Photo by freestocks The issue of rape-related pregnancies is a crucial yet often-overlooked aspect of the broader debate surrounding abortion access. As more states implement strict abortion bans, the implications for survivors of sexual violence become increasingly severe and far-reaching. When Hadley Duvall was just 12 years old, she was raped and impregnated by her stepfather. […]

The post Forced to Carry: The Reality of Rape-Related Pregnancies in a Post-Roe World appeared first on Feminist Majority Foundation.

Em 2024 foram aplicadas quase 200 multas, a maioria por tráfego irregular de veículos, em áreas proibidas. Especialistas veem risco de erosão acelerada das dunas

England prop Ellis Genge admits last year's World Cup semi-final defeat by South Africa is something he will carry for the rest of his career.

According to reports, one of the issues that Donald Trump hopes to address in his second belated term is to institute concealed carry permits reciprocity in every state, allowing a person with a permit in one state to legally carry his firearm in every other state. On Sunday, Donald Trump Jr. posted a video of […]

The post Trump to Work on National Concealed Carry Reciprocity appeared first on The Lid.

A nuclear-powered aircraft carrier, like American carriers, would be a major jump for China, giving its navy a global reach.

α-Linked galactose is a common carbohydrate motif in nature that is processed by a variety of glycoside hydrolases from different families. Terminal Galα1–3Gal motifs are found as a defining feature of different blood group and tissue antigens, as well as the building block of the marine algal galactan λ-carrageenan. The blood group B antigen and linear α-Gal epitope can be processed by glycoside hydrolases in family GH110, whereas the presence of genes encoding GH110 enzymes in polysaccharide utilization loci from marine bacteria suggests a role in processing λ-carrageenan. However, the structure–function relationships underpinning the α-1,3-galactosidase activity within family GH110 remain unknown. Here we focus on a GH110 enzyme (PdGH110B) from the carrageenolytic marine bacterium Pseudoalteromonas distincta U2A. We showed that the enzyme was active on Galα1–3Gal but not the blood group B antigen. X-ray crystal structures in complex with galactose and unhydrolyzed Galα1–3Gal revealed the parallel β-helix fold of the enzyme and the structural basis of its inverting catalytic mechanism. Moreover, an examination of the active site reveals likely adaptations that allow accommodation of fucose in blood group B active GH110 enzymes or, in the case of PdGH110, accommodation of the sulfate groups found on λ-carrageenan. Overall, this work provides insight into the first member of a predominantly marine clade of GH110 enzymes while also illuminating the structural basis of α-1,3-galactoside processing by the family as a whole.

The Canadian Post-Impressionist artist was famous for her evocative landscapes and paintings incorporating motifs from First Nations groups

The 1951 artwork, "La Grande Dame (The Cat Woman)," stands over six feet tall and features paintings of "hybrid creatures and lush dreamscapes"

Team Reid Carruthers has started the search for a new second after Derek Samagalski's decision to step back from the Winnipeg-based rink.

The president of the Canadian Japanese Cultural Centre of Hamilton is Mitchell Akira Kawasaki — an Olympian, judo master, on-call mail carrier and recent recipient of an award from the Japanese government.

"Nothing is ever really lost," Megan Fox captioned the post

Increased competition means more options for Delawareans, employers For the second consecutive year, Delawareans will have access to increased options on the Health Insurance Marketplace, Insurance Commissioner Trinidad Navarro announced today, with 57 total plans offered by four insurers. In the 2024 plan year, consumers will have the opportunity to purchase plans from Celtic Insurance […]

In a recent Instagram story, Bhumi Pednekar can be seen pouring a bit of the sauce on her plate at a restaurant. She has also shared several other foodie updates from her Goa trip.

Attorney General Kathy Jennings today announced a $10.25 million 50-jurisdiction settlement with AT&T Mobility, LLC, Cricket Wireless, LLC, T-Mobile USA, Inc., Cellco Partnership, d/b/a Verizon Wireless, and TracFone Wireless, Inc. (collectively, the “Wireless Carriers”), which resolves the state attorneys general investigations into the Wireless Carriers’ deceptive and misleading advertising practices.   “Today’s settlement further demonstrates […]

A container carrying several cars caught fire on the Hyderabad-Mumbai highway today, causing traffic disruptions.

Announced greenfield projects into China plummeted in early 2020 with the US and Europe taking the lion's share of global foreign investment. 

Taron Egerton finds himself in a "Speed"-like Christmas Eve in the trailer for Netflix's "Carry On." Trailer.

washington — The U.S. military said Monday that it had carried out strikes against nine targets associated with Iranian groups in Syria.  In a statement, the U.S. military said the strikes were made against two locations in Syria and were a response to several attacks on U.S. personnel in Syria in the past 24 hours.  The U.S. has occasionally carried out strikes against targets linked to Iran in both Iraq and Syria. In February, the U.S. launched airstrikes in Iraq and Syria against more than 85 targets linked to Iran's Islamic Revolutionary Guard Corps and militias it backs, in retaliation for a deadly attack on U.S. troops.  "These strikes will degrade the Iranian backed groups' ability to plan and launch future attacks on U.S. and coalition forces," the U.S. military said after the most recent strikes.  The U.S. has 900 troops in Syria and 2,500 in neighboring Iraq, on a mission to advise and assist local forces trying to prevent a resurgence of Islamic State, which in 2014 seized large swaths of both countries but was later defeated.  The U.S. has sent warships and fighter aircraft to the region since the Israel-Hamas conflict erupted on October 7, 2023, to try to deter Iran and Iran-backed groups from getting involved in the conflict.  U.S. forces have also helped shoot down projectiles that Iran launched toward Israel this year. 

IQUIQUE, Chile — Over a thousand years ago, the hundreds of giant geoglyphs carved into the desert in northern Chile were a bustling scene. They marked sources of water in the vast arid landscape and were where locals came together to trade skins, animals and fish. Now the carvings are scarred with hundreds of tire tracks from motorcycles and off-road vehicles tearing through the art creations in the landscape and permanently disfiguring them. "It's practically destroyed by motorcycles, off-roaders," said Jose Barraza, general director of the regional national patrimony office. He said various groups were trying to preserve the site to prevent any more destruction - but also without restoring it to its former glory, to show the error of people's ways in the future. "[It] will be an example that shows future generations what not to do with our heritage, no matter how painful or how much anger, discomfort or resentment we feel towards it," he said. Local resident Angelo Araya says the community has been working with a local museum and authorities to try and "put an end to the destruction." The goal, Araya says, is to stop motorcycle and off-road vehicles from damaging the site further and "to make everyone aware that this is not just a heritage site, but that it belongs to all of us." The site has gone through many phases, going from a place to barter, to an abandoned site, to one where people were looking for gold. Eventually Chile's national forests association CONAF turned the area into part of the Pampa del Tamarugal National Reserve. Sand board instructor Franco Diaz said the government should physically close off access to the sites as the geoglyphs are difficult to spot. "If a jeep driver goes behind the hill, he won't notice if there's a geoglyph," Diaz said. "They should close the perimeter and protect these sites that are over 1,000 years old."

Taiwan was on "alert" as it detected a Chinese aircraft carrier to its south on Sunday, the self-ruled island's defense ministry said.

The strikes were in response to attacks on US personnel over the past 24 hours, CENTCOM reported.

Chris Martin has superstitious belief about his deathColdplay frontman, Chris Martin seems to have a superstitious mindset as he fears that he might die in a plane crash one day just like American singer and songwriter, Buddy Holly. Due to this anxiety, Martin has adopted a very unique habit of...

Some of the creeping impacts of this triple crisis are possibly the most debilitating: Africa is the most severely impacted region by desertification and land degradation, with approximately 45% of its land area affected. In the Horn of Africa and the Sahel alone, it imposes food shortages on more than 23 million people. Just last […]

Title: African Chimps Carry Drug-Resistant, Human-Linked Staph
Category: Health News
Created: 8/24/2012 4:05:00 PM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: Black Women at Raised Risk of Carrying Breast Cancer Genes
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: Common Treatment for Early Prostate Cancer May Carry Heart Risk
Category: Health News
Created: 8/25/2017 12:00:00 AM
Last Editorial Review: 8/28/2017 12:00:00 AM

Title: Even a Little Drinking While Pregnant Ups Miscarriage Odds: Study
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM

Title: Cheap, Same-Day Test Could Help Spot Miscarriage Risk
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Antifolates are important for chemotherapy in non–small cell lung cancer (NSCLC). They mainly rely on reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT) to enter cells. PCFT is supposed to be the dominant transporter of the two in tumors, as it operates optimally at acidic pH and has limited transport activity at physiological pH, whereas RFC operates optimally at neutral pH. In this study, we found RFC showed a slightly pH-dependent uptake of antifolates, with similar affinity values at pH 7.4 and 6.5. PCFT showed a highly pH-dependent uptake of antifolates, with an optimum pH of 6.0 for pemetrexed and 5.5 for methotrexate. The Michaelis-Menten constant (K_m) value of PCFT for pemetrexed at pH 7.4 was more than 10 times higher than that at pH 6.5. Interestingly, we found that antifolate accumulations mediated by PCFT at acidic pH were significantly affected by the efflux transporter, breast cancer resistance protein (BCRP). The highest pemetrexed concentration was observed at pH 7.0–7.4 after a 60-minute accumulation in PCFT-expressing cells, which was further evidenced by the cytotoxicity of pemetrexed, with the IC₅₀ value of pemetrexed at pH 7.4 being one-third of that at pH 6.5. In addition, the in vivo study indicated that increasing PCFT and RFC expression significantly enhanced the antitumor efficacy of pemetrexed despite the high expression of BCRP. These results suggest that both RFC and PCFT are important for antifolates accumulation in NSCLC, although there is an acidic microenvironment and high BCRP expression in tumors.

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared with vehicle 0.3 ± 0.1 (P = 0.01) as determined by tissue mass spectrometry imaging analysis. We hypothesized that increased plasma and kidney levels of IDS could be caused by the simultaneous inhibition of both Slc6a19 and a kidney IDS transporter responsible for excretion of IDS into urine. To test this, we first confirmed the formation of IDS through tryptophan metabolism by feeding rats a Trp-free diet. Inhibiting Slc6a19 with RA836 led to increased IDS in these rats. Next, RA836 and its key metabolites were evaluated in vitro for inhibiting kidney transporters such as organic anion transporter (OAT)1, OAT3, and breast cancer resistance protein (BCRP). RA836 inhibits BCRP with an IC₅₀ of 0.045 μM but shows no significant inhibition of OAT1 or OAT3. Finally, RA836 analogs with either potent or no inhibition of SLC6A19 and/or BCRP were synthesized and administered to rats fed a normal diet. Plasma and kidney samples were collected to quantify IDS using liquid chromatography–mass spectrometry. Neither a SLC6A19 inactive but potent BCRP inhibitor nor a SLC6A19 active but weak BCRP inhibitor raised IDS levels, whereas compounds inhibiting both transporters caused IDS accumulation in rat plasma and kidney, supporting the hypothesis that rat Bcrp contributes to the excretion of IDS. In summary, we identified that inhibiting Slc6a19 increases IDS formation, while simultaneously inhibiting Bcrp results in IDS accumulation in the kidney and plasma.

Great God Grove is, in a word, bonkers. I’ve stopped a small community from completing a blood ritual, played the role of matchmaker to a group of lonely hearts that involved organising a date with god, and plastered a statue with paint as part of a revolutionary movement to uplift the power of art. My time with GGG has been a pick n’ mix of colourful escapades, and together with its story of godly woes, striking art style, vacuum-based puzzle-solving, and nightmare-inducing puppet work, I’m now a die-hard LimboLane devotee.

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Imagine pulling up to a refueling station and filling your vehicle’s tank with liquid hydrogen, as safe and convenient to handle as gasoline or diesel, without the need for high-pressure tanks or cryogenic storage. This vision of a sustainable future could become a reality if a Calgary, Canada–based company, Ayrton Energy, can scale up its innovative method of hydrogen storage and distribution. Ayrton’s technology could make hydrogen a viable, one-to-one replacement for fossil fuels in existing infrastructure like pipelines, fuel tankers, rail cars, and trucks.

The company’s approach is to use liquid organic hydrogen carriers (LOHCs) to make it easier to transport and store hydrogen. The method chemically bonds hydrogen to carrier molecules, which absorb hydrogen molecules and make them more stable—kind of like hydrogenating cooking oil to produce margarine.

A researcher pours a sample of Ayrton’s LOHC fluid into a vial.Ayrton Energy

The approach would allow liquid hydrogen to be transported and stored in ambient conditions, rather than in the high-pressure, cryogenic tanks (to hold it at temperatures below -252 ºC) currently required for keeping hydrogen in liquid form. It would also be a big improvement on gaseous hydrogen, which is highly volatile and difficult to keep contained.

Founded in 2021, Ayrton is one of several companies across the globe developing LOHCs, including Japan’s Chiyoda and Mitsubishi, Germany’s Covalion, and China’s Hynertech. But toxicity, energy density, and input energy issues have limited LOHCs as contenders for making liquid hydrogen feasible. Ayrton says its formulation eliminates these trade-offs.

Safe, Efficient Hydrogen Fuel for Vehicles

Conventional LOHC technologies used by most of the aforementioned companies rely on substances such as toluene, which forms methylcyclohexane when hydrogenated. These carriers pose safety risks due to their flammability and volatility. Hydrogenious LOHC Technologies in Erlanger, Germany and other hydrogen fuel companies have shifted toward dibenzyltoluene, a more stable carrier that holds more hydrogen per unit volume than methylcyclohexane, though it requires higher temperatures (and thus more energy) to bind and release the hydrogen. Dibenzyltoluene hydrogenation occurs at between 3 and 10 megapascals (30 and 100 bar) and 200–300 ºC, compared with 10 MPa (100 bar), and just under 200 ºC for methylcyclohexane.

Ayrton’s proprietary oil-based hydrogen carrier not only captures and releases hydrogen with less input energy than is required for other LOHCs, but also stores more hydrogen than methylcyclohexane can—55 kilograms per cubic meter compared with methylcyclohexane’s 50 kg/m³. Dibenzyltoluene holds more hydrogen per unit volume (up to 65 kg/m³), but Ayrton’s approach to infusing the carrier with hydrogen atoms promises to cost less. Hydrogenation or dehydrogenation with Ayrton’s carrier fluid occurs at 0.1 megapascal (1 bar) and about 100 ºC, says founder and CEO Natasha Kostenuk. And as with the other LOHCs, after hydrogenation it can be transported and stored at ambient temperatures and pressures.

Judges described [Ayrton's approach] as a critical technology for the deployment of hydrogen at large scale.” —Katie Richardson, National Renewable Energy Lab

Ayrton’s LOHC fluid is as safe to handle as margarine, but it’s still a chemical, says Kostenuk. “I wouldn’t drink it. If you did, you wouldn’t feel very good. But it’s not lethal,” she says.

Kostenuk and fellow Ayrton cofounder Brandy Kinkead (who serves as the company’s chief technical officer) were originally trying to bring hydrogen generators to market to fill gaps in the electrical grid. “We were looking for fuel cells and hydrogen storage. Fuel cells were easy to find, but we couldn’t find a hydrogen storage method or medium that would be safe and easy to transport to fuel our vision of what we were trying to do with hydrogen generators,” Kostenuk says. During the search, they came across LOHC technology but weren’t satisfied with the trade-offs demanded by existing liquid hydrogen carriers. “We had the idea that we could do it better,” she says. The duo pivoted, adjusting their focus from hydrogen generators to hydrogen storage solutions.

“Everybody gets excited about hydrogen production and hydrogen end use, but they forget that you have to store and manage the hydrogen,” Kostenuk says. Incompatibility with current storage and distribution has been a barrier to adoption, she says. “We’re really excited about being able to reuse existing infrastructure that’s in place all over the world.” Ayrton’s hydrogenated liquid has fuel-cell-grade (99.999 percent) hydrogen purity, so there’s no advantage in using pure liquid hydrogen with its need for subzero temperatures, according to the company.

The main challenge the company faces is the set of issues that come along with any technology scaling up from pilot-stage production to commercial manufacturing, says Kostenuk. “A crucial part of that is aligning ourselves with the right manufacturing partners along the way,” she notes.

Asked about how Ayrton is dealing with some other challenges common to LOHCs, Kostenuk says Ayrton has managed to sidestep them. “We stayed away from materials that are expensive and hard to procure, which will help us avoid any supply chain issues,” she says. By performing the reactions at such low temperatures, Ayrton can get its carrier fluid to withstand 1,000 hydrogenation-dehydrogenation cycles before it no longer holds enough hydrogen to be useful. Conventional LOHCs are limited to a couple of hundred cycles before the high temperatures required for bonding and releasing the hydrogen breaks down the fluid and diminishes its storage capacity, Kostenuk says.

Breakthrough in Hydrogen Storage Technology

In acknowledgement of what Ayrton’s nontoxic, oil-based carrier fluid could mean for the energy and transportation sectors, the U.S. National Renewable Energy Lab (NREL) at its annual Industry Growth Forum in May named Ayrton an “outstanding early-stage venture.” A selection committee of more than 180 climate tech and cleantech investors and industry experts chose Ayrton from a pool of more than 200 initial applicants, says Katie Richardson, group manager of NREL’s Innovation and Entrepreneurship Center, which organized the forum. The committee based its decision on the company’s innovation, market positioning, business model, team, next steps for funding, technology, capital use, and quality of pitch presentation. “Judges described Ayrton’s approach as a critical technology for the deployment of hydrogen at large scale,” Richardson says.

As a next step toward enabling hydrogen to push gasoline and diesel aside, “we’re talking with hydrogen producers who are right now offering their customers cryogenic and compressed hydrogen,” says Kostenuk. “If they offered LOHC, it would enable them to deliver across longer distances, in larger volumes, in a multimodal way.” The company is also talking to some industrial site owners who could use the hydrogenated LOHC for buffer storage to hold onto some of the energy they’re getting from clean, intermittent sources like solar and wind. Another natural fit, she says, is energy service providers that are looking for a reliable method of seasonal storage beyond what batteries can offer. The goal is to eventually scale up enough to become the go-to alternative (or perhaps the standard) fuel for cars, trucks, trains, and ships.

The California-based Middlebury Institute of International Studies published research this week that showed China has constructed a prototype nuclear reactor that could fit aboard a large surface vessel - a sign that China is making progress toward building a nuclear-powered aircraft carrier.

The post Report: China Builds ‘Prototype’ Nuclear Reactor for Aircraft Carrier appeared first on Breitbart.

Tampa Bay Rays shortstop Wander Franco was charged with illegally carrying a gun in his vehicle during the altercation in a parking lot that led to his arrest in the Dominican Republic over the weekend, prosecutors said Tuesday.

Backbone’s holiday lineup for 2023 included updated controllers for the iPhone 15 series and also the first Backbone One Carrying …

Continue reading "Backbone One Carrying Case Review – A Fancy and Excellent Case With One Flaw"

SEOUL - South Korea's military said it will hold a three-day joint exercise with the United States and Japan starting on Wednesday (Nov 13), featuring fighter jets and marine patrol aircraft as well as the US nuclear-powered aircraft carrier USS George Washington. The Freedom Edge exercise is a response to what the South Korean military said were threats from North Korea, which recently conducted an intercontinental ballistic missile test, drawing condemnation from Seoul, Tokyo and Washington. It also comes as the US State Department said North Korean troops have started engaging in combat operations in Russia's war with Ukraine. The exercise will include South Korean and Japanese fighter jets and maritime patrol aircraft, as well as the USS George Washington, Seoul's Joint Chiefs of Staff (JCS) said in a statement. The trilateral exercise follows a first round held earlier this year after the leaders of the three countries agreed at a summit in 2023 to hold annual training drills. Pyongyang has long condemned joint drills between South Korea and the United States, calling them a rehearsal for invasion.

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This HaBO is from Krysty, who wants to find this romance: Hi, I stumbled upon your website yesterday hoping someone will help me find this book. It’s been in my head for over 10 years and I’m beginning to forget. So the book is about a heroine – Marianne or Mary – can’t quite remember, falls in love with a brooding, standoffish hero with a scarred face who stays in the dark in a big … Continue reading HaBO: Yet Another Scarred Hero, Virgin Heroine →

The Dutch Ministry of Finance has announced that companies will be able to more quickly carry back losses they expect to make this year against profits made in 2019.

The Hong Kong Government has gazetted legislation to provide tax concessions for carried interest distributed by eligible private equity funds operating in Hong Kong.

The Hong Kong Government has gazetted legislation to provide tax concessions for carried interest distributed by eligible private equity funds operating in Hong Kong.

A new enzyme that loads up fat-carrying particles in the liver before transporting it to different parts of the body has been discovered by the researchers.

Miscarriage should be recognized as a bereavement, and not as an illness, during the first 6 months of pregnancy, argues psychiatrist Nathan Hodson in

Early reports of what is in next Tuesday’s Federal Budget indicate “more carrot and less stick” to help lift productivity and tighten the fiscal gap.

सर्दियों में खाने और खिलाने का रिवाज बहुत ज्यादा बढ़ जाता है। खासकर गाजर से बनी डिश। सर्दी के मौसम में गाजर के हलवे का टेस्ट को सभी ने लिया होगा। शादी पार्टी से लेकर घर के छोटे फंक्शन

London : Nick Hern Books, 2021.

London : Nick Hern Books, 2021.