The pyrazolo­pyrimidine moiety in the title mol­ecule, C13H12N4S, is planar with the methyl­sulfanyl substituent lying essentially in the same plane. The benzyl group is rotated well out of this plane by 73.64 (6)°, giving the mol­ecule an approximate L shape. In the crystal, C—H⋯π(ring) inter­actions and C—H⋯S hydrogen bonds form tubes extending along the a axis. Furthermore, there are π–π inter­actions between parallel phenyl rings with centroid-to-centroid distances of 3.8418 (12) Å. A Hirshfeld surface analysis of the crystal structure indicates that the most important contributions to the crystal packing are from H⋯H (47.0%), H⋯N/N⋯H (17.6%) and H⋯C/C⋯H (17.0%) inter­actions. The volume of the crystal voids and the percentage of free space were calculated to be 76.45 Å3 and 6.39%, showing that there is no large cavity in the crystal packing. Evaluation of the electrostatic, dispersion and total energy frameworks indicate that the cohesion of the crystal structure is dominated by the dispersion energy contributions.

The title mol­ecule, C25H23BrN2O2, adopts a cup shaped conformation with the distinctly ruffled imidazolidine ring as the base. In the crystal, weak C—H⋯O hydrogen bonds and C—H⋯π(ring) inter­actions form helical chains of mol­ecules extending along the b-axis direction that are linked by additional weak C—H⋯π(ring) inter­actions across inversion centres. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (51.0%), C⋯H/H⋯C (21.3%), Br⋯H/H⋯Br (12.8%) and O⋯H/H⋯O (12.4%) inter­actions. The volume of the crystal voids and the percentage of free space were calculated to be 251.24 Å3 and 11.71%, respectively, showing that there is no large cavity in the crystal packing. Evaluation of the electrostatic, dispersion and total energy frameworks indicate that the stabilization is dominated by the dispersion energy.

X-ray absorption spectroscopy (XAS) is a promising technique for determining structural information from sensitive biological samples, but high-accuracy X-ray absorption fine structure (XAFS) requires corrections of systematic errors in experimental data. Low-temperature XAS and room-temperature X-ray absorption spectro-electrochemical (XAS-EC) measurements of N-truncated amyloid-β samples were collected and corrected for systematic effects such as dead time, detector efficiencies, monochromator glitches, self-absorption, radiation damage and noise at higher wavenumber (k). A new protocol was developed using extended X-ray absorption fine structure (EXAFS) data analysis for monitoring radiation damage in real time and post-analysis. The reliability of the structural determinations and consistency were validated using the XAS measurement experimental uncertainty. The correction of detector pixel efficiencies improved the fitting χ2 by 12%. An improvement of about 2.5% of the structural fitting was obtained after dead-time corrections. Normalization allowed the elimination of 90% of the monochromator glitches. The remaining glitches were manually removed. The dispersion of spectra due to self-absorption was corrected. Standard errors of experimental measurements were propagated from pointwise variance of the spectra after systematic corrections. Calculated uncertainties were used in structural refinements for obtaining precise and reliable values of structural parameters including atomic bond lengths and thermal parameters. This has permitted hypothesis testing.

Using a 5 µm-diameter X-ray beam, we collected scanning X-ray microdiffraction in both the small-angle (SAXS) and the wide-angle (WAXS) regimes from thin sections of fixed human brain tissue from Alzheimer's subjects. The intensity of scattering in the SAXS regime of these patterns exhibits essentially no correlation with the observed intensity in the WAXS regime, indicating that the structures responsible for these two portions of the diffraction patterns, which reflect different length scales, are distinct. SAXS scattering exhibits a power-law behavior in which the log of intensity decreases linearly with the log of the scattering angle. The slope of the log–log curve is roughly proportional to the intensity in the SAXS regime and, surprisingly, inversely proportional to the intensity in the WAXS regime. We interpret these observations as being due to the presence of sub-micrometre-sized voids formed during dehydration of the fixed tissue. The SAXS intensity is due largely to scattering from these voids, while the WAXS intensity derives from the secondary structures of macromolecular material surrounding the voids. The ability to detect and map the presence of voids within thin sections of fixed tissue has the potential to provide novel information on the degradation of human brain tissue in neurodegenerative diseases.

Micromax forays in the race of in-house mobile launcher driven by Machine Learning and AI to enhance the user experience.

More targeted aircraft testing and simulation should be conducted to uncover design characteristics in new flight control systems that -- in rare circumstances -- may mislead pilots and result in unstable or dangerous flight conditions, says a new report by a National Research Council committee.

Most Americans and Canadians up to age 70 need no more than 600 international units (IUs) of vitamin D per day to maintain health, and those 71 and older may need as much as 800 IUs, says a new report from the Institute of Medicine.

Despite the importance of eyesight, millions of people grapple with undiagnosed or untreated vision impairments — ranging from mild conditions to total blindness — and eye and vision health remain relatively absent from national health priority lists, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Years of sustained and coordinated efforts will be required to contain and reverse the harmful societal effects of the prescription and illicit opioid epidemics, which are intertwined and getting worse, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Halting the opioid epidemic requires aggressive action across multiple dimensions, including informed, active, and determined front-line leadership from health clinicians working in every setting throughout the nation, says a new National Academy of Medicine (NAM) special publication developed at the request of the National Governors Association to assist the nation’s governors as they work with clinicians to counter the opioid crisis.

In recognition of the need for a national coordinated and collective response to the epidemic of opioid addiction in the U.S., the National Academy of Medicine (NAM), in partnership with the Aspen Institute, launched a public-private partnership made up of more than 35 organizations representing federal, state, and local governments, health systems, associations and provider groups, health education and accrediting institutions, pharmacies, payers, industry, nonprofits, and academia.

Medications to Treat Opioid Addiction Are Effective and Save Lives, But Barriers Prevent Broad Access and Use, Says New Report

The National Academy of Medicine (NAM) announced today that more than 100 organizations across the U.S. — including community organizations, hospital and medical systems, academia, nonprofits, and health professional societies — have joined NAM in declaring their commitment to reversing national trends in opioid misuse and overdose.

For severe acute pain due to surgeries and medical conditions, there is a lack of guidance on the appropriate type, strength, and amount of opioid medication that clinicians should prescribe to patients, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The opioid epidemic in the U.S. is driving a simultaneous epidemic of infectious diseases — including HIV, hepatitis C virus (HCV) and bacterial infections, and sexually transmitted infections — but workforce shortages, stigma, and financial and policy barriers are preventing the integration of opioid use disorder (OUD) and infectious disease services, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The use of compounded bioidentical hormone therapies (cBHTs) — an increasingly popular approach to relieve symptoms of menopause and male hypogonadism — should be limited to the small number of patients who cannot benefit from an FDA-approved hormone therapy product, says a new report from the National Academies of Sciences, Engineering, and Medicine.

As it drafts its next decadal strategic plan, the U.S. Global Change Research Program (USGCRP) should shift its focus to providing insights that help society prepare for and avoid the worst potential consequences of climate change, while protecting the most vulnerable, says a new report from the National Academies of Sciences, Engineering, and Medicine.

ESET researchers discovered Arid Viper espionage campaigns spreading trojanized apps to Android users in Egypt and Palestine

The spyware, called AridSpy by ESET, is distributed through websites that pose as various messaging apps, a job search app, and a Palestinian Civil Registry app

ESET researchers discovered a zero-day Telegram for Android exploit that allows sending malicious files disguised as videos

Attackers abusing the EvilVideo vulnerability could share malicious Android payloads via Telegram channels, groups, and chats, all while making them appear as legitimate multimedia files

Android malware discovered by ESET Research relays NFC data from victims’ payment cards, via victims’ mobile phones, to the device of a perpetrator waiting at an ATM

The world of Android threats is quite vast and intriguing. In this episode, Becks and Lukáš demonstrate how easy it is to take over your phone, with some added tips on how to stay secure

Phishing using PWAs? ESET Research's latest discovery might just ruin some users' assumptions about their preferred platform's security

Watch out for schemes where fraudsters trick people into sharing verification codes so they can gain access to their phone numbers

"With the development of Asia's largest airport at Jewar, the freight corridor, data centres, food park, toy park, medical device park, an Integrated Industrial Township in Greater Noida, multi-modal transportation hub, the region managed by the Noida, Greater Noida and Yamuna Expressway authorities has got a new identity," Nand Gopal Gupta said.

Three years ago, the Federal Trade Commission dimmed hopes for the Brightest Flashlight app for Android, slapping its developer with charges of consumer deception. Why? The app was transmitting users' locations and device IDs to third parties without telling the users or getting their permission.

read more

TIC Gums now offers clean-label texture and stabilization options for food manufacturers looking to meet specific labeling requirements.

This tool tip made my co-worker and our customer so happy that he made one and wrote my name on it. 

When property owners need restroom or kitchen facilities in areas without existing plumbing, they often face the challenge of expensive and disruptive work to create below-floor drainage that usually requires breaking through concrete, which is messy, noisy, and costly. This high cost may lead clients to reconsider their projects altogether. For trade professionals, navigating concrete obstacles is just another day at the office. Yet, for others, it might be less welcome.

A ‘differentiation standard’ can help you stand out from the rest as a top contractor.

Not every ad is for leads, and your message is more important than you think.

Whether it is appropriate to attach non-FR embroidery and emblems to flame resistant protective garments is always a difficult question to address.

Researchers at the National Safety Council and the University of Michigan found that about one in 20 adolescents ages 10 to 17 and one in 10 young adults ages 18 to 25 report prescription opioid misuse, based on a new review published in Preventive Medicine. However, effective intervention programs are not in place to address prescription opioid misuse among young people, and NSC and University of Michigan Injury Prevention Center researchers are urgently calling for evidence-based prevention programs to be developed and tested.

The National Safety Council (NSC), in partnership with more than 50 organizations and companies nationwide, released a comprehensive, inclusive strategy to address opioid misuse that all presidential candidates – regardless of party – should either adopt in full or use to close gaps in existing plans and policies.

The need for a comprehensive and accurate evaluation of prospective employees has never been more crucial. The use of a Post-Offer Employment Test (POET) has increasingly become a critical component of many organizations' hiring processes.  

The guide provides a structure by which employers can assess, plan, and implement strategies and practices that support mine worker mental health and address harmful opioid use.  

With plant-based ingredients in high demand, formulators oftentimes are turning to hydrocolloid solutions to deliver the stabilization these beverages need.

As consumers more closely scrutinize beverage labels, recognizable, from nature hydrocolloids have become an essential part of beverage development.

Although hydrocolloids do not provide specific health benefits, experts note that their functional attributes make many of the trendy, health-forward drinks possible.

Due to widespread abuse, the over-prescription of addictive opioids has caused immense suffering. We got in touch with the experts from Chiropractic Doctors Association of Hong Kong (CDAHK), who revealed the newest studies.

The event will be held at Pennsylvania Institute of Technology on Saturday, December 2, 2023 from 2:00 - 4:00 pm

The event was held at Pennsylvania Institute of Technology

Bringing Apple's magnetic ecosystem to everyone, with improved charging efficiency, phone mount feature, and more.

GoCredit.me offers better data security, more advantages for the borrower

A timely and crucial reminder to focus on self-care, and management of healthy routines as the holidays approach

The US Drug Watchdog says, "If a person orders 'Ozempic' from an offshore online pharmacy, there is a very-very good chance the medication will not work-and in the worst-case scenario the drug might be fatal-or cause extremely severe side effects."

Renowned as a keynote speaker, trainer, and Forbes Contributor, Romanella founded 3SIXTY Management Services, LLC. With 40+ years in leadership, he served as CEO and Director at UniTek Global Services after a 36-year UPS career.

The Yoshimoto Atlantic Yield Optimization Corporation (YAYO) launches the long awaited supplement line and Trapezoid Scheme, revolutionizing the realm of crypto in pursuit of physical and financial superiority.

Eco-shell™ can reduce reduce plastic by up to 50%, carbon by up to 70%, and makes 100% recyclable packaging. Patented, fully certified, and ready to go.