Rockville, Maryland : National Institute on Drug Abuse, 1979.

Cristina Butucea, Amandine Dubois, Martin Kroll, Adrien Saumard.

Source: Bernoulli, Volume 26, Number 3, 1727--1764.

Abstract:
We address the problem of non-parametric density estimation under the additional constraint that only privatised data are allowed to be published and available for inference. For this purpose, we adopt a recent generalisation of classical minimax theory to the framework of local $alpha$-differential privacy and provide a lower bound on the rate of convergence over Besov spaces $mathcal{B}^{s}_{pq}$ under mean integrated $mathbb{L}^{r}$-risk. This lower bound is deteriorated compared to the standard setup without privacy, and reveals a twofold elbow effect. In order to fulfill the privacy requirement, we suggest adding suitably scaled Laplace noise to empirical wavelet coefficients. Upper bounds within (at most) a logarithmic factor are derived under the assumption that $alpha$ stays bounded as $n$ increases: A linear but non-adaptive wavelet estimator is shown to attain the lower bound whenever $pgeq r$ but provides a slower rate of convergence otherwise. An adaptive non-linear wavelet estimator with appropriately chosen smoothing parameters and thresholding is shown to attain the lower bound within a logarithmic factor for all cases.

After abdicating the British throne, Edward was appointed governor of the Bahamas, where he temporarily lived in a lavish home in Nassau

The Epson WorkForce ES-500WR delivers fast and accurate scans paired with a robust software package that will appeal to data-crunching offices.

Penn State Schuylkill biology student Eric Thompson will graduate with honors on May 9. After surviving pediatric cancer in his early teens, Thompson has transformed a tragic situation into a passion to help people. This fall, he will embark on a new academic journey at Thomas Jefferson University’s Sidney Kimmel Medical College, where he will commit himself to earning his M.D. and delivering medical expertise to underserved communities.

The highly portable Epson EX3260 delivers solid data-image quality and very good video quality in a projector that's a fine fit for offices and schools.

What's thin, light, and bright, with 1080p resolution? Epson's PowerLite 1795F Wireless Full HD 1080p 3LCD Projector, a highly portable model good with data-heavy images and excellent with video, but packing soft audio.

Accreditation is the highest recognition afforded to museums in the United States.

With the merger we had set out to create a new agency breed — a creative, data and technology agency that can offer genuine end-to-end solutions to our clients.

Douglas R. Simpson of Bridgeville has been named the 2018 Delaware Tree Farmer of the Year for his longtime dedication to forest conservation and landowner education. The award recognizes landowners who practice exceptional management and promote sustainable forestry. Simpson is a Delaware native who owns tree farms on approximately 700 acres in Sussex County, which were first certified in 1995. The award was given at the annual meeting and banquet of the Delaware Forestry Association at the Bridgeville Fire Hall.

W.B. Simpson Elementary School 4th grader Latrell McGinnis spent last spring tending to his cabbage in hopes of growing the best-looking cabbage in Delaware. After all the judging was completed, McGinnis’s hard work paid off when he was announced as the state winner during a presentation at his school this week.

Some social media users are convinced that an early episode of The Simpsons also came close to predicting the ongoing coronavirus pandemic and the invasion of "murder hornets".

TYPSoft FTP Server 1.10 for Windows 9X and WinNT is vulnerable to a denial of service attack when a blank username is supplied.

Title: LeAnn Rimes Brings Battle With Psoriasis to Center Stage
Category: Health News
Created: 4/23/2010 10:10:00 AM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Psoriasis Tied to Obesity, Type 2 Diabetes
Category: Health News
Created: 4/27/2016 12:00:00 AM
Last Editorial Review: 4/28/2016 12:00:00 AM

ABSTRACT

Recent global advocacy efforts have highlighted the importance of development of a vaccine against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that provides protection against GAS skin infection in mice and reduces the severity of pharyngitis in nonhuman primates. However, Combo5 with the addition of aluminum hydroxide (alum) as an adjuvant failed to protect against invasive GAS infection of mice. Here, we show that formulation of Combo5 with adjuvants containing saponin QS21 significantly improves protective efficacy, even though all 7 adjuvants tested generated high antigen-specific IgG antibody titers, including alum. Detailed characterization of Combo5 formulated with SMQ adjuvant, a squalene-in-water emulsion containing a TLR4 agonist and QS21, showed significant differences from the results obtained with alum in IgG subclasses generated following immunization, with an absence of GAS opsonizing antibodies. SMQ, but not alum, generated strong interleukin-6 (IL-6), gamma interferon (IFN-), and tumor necrosis alpha (TNF-α) responses. This work highlights the importance of adjuvant selection for non-M protein-based GAS vaccines to optimize immune responses and protective efficacy.

IMPORTANCE Availability of a group A Streptococcus vaccine remains an unmet public health need. Here, we tested different adjuvant formulations to improve the protective efficacy of non-M protein vaccine Combo5 in an invasive disease model. We show that novel adjuvants can dramatically shape the type of immune response developed following immunization with Combo5 and significantly improve protection. In addition, protection afforded by Combo5 is not mediated by opsonizing antibodies, believed to be the main correlate of protection against GAS infections. Overall, this report highlights the importance of adjuvant selection in raising protective immune responses against GAS invasive infection. Adjuvants that can provide a more balanced Th1/Th2-type response may be required to optimize protection of GAS vaccines, particularly those based on non-M protein antigens.

The global burden of disease caused by extraintestinal pathogenic Escherichia coli (ExPEC) is increasing as the prevalence of multidrug-resistant strains rises. A multivalent ExPEC O-antigen bioconjugate vaccine could have a substantial impact in preventing bacteremia and urinary tract infections. Development of an ExPEC vaccine requires a readout to assess the functionality of antibodies. We developed an opsonophagocytic killing assay (OPA) for four ExPEC serotypes (serotypes O1A, O2, O6A, and O25B) based on methods established for pneumococcal conjugate vaccines. The performance of the assay was assessed with human serum by computing the precision, linearity, trueness, total error, working range, and specificity. Serotypes O1A and O6A met the acceptance criteria for precision (coefficient of variation for repeatability and intermediate precision, ≤50%), linearity (90% confidence interval of the slope of each strain, 0.80, 1.25), trueness (relative bias range, –30% to 30%), and total error (total error range, –65% to 183%) at five serum concentrations and serotypes O2 and O25B met the acceptance criteria at four concentrations (the lowest concentration for serotypes O2 and O25B did not meet the system suitability test of maximum killing of ≥85% of E. coli cells). All serotypes met the acceptance criteria for specificity (opsonization index value reductions of ≤20% for heterologous serum preadsorption and ≥70% for homologous serum preadsorption). The assay working range was defined on the basis of the lowest and highest concentrations at which the assay jointly fulfilled the target acceptance criteria for linearity, precision, and accuracy. An OPA suitable for multiple E. coli serotypes has been developed, qualified, and used to assess the immunogenicity of a 4-valent E. coli bioconjugate vaccine (ExPEC4V) administered to humans.

Despite the progress in the development of novel treatment modalities, a significant portion of patients with psoriasis remains undertreated relative to the severity of their disease. Recent evidence points to targeting the glucose transporter 1 and sugar metabolism as a novel therapeutic strategy for the treatment of psoriasis and other hyperproliferative skin diseases. In this review, we discuss glycoconjugation, an approach that facilitates the pharmacokinetics of cytotoxic molecules and ensures their preferential influx through glucose transporters. We propose pathways of glycoconjugate synthesis to increase effectiveness, cellular selectivity, and tolerability of widely used antipsoriatic drugs. The presented approach exploiting the heightened glucose requirement of proliferating keratinocytes bears the potential to revolutionize the management of psoriasis.

The Simpsons has done it again, this time predicting the COVID-19 pandemic and murder hornets. Here are some other instances of The Simpsons predicting the future.

The Simpsons officials have yet to respond to The Weeknd's public proposal.

The 39-year-old star has fired back at Vogue editor Sally Singer after a piece reflecting on the 2007 Met Gala which criticised her low cut

Warning from head of High Street chain comes as retailers across the UK feel the financial pinch of coronavirus restrictions

Who wants to make sequels forever?

The Simpsons may have predicted 2020's pandemic and murder hornets

Show has proven to be a hit for Netflix

Fans think The Simpsons predicted everything from Trump's presidency to coronavirus

Bill Oakley dug up notes from more than 25 years ago that showed the writers' intentions for that particular scene

Thirty years on from Kelsey Grammer's remarkable cartoon debut, Louis Chilton looks at the legacy of one of the most endearing felons in fiction

Clausen previously alleged he was dismissed over his 'perceived disability and age'

People have noted a certain timeliness in a clip from the 1993 episode 'Marge in Chains'

The 23-year-old actress has revealed via Instagram that she'll be voicing the part of an eight-year-old girl in an upcoming episode

Liverpool legend Phil Thompson has urged Jurgen Klopp to bring Philippe Coutinho back to Anfield, saying he would re-sign the Brazilian "in a heartbeat".

Liverpool legend Phil Thompson has backed calls for his former club to sign RB Leipzig striker Timo Werner.

Chief Executive Mike Thompson is to retire from his role at the Association of the British Pharmaceutical Industry (ABPI) by the end of this year.

His decision to leave the association marks the end of a three-year run beginning in March 2016, when stepped in to take up the mantle from Alison Clough, who had served as the acting Chief Executive for much of 2015.

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Click to view a price quote on TLRY.

Amgen’s Otezla (apremilast), a drug divested by Celgene ahead of its acquisition by Bristol-Myers Squibb,…

Amgen is planning to file for FDA approval of Otezla in mild to moderate plaque psoriasis based on new data showing patients on the drug experienced significant improvements in their symptoms. The label expansion will be key to Amgen's ability to recoup the $13.4 billion it paid to acquire the drug from Celgene last year.

Japanese electronics manufacturer Epson Imaging Devices Corporation (Epson) agreed to plead guilty and pay a $26 million criminal fine for its role in a conspiracy to fix prices in the sale of Thin Film Transistor-Liquid Crystal Display panels (TFT-LCD) sold to Motorola Inc.

Bill Oakley, a writer on "The Simpsons," admitted on Twitter that perhaps the animated TV show did forecast some of our troubling current events.

Actors Emma Thompson and Michelle Thrush are traveling with their daughters to the North Pole, as part of an Greenpeace campaign to create an international sanctuary in the Arctic.

Her incendiary collages of vintage black pinups made her one of the most influential artists of her time. Now she’s battling the ‘insanity’ of Trump’s America

Lorna Simpson is holed up in Los Angeles with her actor daughter right now. She’s been spending lockdown doing one of her favourite things: reflecting on how people present themselves when out in public. All this people-watching has put her in mind of the 1990s, when she would go wig-hunting in Fulton Mall, a blue-collar shopping centre near her home in New York.

“Shop after shop sold all sorts of wigs,” says the 59-year-old. “Human hair, yak hair, synthetic hair.” Simpson bought as many as she could, in every style she saw: from platinum-blonde “Lana Turner” wigs to fake afros and braids. She transferred photographs of each one on to panels of felt before hanging them alongside such seemingly disconnected phrases as: “First impressions are the most lasting.” The wigs were a “surrogate”, she says, a way to explore “the person we see ourselves to be”.

Just as the Caucasian figure in contemporary art is seen as universal, the black figure of African descent should be too

Any society, or self, constructed to always separate itself from the other is doomed

Lorna Simpson: Give Me Some Moments is at Hauser & Wirth’s website

Things have not been going well for The Simpsons. Aside from the fact that it became America's longest running scripted TV series last month, having clocked 636 episodes. Last November, Hari Kondabulu, in his documentary The Problem With Apu, drew the world's attention to what Apu really was — a problem. The characterisation of this immigrant convenience store owner who had a PhD and eight children was sharply criticised. Describing Hank Azaria's voice of Apu, Kondabulu said it resembled "a white guy doing an impression of a white guy, making fun of my father".

The world took note, but, the creators of the series decided there was no problem with Apu. In a veiled attack on Kondabolu's film, the "Apu problem" is dismissed as a hazard of being "politically incorrect" in the words of Lisa, in an episode titled No Good Read Goes Unpunished. That, followed by The Simpsons' creator Matt Groening saying that people "love to pretend they are offended", it was a slippery slope for Apu and his makers. And while keyboard crusaders continue to express their ire, Indian-American producer Adi Shankar and John Rhodes, co-founder of a Hollywood screenwriting talent-discovery platform, launched a contest inviting writers to rewrite Apu. The winning script shall be pitched to the The Simpsons' makers. Here are three writers who have been on the job.

'I changed his voice'
Shreyas Manohar, 23, screenwriter

Nagpur born Shreyas Manohar moved to the US three years ago. He just graduated from Columbia university in English and Creative writing. He had also been working on spec scripts for diversity TV programs conducted by CBS and NBC, especially The Simpsons and Veep, when he came across this contest. "I couldn't comprehend how a show of this calibre could address the controversy in such a tone-deaf manner," he says. Priyanka Chopra was not the only one asked in high school in the US why wouldn't she speak like Apu. "One of my closest friends once remarked, 'If you could talk normally, would you?' It was hurtful, but, not surprising." Manohar's Apu in Much Apu About Nothing enrolls in an accent workshop being taught by Peter Sellers, the actor who inspired the character of Apu. The trials that the episode takes Apu through lends him a manner of speaking that's not a lazy caricature. "I changed Apu's voice, so that his actual voice, and not just his accent, is heard," he says.

'He could be more useful'
Forest Kirst, 61, flight instructor

A flight instructor by profession, 61-year-old Forest Kirst started watching the show in the early 90s. His students would carve Apu, Bart, Lisa in aluminum and brass. When Kirst learnt about the contest, he wanted to try his hand in creating a new Apu, because he too had certain reservations. Having travelled extensively in India and Pakistan, Apu's accent did not sit well with him. "It's annoying, but comical. It's a product of how the writers of the show remember accents of convenience store employees in LA." Kirst's Apu in Apu Saves Springfield is a hero. "I feel Apu could be a more useful character. In my story, world leaders and spies are on the hunt for Apu, the hacker. My Apu could use his knowledge in computers to reprogram a nuclear reactor. He could block Trump from tweeting thus saving the US from much embarrassment. But, Apu must remain a comedy character, who calmly runs his store while keeping his brilliance a secret." He points out that everyone on the show is a stereotype. "They are bumbling idiots. I hope people don't think Americans are as dumb and fat as depicted on this show."

'He reminded me of my dad'
Herman Dhaliwal, 25, aspiring filmmaker

Born to immigrant parents, Herman Dhaliwal grew up in Charlottesville. His dad, who passed away in 2015, used to own a convenience store. "Seeing any Indian guy on TV who owned a convenience store, was of course going to remind me of my father. I would say, both Apu and my dad were comically overqualified for the job. My father was also bit of a workaholic, and, like Apu, he was friendly but also stubborn," says Dhaliwal who was only four when he started watching the show. "Stereotypes are rooted in truth. When taken at face value, and out of context, they become caricatures. As writers, we need to educate ourselves to be able to create something sensitive and human," he says. His script, titled "The World of Apu", is taken from the third installment of Satyajit Ray's The Apu Trilogy. In this story, Apu is mute. "He has an accident at the store and turns mute. The rest of the story has him figuring how to deal with life after that," Dhaliwal says. Apu is not the only character he has changed. "I also wanted to give his wife Manjula something to do. If representation of South Asian men in American media is bad, South Asian women have it worse." In Dhaliwal's story, Manjula, takes on the reins of the store after Apu's accident. The man instead gets to use his skills as a computer science doctorate.

Catch up on all the latest Mumbai news, crime news, current affairs, and also a complete guide on Mumbai from food to things to do and events across the city here. Also download the new mid-day Android and iOS apps to get latest updates

American reality TV star Khloe Kardashian, who has daughter True, two, with basketball player ex-partner Tristan Thompson wants to have more kids. But she is unsure if she wants Tristan to be her sperm donor.

Speaking in a preview of the E! reality show, Keeping Up With The Kardashians, Khloe said: "I've been taking hormone injections for about five days and the injection process has been fine. Dr Huang was saying the bonus of doing embryos is you get to see what are your stronger embryos, which are healthy, you get to already know all that by mixing them with sperm. Which I do have a sperm donor."
But Khloe is worried about the future and said there is a possibility of her changing her mind and wants to have a baby with her new partner rather than go for Tristan.

Tristan and True Thompson

"You never know like if in three years I get married to someone and I'm like, 'You know what? I don't want that.' It's weird, because Tristan and I, we're not together. I don't know which way to go," she added.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

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Singer Jessica Simpson was having a relaxing moment when she almost got hit in the face by son's baseball. Jessica is enjoying the quality family time as she quarantines amid the growing coronavirus pandemic.

 

 

 

View this post on Instagram

Attempted gettin’ some sun and my son smacked a homerun from the driveway that almost nailed me in the face. Proof is in the splash. Needless to say, I got off the mat 😂

A post shared by Jessica Simpson (@jessicasimpson) onApr 25, 2020 at 3:56pm PDT

But it's not all perfect moments for the Texas native as she isolates with her husband and three kids. She posted a photo of her in a bikini on Instagram as her son Ace hit a baseball that nearly collided with her face, reports dailymail.co.uk.

The 39-year-old is seen basking in the sun while floating on a mat. The baseball splashing next to her head is also visible. She wrote: "Attempted gettin' some sun and my son smacked a homerun from the driveway that almost nailed me in the face. Proof is in the splash. Needless to say, I got off the mat."

Simpson shares son Ace Knute and daughters Maxwell Drew and Birdie Mae with husband Eric Johnson.

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Patients with psoriasis found to use complementary or alternative medicine regularly to treat their symptoms, according to a survey of George Washington