Iceland is moving closer to plugging European homes into the volcanic island nation’s geothermal and hydropower reserves via what would be the world’s longest power cable, according to the country’s largest energy producer.

Orix Corp., a Tokyo-based finance and leasing company, plans to build as many as 15 geothermal power stations in Japan in the next five years.

In the midst of a suburban sprawl halfway between the Eiffel Tower and Paris’s busy Orly airport, a drilling crew works night and day burrowing deep into the Earth’s crust in search of underground heat.

Kenya Electricity Generating Co., the East African nation’s biggest power producer, plans joint ventures to complete its geothermal projects in Olkaria, Chief Executive Officer Albert Mugo said.

China could be nearing publication of a plan to guide the development of geothermal energy resources over the next few years as it plunges ahead with efforts to get more of its energy from renewable sources.

New power-generating units at Kenya’s Olkaria I plant are saving East Africa’s biggest economy about 2.2 billion shillings ($24 million) a month on fuel costs, according to the country’s biggest electricity producer.

Squashed between a highway overpass and a towering suburban shopping center east of Paris, a drilling rig is completing the second of two geothermal wells aimed at capturing the earth’s natural heat for homes and offices.

Today's the day to celebrate our moms. In order to honour them on Mother's Day, we've picked out some of our favourite TV matriarchs. From Kevin's mother, Norma (from The Wonder Years) to the superhero mom of the Dunphy tribe, Claire, (from Modern Family) we celebrate mothers who have broken out of their homemaker roles, became the supermoms and excelled in their chosen career paths. Here's a list of TV moms who managed to pull down a paycheck while also packing their kids' lunches!

Norma Arnold, The Wonder Years

While an 80s sitcom mom, Norma, portrayed a mother in the 1960s and 70s. She showed us the transformation of a woman during the burgeoning women's movement. Norma had dropped out of college and gotten married. But she goes back to school, finishes her degree, and lands up as an executive with a software startup. Her inspiring evolution over the years showed us that no matter the decade or circumstance, women could be or do anything. Throughout the series, you see her yearning to break out of her homemaker role, which reflected the rise in feminism in the 1960s US. If you wish to take a trip down memory lane, watch this show currently airing in India on Star World.

Jessica Huang, Fresh Off the Boat

One of the smartest, strongest, and most protective TV moms, Jessica Huang, played by Constance Wu, is a character we have all grown to admire. Whether Jessica is chasing down teens who dine-and-dash at the family's restaurant or is standing up to the middle school principal, she is nothing like a stereotypical Asian woman, or even a typical sitcom mom. She is strong, bold, and unapologetic! Beneath her brash and ambitious exterior self, she is a kind, loving, and caring mother. You see her pursue her career when she takes a step back from helping her husband run his restaurant and goes on to chart her own success as a real estate agent. You can watch the show on Hotstar.

Rainbow Johnson, Black-Ish

The perfectly imperfect TV wife and working mom, Dr Rainbow Johnson on Black-ish is kind, funny, selfless, and usually nice. Played by Tracee Ellis Ross, Bow is an anesthesiologist who is unapologetic about having a career that she loves. Like most moms, she has bouts of feeling guilty about loving her job and being a mom, but she uses those moments as teachable lessons for her children about having ambition and purpose in life. Black-ish can be watched in India on Hotstar.

Joyce Byers, Stranger Things

Joyce Byers was one of the strongest characters throughout the first season of Stranger Things, going the extra mile again and again to find Will. Remember that this is the show set in the 80s. Given the time, Joyce, a single mother, works hard at a low-paying job to support her family. Working at a retail store, she gives her best to make ends meet. And though not a central character, Joyce is a badass mother, who works damn hard and loves her kids! The show is currently streaming on Netflix.

Claire Dunphy, Modern Family

Claire is uptight, bossy, and often frantic. A stay-at-home mother and wife until season five, Claire starts the juggle between work and kids when her father, Jay, hires her to work at his office. A perfectionist when it comes to dealing with her family, Claire is a mother who almost always knows what to do during stressful times, more than Phil. She gave up her career when she got pregnant with her first child, but later returned to work to head up her father's successful closet business. One of the funniest modern moms of this generation, Claire teaches us so much! The series culminated just recently, and can be watched in India on Star World.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

It’s not just us. Women in every country are defined by stereotype

UK Geothermal: boiling beneath the surface?  Power Technology

Green light for Cheshire geothermal energy research  BBC News

The Y128F single mutant of p-hydroxymandelate oxidase (Hmo) is capable of oxidizing mandelate to benzoate via a four-electron oxidative decarboxylation reaction. When benzoylformate (the product of the first two-electron oxidation) and hydrogen peroxide (an oxidant) were used as substrates the reaction did not proceed, suggesting that free hydrogen peroxide is not the committed oxidant in the second two-electron oxidation. How the flavin mononucleotide (FMN)-dependent four-electron oxidation reaction takes place remains elusive. Structural and biochemical explorations have shed new light on this issue. 15 high-resolution crystal structures of Hmo and its mutants liganded with or without a substrate reveal that oxidized FMN (FMNox) possesses a previously unknown electrophilic/nucleophilic duality. In the Y128F mutant the active-site perturbation ensemble facilitates the polarization of FMNox to a nucleophilic ylide, which is in a position to act on an α-ketoacid, forming an N5-acyl-FMNred dead-end adduct. In four-electron oxidation, an intramolecular disproportion­ation reaction via an N5-alkanol-FMNred C'α carbanion intermediate may account for the ThDP/PLP/NADPH-independent oxidative decarboxylation reaction. A synthetic 5-deaza-FMNox cofactor in combination with an α-hydroxyamide or α-ketoamide biochemically and structurally supports the proposed mechanism.

The post Museum Conservation Institute research scientist Ed Vicenzi discusses his work analyzing daguerreotypes appeared first on Smithsonian Insider.

When creating a System Composer architecture model, if the following functions are called with an invalid or missing stereotype, it can cause the model to get corrupted and might lead to a MATLAB crash:

• addComponent
• addPort
• connect

We tend to think of the process of seeing as fairly objective — that our eyes are similar to cameras, neutrally taking in light and turning it into pictures. But research has shown that biases buried beneath our awareness can powerfully shape how we see.

Scientists have reviewed the potential for worldwide development of geothermal energy systems in old, unused mines. The technology is proven in many sites and could therefore help increase the share of renewable energy sources in the energy mix, offering sustainability and job creation, which may make mining operations more appealing to investors, communities and policymakers.

A new screening tool to assess the potential seismic risks (earthquake activity) from deep geothermal energy projects has been outlined in a recent study. The tool provides categories of seismicity risk for projects, which are dependent on factors including geological aspects, as well as social concern and location in relation to urban areas.

Shafts that haven't been closed could be transformed into geothermal boilers to produce heat and hot water for nearby communities.

Geothermal heating and cooling systems are a blend of the old and the new. An ecologically and financially-efficient option.

In North America alone, there is enough energy trapped beneath the Earth's surface to produce 10 times as much electricity as coal currently does.

Brighter Living with Jill Cordes: Some of the biggest companies are meeting the challenge.

The U.S. Department of Energy will provide more than $11 million to support eight geothermal energy projects.

Thousands of drilling rigs are idle and roustabouts are being laid off. Why not put them to work drilling for renewable energy?

Geothermal Heating “Rocks” in Sweden

･ First introduction for a geothermal power plant ･ Enhancing the operation and performance of power generating facilities in close cooperation with customers

Gymnastics Fantastic is an online store for professional and beginner athletes. It offers a 10% discount or free delivery for rhythmic gymnastics competition leotards if you place your order as a team.

Today, a reliable brand of sports products is offering a 20% discount for rhythmic gymnastics leotards, accessories, and other products. Gymnastics Fantastic is known for its high-class training uniforms for all ages.

A famous trademark of sports goods for people of all ages has launched a new collection for the next year. It includes marvelous competition dresses for figure skating and comfortable gymnastic shorts.

The proposal by GEOBROADCAST SOLUTIONS to allow FM boosters to transmit geotargeted programming like ads and news separate from the primary station's programming has gained the support of … more

KARINE HATESA LEOTA-EVANS
Cedar Rapids

Karine Hatesa Leota-Evans, 16, of Cedar Rapids, passed away on April 20, 2020 at St. Luke's Hospital. Home going services will be held at 2 p.m. Sunday, May 17, at Cedar Memorial Park Cemetery, Garden of Serenity.
Karine was a sweet, loving, well-mannered and soft-spoken daughter, granddaughter, sister, niece and cousin.
She loved to watch and take pictures of sunsets, road trips to her aunts and uncles in Missouri and Wisconsin, sing, dance, connecting on social media, shopping and her cat Miss Samoa. She will be greatly missed by her family and everyone who knew and loved her.
Karine was preceded in death by her mother/grandmother, Karine Hatesa Apineru-Evans.
Left to cherish Karine's memories are her parents, Jennifer and Nofoasaefa Leota; sisters, Fagaeolemasina "Mary" and Taofegauia'i "Amayah"; brother, Rapi Quincy; father/grandfather, Shawn Evans; her Apineru Family; and her Leota Family.
Condolences may be left at www.cedarmemeorial.com under obituaries.
Messages from your sisters.
A message to my little sister:
Karine, this was such unexpected timing, I was hoping to go see grandma first, but I guess you beat me to it. You were such a special girl, beautiful and always full of imagination and the resemblance between the two of us is uncanny. This year 2020, I am to graduate high school, and I was hoping to finally get to meet you in person, I loved our long phone calls but I wanted the real life version of everything but I guess that shall wait till it is my turn to join you up there. It has been four years since I have heard your sweet voice, and it pains me to say I was not able to hear it again one final time before your departure. Here on Earth everything feels different, there is an emptiness. I hope you're dancing in the sky; I hope you're singing in the angel's choir, and I hope the angels know what they have. It must be so nice up in Heaven since you arrived. Never had I ever cried a river of tears, but when you decided to leave there was no holding back, the 4 oceans could not withstand the flood of tears that ran quickly down my face. But I am sorry, I never told you all I wanted to say, never had I imagined living without you, but I know you're shining down on me from Heaven. Tell grandma, Mama Susie, Pops, Nana, Pago and everyone we love up there with you that I said I hope one day I can make all of them proud, and that I miss all of them very much. I am your big sister Rine, and I hope you know how much I love you uso! Always and forever, till no end.
-- Taofegauiai Amayah Leota

To my dearest beloved baby sister,
No words can explain how much I love and miss you, it's even harder for me to write this to you because I never thought of losing you in such a short period of time. Ever since I heard the news of your loss I didn't know what to do or how to feel but deep inside there's a pain that I never felt in a long time, especially losing my own baby sister it was something really unexpected and heartbreaking. I was really looking forward to seeing you one day and spending time with you and have a sisterly bond with you that I will cherish every moment of it. But now without you, my life will be like a book without page numbers. The story will go on, but it might feel out of order. I miss her, my sister, her spirit dulled to a whisper. My sister was a gift I never asked for, but I always wanted. A lost sister is like the missing piece in the game of life. When she was alive, I didn't always miss my sister - now I can't stop missing her. See you when I see you ok, kisses to the sky to you uso. I love you with every beat of my heart and I miss you every day of my life.
--Your older sister, Fagaeolemasina Mary Leota.

The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound nucleoside-nucleotide thus obtained with formation of phosphotriester groups, blocking of free primary 5'--OH groups, elimination of a protective group from the terminal 5'--OH group, where appropriate single or multiple repetition of the abovementioned steps to introduce further nucleoside phosphate or oligonucleoside phosphate units, and cleavage of the nucleoside-carrier bond and, where appropriate, elimination of all protective groups present in the oligonucleoside phosphates. The phosphine derivative used is a compound of the general formula III ##STR1## in which X and L can react with OH groups of the sugar units in the oligonucleotides, and R3 is a protective group which can be liberated by β-elimination.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

The present disclosure relates to a process for separating a fluoroolefin from a mixture comprising hydrogen fluoride and fluoroolefin, comprising azeotropic distillation both with and without an entrainer. In particular are disclosed processes for separating any of HFC-1225ye, HFC-1234ze, HFC-1234yf or HFC-1243zf from HF.

To provide a method for efficiently separating 2,3,3,3-tetrafluoropropene (HFO-1234yf) and chloromethane (R40) from a composition comprising HFO-1234yf and R40. An azeotrope-like composition comprising from 58 to 78 mol % of HFO-1234yf and from 22 to 42 mol % of R40, and a method for producing HFO-1234yf, which comprises steps of distilling an initial mixture containing HFO-1234yf in a content exceeding 63 mol % in the total amount of HFO-1234yf and R40, thereby to separate the initial mixture into a first fraction in which the content of HFO-1234yf in the total amount of HFO-1234yf and R40 is lower than the content of HFO-1234yf in the total amount of HFO-1234yf and R40 in the initial mixture, and a second fraction in which the content of HFO-1234yf in the total amount of HFO-1234yf and R40 is higher than the content of HFO-1234yf in the total amount of HFO-1234yf and R40 in the initial mixture, and then obtaining HFO-1234yf having a reduced R40 concentration, from the second fraction.

The invention describes new structures of the nucleotide conjugates (nuc-macromolecules) comprising at lease one nucleotide moiety coupled to at least one macromolecular compound via a short linker. These conjugates can be used as substrates for various kinds of polymerizing enzymes in the enzymatic synthesis of nucleic acids. In particular, these compounds can be used for labeling nucleic acids.

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.

This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate.

The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50% to a polynucleotide of a) or b) above.

The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer.

Provided is an oligonucleotide containing an azobenzene derivative, represented by Formula (1) or (2) below: (in the formulae, A1 and A2 each independently represent a hydrogen atom, nucleotide or oligonucleotide, B1 and B2 each independently represent a hydroxyl group, nucleotide or oligonucleotide, R11 and R12 each independently represent a C1-20 alkyl group, R21 and R22 each independently represent a hydrogen atom or C1-20 alkyl group, and R13 to R18 and R23 to R28 each independently represent a hydrogen atom; a C1-20 alkyl group or alkoxy group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a C2-20 alkenyl group or alkynyl group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a hydroxyl group; a halogen atom; an amino group; a nitro group; or a carboxyl group).

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.

A geotextile container has a bag section, a cover section and a stuffing space. The bag section has a bag cloth, a bag non-woven fabric and a trapezoidal longitudinal section. The cover section is integrally connected with the bag section and has a cover cloth and a cover non-woven fabric. The stuffing space is formed inside the bag section and has a first margin portion. A longitudinal section of the stuffing space is trapezoidal. The first margin portion is formed at a side of a bottom of the stuffing space. The first margin portion can be immediately unfolded and contain filling materials once the geotextile container is projected into the sea.

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

A plurality of osteotomes that are linked together via a recess and a matching projection such that the osteotomes remain linked when used to manipulate bone.

A wastewater geothermal heat system is supplied with processed wastewater through a drip field in proximity to a thermal array part of a geothermal heat pump system. The wastewater treatment system portion provides a periodic source of treated wastewater. Several sensors and a control system regulate a pump that discharges wastewater from the treatment system and enters a drip field where it is released into the surrounding soil. The dampened soil provides an efficient vehicle to transfer heat into or out of a thermal array which is positioned adjacent to the drip field such that it is in contact with the soil that is dampened by the discharged wastewater.

A low alloy steel ingot contains from 0.15 to 0.30% of C, from 0.03 to 0.2% of Si, from 0.5 to 2.0% of Mn, from 0.1 to 1.3% of Ni, from 1.5 to 3.5% of Cr, from 0.1 to 1.0% of Mo, and more than 0.15 to 0.35% of V, and optionally Ni, with a balance being Fe and unavoidable impurities. Performing quality heat treatment including a quenching step and a tempering step to the low alloy steel ingot to obtain a material, which has a grain size number of from 3 to 7 and is free from pro-eutectoid ferrite in a metallographic structure thereof, and which has a tensile strength of from 760 to 860 MPa and a fracture appearance transition temperature of not higher than 40° C.