Two rounds of the Survey of Adult Skills are under way: Round 1 (2008-13) with 24 participating countries, whose results were released in October 2013, and Round 2 (2012-16) with 9 participating countries, whose results will be released in 2016. A third round is scheduled to begin in May 2014.

Canada has experienced solid economic growth since the global crisis, allowing it to reverse recession-induced job losses and put federal public finances on a sound footing, says the OECD. Growth is expected to accelerate from 2.5% this year to 2.7% in 2015.

Two rounds of the Survey of Adult Skills are under way: Round 1 (2008-13) with 24 participating countries, whose results were released in October 2013, and Round 2 (2012-16) with 9 participating countries, whose results will be released in 2016. A third round is scheduled to begin in May 2014.

Archives, Room Use Only - TK5452.W47 1920

An extended analysis of structural ensembles obtained from small-angle X-ray scattering data reveals subclass-specific conformational preferences of IgG antibodies, which are largely determined by the hinge-region structure.

Human septins 3, 9 and 12 are the only members of a specific subgroup of septins that display several unusual features, including the absence of a C-terminal coiled coil. This particular subgroup (the SEPT3 septins) are present in rod-like octameric protofilaments but are lacking in similar hexameric assemblies, which only contain representatives of the three remaining subgroups. Both hexamers and octamers can self-assemble into mixed filaments by end-to-end association, implying that the SEPT3 septins may facilitate polymerization but not necessarily function. These filaments frequently associate into higher order complexes which associate with biological membranes, triggering a wide range of cellular events. In the present work, a complete compendium of crystal structures for the GTP-binding domains of all of the SEPT3 subgroup members when bound to either GDP or to a GTP analogue is provided. The structures reveal a unique degree of plasticity at one of the filamentous interfaces (dubbed NC). Specifically, structures of the GDP and GTPγS complexes of SEPT9 reveal a squeezing mechanism at the NC interface which would expel a polybasic region from its binding site and render it free to interact with negatively charged membranes. On the other hand, a polyacidic region associated with helix α5', the orientation of which is particular to this subgroup, provides a safe haven for the polybasic region when retracted within the interface. Together, these results suggest a mechanism which couples GTP binding and hydrolysis to membrane association and implies a unique role for the SEPT3 subgroup in this process. These observations can be accounted for by constellations of specific amino-acid residues that are found only in this subgroup and by the absence of the C-terminal coiled coil. Such conclusions can only be reached owing to the completeness of the structural studies presented here.

U.S. adults perform comparably to adults in other economically developed countries on most measures of science knowledge and support science in general, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Effective flood-risk communications should include specific information on how householders can protect themselves and their property against flooding, a recent Dutch study concludes. The researchers’ evaluation of communication strategies also highlights an important role for social media in spreading messages about flood risk and protection.

A new oil-spill risk-management system has been developed by researchers, which shows the likely effects of a coastal spill on the environment and economic activities for specific locations. It provides maps of oil-spill risk through a web portal and could help decision makers and emergency-response authorities protect the local environment and businesses through targeted and efficient planning and responses.

Consumers are willing to pay more for food that has been produced via sustainable processes and with a reduced environmental impact. A large-scale US survey, that questioned strawberry consumers on aspects of sustainable food production, suggests that food producers could benefit from increased premiums if product ecolabels were to advertise specific environmental virtues.

Agri-environmental measures (AEM) are designed to encourage farmers to protect and enhance the environment on their farmland by paying them for the provision of environmental services. This study suggests that AEM would be more effective if payments were targeted to areas under the greatest environmental pressures, such as intensive agricultural regions — to gain maximum environmental benefits.

New research in harbours has explored the most influential environmental and human factors on the release of contaminants from sediment. The scientists suggest that the rate of release can vary considerably between locations and risk assessments of water pollution could be improved if they account for this.

New research has shown that policy measures in Denmark have successfully reduced total nitrogen loading to 10 estuaries by 39% in recent decades. However, to fully meet the targets of the EU Nitrates Directive and comply with the EU Water Framework Directive in a cost-effective manner, further mitigation measures must be tailored and focused to particular areas.

New features in youth mental wellness app help students connect and share resources to confront the stresses of the pandemic and ensuing social isolation

Margaret Parker, MD, MCCM, speaks with James L. Wynn, MD.

Spurred by the insurance regulator to come up with Covid-specific products, several such plans have flooded the market in the past month or so from players such as Star Health & Allied Insurance, Bharti AXA Health Insurance, etc.

The Maryland Jockey Club has released a spring condition book for Laurel Park covering a period of 15 days ahead of the still-undetermined resumption of live racing in the state. Specific dates have not been set. As part of Gov. Larry Hogan's statewide shutdown, live racing was paused in Maryland following the March 15 program […]

The post Maryland Jockey Club Releases Spring Condition Book; No Specific Dates Set For Live Racing appeared first on Horse Racing News | Paulick Report.

IE10 grid layout with three columns a central exclusion zone and touch screen scrolling gallery

Estimates of national forest recreation use are available at the national, regional, and forest levels via the USDA Forest Service National Visitor Use Monitoring (NVUM) program. In some resource planning and management applications, analysts desire recreation use estimates for subforest areas within an individual national forest or for subforest areas that combine portions of several national forests. In this research note we have detailed two approaches whereby the NVUM sampling data may be used to estimate recreation use for a subforest area within a single national forest or for a subforest area combining portions of more than one national forest. The approaches differ in their data requirements, complexity, and assumptions. In the "new forest" approach, recreation use is estimated by using NVUM data obtained only from NVUM interview sites within the area of interest. In the "all-forest information" approach, recreation use is estimated by using sample data gathered on all portions of the national forest(s) that contain the area of interest.

Research Highlights: Researchers have found a specific bacterial profile in the gut of people with pulmonary arterial hypertension, a chronic and progressive disease that causes constriction of arteries in the lungs. The unique bacterial profile...

Now that we have most of the basics of HTML and CSS in the browser, we’ve begun implementing new features that I would consider “quality of life” improvements, many of which have been inspired by mobile. One great example is the CSS prefers-color-scheme media query, which allows developers to cater their design to system theme […]

The post How to Display Mode-Specific Images appeared first on David Walsh Blog.

Multimodal Sentiment Analysis is an active area of research that leverages multimodal signals for affective understanding of user-generated videos. The predominant approach, addressing this task, has been to develop sophisticated fusion techniques. However, the heterogeneous nature of the signals creates distributional modality gaps that pose significant challenges. In this paper, we aim to learn effective modality representations to aid the process of fusion. We propose a novel framework, MISA, which projects each modality to two distinct subspaces. The first subspace is modality invariant, where the representations across modalities learn their commonalities and reduce the modality gap. The second subspace is modality-specific, which is private to each modality and captures their characteristic features. These representations provide a holistic view of the multimodal data, which is used for fusion that leads to task predictions. Our experiments on popular sentiment analysis benchmarks, MOSI and MOSEI, demonstrate significant gains over state-of-the-art models. We also consider the task of Multimodal Humor Detection and experiment on the recently proposed UR_FUNNY dataset. Here too, our model fares better than strong baselines, establishing MISA as a useful multimodal framework.

Neural machine translation (NMT) needs large parallel corpora for state-of-the-art translation quality. Low-resource NMT is typically addressed by transfer learning which leverages large monolingual or parallel corpora for pre-training. Monolingual pre-training approaches such as MASS (MAsked Sequence to Sequence) are extremely effective in boosting NMT quality for languages with small parallel corpora. However, they do not account for linguistic information obtained using syntactic analyzers which is known to be invaluable for several Natural Language Processing (NLP) tasks. To this end, we propose JASS, Japanese-specific Sequence to Sequence, as a novel pre-training alternative to MASS for NMT involving Japanese as the source or target language. JASS is joint BMASS (Bunsetsu MASS) and BRSS (Bunsetsu Reordering Sequence to Sequence) pre-training which focuses on Japanese linguistic units called bunsetsus. In our experiments on ASPEC Japanese--English and News Commentary Japanese--Russian translation we show that JASS can give results that are competitive with if not better than those given by MASS. Furthermore, we show for the first time that joint MASS and JASS pre-training gives results that significantly surpass the individual methods indicating their complementary nature. We will release our code, pre-trained models and bunsetsu annotated data as resources for researchers to use in their own NLP tasks.

This paper proposes a fully automated atlas-based pancreas segmentation method from CT volumes utilizing atlas localization by regression forest and atlas generation using blood vessel information. Previous probabilistic atlas-based pancreas segmentation methods cannot deal with spatial variations that are commonly found in the pancreas well. Also, shape variations are not represented by an averaged atlas. We propose a fully automated pancreas segmentation method that deals with two types of variations mentioned above. The position and size of the pancreas is estimated using a regression forest technique. After localization, a patient-specific probabilistic atlas is generated based on a new image similarity that reflects the blood vessel position and direction information around the pancreas. We segment it using the EM algorithm with the atlas as prior followed by the graph-cut. In evaluation results using 147 CT volumes, the Jaccard index and the Dice overlap of the proposed method were 62.1% and 75.1%, respectively. Although we automated all of the segmentation processes, segmentation results were superior to the other state-of-the-art methods in the Dice overlap.

Web services often impose inter-parameter dependencies that restrict the way in which two or more input parameters can be combined to form valid calls to the service. Unfortunately, current specification languages for web services like the OpenAPI Specification (OAS) provide no support for the formal description of such dependencies, which makes it hardly possible to automatically discover and interact with services without human intervention. In this article, we present an approach for the specification and automated analysis of inter-parameter dependencies in web APIs. We first present a domain-specific language, called Inter-parameter Dependency Language (IDL), for the specification of dependencies among input parameters in web services. Then, we propose a mapping to translate an IDL document into a constraint satisfaction problem (CSP), enabling the automated analysis of IDL specifications using standard CSP-based reasoning operations. Specifically, we present a catalogue of nine analysis operations on IDL documents allowing to compute, for example, whether a given request satisfies all the dependencies of the service. Finally, we present a tool suite including an editor, a parser, an OAS extension, a constraint programming-aided library, and a test suite supporting IDL specifications and their analyses. Together, these contributions pave the way for a new range of specification-driven applications in areas such as code generation and testing.

The generation of individual-specific information having a good reliability and uniqueness is made possible with a little circuit scale. For this purpose, in an individual-specific information generation apparatus, a plurality of digital circuits are in the same circuit configuration. Each of the digital circuits outputs a fixed or a random number output value individually without their output with respect to a certain input being determined unambiguously among the digital circuits. In each of the digital circuit, an order is defined in advance. A random number judgment unit judges whether the output value is a random value or fixed, for each of the plurality of digital circuits. An individual-specific information generation unit generates the individual-specific information based on information of the order defined in the digital circuit judged by the random number judgment unit as having a fixed output value among the plurality of digital circuits and the output value.

A microprocessor capable of running both x86 instruction set architecture (ISA) machine language programs and Advanced RISC Machines (ARM) ISA machine language programs. The microprocessor includes a mode indicator that indicates whether the microprocessor is currently fetching instructions of an x86 ISA or ARM ISA machine language program. The microprocessor also includes a plurality of model-specific registers (MSRs) that control aspects of the operation of the microprocessor. When the mode indicator indicates the microprocessor is currently fetching x86 ISA machine language program instructions, each of the plurality of MSRs is accessible via an x86 ISA RDMSR/WRMSR instruction that specifies an address of the MSR. When the mode indicator indicates the microprocessor is currently fetching ARM ISA machine language program instructions, each of the plurality of MSRs is accessible via an ARM ISA MRRC/MCRR instruction that specifies the address of the MSR.

An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory.

An abstraction for storage class memory is provided that hides the details of the implementation of storage class memory from a program, and provides a standard channel programming interface for performing certain actions, such as controlling movement of data between main storage and storage class memory or managing storage class memory.

A composition comprising an SL0101 [kaempferol 3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.

Systems and methods are disclosed for evaluating cardiovascular treatment options for a patient. One method includes creating a three-dimensional model representing a portion of the patient's heart based on patient-specific data regarding a geometry of the patient's heart or vasculature; and for a plurality of treatment options for the patient's heart or vasculature, modifying at least one of the three-dimensional model and a reduced order model based on the three-dimensional model. The method also includes determining, for each of the plurality of treatment options, a value of a blood flow characteristic, by solving at least one of the modified three-dimensional model and the modified reduced order model; and identifying one of the plurality of treatment options that solves a function of at least one of: the determined blood flow characteristics of the patient's heart or vasculature, and one or more costs of each of the plurality of treatment options.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring an anatomical model of at least part of the patient's vascular system; performing, using a processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model; and identifying, using the processor, a personalized cardiovascular device for the patient, based on results of one or more of the geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of anatomical model.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining pathology characteristics from cardiovascular geometry of the patient specific model; defining an objective function for a device based on design considerations and one or more estimates of hemodynamic and mechanical characteristics; optimizing the objective function, by simulating at least one change in devices and evaluating the objective function using fluid dynamic or structural mechanic analysis; and using the optimized objective function to either (i) select a device from a set of available devices or (ii) manufacture a desired device.

A method for tracking a user's movements between network addresses can include, subsequent to a request for a (current) network address from a user, receiving the network address and an identifier for a region associated with the network address. The method can also include locating a record that contains the identifier for the region and a time that immediately precedes the request for the network address from the user. The record may further contain a prior network address. The method can further include generating an entry for a table that includes the identifier for the region, the current network address, and the prior network address. A server computer or a client computer can generate the entry. Improved accountability and improved user profile accuracy can be obtained with the method. A data processing system readable medium can comprise code that includes instructions for carrying out the method.

The present invention relates to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis used in the surgery, and particularly, to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis which are intended to solve a problem of damage to a spine caused by installing a spinal prosthesis used in spinal surgery, by introducing an image of a patient to manufacture an insertable spinal prosthesis that is customized for a shape of a spine of an individual patient in a polymer-based material.

The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

The invention relates to melanocortin receptor-specific cyclic peptides of Formula (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4a, R4b, R4c, R5, x and y are as defined in the specification. These compounds are particularly useful in the treatments of energy homeostasis and metabolism related (e.g. diabetes), food intake related and/or energy balance and body weight related diseases, disorders and/or conditions, including obesity, overweight and diseases, disorders and/or conditions associated with obesity and/or overweight, such as type 2 diabetes and metabolic syndrome.

Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab')2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.

A processing system decodes packetized program information including ancillary program specific information comprising a plurality of hierarchically ordered information tables. The ancillary information is used in acquiring and decoding packetized program information to provide a video program for display. The processing system employs a method involving detection of a mismatch between a version number of a first table of the program specific information (e.g. a virtual channel table (VCT), or channel information table (CIT)) and a corresponding version number of the first table conveyed in a second table (e.g. a master guide table (MGT)). If a mismatch is detected, the first and second tables are forced to contain a compatible first table version number. The packetized program information is decoded to provide a video program for display using the program specific information including the first and second tables including the forced compatible version number. A detected mismatch may also be disregarded to enable the decoding of the packetized program information and a User's channel line-up may be edited to remove channels associated with a detected mismatch or other program specific information error condition.

A television receiver including a tuner and one or more processors may be presented. The television receiver may be configured to tune the tuner to a television channel. The television receiver may be configured to create and store an omnibus channel file containing a plurality of television programs broadcast consecutively on the television channel over a period of time. The television receiver may be configured to, after a predefined period of time, select the omnibus channel file for deletion. The television receiver may be configured to determine a television program to receive extended storage. The television receiver may be configured to store a portion of the omnibus channel file as an individual program file, wherein the portion of the omnibus channel file corresponds to the television program. The television receiver may be configured to, after storing the portion of the omnibus channel file, delete the omnibus channel file.

A synergy-based human-machine interface that uses low-dimensional command signals to control a high dimensional virtual, robotic or paralyzed human hand is provided. Temporal postural synergies are extracted from angular velocities of finger joints of five healthy subjects when they perform hand movements that are similar to activities of daily living. Extracted Synergies are used in real-time brain control, where a virtual, robotic or paralyzed human hand is controlled to manipulate virtual or real world objects.

The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.

Systems and methods for applying customer-specific labels to an unprinted or non-displayed side of printed products.

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.