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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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OSCE Mission to Bosnia and Herzegovina’s youth summits challenge stereotypes and promote tolerance to counter violent extremism

Some 100 high school students, pedagogues and psychologists from across Bosnia and Herzegovina (BiH) took part in two youth summits in Teslić and Vogosća this week co-hosted by the OSCE Mission to BiH and the BiH Security Ministry ...




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Clumped isotope geothermometry of an Ordovician carbonate mound, Hudson Bay Basin

Jautzy, J J; Savard, M M; Lavoie, D; Ardakani, O H; Dhillon, R S; Defliese, W F; Castagner, A. Journal of the Geological Society vol. 178, issue 1, jgs2020-102, 2020 p. 1-11, https://doi.org/10.1144/jgs2020-102
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200066.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200066.jpg" title="Journal of the Geological Society vol. 178, issue 1, jgs2020-102, 2020 p. 1-11, https://doi.org/10.1144/jgs2020-102" height="150" border="1" /></a>




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The Oligonucleotide Synthesis Market was is expected to grow US$ 17.43 Bn by 2030, as per Maximize Market Research.

(EMAILWIRE.COM, October 24, 2024 ) The oligonucleotide synthesis market is experiencing significant growth due to its applications in diagnostics, therapeutics, and research. North America holds the largest market share due to established research infrastructure and strong demand. Asia Pacific...




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1997 Peugeot Speedfight 50cc LC from Portugal




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Nicotinamide Mononucleotide (NMN) Supplements: A Deep Dive into Their Potential Benefits and Uses

Science behind NMN, nicotinamide mononucleotide supplements - possible better aging and longer longevity health benefits and points to consider for those who want to include it in their health and wellness program.




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Videotron adds 28 more destinations to Canada-International wireless plan

(Telecompaper) Videotron has added 28 more international destinations to its Canada-International wireless plan...




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US Air Force Pursues Green Hydrogen Via Geothermal Energy

The US Department of Defense is pursuing next-generation geothermal energy systems that can produce zero emission electricity and green hydrogen, too.

The post US Air Force Pursues Green Hydrogen Via Geothermal Energy appeared first on CleanTechnica.




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Holy Tradition and the Most-Holy Theotokos

Frederica gives a lecture at St. Barbara Greek Orthodox Church in Santa Barbara, CA, on Orthodox Tradition concerning the Theotokos.




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The Akathist to the Theotokos

On Fridays during Great Lent, it is the tradition of the Church to sing a hymn to the Theotokos known as the Akathist. These beautiful words were penned by St. Romanos the Melodist, and today Frederica reads her own translation of this inspiring hymn taken from her book, Lost Gospel of Mary.




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Lamentation of the Theotokos

As we approach Holy Week, you won't want to miss this powerful reading by Frederica of the Lamentation of the Theotokos written by St. Romanos the Melodist and translated by Fr. Ephrem Lash. It was taken from the book On the Life of Christ: Kontakia, published in 1994.




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The Theotokos and Prayers to the Saints

Frederica reads another selection from her new book Welcome to the Orthodox Church: An Introduction to Eastern Christianity, published by Paraclete Press.




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The Protecting Veil of the Holy Theotokos

Whether you celebrate it on October 1 or on October 28 (traditions differ), you will enjoy Fr. Thomas' account of how the Mother of God protected a Constantinople church from an invading army, and how that inspires our own worship.




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The Entrance of the Theotokos Into the Temple

Fr. Tom teaches on this significant feast at the beginning of the Nativity season.




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Dormition of the Theotokos

On August 15, the Church celebrates the Dormition of the Mother of God. Fr.Tom explores the theology associated with this Feast and the implications on our own resurrection.




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The Theotokos and Ponder Me This

As we approach the Cave wherein God becomes a Babe, may we, like His mother, be granted the gift of pondering. Fr Joseph in Chicago, 2010.




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The Nativity of the Theotokos

Fr. John shares about the Nativity of the Theotokos.




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The Entry of the Theotokos into the Temple

Metropolitan Jonah reflects on the importance of the Temple and Mary's role in our salvation.




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The Theotokos as an Ideal of Motherhood

Fr. John Whiteford describes the important role of motherhood as seen through life of the Theotokos, the mother of our Lord.




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Animated Films Perpetuate Harmful Stereotypes About Eye Conditions




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Wednesday Nov 21 - Entry of Theotokos to the Temple




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Nov 21 - The Entry Of The Theotokos Into The Temple




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The Entry of the Most Holy Theotokos into the Temple in Jerusalem




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The Entry of the Most Holy Theotokos into the Temple in Jerusalem




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The Entry of the Most Holy Theotokos into the Temple in Jerusalem




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Mar 25 - The Annunciation Of Our Most Holy Lady, The Theotokos And Ever-Virgin Mary




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Mar 25 - The Annunciation of the Holy Theotokos




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Mar 25 - Annunciation Of Our Most Holy Lady, The Theotokos And Ever-Virgin Mary




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The Annunciation of Our Most Holy Lady the Theotokos and Ever-Virgin Mary




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Aug 15 - Dormition of the Holy Theotokos




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The Dormition of Our Most Holy Lady the Theotokos and Ever-Virgin Mary




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The Dormition of Our Most Holy Lady the Theotokos and Ever-Virgin Mary




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The Dormition of Our Most Holy Lady the Theotokos and Ever-Virgin Mary




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The Dormition of Our Most Holy Lady the Theotokos and Ever-Virgin Mary




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Oct 01 - Protection Of The Holy Theotokos




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Appearance of the “Kazan” Icon of the Most Holy Theotokos




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Jun 28 - Synaxis Of The Icon Of The Theotokos “Of The Three Hands”




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Synaxis of the Icon of our Most Holy Lady the Theotokos “Of the Three Hands”




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Dormition of the Righteous Anna, Mother of the Most Holy Theotokos




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The Placing of the Sash of the Most Holy Theotokos




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The Placing of the Sash of the Most Holy Theotokos




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The Entry of the Most Holy Theotokos into the Temple in Jerusalem




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Appearance of the “Kazan” Icon of the Most Holy Theotokos




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Appearance of the “Kazan” icon of the Most Holy Theotokos




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Dormition of the Righteous Anna, Mother of the Most Holy Theotokos




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The Dormition of Our Most Holy Lady the Theotokos and Ever-Virgin Mary




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The Entry of the Most Holy Theotokos into the Temple in Jerusalem




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Dormition of the Righteous Anna, Mother of the Most Holy Theotokos




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The Dormition of Our Most Holy Lady the Theotokos and Ever-Virgin Mary




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The Entry of the Most Holy Theotokos into the Temple in Jerusalem