nuo Continuous Integration/Continuous Delivery – Using Python and REST APIs for SAS Visual Analytics reports By feedproxy.google.com Published On :: Tue, 28 Apr 2020 14:05:41 +0000 With increasing interest in Continuous Integration/Continuous Delivery (CI/CD), many SAS Users want to know what can be done for Visual Analytics reports. In this article, I will explain how to use Python and SAS Viya REST APIs to extract a report from a SAS Viya environment and import it into another environment. Continuous Integration/Continuous Delivery – Using Python and REST APIs for SAS Visual Analytics reports was published on SAS Users. Full Article Tech API continuous integration continuous delivery programming Python REST API SAS Viya 3.5 Administration VA Visual Analytics Viya
nuo Hồi chuông cảnh tỉnh: Làm thế nào các doanh nghiệp nhà nước có thể huy động tài trợ nước ngoài cho cơ sở hạ tầng -- by Donald Lambert By blogs.adb.org Published On :: Fri, 20 Sep 2019 08:38:42 +0800 Các doanh nghiệp nhà nước phải đối mặt với những thách thức riêng khi mời gọi tài chính nước ngoài cho các dự án cơ sở hạ tầng. Nhưng không phải không có giải pháp. Full Article
nuo Space is the Place: Effects of Continuous Spatial Structure on Analysis of Population Genetic Data [Population and Evolutionary Genetics] By www.genetics.org Published On :: 2020-05-05T06:43:41-07:00 Real geography is continuous, but standard models in population genetics are based on discrete, well-mixed populations. As a result, many methods of analyzing genetic data assume that samples are a random draw from a well-mixed population, but are applied to clustered samples from populations that are structured clinally over space. Here, we use simulations of populations living in continuous geography to study the impacts of dispersal and sampling strategy on population genetic summary statistics, demographic inference, and genome-wide association studies (GWAS). We find that most common summary statistics have distributions that differ substantially from those seen in well-mixed populations, especially when Wright’s neighborhood size is < 100 and sampling is spatially clustered. "Stepping-stone" models reproduce some of these effects, but discretizing the landscape introduces artifacts that in some cases are exacerbated at higher resolutions. The combination of low dispersal and clustered sampling causes demographic inference from the site frequency spectrum to infer more turbulent demographic histories, but averaged results across multiple simulations revealed surprisingly little systematic bias. We also show that the combination of spatially autocorrelated environments and limited dispersal causes GWAS to identify spurious signals of genetic association with purely environmentally determined phenotypes, and that this bias is only partially corrected by regressing out principal components of ancestry. Last, we discuss the relevance of our simulation results for inference from genetic variation in real organisms. Full Article
nuo Establishment of 5'-3' interactions in mRNA independent of a continuous ribose-phosphate backbone [ARTICLE] By rnajournal.cshlp.org Published On :: 2020-04-16T06:30:22-07:00 Functions of eukaryotic mRNAs are characterized by intramolecular interactions between their ends. We have addressed the question whether 5' and 3' ends meet by diffusion-controlled encounter "through solution" or by a mechanism involving the RNA backbone. For this purpose, we used a translation system derived from Drosophila embryos that displays two types of 5'–3' interactions: Cap-dependent translation initiation is stimulated by the poly(A) tail and inhibited by Smaug recognition elements (SREs) in the 3' UTR. Chimeric RNAs were made consisting of one RNA molecule carrying a luciferase coding sequence and a second molecule containing SREs and a poly(A) tail; the two were connected via a protein linker. The poly(A) tail stimulated translation of such chimeras even when disruption of the RNA backbone was combined with an inversion of the 5'–3' polarity between the open reading frame and poly(A) segment. Stimulation by the poly(A) tail also decreased with increasing RNA length. Both observations suggest that contacts between the poly(A) tail and the 5' end are established through solution, independently of the RNA backbone. In the same chimeric constructs, SRE-dependent inhibition of translation was also insensitive to disruption of the RNA backbone. Thus, tracking of the backbone is not involved in the repression of cap-dependent initiation. However, SRE-dependent repression was insensitive to mRNA length, suggesting that the contact between the SREs in the 3' UTR and the 5' end of the RNA might be established in a manner that differs from the contact between the poly(A) tail and the cap. Full Article
nuo Effects of Continuous Glucose Monitoring on Metrics of Glycemic Control in Diabetes: A Systematic Review With Meta-analysis of Randomized Controlled Trials By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 BACKGROUND Continuous glucose monitoring (CGM) provides important information to aid in achieving glycemic targets in people with diabetes. PURPOSE We performed a meta-analysis of randomized controlled trials (RCTs) comparing CGM with usual care for parameters of glycemic control in both type 1 and type 2 diabetes. DATA SOURCES Many electronic databases were searched for articles published from inception until 30 June 2019. STUDY SELECTION We selected RCTs that assessed both changes in HbA1c and time in target range (TIR), together with time below range (TBR), time above range (TAR), and glucose variability expressed as coefficient of variation (CV). DATA EXTRACTION Data were extracted from each trial by two investigators. DATA SYNTHESIS All results were analyzed by a random effects model to calculate the weighted mean difference (WMD) with the 95% CI. We identified 15 RCTs, lasting 12–36 weeks and involving 2,461 patients. Compared with the usual care (overall data), CGM was associated with modest reduction in HbA1c (WMD –0.17%, 95% CI –0.29 to –0.06, I2 = 96.2%), increase in TIR (WMD 70.74 min, 95% CI 46.73–94.76, I2 = 66.3%), and lower TAR, TBR, and CV, with heterogeneity between studies. The increase in TIR was significant and robust independently of diabetes type, method of insulin delivery, and reason for CGM use. In preplanned subgroup analyses, real-time CGM led to the higher improvement in mean HbA1c (WMD –0.23%, 95% CI –0.36 to –0.10, P < 0.001), TIR (WMD 83.49 min, 95% CI 52.68–114.30, P < 0.001), and TAR, whereas both intermittently scanned CGM and sensor-augmented pump were associated with the greater decline in TBR. LIMITATIONS Heterogeneity was high for most of the study outcomes; all studies were sponsored by industry, had short duration, and used an open-label design. CONCLUSIONS CGM improves glycemic control by expanding TIR and decreasing TBR, TAR, and glucose variability in both type 1 and type 2 diabetes. Full Article
nuo Providing Continuous Renal Replacement Therapy in Patients on Extracorporeal Membrane Oxygenation By cjasn.asnjournals.org Published On :: 2020-05-07T10:00:25-07:00 Full Article
nuo Prebiotics Inhibit Proteolysis by Gut Bacteria in a Host Diet-Dependent Manner: a Three-Stage Continuous In Vitro Gut Model Experiment [Food Microbiology] By aem.asm.org Published On :: 2020-05-05T08:00:35-07:00 Dietary protein residue can result in microbial generation of various toxic metabolites in the gut, such as ammonia. A prebiotic is "a substrate that is selectively utilised by host microorganisms conferring a health benefit" (G. R. Gibson, R. Hutkins, M. E. Sanders, S. L. Prescott, et al., Nat Rev Gastroenterol Hepatol 14:491–502, 2017, https://doi.org/10.1038/nrgastro.2017.75). Prebiotics are carbohydrates that may have the potential to reverse the harmful effects of gut bacterial protein fermentation. Three-stage continuous colonic model systems were inoculated with fecal samples from omnivore and vegetarian volunteers. Casein (equivalent to 105 g protein consumption per day) was used within the systems as a protein source. Two different doses of inulin-type fructans (Synergy1) were later added (equivalent to 10 g per day in vivo and 15 g per day) to assess whether this influenced protein fermentation. Bacteria were enumerated by fluorescence in situ hybridization with flow cytometry. Metabolites from bacterial fermentation (short-chain fatty acid [SCFA], ammonia, phenol, indole, and p-cresol) were monitored to further analyze proteolysis and the prebiotic effect. A significantly higher number of bifidobacteria was observed with the addition of inulin together with reduction of Desulfovibrio spp. Furthermore, metabolites from protein fermentation, such as branched-chain fatty acids (BCFA) and ammonia, were significantly lowered with Synergy1. Production of p-cresol varied among donors, as we recognized four high producing models and two low producing models. Prebiotic addition reduced its production only in vegetarian high p-cresol producers. IMPORTANCE Dietary protein levels are generally higher in Western populations than in the world average. We challenged three-stage continuous colonic model systems containing high protein levels and confirmed the production of potentially harmful metabolites from proteolysis, especially replicates of the transverse and distal colon. Fermentations of proteins with a prebiotic supplementation resulted in a change in the human gut microbiota and inhibited the production of some proteolytic metabolites. Moreover, we observed both bacterial and metabolic differences between fecal bacteria from omnivore donors and vegetarian donors. Proteins with prebiotic supplementation showed higher Bacteroides spp. and inhibited Clostridium cluster IX in omnivore models, while in vegetarian modes, Clostridium cluster IX was higher and Bacteroides spp. lower with high protein plus prebiotic supplementation. Synergy1 addition inhibited p-cresol production in vegetarian high p-cresol-producing models while the inhibitory effect was not seen in omnivore models. Full Article
nuo Continuous professional development: elevating sleep and breathing disorder education in Europe By breathe.ersjournals.com Published On :: 2020-03-18T06:44:39-07:00 Sleep and breathing disorders are highly prevalent, representing a growing subspecialty of respiratory medicine. The term sleep disordered breathing (SDB) encompasses a range of conditions characterised by abnormal breathing during sleep, from chronic or habitual snoring, to frank obstructive sleep apnoea (OSA) or, in some cases, central sleep apnoea (CSA) and hypoventilation syndromes. OSA is the commonest form of SDB, leading to many potential consequences and adverse clinical outcomes, including excessive daytime sleepiness, impaired daytime function, metabolic dysfunction, and an increased risk of cardiovascular disease and mortality [1]. The estimated reported prevalence of moderate-to-severe SDB (≥15 events·h–1) was 23.4% in women and 49.7% in men, and the prevalence of symptomatic OSA was 9% and 13%, respectively [2]. However, in some populations, the prevalence of OSA is substantially higher, such as in patients been evaluated for bariatric surgery (estimated range 70–80%), in patients who have had a transient ischaemic attack or stroke (estimated range 60–70%) and in patients with cardiometabolic disease [3–6]. Limited data have been reported on CSA and non-obstructive sleep-related hypoventilation, which have received considerable interest in the sleep field within the past 10 years. Even if their prevalence was noted to be quite low relative to the prevalence of OSA [7], they are quite common in specific subpopulations [8–10]. Full Article
nuo Optimizing Diabetes Care With the Standardized Continuous Glucose Monitoring Report By clinical.diabetesjournals.org Published On :: 2020-04-15T12:00:21-07:00 Full Article
nuo Flash Continuous Home Glucose Monitoring to Improve Adherence to Self-Monitoring of Blood Glucose and Self-Efficacy in Adolescents With Type 1 Diabetes By clinical.diabetesjournals.org Published On :: 2020-04-15T12:00:21-07:00 Adolescents with type 1 diabetes face self-management challenges that make it difficult for them to achieve good glycemic control. In our population of adolescents with poorly controlled type 1 diabetes, the use of continuous glucose monitoring (CGM) improved patients’ glycemic time in range (TIR) and identified hypoglycemia more frequently than with intermittent self-monitoring of blood glucose throughout a 4-week interval. However, the adolescents were unable to synthesize this information to problem-solve or reduce the frequency of hypoglycemic events. Setting SMART (specific, measurable, achievable, relevant, and time-bound) diabetes management goals and providing intensive diabetes education and support could increase adolescents’ TIR and prevent hypoglycemia. Full Article
nuo Continuous Glucose Monitoring As a Behavior Modification Tool By clinical.diabetesjournals.org Published On :: 2020-04-15T12:00:21-07:00 Real-time continuous glucose monitoring (CGM) use may lead to behavioral modifications in food selection and physical activity, but there are limited data on the utility of CGM in facilitating lifestyle changes. This article describes an 18-item survey developed to explore whether patients currently using CGM believe the technology has caused them to change their behavior. Full Article
nuo Chuyển nhượng nhà chung cư cho người nước ngoài By batdongsan.com.vn Published On :: Sat, 30 Jun 2018 09:30:53 GMT Tôi có căn nhà chung cư, trước đây chỉ có tên vợ trên sổ hồng, bây giờ muốn bổ sung thêm tên chồng (là người nước ngoài) thì có được không? Sau này chúng tôi có nhu cầu muốn chuyển nhượng thì có bán được cho người nước ngoài không? Thủ tục như thế nào? Full Article
nuo Chuyển quyền sử dụng đất cho người Việt định cư ở nước ngoài By batdongsan.com.vn Published On :: Sat, 30 Jun 2018 21:43:18 GMT Có hai chị em, người em là Việt Kiều Canada, có hai quốc tịch VN và Canada, chồng quốc tịch Canada. Trước đây người chồng của người em có gửi tiền về cho chị vợ nhờ mua đất ở Long An. Hai bên vẫn còn giữ giấy chuyển tiền ngân hàng, có lập giấy ủy quyền có công chứng nội dung nhờ đứng tên đất ở VN. Mảnh đất rộng hơn 4.000m2, trong giấy chứng nhận ghi mục đích sử dụng là nuôi trồng thủy sản, trong đó có 150m2 vừa xin được chuyển mục đích sang đất ở. Trên đất đó có ao nuôi cá, vịt, lúc trước có một chòi để người chăm sóc ở, sau này xây lại thành một nhà tường nhỏ hơn nhà cấp 4 một chút, nhưng nhà này chưa đăng ký giấy tờ gì. Người em muốn đứng tên sổ đỏ mảnh đất trên nhưng nghe nói cần phải có nhà ở và cần người chị bán nhà đó kèm đất thì người em mới được đứng tên đất. Vậy cho hỏi: - Có thể dùng căn nhà trên đi đăng ký, bán cho người em để người em được đứng tên sổ đỏ không? Cần thủ tục gì? - Nếu không thể thì người em có thể gửi tiền về nhờ chị xây nhà cấp 4, sau này bán lại cho người em để người em đứng tên sổ đỏ? Quy mô nhà như thế nào để nhận được 4.000m2 đất? - Do mảnh đất 4.000m2 nhưng chỉ có 150m2 đất ở vậy nên xây nhà như thế nào, và như thế có thể nhận được 4.000m2 luôn hay chỉ được 150m2? - Nếu xây nhà xong, người chị tặng cho lại nhà đất cho em thì người em có phải đóng lệ phí trước bạ nữa không? - Sau khi có hướng giải quyết, cho em hỏi, người em cần đem những giấy tờ gì về Việt Nam? Thường quy trình sau khi cất xong nhà đến khi người Việt kiều nhận được sổ đỏ là khoảng bao lâu? Mức phí khi nhờ luật sư thực hiện tất cả thủ tục sau khi cất nhà xong là bao nhiêu? Rất cần luật sư tư vấn hướng giải quyết tốt nhất. Rất mong nhận được giải đáp, em chân thành cảm ơn. Full Article
nuo 10 ý tưởng phối màu tủ bếp đáng thử cho không gian nấu nướng hiện đại By batdongsan.com.vn Published On :: 17:02 11/10/2019 Lựa chọn gam màu đơn sắc cho tủ bếp vốn không hề đơn giản, thế nên việc kết hợp hai màu sắc khác nhau cho tủ bếp lại càng khó khăn hơn gấp bội. May mắn thay, dù yêu thích phong cách táo bạo hay vẻ yên bình tĩnh lặng thì vẫn có những cách phối màu tủ bếp phù hợp với bạn. Full Article
nuo Chọn bàn nước vừa đẹp vừa tiết kiệm diện tích cho nhà nhỏ By batdongsan.com.vn Published On :: 08:20 10/12/2018 Những mẫu bàn nước dưới đây có thiết kế vô cùng sáng tạo khi có thể lồng ghép với nhau để không chiếm quá nhiều diện tích trong phòng khách. Full Article
nuo Tối ưu hóa không gian nấu nướng với 10 ý tưởng tận dụng góc bếp chữ L, chữ U By batdongsan.com.vn Published On :: 20:17 25/03/2020 Trong một hệ tủ bếp chữ L hay chữ U thì phần góc chết luôn là vị trí khiến mọi gia chủ đau đầu bởi không dễ gì tận dụng được khoảng diện tích này. Với 10 ý tưởng thiết kế góc tủ bếp dưới đây, vấn đề trên sẽ được giải quyết một cách êm thấm. Full Article
nuo Ngân hàng Nhà nước bác đề xuất tái cấp vốn cho dự án NOXH By batdongsan.com.vn Published On :: 16:39 15/09/2016 Ngân hàng Nhà nước cho rằng, trong thời gian qua các doanh nghiệp đã được hưởng nhiều ưu đãi về thuế, đất đai... vì vậy không còn cơ sở để ngân hàng tiếp tục tái cấp vốn cho các dự án còn dở dang. Full Article
nuo Cho thuê nhà ngõ đường Nước Phần Lan, phường Tứ Liên, Tây Hồ, HN. LH 0976085989 By batdongsan.com.vn Published On :: Wed, 29 Apr 2020 09:06:15 GMT Cho thuê nhà ngõ đường Nước Phần Lan, phường Tứ Liên, Tây Hồ, HN, LH 0976085989. Khu vực: Cho thuê nhà trong ngõ đường Nước Phần Lan, phường Tứ Liên, Tây Hồ, HN. Diện tích đất 70m2. Diện tích xây dựng 70m2. Xây 4 tầng, bao gồm: 4 phòng ngủ, 2 phòng tắm. Tầng 1 - phòng khách, phòn... Full Article
nuo Kiến nghị tăng tỷ lệ người nước ngoài được mua nhà tại Việt Nam By batdongsan.com.vn Published On :: 15:26 27/04/2020 Để góp phần tháo gỡ khó khăn cho thị trường, Hội Môi giới bất động sản Việt Nam đề xuất tăng tỷ lệ người nước ngoài được mua nhà tại các dự án cao cấp. Full Article
nuo Loạt kiến nghị "gỡ vướng" cho người nước ngoài mua nhà tại Việt Nam By batdongsan.com.vn Published On :: 08:43 29/04/2020 Các quy định liên quan đến vấn đề cho phép người nước ngoài mua nhà tại Việt Nam tiếp tục được Hiệp hội Bất động sản Việt Nam kiến nghị tháo gỡ. Full Article
nuo Chuyên gia "mách nước" cách khắc phục 4 vấn đề thường gặp về sơn nhà By batdongsan.com.vn Published On :: 16:02 23/08/2019 Một lớp sơn mới là cách nhanh chóng và rẻ tiền giúp “lên đời” cho ngôi nhà, che giấu đi các khuyết điểm hay làm nổi bật các chi tiết kiến trúc... Tuy nhiên, nếu lựa chọn loại sơn kém chất lượng hay thi công không đúng quy trình kỹ thuật sẽ làm giảm giá trị thẩm mỹ, thậm chí là chất lượng của công trình. Full Article
nuo Trong phòng ngủ có giếng nước thì có vấn đề gì không ạ By batdongsan.com.vn Published On :: Sat, 30 Jun 2018 14:54:22 GMT Trong phòng ngủ có giếng nước thì có vấn đề gì không ạ? Xin tư vấn giúp! Full Article
nuo Giá nhà trung bình ở con phố đắt nhất nước Anh lên tới gần 33 triệu bảng By batdongsan.com.vn Published On :: 15:28 26/09/2019 Năm thứ 11 liên tiếp, phố Kensington Palace Gardens được xếp hạng là con phố có giá bất động sản đắt đỏ nhất nước Anh, theo báo cáo của website nhà đất Zoopla. Giá nhà trung bình ở đây lên tới 32,9 triệu bảng Anh (40,8 triệu USD). Full Article
nuo BĐS Bồ Đào Nha hút khách nước ngoài, dân bản địa ngày càng khó mua nhà By batdongsan.com.vn Published On :: 18:53 28/09/2019 Giới đầu tư nước ngoài, đặc biệt là các đại gia châu Á, đã bơm tổng cộng 4,3 tỷ euro vào bất động sản Bồ Đào Nha thông qua chương trình ưu đãi cư trú “Visa vàng” kể từ khi chương trình có hiệu lực vào năm 2012. Full Article
nuo Security risks: The tenuous link between climate change and national security By webfeeds.brookings.edu Published On :: Thu, 21 May 2015 16:25:00 -0400 During his address at the U.S. Coast Guard Academy graduation this week, President Obama highlighted climate change as “a serious threat to global security, an immediate risk to (U.S.) national security.” Is President Obama right? Are the national security threats from climate change real? When I listen to the “know-nothing” crowd and their front men in Congress who actively ignore ever-stronger scientific evidence about the pace of climate change, I want to quit my day job and organize civic action to close them down. The celebration of anti-knowledge, the denial of science, the treatment of advanced education as a mark of ignominy rather than the building block of American innovation and citizenship—these are as grave a threat to America’s future as any I can identify. So I’m sympathetic to the Obama administration’s desire to take a bludgeon to climate deniers. But is “national security” the right stick to move the naysayers forward? The Danger of Overstating for Effect The White House’s report on the national security implications of climate change is actually pretty measured and largely avoids waving red flags, but it overstates for effect, as do the President’s remarks to the Coast Guard Academy. The report gets right the notion that climate change will hit hardest where governance is weakest and that this will exacerbate the challenge of weak states; but it’s a pre-existing challenge and almost all weak states are already embroiled in forms of internal war—climate change may exacerbate this problem, but it certainly won’t create it. The White House report also asserts a link to terrorist havens, and of course there are risks here—but it’s far from a 1:1 relationship, and there’s little evidence that the countries where climate will hit governance worst are the places where the terrorism problem is most serious. The report also highlights the Arctic as a region most dramatically effected by climate change, and that is true—but so far what we’re seeing in the Arctic is that receding ice is triggering commercial competition and governance cooperation; not conflict. The security challenge from the Arctic is modest: the climate challenge of melting ice caps and potential release of trapped greenhouse gases is potential very serious indeed. Then there are the domestic effects. The report highlights that the armed services may be drawn in more to dealing with coastal flooding and similar crises, and that’s a fair point—though it’s a National Guard point more than its an armed forces point. That is to say, it’s about the question of whether we have enough domestic disaster response capacity: an important question, not obviously a national security question. And it oddly passes over what’s likely to be the most important consequence of climate change in the United States, namely declining agricultural productivity in the American heartland. America’s farmers, not just its coastal cities, are in the front lines here. All of these are real issues and the U.S. government will have to plan for lots of them, including in the armed services; all fair. But is national security really the right way to frame this? Is linking it directly to the capacities needed for America’s armed services the right way to mobilize support for more serious action on climate change? Of course the term “security” has been evolving, and has long since extended beyond the limited purview of nuclear risks and great power conflict. Civil wars and weak governance and rising sea leaves are certainly a security issue to somebody, and we’re sure to be involved—whether it’s in dealing with refugee flows, or more acute crises where severe impacts overlay on pre-existing tensions. These are global security issues for someone, to be sure; I’m not sure they are “immediate risks to our national security. Words Matter Why does the rhetoric matter? Am I glad that we have a President who cares about climate change? Yes. Do I want the Obama administration to be focusing on mobilizing the American public on this? Yes. So why does it bother me if they use a national security lens? A national security framework implicitly does several things: it invokes a sense of direct threat, which I think distorts the nature of the challenge; it puts military responses front forward, which is the wrong emphasis; and although the report doesn’t get into this question, if the President highlights the immediate national security risk from climate, it displaces other security threats that we confront and truly require U.S. strategic planning, preparedness, and resources. None of this is totally wrong, but surely there are other ways to mobilize the American public to an erosion of our natural and agricultural environment than to invoke the security frame? Every piece of evidence I’ve seen about the state of temperature change; the real pathway we are on in terms of carbon-based fuels consumption (despite optimistic pledges in the lead up to the Paris climate conference); realistic projections of growth in renewable energies; and demand growth in the developing world (especially India) tells me that we’re rapidly blowing past the two degree target for limiting the rise in average global temperatures, and we’re well on our way to a four degree shift. We need urgently to pivot our scientific establishment away from the now well-trod field of predicting temperature shift to getting a much more granular understanding about the ways in which changing temperature will affect water sources, agricultural productivity, biodiversity, and dramatic weather events. And we need to treat those who willfully deny science—in climate and other areas—as a serious threat to our nation’s future. I’m just not convinced that national security is the right or best way to frame the arguments and mobilize the America public’s will around this critically important issue. Authors Bruce Jones Image Source: © Fabrizio Bensch / Reuters Full Article
nuo Promoting continuous manufacturing in the pharmaceutical sector By webfeeds.brookings.edu Published On :: Mon, 19 Oct 2015 09:00:00 -0400 Event Information October 19, 20159:00 AM - 4:00 PM EDTThe Brookings Institution1775 Massachusetts Ave., NWWashington, DC Over the past decade, drug shortages and product recalls in the U.S. have occurred at unprecedented rates, limiting patient access to critical medicines and undermining health care. A majority of these shortages and recalls have been due to manufacturing quality issues. In response to these problems, and as part of its ongoing efforts to ensure a continuous supply of high-quality pharmaceuticals in the U.S., the U.S. Food and Drug Administration (FDA) is pursuing a range of strategies designed to improve the flexibility, reliability, and quality of pharmaceutical manufacturing. Among these strategies is the promotion of new manufacturing technologies, including continuous manufacturing. Continuous manufacturing offers several important advantages over current approaches to manufacturing and has the potential to significantly mitigate the risks of quality failures. At present, however, these technologies and processes are not widely used by the pharmaceutical industry, and there remain a number of barriers to their broader adoption. In collaboration with a range of stakeholders, FDA is currently exploring ways in which it can help to address these barriers and facilitate the uptake of new manufacturing technologies. Under a cooperative agreement with FDA, the Center for Health Policy at Brookings held a workshop on October 19 entitled “Promoting Continuous Manufacturing in the Pharmaceutical Sector.” This workshop provided an opportunity for industry, academia, and government partners to identify the major barriers to the adoption of continuous manufacturing, discuss regulatory policies and strategies that could help to address those barriers, and explore approaches to improving public and private sector alignment and collaboration to promote the adoption of continuous manufacturing. Event Materials Continuous Manufacturing AgendaCM Panelist Bio SheetParticipant listContinuous manufacturing discussion guideallslides_Continuousmanufacturingworkshop_101915meetingsummary_101915_continuousmanufacturing Full Article
nuo Italia: Le riforme assicurano nuove prospettive per rilanciare la crescita e l’occupazione – OCSE By www.oecd.org Published On :: Thu, 19 Feb 2015 11:31:00 GMT Cambiare il quadro politico-istituzionale in Italia è fondamentale per garantire che le ambiziose riforme in corso rilancino la crescita e aumentino la qualità della vita, secondo un nuovo rapporto dell’OCSE. Full Article
nuo Mexico Imports of Wood Continuously Shaped By tradingeconomics.com Published On :: Sat, 09 May 2020 12:17:00 GMT Imports of Wood Continuously Shaped in Mexico decreased to 9201 USD THO in March from 12076 USD THO in February of 2020. Imports of Wood Continuously Shaped in Mexico averaged 13612.37 USD THO from 2014 until 2020, reaching an all time high of 20812 USD THO in August of 2018 and a record low of 8985 USD THO in January of 2020. This page includes a chart with historical data for Mexico Imports of Wood Continuously Shaped. Full Article
nuo Sleuth raises $3M Seed to bring order to continuous deployment By feedproxy.google.com Published On :: Tue, 05 May 2020 16:00:51 +0000 Sleuth, an early stage startup from three former Atlassian employees, wants to bring some much-needed order to the continuous delivery process. Today, the company announced it has raised a $3 million seed round. CRV led the round with participation from angel investors from New Relic, Atlassian and LaunchDarkly. “Sleuth is a deployment tracker built to […] Full Article Cloud Developer Enterprise Funding Startups TC continuous delivery CRV devops
nuo Australian fans left ‘furious’ with Optus Sport after streaming services continuously cut out By www.dailymail.co.uk Published On :: Sat, 16 Jun 2018 02:33:18 GMT Optus won the rights to stream all 64 games of the World Cup to Australian audiences via their online and mobile services. But thousands of viewers were left frustrated by a troubling error message. Full Article
nuo A continuous struggle between ‘power’ and the people By indiatogether.org Published On :: Thu, 04 Dec 2014 05:06:20 +0000 In yet another contested environmental approval decision, a 300-MW power plant in Gujarat has been granted changes in technology, relaxing certain original conditions, without any public consultation. Kanchi Kohli reports on the grievances of the local people. Full Article
nuo Neidonuo Angami, mother of peace By indiatogether.org Published On :: Fri, 18 Nov 2005 00:00:00 +0000 Sustaining the ceasefire between underground groups in Nagaland and New Delhi has never been easy. But led by Padmashree award winner Neidonuo Angami, a number of Naga women have been organising themselves for years in trust-building and conflict prevention. A Women's Feature Service and Sangat report. Full Article
nuo Enhancing Retirement Success Rates in the United States [Electronic book] : Leveraging Reverse Mortgages, Delaying Social Security, and Exploring Continuous Work / Chia-Li Chien. By encore.st-andrews.ac.uk Published On :: Cham : Palgrave Macmillan, c2019. Full Article
nuo Arbitrage theory in continuous time [Electronic book] / Tomas Björk. By encore.st-andrews.ac.uk Published On :: Oxford : Oxford University Press, 2020. Full Article
nuo Numerical simulation of multiphase reactors with continuous liquid phase / Chao Yang and Zai-Sha Mao By library.mit.edu Published On :: Sun, 28 Dec 2014 06:00:02 EST Barker Library - TA357.5.M84 Y36 2014 Full Article
nuo Optimal modified continuous Galerkin CFD / A. J. Baker By library.mit.edu Published On :: Sun, 15 Mar 2015 06:00:01 EDT Barker Library - TA357.B273 2014 Full Article
nuo Rapid production of block copolymer nano-objects via continuous-flow ultrafast RAFT dispersion polymerisation By feeds.rsc.org Published On :: Polym. Chem., 2020, Advance ArticleDOI: 10.1039/D0PY00276C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sam Parkinson, Stephen T. Knox, Richard A. Bourne, Nicholas J. WarrenContinuous-flow reactors are exploited for conducting ultrafast RAFT dispersion polymerisation for the preparation of diblock copolymer nanoparticles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
nuo Evidence for Educators by Educators: New Approaches to Building Evidence for Continuous Improvement By www.mathematica.org Published On :: Wed, 29 Jan 2020 20:00:00 Z Join us for a webinar for a discussion about the role of evidence in a continuous improvement process and how a free, online platform—the Evidence to Insights Coach—can help educators generate the evidence they need when they need it. Full Article
nuo Visible light promoted continuous flow photocyclization of 1,2-diketones By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Advance ArticleDOI: 10.1039/D0OB00532K, PaperFrancesco Secci, Stefania Porcu, Alberto Luridiana, Angelo Frongia, Pier Carlo RicciA continuous flow Norrish–Yang photocyclization of 1,2-diketones has been developed and applied to the synthesis of functionalized 2-hydroxycyclobutanones, under blue light irradiation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
nuo Modular continuous flow synthesis of orthogonally protected 6-deoxy glucose glycals By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3254-3257DOI: 10.1039/D0OB00522C, CommunicationSubbarao Yalamanchili, Tu-Anh V. Nguyen, Nicola L. B. Pohl, Clay S. BennettThe use of a continuous flow platform for the rapid and highly efficient construction of differentially protected glycals from commercial sources is described.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
nuo E-learning [electronic resource] : nuovi strumenti per insegnare, apprendere, comunicare online / Silvia Selvaggi, Gennaro Sicignano, Enrico Vollono By darius.uleth.ca Published On :: Milano : Springer, [2007] Full Article
nuo [ASAP] Predicting Reactive Cysteines with Implicit-Solvent-Based Continuous Constant pH Molecular Dynamics in Amber By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Chemical Theory and ComputationDOI: 10.1021/acs.jctc.0c00258 Full Article
nuo Continuous semigroups of holomorphic self-maps of the unit disc Filippo Bracci, Manuel D. Contreras, Santiago Díaz-Madrigal By library.mit.edu Published On :: Sun, 15 Mar 2020 07:45:28 EDT Online Resource Full Article
nuo Continuous and discontinuous piecewise-smooth one-dimensional maps: invariant sets and bifurcation structures / Viktor Avrutin (University of Stuttgart, Germany), Laura Gardini (University of Urbino, Italy), Irina Sushko (National Academy of Sciences of U By library.mit.edu Published On :: Sun, 15 Mar 2020 07:45:28 EDT Dewey Library - QA614.8.A97 2019 Full Article
nuo Continuous manufacturing for the modernization of pharmaceutical production: proceedings of a workshop / Joe Alper, rapporteur ; Board on Chemical Sciences and Technology, Division on Earth and Life Studies, the National Academies of Sciences, Engineering By library.mit.edu Published On :: Sun, 28 Apr 2019 07:25:40 EDT Online Resource Full Article
nuo Vibration of discrete and continuous systems / Ahmed Shabana By library.mit.edu Published On :: Sun, 17 Nov 2019 06:24:26 EST Online Resource Full Article
nuo [ASAP] Growth and Characterization of KDP Crystals Grown by the 2D-Translation Method Equipped with Continuous Filtration By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Crystal Growth & DesignDOI: 10.1021/acs.cgd.0c00034 Full Article
nuo [ASAP] Fluid Dynamic and Heat Transfer Simulations of Solid Hollow Fiber Cooling Crystallizer for Continuous Synthesis of Drug Nanoparticles By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Crystal Growth & DesignDOI: 10.1021/acs.cgd.0c00307 Full Article
nuo Sonata XXV D Dur für Traversflöte und Basso continuo / Georg Philipp Telemann By library.mit.edu Published On :: Sun, 23 Feb 2020 08:25:02 EST STACK SCORE Mu pts T236 soflc41:D10 Full Article
nuo Sonata in D-Dur für Traversflöte, Violine und Basso continuo: nach der Sonate für Viola da gamba bzw. Violine und obligates Cembalo, BWV 1028 / Johann Sebastian Bach ; Rückübertragen von Hans Bergmann By library.mit.edu Published On :: Sun, 23 Feb 2020 08:25:02 EST STACK SCORE Mu pts B122 sovah1028 ar Full Article