Distribution of infant formula discharge packs to breastfeeding mothers is common practice in maternity care facilities in the United States. Receiving discharge packs is associated with shortened exclusive breastfeeding duration. Many efforts have been made to discourage this practice.

From 2007 to 2013, there has been a marked reduction in distribution of discharge packs containing infant formula to breastfeeding mothers in hospitals and birth centers in the United States. (Read the full article)

Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and there is a necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeting local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food-additive, with a probiotic and investigated its antifungal activity against Candida albicans. Lactobacillus paracasei 28.4, a strain recently isolated from the oral cavity of a caries-free individual, was incorporated in several concentrations of gellan gum (0.6% to 1%). All tested concentrations could incorporate L. paracasei cells while maintaining bacterial viability. Probiotic/gellan formulations were stable for 7 days when stored at room temperature or 4°C. Long-term storage of bacteria-impregnated gellan gum was achieved when L. paracasei 28.4 was lyophilized. The probiotic/gellan formulations provided a release of L. paracasei cells over 24 hours that was sufficient to inhibit the growth of C. albicans with effects dependent on the cell concentrations incorporated into gellan gum. The probiotic/gellan formulations also had inhibitory activity against Candida spp. biofilms by reducing the number of Candida spp. cells (p < 0.0001), decreasing the total biomass (p = 0.0003), and impairing hyphae formation (p = 0.0002), compared to the control group which received no treatment. Interestingly, probiotic formulation of 1% w/v gellan gum provided an oral colonization of L. paracasei in mice with approximately 6 log of CFU/mL after 10 days. This formulation inhibited the C. albicans growth (p < 0.0001), prevented the development of candidiasis lesions (p = 0.0013), and suppressed inflammation (p = 0.0006) when compared to the mice not treated in the microscopic analysis of the tongue dorsum. These results indicate that gellan gum is a promising biomaterial and can be used as a carrier system to promote oral colonization for probiotics that prevent oral candidiasis.

Treatment of dogs naturally infected with Leishmania infantum using meglumine antimoniate (MA) encapsulated in conventional liposomes (LC) in association with allopurinol has been previously reported to promote marked reduction in the parasite burden in the main infection sites. Here, a new assay in naturally infected dogs was performed using a novel liposome formulation of MA consisting of a mixture of conventional and long-circulating (PEGylated) liposomes (LCP), with expected broader distribution among affected tissues of the mononuclear phagocyte system. Experimental groups of naturally infected dogs were as follows: LCP+Allop, receiving LCP intravenously as 2 cycles of 6 doses (6.5 mg Sb/kg/dose) at 4-day intervals, plus allopurinol at 30 mg/kg/12 h p.o. during 130 days; LC+Allop, receiving LC intravenously as 2 cycles of 6 doses (6.5 mg Sb/kg/dose), plus allopurinol during 130 days; Allop, treated with allopurinol only; non-treated control. Parasite loads were evaluated by quantitative PCR in liver, spleen and bone marrow and by immunohistochemistry in the ear skin, before, just after treatment and 4 months later. LCP+Allop and LC+Allop groups, but not the Allop group, showed significant suppression of the parasites in the liver, spleen and bone marrow 4 months after treatment, compared to the pre-treatment period or the control group. Only LCP+Allop group showed significantly lower parasite burden in the skin, in comparison to the control group. On the basis of clinical staging and parasitological evaluations, LCP formulation exhibited a more favorable therapeutic profile, when compared to LC one, being therefore promising for treatment of canine visceral leishmaniasis.

Daniel Ricciardo, waiting out the crisis on his farm near Perth, Western Australia, believes a dramatic season-opener is in prospect at the Red Bull Ring.

Agency: HSS Closing Date: 5/18/2020

During the 1950s and 1960s, Formula racing lost more drivers than the next three decades. Instead, in the 1980s, accident-related deaths were four, which is still higher than the last three decades of Formula racing.

Formula E uses electric vehicles and hence these lithium-ion batteries go through the perfect endurance tests, with learnings percolating to road-legal vehicles in future.

Warsaw already offers a skilled workforce and has improved its infrastructure – now it must focus on climate change and reducing congestion, mayor Rafał Trzaskowski tells fDi.

LAHORE: A formula has been devised in Punjab to promote students of matric and Inter to the next classes. New suggestions have been prepared after cancellation of examinations in the wake of the...

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The next season of the ABB FIA Formula E Championship kicks off in December 2018, and is already shaping up to be exceptional. Featuring new cars, a new race format, new cities, new power modes, new teams, and new drivers, season five promises to ramp up...

The fifth season of the ABB FIA Formula E Championship has kicked off in style in December 2018 with the SAUDIA Ad Diriyah E-Prix. Since then, the Championship’s 22 participating Gen2 electric cars and drivers have been crisscrossing the planet in 13...

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung condition, causing progressive decline in lung function leading to premature death. Acute exacerbations in COPD patients are predominantly associated with respiratory viruses. Ribavirin is a generic broad-spectrum antiviral agent that could be used for treatment of viral respiratory infections in COPD. Using the Particle Replication In Nonwetting Templates (PRINT) technology, which produces dry-powder particles of uniform shape and size, two new inhaled formulations of ribavirin (ribavirin-PRINT-CFI and ribavirin-PRINT-IP) were developed for efficient delivery to the lung and to minimize bystander exposure. Ribavirin-PRINT-CFI was well tolerated in healthy participants after single dosing and ribavirin-PRINT-IP was well tolerated in healthy and COPD participants after single and repeat dosing. Ribavirin-PRINT-CFI was replaced with ribavirin-PRINT-IP since the latter formulation was found to have improved physicochemical properties and it had a higher ratio of active drug to excipient per unit dose. Ribavirin concentrations were measured in lung epithelial lining fluid in both healthy and COPD participants and achieved target concentrations. Both formulations were rapidly absorbed with approximately dose proportional pharmacokinetics in plasma. Exposure to bystanders was negligible based on both the plasma and airborne ribavirin concentrations with the ribavirin-PRINT-IP formulation. Thus, ribavirin-PRINT-IP allowed for an efficient and convenient delivery of ribavirin to the lungs while minimizing systemic exposure. Further clinical investigations would be required to demonstrate ribavirin-PRINT-IP antiviral characteristics and impact on COPD viral-induced exacerbations. (The clinical trials discussed in this study have been registered at ClinicalTrials.gov under identifiers NCT03243760 and NCT03235726.)

SHE’S the Chinese social media star who shot to fame after a cute pic went viral, now an Aussie company is banking on her to boost its baby formula sales.

The French Grand Prix cancelled its race scheduled for June 28 rather than postponing it, making July 5 the targeted start date at the Austrian GP in Spielberg.

This week, I’m rerunning some popular posts while I prepare for this Friday’s video webinar: Industry Update and COVID-19 Impact: PBMs & Payers.

Today's rerun highlights one of the most effective tactics that PBMs have developed to extract deeper discounts from brand-name drug makers. COVID-19 seems likely shift the U.S. payer mix away from commercial health plans. Expect even tighter formulary management and more restrictions as PBMs work even harder to cut costs for their plan sponsor clients.

Click here to see the original post and comments from January 2020.

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For 2020, the two largest pharmacy benefit managers (PBMs)—Express Scripts and the Caremark business of CVS Health—have again increased the number of drugs they have excluded from their standard formularies. The 2020 formulary exclusion lists are available below for your downloading pleasure.

Below, I highlight my key takeaways from the 2020 lists:

• The number of exclusions

• Management of specialty drugs

• Indication-based formularies

• The slow adoption of biosimilars

• The PBMs’ patient-unfriendly exclusions in the hepatitis C category

Formulary exclusions have emerged as a powerful tool for PBMs to gain additional negotiating leverage against manufacturers. The prospect of exclusion leads manufacturers to offer deeper rebates to avoid being cut from the formulary. Exclusions are therefore a key factor behind falling brand-name net drug prices.

Read on for a look at this year’s exclusions along with some closing thoughts on what exclusions mean for patients.
Read more »

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This product is promoted with unapproved claims to prevent, treat, mitigate, or cure COVID-19. FDA warns consumers to avoid unproven and potentially unsafe products. See the Warning Letter for more information:

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This photo is free of all copyright restrictions and available for use and redistribution without permission. Credit to FDA's Office of Regulatory Affairs, Health Fraud Branch is appreciated but not required.

Carpeting may be something we give little thought to, but the ubiquitous floor covering is actually a serious environmental problem. Not only are toxic chemicals often used in the making of most carpeting, they are

This fascinating film reveals disturbing facts about malnutrition and infant mortality, and the role of insidious corporations in perpetuating these problems.

FORMULA X #ColorCurators Song of Style Edition featuring fashion it-girl Aimee Song

The Belgian Formula One Grand Prix scheduled for August 30 is in doubt after the country's ban on public gatherings was extended until the end of that month, organisers said. "All scenarios are being studied: postponement, holding it behind closed doors, or cancelling it. No-one can say what the situation will be in four and a half months," Vanessa Maes, the grand prix's director general, told Belga news agency.

Holding the event behind closed doors is unlikely with local backers unhappy with the financial fallout, according to the newspaper La Derniere Heure. The race is expected to join nine other grands prix that have already been cancelled or postponed this season as Formula One grapples with the consequences of the coronavirus pandemic.

"Our absolute priority remains the health of the Belgian people and the spectators who come to Spa-Francorchamps," the race venue, said Maes.
The French Grand Prix scheduled for June 28 is also in doubt. A decision on whether to go ahead with the race behind closed doors or to postpone or scrap the event is expected in the coming days.

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Formula One boss Chase Carey on Monday targeted the Coronavirus-hit season eventually starting in Austria on July 5 after the French Grand Prix was cancelled and fans barred from the British race at Silverstone.

The French Grand Prix, which was to have been held on June 28, was the tenth race of the season to be scrapped or postponed. "We're targeting a start to racing in Europe through July, August and beginning of September, with the first race taking place in Austria on 3-5 July weekend," Carey said in a statement.

"September, October and November, would see us race in Eurasia, Asia and the Americas, finishing the season in the Gulf in December with Bahrain before the traditional finale in Abu Dhabi, having completed between 15-18 races."

Chase Carey

French GP called off
Carey's statement followed quickfire announcements from the French organisers and a statement from the owners of the Silverstone track where the British Grand Prix is due to take place on July 19.

"Given the evolution of the situation linked to the spread of the Covid-19 virus, the French Grand Prix takes note of the decisions announced by the French state, making it impossible to maintain our event," the race's managing director Eric Boullier said.

It joins nine other races in the decimated 2020 championship to be either cancelled (Australia, Monaco) or postponed (Bahrain, China, Vietnam, Netherlands, Spain, Azerbaijan, Canada).

Organisers of the race at Le Castellet were forced to act after President Emmanuel Macron's announcement last week that the lockdown in France will be extended until May 11 and public gatherings banned until mid-July. Ruling out holding the race behind closed doors, Boullier said: "Le Castellet are already turning towards the summer of 2021".

What about the fans?
F1 supremo Carey said he expected "the early races to be without fans" but hoped that spectators would be allowed back "as we move further into the schedule". He added: "We still have to work out many issues like the procedures for the teams and our other partners to enter and operate in each country. The health and safety of all involved will continue to be priority one and we will only go forward if we are confident we have reliable procedures to address both risks and possible issues."

Revised F1 calendar

July 5: Austria
July 19: Great Britain
August 2: Hungary
August 30: Belgium
September 6: Italy
September 20 Singapore
September 27: Russia
October 11: Japan
October 25: United States
November 1: Mexico
November 15: Brazil
November 29: Abu Dhabi

Races postponed: Bahrain (March 22), Vietnam (April 5), China (April 19), Netherlands (May 3), Spain (May 10), Monaco (May 24), Azerbaijan (June 7), Canada (June 14)

Races cancelled: Australia (March 15), France (June 28)

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

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Silverstone owners said on Monday that no spectators would be able to attend the British Grand Prix due to the coronavirus pandemic but the race is still scheduled to go ahead.

The French Grand Prix scheduled for June 28 was cancelled on Monday but while organisers have not yet made a final decision on postponing or cancelling the July 19 British race, Silverstone managing director Stuart Pringle paved the way for a behind-closed-doors race.

"I am extremely disappointed to tell you that we are unable to stage this year's British Grand Prix in front of the fans at Silverstone," Pringle in his statement on Silverstone's Twitter account. "We have left this difficult decision for as long as possible, but it is abundantly clear given the current conditions... that a grand prix under normal conditions is just not going to be possible."

Britain has been one of the countries worst affected by the COVID-19 outbreak, with the number of deaths topping 20,000. The actual toll could be much higher when deaths in the community are taken into account, particularly at care homes. The French Grand Prix is the 10th leg of the 2020 championship to be either scrapped (Australia, Monaco, France) or postponed (Bahrain, China, Vietnam, Netherlands, Spain, Azerbaijan, Canada).

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

F1 leader Lewis Hamilton heads into this weekend's Japanese GP grateful to have extended his overall championship advantage, but conscious that his Mercedes team have their work cut out to rediscover their car's lost speed. The German team were the third slowest team for the second weekend in a row at the last race in Malaysia, after also similarly struggling for pace in Singapore.

Lewis Hamilton

The Briton heads into Sunday's race at the Suzuka circuit, where he has won twice before, with a heftier 34-point lead over the Ferrari driver with five races to go, but only because of the misfortune that has blunted the German's championship charge.

Mercedes' Lewis Hamilton after claiming pole in Melbourne on Saturday. Pic/Getty Images

World champion Lewis Hamilton claimed the first pole position of the 2018 Formula One season, unleashing a dazzling display of speed that stunned his rivals in the dying seconds of qualifying for the Australian Grand Prix.

The Mercedes driver, who goes into the season as favourite to clinch a fifth world championship, lit up the timing screens with a late one minute 21.164-second lap, the fastest ever around Melbourne’s Albert Park circuit.

That put him a gaping 0.664 seconds clear of his closest challenger Kimi Raikkonen, who will line up alongside the Briton on the front row. The Finn’s Ferrari team-mate and 2017 title runner-up Sebastian Vettel was third 0.674 seconds off the pace.

Yesterday’s pole was the 73rd of Hamilton’s career. The 33-year-old is already Formula One’s most successful qualifier, having surpassed Michael Schumacher’s previous benchmark of 68 pole positions last year. He now also holds the record for most poles at Albert Park, with yesterday’s effort his seventh around the 5.3-kilometer long circuit.

“You would think it had become the norm with all the success we've had these last years, but it's still just as intense,” said Hamilton whose Mercedes team have swept to four straight constructors' titles.

“My heart is racing. I'm always striving for perfection and that was as close as I could get today."

Qualifying offered the first chance of the season for fans to see how the teams all stacked up against each other.

The initial runs in the final pole-position shoot-out phase of qualifying fuelled hopes of a three way battle between Mercedes, Ferrari and Red Bull at the front.

Hamilton held provisional pole after the initial laps, but only just, with Vettel a marginal 0.034 seconds adrift and Max Verstappen 0.061 seconds off the pace. He then dashed all hopes of an evenly matched contest, pulling out all the stops and banging in the lap that clinched him pole.

Vettel, who won at Albert Park last year after starting alongside pole-sitter Hamilton, and Raikkonen were refusing to write off their chances, however.

Mercedes are known to switch the engine on to a more powerful qualifying-only mode — dubbed the ‘party mode’ this year — with their advantage shrinking on race day as they opt for a more normal setting.

“Yeah, I hope they did turn it on today, as that means they have to turn it off tomorrow,” said Vettel.

“I think it’s very close. I think we saw yesterday in the long runs that the pace is very close, so let’s see.”

Hamilton denied turning the engine up between the two runs with team boss Toto Wolff putting it down to the Briton simply getting the car and tyres into the sweet spot.

“What were you doing before?” Vettel asked kicking off an amusing round of banter between the two four-time champions who, in an unprecedented scenario in Formula One history, will be going head-to-head for a fifth title.

“I was waiting to put a good lap in, wipe the smile off your face!” Hamilton shot back.

Verstappen had to eventually settle for fourth, with Red Bull team-mate Daniel Ricciardo fifth. The Australian, however, will start his home race eighth after copping a three-place grid penalty for speeding under red flags in practice on Friday. Both Red Bulls have opted to start the race on the more durable supersoft tyre as opposed to their rivals who will start today’s race on the ultra-soft.

Kevin Magnussen will instead start fifth for Haas ahead of team-mate Romain Grosjean as the American team continued to turn heads with their speed after chalking up their best ever qualifying result.

Nico Hulkenberg qualified eighth but will start seventh on account of Ricciardo’s penalty. His Renault team-mate Carlos Sainz will start ninth.

Fernando Alonso and Stoffel Vandoorne just failed to make it through into the top-ten shootout in McLaren’s first qualifying session since ditching Honda for Renault power. The pair set the 11th and 12th fastest times.

Valtteri Bottas provided the biggest drama of the session, crashing his Mercedes in the final phase of qualifying without setting a time. The incident brought a brief red flag.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates

Fernando Alonso, 37, who announced that he will retire from Formula One at the end of the season, could get married to Italian supermodel Linda Morselli, 29, soon.

According to reports in Socialite program, one of the reasons that could have made Alonso take the decision to leave F1 is that he wants to lead a happy married life and start a family with his girlfriend of two years.

Linda Morselli. Pic/Getty Images

While announcing his retirement, Alonso, had said in a statement: "After 17 wonderful years in this amazing sport, it's time for me to make a change and move on. I'm having one of the happiest times ever in my life but I need to go on exploring new adventures."

Recently, Morselli posted this picture on social media kissing Alonso and captioned it: "Love you." If Alonso gets married, it will be his second wedding. He was married to singer Raquel del Rosario till 2011.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates

Candidiasis treatment could be improved using new drug formulation. Specific chemical signal released from a bacterium can be used to improve the activity

New oral formulation of Amphotericin B is identified to treat systemic fungal and parasitic infections by the researchers at the Wasan Laboratory in the

Nutraceutical formulation that combines three plant extracts along with standard hypertension treatments can keep your blood pressure in check, suggests a new study.

Company: International Trade Links
Qualification: Bachelor Of Technology (B.Tech/B.E), Bachelor of Science (B.Sc)
Experience: 8 to 15
location: Saudi Arabia
Ref: 24818613
Summary: DEVELOPMENT/ FORMULATION CHEMIST FOR ARABIAN MINERALS & CHEMICALS CO, SAUDI

Company: Nanu India Recruitment Co
Qualification: Bachelor Of Pharmacy (B.Pharm), Bachelor of Science (B.Sc), Masters in Technology (M.Tech/M.E/M.Sc)
Experience: 0 to 2
Salary: 1.60 to 4.00
location: Vadodara, Bhavnagar
Ref: 24823657
Summary: We have Requirement for Executive - Formulation -....

Move boosts chemicals group’s growing sports investment portfolio

WILL JEANES IN MARRAKESH: Da Costa, who drives for DS Techeetah, had finished second in the previous two races of the season in Chile and Mexico but led from pole.

With games set to be played behind closed doors, some clubs are opposed to 'neutral hubs' to finish the season, but Purslow says it is the 'duty' of all 20 clubs to find a workable solution.

Five people have been charged with allegedly stealing thousands of dollars' worth of baby formula in a string of robberies across Melbourne. 

Lewis Hamilton is one of the favourites to win the race that could see him clinch the world championship in Mexico, which means the driver could cap his sixth victory by celebrating with his car.

The experiment would have seen the Saturday qualifying replaced with a sprint race, in which drivers lined up in reverse championship order, with the leading driver starting at the back.

JONATHAN McEVOY IN AUSTIN: At 34, he moved one title ahead of Fangio, completing yet another milestone in his transformation from a council estate boy into a global F1 star.

Lewis Hamilton has been backed by his Mercedes boss to rewrite the sport's record books for years to come after winning the Formula One world title for the sixth time.

EXCLUSIVE BY JONATHAN McEVOY: As Lewis Hamilton whisked friends and family away to celebrate his sixth world championship the great and good were working on another important trip.

JONATHAN McEVOY: Formula One's image of oil and engines, noise and smells, is to be cast off as owners Liberty Media promise to make grand prix racing net zero carbon by 2030.

He's a six-time Formula One world champion and she's won an MTV Movie Award for Best Kiss.

Formula One champion Lewis Hamilton has pledged to donate $500,000 to bushfire relief. 

Freddie Flintoff, Paddy McGuinness and Chris Harris are set to star in a new reboot of BBC's Top Gear. The Trio told how their series compares to previous shows.

I wasn't sure what to write this week. We're all thinking about the spread of a global pandemic, so I see my role as offering some light relief from that

With games set to be played behind closed doors, some clubs are opposed to 'neutral hubs' to finish the season, but Purslow says it is the 'duty' of all 20 clubs to find a workable solution.

The RFU will determine the final places of the Championship - the second tier of domestic competition - with a 'best playing record formula' after ending the season early due to coronavirus.

The campaign has yet to get going due to the coronavirus pandemic.

Asher-Smith could have a shot at three gold medals in a mad six-week stretch after Sebastian Coe revealed plans are being formulated to squeeze a trio of major events into the summer of 2022.

Captain Tom Moore has backed Lewis Hamilton to win a record-equaling seventh Formula One world championship when the series resumes following the coronavirus-enforced shutdown.