Filed under: Food and Drink, North America, United States

• Regardless of the area's suitability for growing grapes, plop down a vineyard or winery and travelers will come for a taste and buy a sympathy bottle (pro tip: go for the ice wine as it's harder to mess up)
• Ski resorts looking to attract off-season dollars or stale attractions looking to draw media coverage and visitors hook up a zipline

Continue reading Vineyard and Zipline Trends Collide at the Pinot Express

Vineyard and Zipline Trends Collide at the Pinot Express originally appeared on Gadling on Wed, 11 Dec 2013 16:54:00 EST. Please see our terms for use of feeds.

As Quebec begins to reopen schools and businesses, Prime Minister Justin Trudeau said he’s ‘worried’ about the province’s deconfinement plans, particularly in Montreal.

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

'Destination Wedding' book review: The land of contradictions  The New Indian Express

OM Belgium and OM Arts creatively connect with the local community through drawings, song, poetry and flowers.

Coronavirus numbers explained: New cases start dipping  The Indian Express

February fourteenth, a day associated with love; a day that brings with it a sweet flavor of romance; a day that sees

OECD Secretary General Angel Gurría welcomes the initiative of President Francois Hollande and Chancellor Angela Merkel to put forward a structural and ambitious response to the current refugee crisis.

OECD Secretary General Angel Gurría welcomes the initiative of President Francois Hollande and Chancellor Angela Merkel to put forward a structural and ambitious response to the current refugee crisis.

1. Happy Mother’s Day 2020: Wishes, images, Whatsapp messages, status, quotes and photos  The Indian Express
2. Mother’s Day 2020: 5 Easy DIY Gift Ideas to Make Your Mom Smile  News18
3. Happy Mother's Day Greeting Card: Easy ways to make a greeting card at home  Times of India
4. Five ways to make your mother feel special, every day  The Indian Express
5. Mother’s Day 2020: These apps might be the best gifts (you can install) for mom  Hindustan Times
6. View Full coverage on Google News

Qantas will more than double the number of flights between Adelaide and Kangaroo Island after a decision by Regional Express to withdraw from the route.

Credit ratings agency Standard & Poor's said the latest measure was agreed ahead of deadlines for two smaller loans due in August.

Leyton Orient captain Jobi McAnuff fears black footballers are at an increased risk of dying if the season is resumed amid the coronavirus crisis.

Most public matters before judges are simply 'in court', and not necessarily sub judice to the extent that voicing one's views about them publicly would merit contempt charges. The courts should recognise the distinction formally, with a clear standard for separating the two. The India Together editorial.

The beating of media persons at Kozhikode's airport had its fallout all over Kerala. It has pitted the media against the state government. Several issues concerning rights and privacy need to be discussed, including some of the media’s own failings says N P Chekkutty.

Archives, Room Use Only - F594.V57 1946

This article explains the effects of the new u flag for regular expressions in ES2015.

ES2018 adds support for Unicode property escapes of the form p{…} and P{…} to JavaScript regular expressions. This article explains what Unicode property escapes are, how they work, and why they’re useful.

This article highlights what’s happening in the world of JavaScript regular expressions right now. Spoiler: it’s quite a lot — there are more RegExp-related proposals currently advancing through the TC39 standardization process than there have been updates to RegExp in the history of ECMAScript!

Rs 1 lakh crore Delhi-Mumbai Expressway project offers huge investment opportunities: Gadkari

Mother’s Day 2020: ‘One Day isn’t enough to thank our mothers’, says Divya Khosla Kumar who feels we should express our gratitude towards them whenever we feel it

Mumbai: Filled travel forms week ago, can’t wait, say fresh migrants on Eastern Express Highway

‘State government has failed to protect the people of Delhi from the virus’

Coronavirus shock: Pandemic lockdowns have changed how the planet SOUNDS and vibrates  Express.co.uk

What is a sinkhole and are they caused by bad weather?  expressandstar.com

Tsunami warning: Britain could be hit by 30m wave - Professor warns of hazards to Britain  Express.co.uk

Explained: How coronavirus lockdown reduced Earth’s seismic noise levels  The Indian Express

Why the UK's streets have turned silent during coronavirus lockdown  Express.co.uk

UK sees notable reduction in seismic noise caused by human activity – experts  Aberdeen Evening Express

Ancient underwater landslides help predict tsunami risk  Aberdeen Evening Express

Fossil believed to show squid-like creature attacking fish 200 million years ago  Aberdeen Evening Express

In chemistry, stereochemically active lone pairs are typically described as an important non-bonding effect, and recent interest has centred on understanding the derived effect of lone pair expression on physical properties such as thermal conductivity. To manipulate such properties, it is essential to understand the conditions that lead to lone pair expression and provide a quantitative chemical description of their identity to allow comparison between systems. Here, density functional theory calculations are used first to establish the presence of stereochemically active lone pairs on antimony in the archetypical chalcogenide MnSb2O4. The lone pairs are formed through a similar mechanism to those in binary post-transition metal compounds in an oxidation state of two less than their main group number [e.g. Pb(II) and Sb(III)], where the degree of orbital interaction (covalency) determines the expression of the lone pair. In MnSb2O4 the Sb lone pairs interact through a void space in the crystal structure, and their their mutual repulsion is minimized by introducing a deflection angle. This angle increases significantly with decreasing Sb—Sb distance introduced by simulating high pressure, thus showing the highly destabilizing nature of the lone pair interactions. Analysis of the chemical bonding in MnSb2O4 shows that it is dominated by polar covalent interactions with significant contributions both from charge accumulation in the bonding regions and from charge transfer. A database search of related ternary chalcogenide structures shows that, for structures with a lone pair (SbX3 units), the degree of lone pair expression is largely determined by whether the antimony–chalcogen units are connected or not, suggesting a cooperative effect. Isolated SbX3 units have larger X—Sb—X bond angles and therefore weaker lone pair expression than connected units. Since increased lone pair expression is equivalent to an increased orbital interaction (covalent bonding), which typically leads to increased heat conduction, this can explain the previously established correlation between larger bond angles and lower thermal conductivity. Thus, it appears that for these chalcogenides, lone pair expression and thermal conductivity may be related through the degree of covalency of the system.

The membrane protein EsaA is a conserved component of the type VIIb secretion system. Limited proteolysis of purified EsaA from Staphylococcus aureus USA300 identified a stable 48 kDa fragment, which was mapped by fingerprint mass spectrometry to an uncharacterized extracellular segment of EsaA. Analysis by circular dichroism spectroscopy showed that this fragment folds into a single stable domain made of mostly α-helices with a melting point of 34.5°C. Size-exclusion chromatography combined with multi-angle light scattering indicated the formation of a dimer of the purified extracellular domain. Octahedral crystals were grown in 0.2 M ammonium citrate tribasic pH 7.0, 16% PEG 3350 using the hanging-drop vapor-diffusion method. Diffraction data were analyzed to 4.0 Å resolution, showing that the crystals belonged to the enantiomorphic tetragonal space groups P41212 or P43212, with unit-cell parameters a = 197.5, b = 197.5, c = 368.3 Å, α = β = γ = 90°.

The true identity of the protein found in the crystals reported by Bondoc et al. [(2019), Acta Cryst. F75, 646–651] is given.

Club doctors are reported to have expressed concerns about the Premier League's Project Restart proposals, which aim to have clubs back training in small groups within the next two weeks.

FAIRFAX, Va. - The left exit ramp from eastbound I-66 to both north and southbound I-495 Express Lanes is scheduled to close tonight, Tuesday,...

American Express cardholders can sync their accounts with Twitter, Facebook and Foursquare and receive special savings offers at select merchants. But the whole