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In this episode James and I are in Los Angeles, losing track of time, but enjoying the California sunshine. We chat about our time here, before turning attention to Arsenal's game against Bournemouth on Wednesday, and some of the young players involved – in particular Ethan Nwaneri. As a new star potentially emerges, another departs as it looks like Emile Smith Rowe's time as a Gunner is over – we reflect on how it has come to this point. There's also transfer talk about potential arrivals, some Academy chat, and lots more.

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In this episode I'm joined by The Man from East Lower and Andrew Allen to discuss the final few hours of the transfer window. We chat about the goalkeeping position in light of Aaron Ramsdale's expected departure, how we might replace him, and what it might cost. Then there's discussion of midfield with two out and two in, before attention turns to the attacking end of the pitch. We chat about whether we think Arsenal need to bring somebody in, whether we expect that to happen before Friday's 11pm deadline, and lots more.

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In this episode of the Arsenal Women Arsecast, Tim and Jamie comb through the 2-0 victory at West Ham. Tim and Jamie look at Arsenal's tactical approach and selection and some of the issues with chance creation rearing their head again, question how much has changed and how much change we could expect from Renee Slegers' interim charge and look at the impact of the quadruple substitution early in the second half. In the second half, Tim and Jamie take your questions on the midfield, whether Kafaji should have an increased role now, Steph Catley at centre-back, the goalkeeper situation, whether Arsenal need a 'clean break' with a new manager ASAP and then Tim and Jamie consider Manu Zinsberger's recent LinkedIn post and consider the lines between criticism and abuse.

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The post Beauties of the 1950s – 1970s appeared first on English Russia.

Princeton Jazz Vocal Ensemble, directed by Michelle Lordi, presents a series of jazz pieces from the year 1959.

In addition to his philanthropy, Marcus was an outspoken advocate for free-market capitalism and small businesses.

James Barnor, who has photographed the likes of Muhammad Ali, is being honoured in Accra.

Remembering Rosemary Hollis (1952-2020) News Release sysadmin 12 June 2020

Professor Rosemary Hollis, a highly respected authority on the Middle East, died suddenly last week. Rosy is remembered with great respect and affection, as a colleague and a friend.

In SAS Infrastructure for Risk Management, the message "ERROR: Could not move and link one or more files to..." occurs while running a job-flow instance if an orphaned folder exists in the persistent area.

Equipped with wings and a propeller, Moulton Taylor Aerocar aerobile was capable of taking off from a stoplight or the runway

Watch a selection from the Smithsonian Institution's submission for the UNESCO Memory of the World Register of historic artifacts

By 1953, six years after the Bell X-1 first went supersonic, that airplane and others were routinely flying at more than twice the speed of sound. On December 17, 1953the 50th anniversary of the Wright brothers first powered flight at Kitty HawkMajor Yeager sat down at the Pentagon for an informal press briefing to discuss his own Mach 2.43 flight in the X-1 five days earlier. Video: Department of Defense, Courtesy National Archives and Records Administration

The First State is one giant step closer to being a national leader on transparency.  I’m thrilled that more than a year’s worth of hard work and dedication now means that a statewide body camera program heads to the Governor’s desk. This will mean stronger community relationships, trust, and accountability. This legislation makes Delaware a […]

Delaware- In 2014 the International Association of Chiefs of Police (IACP) initiated the “Drive to Save Lives” campaign to reduce deaths on U.S. highways. The campaign targeted distracted and impaired driving, speeding, the use of seatbelts and the unsafe driving behaviors of operators of large trucks and buses. A combination of education and awareness, partnering with […]

The Delaware Department of Transportation (DelDOT) in partnership with the Delaware State Police announce that beginning Monday, January 17, 2022, the pilot Electronic Speed Safety Program will be active only in the I-95 construction zone in Wilmington and will last until the end of the project. The goal of the pilot program is to reduce […]

The Delaware Department of Transportation (DelDOT) in partnership with the Delaware State Police announce the warning period for the Electronic Speed Safety Program in the I-95 construction zone in Wilmington ends on Sunday, April 17, 2022. Beginning Monday, April 18, 2022, first-time offenders will receive a warning and all subsequent violations will result in a […]

The Delaware Department of Transportation (DelDOT) in partnership with the Delaware State Police announce that beginning Monday, July 8, 2024, the Electronic Speed Safety Program (ESSP) will be active in the I-95/Route 896 construction zone in Newark and will last until the end of the project.

The State of Delaware took a significant step towards a cleaner transportation future today, celebrating its receipt of 14.3 million thanks to the U.S. Environmental Protection Agency’s (EPA) “Climate Pollution Reduction Grant” (CPRG) program. This grant, the result of the Federal Inflation Reduction Act and the Biden-Harris Administration’s Investing in America agenda, will be used to […]

Read the in depth Review of AMD Ryzen 9 5950X Desktop Processor PC Components. Know detailed info about AMD Ryzen 9 5950X Desktop Processor configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Samsung Soundbar HW-Q950A Audio Video. Know detailed info about Samsung Soundbar HW-Q950A configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Dell Latitude 9520 Laptops. Know detailed info about Dell Latitude 9520 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of AMD Ryzen 9 7950X Desktop Processor PC Components. Know detailed info about AMD Ryzen 9 7950X Desktop Processor configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of AMD Ryzen 9 7950X3D Desktop Processor PC Components. Know detailed info about AMD Ryzen 9 7950X3D Desktop Processor configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of TP-Link Archer AXE95 AXE7800 Tri-Band Wi-Fi 6E Router Networking. Know detailed info about TP-Link Archer AXE95 AXE7800 Tri-Band Wi-Fi 6E Router configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of MSI Titan GT77 HX 13VI 13th Gen Core i9-13950HX Laptops. Know detailed info about MSI Titan GT77 HX 13VI 13th Gen Core i9-13950HX configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

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Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

Kelley's cat tosses a coin to The Witcher. Chris finds out there's just too many pigs. And Josh goes to Reddit, but all he finds is a meme.

The post RPG Cast – Episode 595: “I’m With the PS5, I Don’t Like Your Range Extender” appeared first on RPGamer.

Sam wants two things, coke and nuggs. Robert hails the hypnobooty. Ryan has to go recruit more Ryans. And Chris commissions a new Sesame Street horror adventure. Guard your eyes.

The post RPG Cast – Episode 695: “Jason Statham Is the Best Dinosaur” appeared first on RPGamer.

Square Enix has revealed the lifetime sales for two of its biggest franchises Final Fantasy and Dragon Quest.

The Final Fantasy series has now sold over 195 million units worldwide and the Dragon Quest series has sold over 91 million units worldwide.

"The Square Enix Group also boasts a valuable portfolio of intellectual property including: Final Fantasy, which has sold over 195 million units worldwide; Dragon Quest, which has sold over 91 million units worldwide; and the legendary Space Invaders," said Square Enix.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463021/final-fantasy-series-sales-top-195m-dragon-quest-series-tops-91m/

Torrential rain, made worse by climate change, has lashed Spain, with Valencia bearing the brunt of the floodwaters

During a March 28 meeting with Assistant Secretary or South and Central Asian Affairs Boucher, Foreign Minister-designate Shah Mehmood Qureshi confirmed that the new government wanted to work with the U.S. to combat extremism, increase trade and extend cooperation with India and Afghanistan.

Even with support from the government, serious threats against Bhutto will persist.

Between August 2006 and July 2007, we received a claim for 26 million USD in barbed wire and pickets. While these items are no doubt helpful in protecting outposts, the claim figures are highly suspect.

The Est�e Edit by Estee Lauder brand video with Guest Editors Kendall Jenner and Irene Kim

Introducing the new Pivotal Living Smart Scale, which tracks five key metrics including Weight, Lean Body Mass, Body Fat Percentage, Basal Metabolic Rate (BMR) and Body Mass Index (BMI).

VolitionRx�s Nucleosomics� diagnostic platform detects epigenetic changes to fragments of chromosomes, called nucleosomes, that circulate in the blood of cancer patients. Credit: VolitionRx.

Sara Little Turnbull used materials science to invent and design products for the modern world

Who or what is your most exceptional hospitality icon? That was the question posed by Hotelschool The Hague as it marked its 95th anniversary, inviting industry professionals, students, employees, and alumni to join in celebrating the people and objects that shape the world of hospitality.

Jack Dorsey’s Block (the company formerly known as Square) announced today that it is releasing its hardware Bitcoin wallet, Bitkey, in 95 countries. However, users can only preorder the device at the moment, with shipping starting in early 2024. The device will cost $150 USD. Block’s pitch to Bitcoin holders is that using a self-custodial […]

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1. Mercedes Benz AMG C63 S E Performance Sedan Launched In India At Rs. 1.95 Crore  CarToq.com
2. Mercedes-AMG C 63 S E Performance Launched At Rs 1.95 Crore  NDTV
3. Top News of Nov 12: Market crash; Air India-Vistara merger; Nykaa Q2 results; CISF first-ever all-women battalion; more  Mint
4. Mercedes-AMG C63 SE Performance launched with world's most powerful 4-cylinder engine!  The Times of India
5. Mercedes AMG C63S E Performance Launch Price Rs 1.95 Cr - 680bhp, 1020Nm, 0-100 3.4s  RushLane

জীবনের সবচেয়ে বড় ফাড়া কাটিয়ে সুস্থতার পথে বলিউড অভিনেত্রী সুস্মিতা সেন। কয়েকদিন আগে হার্ট অ্যাটাকের শিকার হয়েছিলেন অভিনেত্রী। সেই খবর তিনি নিজেই সোশ্যাল মিডিয়ায় শেয়ার করেছিলেন। খবরটি শুনেই দিশেহারা হয়ে উঠে ছিলেন ভক্তরা। অভিনেত্রী সম্প্রতি একটি লাইভ শেয়ার করে তার

ಐಟೆಲ್ (Itel) ತನ್ನ ಅಭಿಮಾನಿಗಳಿಗೆ ಸರ್ಪ್ರೈಸ್ ಗಿಫ್ಟ್ ನೀಡಿದೆ. ಸದ್ದಿಲ್ಲದೆ ಎರಡು ಹೊಸ ಮೊಬೈಲ್‌ಗಳನ್ನು ಬಿಡುಗಡೆ ಮಾಡಿದೆ. ಅದೂ ಅಗ್ಗದೆ ಬೆಲೆಗೆ ಎನ್ನುವುದು ವಿಶೇಷ. ಹೌದು, ಕಂಪನಿಯು ತನ್ನ S25 ಸರಣಿಯನ್ನು ಅನಾವರಣಗೊಳಿಸಿದೆ. ಇದರಲ್ಲಿ ಐಟೆಲ್ S25 (Itel S25) ಮತ್ತು ಐಟೆಲ್ S25 ಅಲ್ಟ್ರಾ (itel S25 Ultra) ಫೋನ್‌ಗಳು ಮಾರುಕಟ್ಟೆಗೆ ಲಗ್ಗೆ ಇಟ್ಟಿವೆ. ಇವೆರಡೂ

വിൻ-വിൻ ഭാ​ഗ്യക്കുറിയുടെ നറുക്കെടുപ്പ് ഫലം ഇന്ന് പ്രഖ്യാപിച്ചു. ഇന്ന് തിരുവനന്തപുരം ബേക്കറി ജം​ങ്ഷന് സമീപമുള്ള ഗോർക്കി ഭവനിൽ വെച്ചാണ് വിൻ-വിൻ W 795 ലോട്ടറിയുടെ ഇന്നത്തെ ഭാ​ഗ്യശാലികളെ കണ്ടെത്തിയത്. ഈ ആഴ്ചയിലെ നറുക്കെടുപ്പിലൂടെ വിൻ-വിൻ W 795 ലോട്ടറിയുടെ 75 ലക്ഷം നേടുന്നത് കാസർഗോഡുള്ള WS 590871 ഈ നമ്പറിലുള്ള ഭാ​ഗ്യശാലിക്കാണ്. താഴെ കൊടുത്ത നറുക്കെടുപ്പ് ഫലം നോക്കിയാൽ

German luxury carmaker Mercedes has launched the Mercedes-AMG C 63 S E-Performance sedan in India. The Mercedes-AMG C 63 S E-Performance is priced at Rs 1.95 crore (ex-showroom) and is the 14th and final product launch for the German marque for

Abingdon, Oxon ; New York : Routledge, 2012.