Tottenham have been compared to Stoke sides of the past after their loss to Chelsea.

Coca-Cola European Partners is issuing precautionary advice for opening Coca-Cola Original Taste 1.5 litre PET bottles because the bottles may have damaged neck rings which means that the bottle mi

A DOG was thrown over a bridge into a river to drown in Romania during the coronavirus lockdown, an animal charity has revealed.

Manchester United have made Jude Bellingham one of their top transfer targets, although the Red Devils face competition from Liverpool and Manchester City to sign the Birmingham City star.

The PDC Home Tour sees the world's leading darts players battle it out from their homes and Express Sport is on hand with the latest schedule and results.

FOLLOWING the Windrush scandal the NHS says that its records will no longer be used to track down illegal immigrants.

Marathon Oil Corporation designs, delivers and maintains strategic and complex assets for its customers across the global energy and related sectors. Marathon Oil Corporation career is not just a job. It's an extraordinary opportunity to help create the future of energy. No matter what type of

MRS HINCH - aka Sophie Hinchcliffe - is an Instagram cleaning sensation who has inspired millions over the past year to clean their homes. She reveals cheap and quick cleaning hacks online to help people speed clean their homes. A fan has recently revealed a quick hack on how to remove hair and dust from carpets with easy to follow steps.

Nothing better illustrates than the EAT-Lancet Commission on Food, Planet, Health, the relentless appetite for state control and removal of personal choice that exists as much in academic circles as political ones. The report's contents are even more indigestible than its title.

It's the Caption Competition.

Caption competition is now closed. Full rules can be seen here [PDF].

This week, a new look is unveiled.

6. trisarahtops:
Catwalk face-off

5. StoneyMast:
We come, with our new look, in peace. Take me to your leader

4. George Huber:
Mannequin Skywalker

3. abz:
Terracotta Armani

2. Fi:
After 35 years, someone finally designed a collection to cover Morph's modesty...

1. SkarloeyLine:
Eighth new social class discovered - the faceless minority

Reiner directed the movie "LBJ," which was being screened at the film festival.

It may not be out on the asphalt, but Robert Wickens is energized to be back competing against the IndyCar paddock this weekend.

Avon grad among four local transfers trying to become starting QBs

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

Lahey'deki Uluslararası Tahkim Mahkemesi, hem hükümetin hem de güneydeki özerk yönetimin hak iddia ettiği petrol zengini Abyei bölgesinin sınırlarının hükümet lehinde değişmesini kararlaştırdı.

Annapolis, Maryland

"I don't care where he was born. I just wish he would do something abut gas [petrol] prices," a man in Chick and Ruth's diner on the main street of Annapolis in the US state of Maryland told me.

That is the sort of reaction President Barack Obama hopes for. His message is that the fuss about where he was born is bemusing, puzzling, silly and a "sideshow" distracting from the huge economic issues facing America.

But Mr Obama had to kick over the sideshow if the customers at the diner were anything to go by. Most people I spoke had a hazy perception that there was something slightly untrustworthy about the document released by the Obama campaign two and a half years ago. Most thought this had dragged on far too long and deserved to be cleared up.

The argument that Mr Obama isn't eligible to be US president because he wasn't born in the US was once thought to be the preserve of the political fringes, those whose "birther" nickname equates them with the "truthers" who believe 9/11 was carried out by the US government.

But it was plonked centre stage by potential Republican candidate, billionaire property developer and TV star Donald Trump, who has said several times that he doubts Mr Obama was born in Hawaii and that he has put private detectives on the case.

Mr Trump was in New Hampshire today doing multiple stops in this key state. Mr Obama's press conference both stymies his big day and gives him even more publicity. Mr Obama's aim must be to make him look deeply unserious.

Many Obama supporters feel racism motivates the birthers - disbelief that a black man can be an American president. Some birthers are opponents who hate his values so much they think he must be un-American literally as well as metaphorically.

But there's no doubt his team has handled this appallingly.

They have today released the full birth certificate. In 2008 they released a "certification of live birth". The White House communications director writes:

When any citizen born in Hawaii requests their birth certificate, they receive exactly what the president received. In fact, the document posted on the campaign website is what Hawaiians use to get a driver's license from the state and the document recognised by the federal government and the courts for all legal purposes. That's because it is the birth certificate.

That appears to be true, and the Hawaiian authorities were apparently reluctant to publish the full thing. But what could be more delicious to conspiracy theorists than the existence of an unseen document that apparently the authorities were keen to keep from the full public gaze?

In Chick and Ruth's I found a full variety of views about the issue. A waitress said it was crazy that anyone ever doubted when Mr Obama was born, an older man still thought that his president may have been born in Kenyan and wanted to study the document. A younger man had no real doubts but thought this was overdue.

It may not go away. I have already had one e-mail from someone who said he had no interest in were Mr Obama was born but claimed the new document had been doctored.

But one thing is very clear. I was in Annapolis filming a story on the economy, and nearly every customer I spoke to ended up talking, unprompted, about the price of petrol. That was the real issue for them. Like the president, they regarded anything else as a sideshow, albeit an entertaining one.

Mike Conley is Tamika Catchings' first-round opponent in the NBA's HORSE event on ESPN; competitors will remain separated

Life changed for Avon High School alum Jesse Kramer in June, when he made his TV network debut on "The Four: Battle for Stardom."

Cats and dogs, get ready for take off! The world's first airline for pets has been launched in the United States.

It's illegal to leave a pet outside in Indianapolis when temperatures drop below 20 degrees Fahrenheit or during a wind chill advisory.

Former South Bend, Indiana, mayor and former Democratic hopeful for president Pete Buttigieg responded to the shooting of Dreasjon Reed.

James Maddison backs up his trash-talk while Irish international team-mates John Egan and Aaron Connolly compete against each other in the Premier League Fifa invitational.

With streaming services now established, is it time we started speaking of YouTube or Netflix in the same breath as the BBC or Sky?

TidalWave Productions is releasing Buttigieg and Bloomberg comic books to sit alongside its Warren biography.

Six teams are on a bye this week, giving stars like Saquon Barkley, Odell Beckham Jr., Andrew Luck, Zach Ertz and A.J. Green the week off. Here are three players that could have big games in their stead.

The small town mayor is raking in some cash from A-list donors.

You know about Beto O'Rourke on the guitar, of course, but what about Bernie Sanders's spoken-word album?

New cuts are actually expansions, according to Mike Pence.

OLX Brazil, the 50/50 joint venture between Naspers-owned Prosus and Adevinta, which is owned by Norway’s Schibsted, will buy its competitor Grupo Zap in a deal worth almost R10 billion.

What happens when memers meet the subject of their memes? In the case of the BA Test Kitchen meeting the brains behind @meme_appetit, pure gold. Harry Kersh and Will Martin started the accounts when they discovered their shared love of BA videos, and the Instagram and Twitter accounts have since taken off. 

Now with almost 400,000 followers on Instagram, the account has a lot of fans — including some members of the test kitchen. In this video, the BA cooks explain why they love (or dislike) some of the account's memes, whether it's accurate, and whether they even "get it." Watch them react to various memes and Kersh and Martin attempt to explain their reasoning behind them. Read more...

Yesterday saw the online premier of a mini-episode of a new animated comic series based on the classic Gilbert Shelton underground comic, the Fabulous Furry Freak Brothers. As a hippie wannabe teen in the 70s, this (and Zap! Comics) was everything to me.

In 1969, life in San Francisco consists of free love, communal living, and political protest. Freewheelin’ Franklin Freek (Harrelson), Fat Freddy Freekowtski (Goodman), Phineas T. Phreakers (Davidson) and their mischievous, foul-mouthed cat, Kitty (Haddish) spend their days dodging many things —- the draft, the narcs, and steady employment -– all while searching for an altered state of bliss.

But after partaking of a genetically-mutated strain of marijuana, the Freaks wake up 50 years later to discover a much different society. Quickly feeling like fish out of water in a high-tech world of fourth-wave feminism, extreme gentrification and intense political correctness, the Freaks learn how to navigate life in 2020 -— where, surprisingly, their precious cannabis is now legal.

OK, sounds good. But is it? If the reaction to the first mini-episode is any indication, maybe the Freaks should have remained in their drug-induced coma. As one Facbooker commented: "Get yourself a collected set of the original comic and skip this drivel!"

Read the rest

Peter Kay’s Car Share Synopsis Peter Kay’s Car Share is a situation comedy television series produced by BBC One that premiered in April of 2015. Peter Kay’s Car Share follows the story of John (played by Peter Kay), an assistant manager in a supermarket and his co-worker and promotions rep Kayleigh (played by Sian Gibson). […]

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

Type IV filaments (T4F), which are helical assemblies of type IV pilins, constitute a superfamily of filamentous nanomachines virtually ubiquitous in prokaryotes that mediate a wide variety of functions. The competence (Com) pilus is a widespread T4F, mediating DNA uptake (the first step in natural transformation) in bacteria with one membrane (monoderms), an important mechanism of horizontal gene transfer. Here, we report the results of genomic, phylogenetic, and structural analyses of ComGC, the major pilin subunit of Com pili. By performing a global comparative analysis, we show that Com pili genes are virtually ubiquitous in Bacilli, a major monoderm class of Firmicutes. This also revealed that ComGC displays extensive sequence conservation, defining a monophyletic group among type IV pilins. We further report ComGC solution structures from two naturally competent human pathogens, Streptococcus sanguinis (ComGCSS) and Streptococcus pneumoniae (ComGCSP), revealing that this pilin displays extensive structural conservation. Strikingly, ComGCSS and ComGCSP exhibit a novel type IV pilin fold that is purely helical. Results from homology modeling analyses suggest that the unusual structure of ComGC is compatible with helical filament assembly. Because ComGC displays such a widespread distribution, these results have implications for hundreds of monoderm species.

8 January 2020 , Volume 96, Number 1

6 November 2019 , Volume 96, Number 1

The first issue of International Affairs in 2020 explores the geopolitics of the 'Indo-Pacific' region.

7 November 2019

The current dispute between the US and China goes far beyond trade tariffs and tit-for-tat reprisals: the underlying driver is a race for global technological supremacy. This paper examines the risks of greater strategic competition as well as potential solutions for mitigating the impacts of the US–China economic confrontation.

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

Research Event

Expert

Expert

7 November 2019

The current dispute between the US and China goes far beyond trade tariffs and tit-for-tat reprisals: the underlying driver is a race for global technological supremacy. This paper examines the risks of greater strategic competition as well as potential solutions for mitigating the impacts of the US–China economic confrontation.

8 January 2020 , Volume 96, Number 1

6 November 2019 , Volume 96, Number 1

The first issue of International Affairs in 2020 explores the geopolitics of the 'Indo-Pacific' region.

euromicron AG, a medium-sized technology group and specialist for the digital support of business processes through secure infrastructures, is pooling its digital expertise at KORAMIS GmbH, the group subsidiary that specializes in cyber security and automation. With focus on digital platforms and services KORAMIS’ portfolio will also cover the areas Smart IoT, Smart Building as well as Data Management in the future. For this step the management of KORAMIS GmbH was extended by Andreas Schmidt.