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In silico investigation of the interaction between α-synuclein aggregates and organic supramolecular assemblies

Mol. Syst. Des. Eng., 2024, 9,1155-1166
DOI: 10.1039/D4ME00071D, Paper
Laura Le Bras, Yves L. Dory, Benoît Champagne
An α-synuclein aggregate with the PreNAC and NACore areas, responsible for the aggregation, highlighted.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Adsorption of nucleotides and nucleic acids on goethite nanoparticle: mode, sites and relationship with phosphate and non-phosphate structure

Environ. Sci.: Nano, 2024, Accepted Manuscript
DOI: 10.1039/D3EN00891F, Paper
Huajun Feng, Shanshan Ma, Zaiming Chen, Yungui Li, Meizhen Wang, Yangcheng Ding
The impact of iron (hydr)oxide adsorption on nucleotides and nucleic acids (NNA) in the environment varies. However, there is a lack of quantitative reports on how iron (hydr)oxide adsorption changes...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effects of nucleating agents on the II–I transition of iPB-1

CrystEngComm, 2024, 26,1940-1951
DOI: 10.1039/D3CE01303K, Paper
Zhiqi Li, Jingqing Li, Shichun Jiang
For iPB-1, II–I transition is of industrial importance; whereas, the traditional solid–solid II–I transition mechanism encountered challenges. It is form I formation in amorphous phase that triggers II-I transition with crystal reorganizations.
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Solvent-polarity-controlled assembly of polynuclear titanium-calixarene complexes: constructing isolated {Ti7}, {Ti13}, {Ti24} and {Tb2Ti13} clusters

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D3CE01275A, Paper
Yanyan Wang, Ying Xiong, Wuping Liao
The assembly of polynuclear titanium-calixarene complexes is based on Ti4–C8A SBUs.
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Extended isomerism in heteronuclear metal-organic frameworks: synthetic strategies and crystal structures of lanthanide-cobalt-oxydiacetate systems

CrystEngComm, 2024, Accepted Manuscript
DOI: 10.1039/D4CE00168K, Paper
Fernando Igoa, Agustín López Cabrera, Javier Gonzalez-Platas, Leopoldo Suescun, Carlos Kremer, Julia Torres
Here, we present the synthesis and crystal structure of a series of heteronuclear metal-organic frameworks, which consists of cobalt(II) and lanthanide(III) ions or yttrium(III), connected by oxydiacetato (oda2-) as ligand....
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Nitro group and K+-based secondary building units for the self-assembly of 3D coordination polymers built on dinuclear dianionic helicate connectors

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D4CE00255E, Paper
Open Access
Raúl Mendoza-Báez, Alan Molina-Renteria, Juan Olguín
Two dinuclear dianionic helicates, K2[MII2(L)3] M = MnII (1) and NiII (2), based on 2-hydroxy-5-nitrobenzaldehyde, self-assemble into novel 3D coordination polymers due to nitro groups acting as secondary assembly instruction.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00358F, Paper
Open Access
Yuma Matsuura, Shinichiro Fuse
Various 2,5-disubstituted furans were synthesized via 5-substituted 2-halomethylfurans using microflow technology.
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Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00402G, Paper
Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari
5-(Benzimidazol-2-yl)- and 5-(benzothiazol-2-yl)-pyrimidine bases-modified oligonucleotides were prepared by post-synthetic trifluoromethyl conversion and their fluorescence properties were measured.
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A phosphamide nucleotide analog: a substrate for polymerase synthesis of DNA

Org. Biomol. Chem., 2024, 22,2963-2967
DOI: 10.1039/D4OB00089G, Communication
Jiong Meng, Qiaqia Guo, Xiaona Zhai, Song Yang, Shuai Wang, Pengcheng Wang, Debin Ji
A phosphamide nucleotide analog (dNTPγNH2) exhibited higher stability than dNTPs and can be recognized by DNA polymerases in PCR.
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Synthesis of alkynyl sulfides via base-promoted nucleophilic ring-opening of α-bromostyrene sulfonium salt

Org. Biomol. Chem., 2024, 22,2953-2957
DOI: 10.1039/D4OB00203B, Communication
Junqi Zhou, Ziyu Wang, Hanmiao Xu, Mengke Su, Jian Wen
An effective method for synthesizing various alkynyl sulfides has been developed using tetramethylene sulfoxide as a sulfur source through base-promoted nucleophilic ring-opening reactions.
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Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering

Org. Biomol. Chem., 2024, 22,3025-3034
DOI: 10.1039/D4OB00279B, Paper
Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Evidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.
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Nuclear excitation by electron capture seen at long last

Breakthrough could lead to new type of energy source




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The worst accident in the world : Chernobyl, the end of the nuclear dream / Nigel Hawkes [and others] ; illustrations by Duncan Mil.

London : Pan Books Ltd : William Heinemann Ltd, 1986.




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Inside JET: The world's biggest nuclear fusion experiment | On Location

Inside these walls, scientists have been trying for decades to create an unlimited source of energy, nuclear fusion. Welcome to JET, the world's biggest nuclear fusion experiment. Scientists argue that fusion could replace coal gas and nuclear fission in the energy mix alongside renewable energy, which can prove to be unreliable. If we can learn to control it, nuclear fusion could change life as we know it. But that's a big if. This video was produced as part of Digital Society, a publishing partnership between WIRED and Vontobel where all content is editorially independent. Visit Vontobel Impact for more stories on how technology is shaping the future of society: https://www.vontobel.com/en-int/about-vontobel/impact/ With thanks to the CCFE: https://ccfe.ukaea.uk #WIRED #NuclearFusion #NuclearReactor




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Re:WIRED GREEN 2022: Alan Ahn on the Future of US Nuclear Power

Alan Ahn, senior resident fellow of the Climate and Energy program at Third Way, an organization that advocates for sustainable nuclear power, will take the stage to discuss the future of nuclear power in the United States and how recent events in Ukraine and Japan have changed people’s perceptions of nuclear energy as a clean solution.




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Re:WIRED GREEN 2022: Alan Ahn on the Future of US Nuclear Power

Alan Ahn, senior resident fellow of the Climate and Energy program at Third Way, an organization that advocates for sustainable nuclear power, will take the stage to discuss the future of nuclear power in the United States and how recent events in Ukraine and Japan have changed people’s perceptions of nuclear energy as a clean solution.




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MIT Professor Explains Nuclear Fusion in 5 Levels of Difficulty

Nuclear fusion underpins some of the most basic processes in our universe and holds the promise of virtually limitless, clean, carbon-free energy. Dr. Anne White, Professor of Nuclear Science and Engineering at The Massachusetts Institute of Technology, has been challenged to explain the nature of nuclear fusion to 5 different people; a child, a teen, a college student, a grad student, and an expert.




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Improvements in low-level radionuclide measurement capability through use of the Apex Q sample introduction system combined with ICP-MS/MS

J. Anal. At. Spectrom., 2024, 39,2929-2936
DOI: 10.1039/D4JA00216D, Paper
Ben Russell, Frankie Falksohn, Alexandre Tribolet, Hibaaq Mohamud, Olivia Pearson, Emma Braysher, Saskia Burke, Anu Bhaisare
Improvement in sensitivity and interface removal capability for radionuclide measurement using desolvating sample introduction combined with ICP-MS/MS.
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Advancing energy safety via stepwise nucleophilic substitution on tetrazine

J. Mater. Chem. A, 2024, 12,30548-30557
DOI: 10.1039/D4TA06039C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jatinder Singh, Richard J. Staples, Jean'ne M. Shreeve
This study presents a feasible approach to synthesizing hydrazine/nitroamine and amino/nitroamine substituted tetrazine derivatives.
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CERN, the world’s biggest nuclear research centre, turns 70; in search of funding for next project

The nuclear physics hub needs to finance the construction of the Future Circular Collider as its existing particle accelerator — famed for discovering the Higgs Boson — edges toward the end of its useful life




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India asks states away from coal to consider nuclear power

India has pledged to achieve net-zero by 2070 and has a target to generate 500 GW of renewable energy a year by 2030




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Having private participation in India’s nuclear energy

With the government proposing such a partnership, the existing framework governing the nuclear energy sector needs to be assessed




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Quadrupolar dinuclear hypervalent tin(IV) compounds with near-infrared emission consisting of Schiff bases based on π-conjugated scaffolds

Chem. Sci., 2024, 15,17950-17961
DOI: 10.1039/D4SC05006A, Edge Article
Open Access
Kazuya Tanimura, Kento Tanaka, Masayuki Gon, Kazuo Tanaka
The study focuses on dinuclear hypervalent tin(IV) compounds with near-infrared (NIR) emission and unique quadrupolar orientations, showing potential for constructing electronic structures with narrow energy gaps.
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Merging nucleophilic phosphine catalysis and photocatalysis for the rapid assembly of 2-oxabicyclo-[2.1.1]hexane scaffolds from feedstock allyl alcohols

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06684G, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
David M. Whalley, Luca Carlino, Okky Dwichandra Putra, Niall A. Anderson, Susannah C. Coote, Olivier Lorthioir
A synthesis of 2-oxabicyclo-[2.1.1]hexanes from readily available allyl alcohols and electron-poor arylalkynes. The transformation utilises phosphine catalysis and energy transfer catalysis for rapid assembly of these diverse scaffolds.
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Rare-earth metal complexes bearing electrophilic and nucleophilic carbon centres and their unique reactivity patterns towards pyridine derivatives

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04197F, Edge Article
Open Access
weikang Wu, Thayalan Rajeshkumar, Shan Zhu, Fuxiang Chai, Dongjing Hong, ZeMing Huang, Qingbing Yuan, Laurent Maron, Shaowu Wang
The rare-earth metal dialkyl complexes (κ2-L1)RE(CH2SiMe3)2(THF)2 [RE = Lu(1a), Yb(1b), Er(1c), Y(1d), Dy(1e)] (L1 = 1-(2-N-C5H10NCH2CH2)-3-(2,6-iPr2C6H3N=CH)-C8H4N) and the rare-earth metal monoalkyl complexes (κ2-L1)2RE(CH2SiMe3)(THF)n [n = 0, RE = Lu(2a), Yb(2b);...
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Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00752B, Paper
Open Access
Felix Ansah, Marziyeh Hajialyani, Fatemeh Ahmadi, Yuming Gu, Ergün Alperay Tarım, Michael G. Mauk, Gordon A. Awandare, Haim H. Bau
Self-actuated chiplet for Penn-RAMP assay.
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Integrated device for plasma separation and nucleic acid extraction from whole blood toward point-of-care detection of bloodborne pathogens

Lab Chip, 2024, 24,5124-5136
DOI: 10.1039/D4LC00571F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Abigail G. Ayers, Christia M. Victoriano, Samuel K. Sia
This work presents PRECISE, a device that integrates plasma separation and nucleic acid extraction, enabling streamlined sample preparation of whole blood for point-of-care diagnostics without external equipment or electricity.
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Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00561A, Paper
Yidi Zhang, Han Zhao, Zhenlin Chen, Zhen Liu, Hanjin Huang, Yun Qu, Yaowei Liu, Mingzhu Sun, Dong Sun, Xin Zhao
We developed a somatic cell nuclear transfer-electrofusion system for pairing and fusing oocytes and somatic cells with a thousand-fold volume difference. The system showed a 90.56% pairing efficiency, potentially boosting batch cloning efficiency.
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Dual-drive acoustic micromixer for rapid nucleation and ultrafast growth of perovskite nanoparticles

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00721B, Paper
Zhifang Liu, Yuwen Lu, Wei Tan, Guorui Zhu
An acoustic micromixer driven by bubbles and sharp edges, controlling the nucleation and growth of perovskite nanoparticles.
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200-member CISF team to guard Nuclear Fuel Complex at Rawatbhata

Located around 50 km from Kota, the facility is key for meeting fuel needs of upcoming nuclear reactors




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An on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides present in biological fluids

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00100A, Paper
Yi-Ming Liu, Shuguan Wang, Amani Dickenson, Jinghe Mao, Xiaolin Bai, Xun Liao
A facile on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides in urine and saliva.
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Study on the affinity sites of cadmium's binding to ligands by thermodynamics and nuclear magnetic resonance spectroscopy

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02253F, Paper
Jinsong Yu, Xu Huang, Xiuxiu Wu, Hui Cao, Min Yuan, Tai Ye, Fei Xu
According to the experimental parameters for the interaction of Cd(II) with ligands, the binding sites of Cys and GSH were –SH, –NH2 and –COOH, and the thermodynamic behaviour of Cd(II) with Cys/GSH in boric acid and HEPES buffers was different, exothermic in HEPES but endothermic in boric acid.
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Rapid detection of monkeypox virus and differentiation of West African and Congo Basin strains using endonuclease restriction-mediated real-time PCR-based testing

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00492B, Paper
Juan Zhou, Fei Xiao, Xiaolan Huang, Jin Fu, Nan Jia, Chunrong Sun, Min Chen, Zheng Xu, Hui Huang, Yi Wang
A novel multiplex ET-PCR assay that integrates PCR amplification, restriction endonuclease cleavage and real-time fluorescence detection was devised to diagnose MPXV infection and distinguish the Congo Basin and West Africa MPXV strains.
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​Mad doctrine: On Russia’s revision of its nuclear doctrine

Any threat of use of nuclear weapons must be viewed seriously 




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Chain stretching in brushes favors sequence recognition for nucleobase-functionalized flexible precise oligomers

Soft Matter, 2024, 20,8303-8311
DOI: 10.1039/D4SM00866A, Paper
Kseniia Grafskaia, Qian Qin, Jie Li, Delphine Magnin, David Dellemme, Mathieu Surin, Karine Glinel, Alain M. Jonas
Flexible oligomers having precise sequences of nucleobases do not specifically recognize surface-grafted target chains at low grafting density. Moderately higher grafting densities promote sequence-specific recognition thanks to chain stretching.
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Nanoconfinement effects on the dynamics of an ionic liquid-based electrolyte probed by multinuclear NMR

Soft Matter, 2024, 20,8436-8445
DOI: 10.1039/D4SM01058B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Andrei Filippov, Maiia Rudakova, Victor P. Archipov, Faiz Ullah Shah
Diffusivity is controlled by exchange of ions between “narrow” and “large” pores that results in an abnormal temperature variation. Li+ ions are solvated inside the porous glasses and their diffusivity remains slower as compared to the organic ions.
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Editorial. Small-scale commercial nuclear reactors, the way forward

It is increasingly being realised that achieving net-zero is not possible without nuclear energy




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Kerala’s nuclear power dilemma

Experts suggest exploring alternative energy sources, such as solar power




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Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives

Org. Chem. Front., 2024, 11,6319-6326
DOI: 10.1039/D4QO01368A, Research Article
Yu Lan, Peng Liu, Zekai Fang, Lili Shao, Qilong Cai, Xiaoming Wang
A variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.
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Activation of donor–acceptor cyclopropanes under basic conditions: ring opening of 2-(p-siloxyaryl)cyclopropane 1,1-dicarboxylates with nitro compounds and other C-nucleophiles

Org. Chem. Front., 2024, 11,6483-6494
DOI: 10.1039/D4QO01472C, Research Article
Yulia A. Antonova, Andrey A. Tabolin
A new activation mode for donor–acceptor cyclopropanes was proposed and implemented in their reaction with nitro compounds and other common C-nucleophiles.
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Modular dehydrogenative cross-nucleophile coupling for direct construction of tetrasubstituted carbons

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01641F, Research Article
Peng Wang, Qiang Wang, Meng Wang, Liang Wang, Lubin Xu, Xiong-Li Liu, Fangzhi Hu, Shuai-Shuai Li
An FeCl3-catalyzed cross-dehydrogenative coupling reaction for the construction of various types of C–Y (Y = C, N, O, S) bonds with air as a green oxidant.
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Dissolution of simulated nuclear waste glass at high surface area to solution volume, high pH and 70 °C: comparison of international simple glass and SON68 glass

RSC Adv., 2024, 14,35114-35127
DOI: 10.1039/D4RA04936E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Felix Brandt, Sébastien Caes, Martina Klinkenberg, Juri Barthel, Sanheng Liu, Karel Lemmens, Dirk Bosbach, Karine Ferrand
Long-term dissolution experiments on two nuclear waste glasses indicate a diffusion-controlled dissolution mechanism including the formation of a porous surface altered layer and secondary phases without a resumption to higher rates.
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Review of iodine behavior from nuclear fuel dissolution to environmental release

RSC Adv., 2024, 14,35255-35274
DOI: 10.1039/D4RA06494A, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chelsie L. Beck, Juan Cervantes, Steven Chiswell, Allison T. Greaney, Katherine R. Johnson, Tatiana G. Levitskaia, Leigh R. Martin, Gavin McDaniel, Stephen Noble, Jason M. Rakos, Brian J. Riley, Andrew Ritzmann, Joel M. Tingey
During nuclear fuel reprocessing, radioiodine, can be released.
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Robot collects melted fuel from Fukushima nuclear reactor

Operated by Tokyo Electric Power Company Holdings, the robot collected a fragment measuring approximately 5 millimetres in size




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An octanuclear 3-phenyl-5-(2-pyridyl)pyrazolate/phenylsilsesquioxane complex: synthesis, unique structure, and catalytic activity

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02690J, Communication
Alexey Bilyachenko, Victor N Khrustalev, Zhibin Huang, Lidia S. Shul'pina, Pavel Dorovatovskii, Elena Shubina, Nikolay S. Ikonnikov, Nikolai N. Lobanov, Karim G. Rahimov, Di Sun
First metallasilsesquioxane bearing pyrazolylpyridine ligands, Cu8-based complex 1, adopts cage structure with two zigzag-like copper tetramers sandwiched by two cyclic Si5 silsesquioxane ligands. Four 3-phenyl-5-(2-pyridyl)pyrazolate ligands in 1 exhibit dual...
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Heteroleptic mononuclear Cu(I) halide complexes containing carbazolyl substituted phenyl diphosphine and monophosphine: structures and photophysical and electroluminescent properties

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02469A, Paper
Zhun Chen, Wei Xu, Ruiqin Zhu, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Guijiang Zhou, Hai-Mei Qin
Heteroleptic mononuclear Cu(I) halide complex 4 containing carbazolyl groups in diphosphine and monophosphine shows high PLQY (0.75) and a short decay lifetime (1.9 μs) with a high kr value of 3.95 × 105 s−1.
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Chemistry of organometallic nucleic acid components: personal perspectives and prospects for the future

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02634A, Perspective
Mateusz Klarek, Konrad Kowalski
Article summarizes over 12 years of studies on organometallic nucleic acid components in our laboratory. It outlines synthetic chemistry, redox, photophysical and biological properties alike. It also shows directions for future development.
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Electrostatic vs. electronic interactions within oxidized multinuclear Pt(bipyridine)(dithiolene) complexes

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02514H, Paper
Khalil Youssef, Antoine Vacher, Thanaphon Khrueawatthanawet, Thierry Roisnel, Frédéric Barrière, Dominique Lorcy
Multinuclear complexes involving two or three redox active Pt(dithiolene) moieties were synthesized and electronic interactions were analysed through a combination of experimental and theoretical investigations.
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Effect of mono- and dinuclear thiosemicarbazone platinacycles in the proliferation of a colorectal carcinoma cell line

Dalton Trans., 2024, 53,17803-17818
DOI: 10.1039/D4DT01490A, Paper
Open Access
Francisco Reigosa-Chamorro, Sandra Cordeiro, M. Teresa Pereira, Beatriz Filipe, Pedro V. Baptista, Alexandra R. Fernandes, José M. Vila
The study of the antiproliferative activity of thiosemicarbazone platinacycles puts forward their high selectivity and low IC50 values.
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