture of constructive feedback and continuous improvement has inspired countless members to pursue their dreams with renewed determination and optimism. The Cadence Bangalore Toastmasters Club's journey is a living testament to the power of community and the potential within each of us to grow and achieve greatness. As the club continues to evolve and inspire, it serves as a beacon for those aspiring to transform their skills and seize their moment in the spotlight. Learn more about life at Cadence.

About 50 settlers gathered to attack the IDF soldiers, injuring one soldier who was taken to hospital with head injuries.

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

A stone wall nearly a kilometre long found under the Baltic Sea may have been built by ancient hunters to channel deer into a confined space

A modern butchery experiment using replicas of Stone Age tools raises new questions about how often prehistoric peoples hunted large animals such as bison or mammoths

In an effort to understand ancient Neanderthal food preparation techniques, researchers butchered five wild birds using flint stone tools and roasted them

The nearest source of the altar stone at the centre of Stonehenge has finally been identified – and it is at least 750 kilometres away in north-east Scotland

Ancient stone goods found across France may have been made by skilled craftspeople in what is now Paris, who traded along vast networks

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Title: Gallstones in Kids, Teens Linked to Obesity
Category: Health News
Created: 8/25/2012 11:00:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: Kidney Stones May Be Tied to Later Kidney Problems
Category: Health News
Created: 8/31/2012 10:05:00 AM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Women Increasingly Prone to Kidney Stones
Category: Health News
Created: 8/28/2013 4:35:00 PM
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Title: Health Tip: Preventing Kidney Stones
Category: Health News
Created: 8/30/2019 12:00:00 AM
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Title: When Removing a Big Kidney Stone, Get the Little Ones, Too
Category: Health News
Created: 8/11/2022 12:00:00 AM
Last Editorial Review: 8/11/2022 12:00:00 AM

Advancements in immunotherapy in the perioperative setting have revolutionised the treatment of resectable nonsmall cell lung cancer (NSCLC). Here we present the methodology and results of the clinical trial CheckMate 816 demonstrating the benefit of neoadjuvant therapy with nivolumab plus chemotherapy compared with chemotherapy alone. Furthermore, this article discusses the implications for future practice in resectable NSCLC and the need for future research.

Google, Microsoft and others have taken big steps towards error-free devices, hinting that quantum computers that solve real problems aren’t far away

Using a laser-based detection system, archaeologists have discovered over 6,500 pre-Hispanic structures -- including a previously unknown Maya city named Valeriana -- in Campeche, Mexico.

The post Laser Mapping Reveals Previously Unknown Maya City with Stone Pyramids in Mexico appeared first on Sci.News: Breaking Science News.

Viewers were left stunned by ‘savage’ exit of character in first episode of new season

Discover the calming power of a worry stone! Learn how this ancient tool relieves stress, boosts mindfulness, and promotes emotional balance through touch.

Discover agate meaning: learn how this beautiful crystal supports emotional healing, balance, and grounding energy, making it a must-have for spiritual wellness.