While the OnePlus 13 has only been revealed in China so far, speculations are that it will arrive on the global market in the coming months. In India, the phone is expected to be launched in January 2025.

Laptop is ‘crafted with US military-grade certification’ for mobility

Property prices have stayed soft for the past year and it might pay to tread cautiously

National Bureau of Economic Research

IEEE / Institute of Electrical and Electronics Engineers Incorporated

Recently I came across a CodePen demo by a developer/engineer named Jane that was Tweeted out by Šime Vidas. The demo has a neat collection of HTML and CSS tricks rolled into one that I thought was worth examining in detail.

The page displays a secret message based on specific text input. Ok, that’s no big deal, right? Well this is done using pure HTML and CSS – no JavaScript. I’ve seen stuff like this before, but I thought it would be cool to break down exactly how this works. There are a few notable things happening in the code so I’ll break down each of the parts.

The post Detecting Specific Text Input with HTML and CSS appeared first on Impressive Webs.

The mixed reality headset blends both the physical and digital worlds covering from augmented reality to virtual reality.

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

The BMW 310 twins might not have a features upgrade or riding modes compared to the updates the TVS Apache RR310 got.

The Suzuki Gixxer and the SF250 BS6 might be priced Rs 3,000 over the BS4 offerings while the launch will be post lockdown.

BS6 Yamaha FZ 25 will be on sale in two colour options while the FZS 25 will get three shades.

Scientists claim that delayed appearance of IgG3 antibodies (a naturally-acquired antibody) serves as a specific biomarker that increases the risk of the more severe form of Chikungunya.

This paper describes MOLES 1.0, an integrated land-use and transport model developed with Object-Oriented Programming principles in order to combine selected characteristics from Spatial Computable General Equilibrium and microsimulation models. MOLES 1.0 models the links between urban land use, mobility patterns, urban economic activities and their environmental impacts, in particular air pollution and emissions of greenhouse gases.

Two rounds of the Survey of Adult Skills are under way: Round 1 (2008-13) with 24 participating countries, whose results were released in October 2013, and Round 2 (2012-16) with 9 participating countries, whose results will be released in 2016. A third round is scheduled to begin in May 2014.