CNA Staff, May 5, 2020 / 03:01 pm (CNA).- At least 51 workers have been infected with the novel coronavirus at the Grasberg mine in Indonesia, the world’s largest gold mine.

Nine employees of Freeport McMoRan, the organization who operates the mine, have been hospitalized due to COVID-19 and another 42 have been forced into quarantine, UCA News reported May 5.

The mine is located in Papua and is known for its production of gold and copper. The operation includes around 20,000 employees.

Riza Pratama, vice president of Freeport, said the company will fully cooperate with the government's coronavirus task force but will continue mining operations to support the national economy. He said the company will prioritize the health and safety of workers and will conduct regular health screenings, implement social distancing, provide a quarantine area for employees, according to UCA News.

Father Ansel Amo, who heads the Justice, Peace, and Integrity of Creation Commission for the Archdiocese of Merauke, said these measures are not enough to protect workers.

“Freeport management should limit workers’ activities so that they don’t transmit the disease to other people, including local people. They should stop its operations temporarily,” he told UCA News.

Indonesia has seen more than 12,000 cases from the coronavirus, leading to 872 reported deaths as of May 5. Globally, more than 3.7 million cases of the virus have been reported, and a quarter of a million deaths.

OBJECTIVES:

Reduce postoperative hypothermia by up to 50% over a 12-month period in children’s hospital NICUs and identify specific clinical practices that impact success.

ANDY MURRAY may need to have another operation as he continues his bid to return to top-level tennis.

VE DAY in 1945 was obviously an occasion for major celebration in Britain and throughout Europe. But there is reasonable debate as to what we should make of it now.

Recent studies have called into question the benefit of perioperative corticosteroids in children undergoing heart surgery, but have been limited by small sample size, the lack of placebo control, and the grouping of various steroid regimens together in analysis.

We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates and found no mortality or length-of-stay benefit associated with any regimen, and a higher risk of infection in certain subgroups. (Read the full article)

Previous observational studies and randomized trials have reported an association between the use of epidural analgesia for pain relief in labor and intrapartum maternal fever. Studies have also reported an increase in adverse neonatal outcomes with intrapartum maternal fever.

Among low-risk women receiving epidural analgesia, intrapartum maternal temperature >99.5°F was associated with adverse neonatal outcomes, with the rate of adverse outcomes increasing directly with maximum maternal temperature. Without temperature elevation, epidural use was not associated with adverse neonatal outcomes. (Read the full article)

Disparities are known to exist in the prescription of opioid analgesics among racial and ethnic groups in the management of postoperative, cancer, and emergency department pain in patients across all ages, including children.

Race is associated with an unequal burden of perioperative pain and opioid adverse effects in children. Relatively, African American children had higher postoperative pain, and Caucasian children had higher incidences of opioid related adverse effects. (Read the full article)

Although previous studies indicate that perinatal factors are associated with altered neurodevelopment, data on the association between ischemic-hypoxic conditions and attention-deficit/hyperactivity disorder in children are sparse.

This study demonstrates that preeclampsia, birth asphyxia, and respiratory distress syndrome are independently associated with increased risk of attention-deficit/hyperactivity disorder in a large population-based study. (Read the full article)

Several studies have shown that behavioral problems can be associated with defecation and voiding disorders, although few studies have looked directly at a link between a diagnosis of attention-deficit/hyperactivity disorder (ADHD) and constipation or fecal incontinence.

We identified an increased risk for both constipation and fecal incontinence in children with ADHD. In patients with concomitant ADHD and defecation disorders, more aggressive medical and behavioral treatment of the constipation or fecal incontinence may be warranted. (Read the full article)

Although providing improved survival for infants with very severe cardiorespiratory problems, the use of neonatal extracorporeal membrane oxygenation has high rates of disability in survivors. Mild hypothermia has been shown to limit brain injury in a range of patient groups, including newborns.

Infants who received extracorporeal membrane oxygenation and mild hypothermia did not show an improved neurodevelopmental outcome, and nonsignificant trends in the data suggested a small adverse effect. Use of hypothermia in other potential patient groups should be thoroughly tested. (Read the full article)

Attention-deficit/hyperactivity disorder (ADHD) is the most common mental health condition diagnosed in childhood, is highly heritable, and more common in boys. Although studies have identified perinatal risk factors, no one has investigated perinatal risk factors separately in boys and girls.

Contrary to other studies, low birth weight, postterm pregnancy, low Apgar scores, and fetal distress were not risk factors for ADHD irrespective of gender. Early term deliveries increased the risk of ADHD, and oxytocin augmentation in girls may be protective. (Read the full article)

Tonsillectomy is one of the most commonly performed surgeries in children and is one of the most cumulatively expensive conditions in pediatric hospital care. Little is known about how the quality of tonsillectomy care varies across hospitals.

In a large cohort of low-risk children undergoing same-day tonsillectomy, there was substantial variation in quality measures of process, dexamethasone and antibiotic use, and outcome, revisits to the hospital within the first 30 days after surgery. (Read the full article)

Approximately 50% of children diagnosed with attention-deficit/hyperactivity disorder (ADHD) at <7 years of age in the community do not meet criteria for ADHD over time. There is a need to examine predictors of diagnostic stability in young children with ADHD.

Predictors of diagnostic stability from early to middle childhood include child’s baseline externalizing and internalizing symptoms, parental history of psychopathology, and socioeconomic status. These predictors may guide treatment planning at the time of ADHD diagnosis. (Read the full article)

Up to 50% of children with attention-deficit/hyperactivity disorder (ADHD) meet criteria for a comorbid anxiety disorder. Despite the high prevalence of anxiety in these children, the impact of anxiety on the lives of children with ADHD has been largely overlooked.

Presence of ≥2 anxiety comorbidities in children with ADHD was associated with poorer child quality of life, daily functioning, and behavior. Multiple anxiety comorbidities were associated with poorer functioning for children with both ADHD-Inattentive and ADHD-Combined presentation. (Read the full article)

Sleep disorders are common in children and adolescents and have a substantial negative impact on daily life and school performance. Long-term evaluations of the efficacy and safety of pharmacologic treatment options for sleep disorders are lacking in pediatric patients.

These 2 studies provide the first evaluation of the effectiveness and safety of eszopiclone in children and adolescents with insomnia associated with ADHD. Data presented here encompass longer-term (up to 1 year) pediatric exposure to eszopiclone. (Read the full article)

Heart rate (HR) increases with increasing body temperature. Previous studies have characterized the relationship among HR, age, and temperature for patients in primary care and emergency department settings but not in hospitalized children.

Our data demonstrate an overall increase in HR by ~10 beats/minute for each 1°C increase in body temperature. Expected heart rates for hospitalized children differ from those for primary care and emergency department patients at the same age and temperature. (Read the full article)

Clinical pain assessment methods in youth are vulnerable to underestimation bias and underrecognition. Facial expressions are sensitive, specific biomarkers of the presence and severity of pain. Computer vision–based pattern recognition enables measurement of pain-related facial expressions from video.

This study demonstrates initial validity for developing computer vision algorithms for automated pain assessment in children. The system developed and tested in this study could provide standardized, continuous, and valid patient monitoring that is potentially scalable. (Read the full article)

Tonsillectomy guidelines make evidence-based recommendations for the perioperative use of dexamethasone, no routine use of antibiotics, and discharge education of families and for surgeons to monitor bleeding complication rates. The impact of the guidelines on processes and outcomes is unknown.

The guidelines were associated with improvement in perioperative care processes but no improvement in outcomes. Perioperative dexamethasone use increased slightly, and antibiotic use decreased substantially. Bleeding rates were stable, but revisit rates for complications increased because of revisits for pain. (Read the full article)

Infants born very prematurely or with a very low birth weight are known to have an increased risk of attention-deficit/hyperactivity disorder (ADHD). Results concerning late preterm children are controversial and studies examining fetal growth represented by weight for gestational age are scarce.

We demonstrate that each declining week of gestation increases the risk of ADHD. Also, late preterm infants have an increased risk. Furthermore, as weight for gestational age becomes smaller than 1 SD below the mean, the risk of ADHD increases. (Read the full article)

Many studies have suggested that autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are commonly co-occuring neurodevelopmental conditions.

In children with co-occurring ASD and ADHD, an initial ADHD diagnosis may be associated with delayed ASD diagnosis and a higher likelihood of ASD diagnosis older than 6 years of age. Clinicians should consider ASD when evaluating young children presenting with ADHD symptoms. (Read the full article)

Sleep disturbances in infants associate with individual differences in temperament. However, little is known about interindividual differences and potential moderating factors, such as genotype.

The results suggest that the cumulative effect of total sleep duration during the first 3 years of life on temperament is moderated by child 5-HTTLPR genotype following a differential susceptibility model. (Read the full article)

The National Sustainable Structures Center of Pennsylvania College of Technology, the mid-Atlantic administrator of the Building Operator Certification, will offer two BOC Level I courses at a 75% discount made possible by a grant from the Pennsylvania Department of Environmental Protection.

Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams. In an observational study, unbound piperacillin concentrations (n=196) were assessed in 78 critically ill patients following continuous infusion of piperacillin/tazobactam (ratio 8:1). The initial dose of 8, 12 or 16 g (piperacillin component) was determined by individual creatinine clearance (CRCL). Piperacillin concentrations were compared to the EUCAST clinical breakpoint MIC for Pseudomonas aeruginosa (16 mg/L), and the following PK/PD targets were evaluated: 100% fT>1xMIC and 100% fT>4xMIC. A population pharmacokinetic model was developed using NONMEM 7.4.3 consisting of a one-compartment disposition model with linear elimination separated into non-renal and renal (linearly increasing with patient CRCL) clearances. Target attainment was predicted and visualized for all individuals based on the utilized CRCL dosing algorithm. The target of 100% fT>1xMIC was achieved for all patients based on the administered dose, but few patients achieved the target of 100% fT>4xMIC. Probability of target attainment for a simulated cohort of patients showed, that increasing the daily dose by 4 g increments (piperacillin component) did not result in substantially improved target attainment for the 100% fT>4xMIC target. To conclude, in patients with high CRCL combined with high-MIC bacterial infections, even a CI regimen with a daily dose of 24 g may be insufficient to achieve therapeutic concentrations.

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicentre trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90ms mean QTc-prolongation per 100ng/mL increase in piperaquine concentration. The effect of piperaquine on absolute QTc-interval estimated a mean maximum QTc-interval of 456ms (EC₅₀=209ng/mL). Simulations from the pharmacokinetic-pharmacodynamic models predicted 1.98-2.46% risk of having QTc-prolongation > 60ms in all treatment settings. Although piperaquine administration resulted in QTc-prolongation, no cardiovascular adverse events were found in these patients. Thus, the use of dihydroartemisinin-piperaquine should not be limited by this concern.

BACKGROUND AND OBJECTIVES:

Annual incidence of venous thromboembolism (VTE) including postoperative VTE in hospitalized children is rising significantly. A growing body of evidence supports the role of red blood cells (RBCs) in pathologic thrombosis. In this study, we examined the association of perioperative RBC transfusion with postoperative VTE in pediatric patients.

Emilee Yaeger, an undergraduate student in the Science BS/MBA accelerated joint degree program, has been selected as the recipient of the 2019 Eberly College of Science Cooperative Education Student of the Year Award. The award recognizes the student’s academic achievements and contributions to the participating employer, the University, the community, and the field of cooperative education.

As scheduled, trial operations began at the Airport Berlin Brandenburg, BER, on 30 April with around 280 employees.

Lebanon’s Ministry of Telecommunications has been authorized by the Cabinet to temporarily operate the country’s two cellular networks until a new tender is launched, Minister of Telecommunications Talal Hawat said Tuesday.

Other defendants convicted on murder, manslaughter, weapons, and drug charges Three men at the helm of a massive drug dealing enterprise were sentenced to prison in Superior Court. Dwayne White, 36, of Wilmington, Eric Lloyd, 40, of New Castle, and Damon Anderson, 40, were convicted of numerous charges in June for their roles in the […]

JK Tyre has resumed partial operations in India after adhering to the guidelines laid down by the government and getting permissions from local and state authorities.

While few auto component manufacturers in the green zone are planning to restart operations, others operating in orange zones are seeking permission to resume their work again. Needless to say, those...

Volkswagen and Northvolt formed a strategic alliance last year for making lithium-ion batteries on a larger scale in Germany. The joint venture seems to be getting a further momentum wherein...

Post the NTO implementation, the dynamics have tilted in favour of the broadcasters.

"India is at the onset of a brand revolution where, in the coming decade, I hope homegrown brands will make it to the top," says JB Singh, President and CEO, InterGlobe Hotels

Success in today’s digital-first world depends on a marketing organisation’s ability to create and activate hyper-relevant, data-driven and omnichannel customer experiences, says Nikki Mendonca.

Delaware One Stop is a convenient, centralized transactional platform created to help business owners work through the necessary steps to begin operation in Delaware.

DOVER, Del. – The steady increase in daily temperatures has spurred spotted lanternfly nymphs to hatch out of their egg masses. While the hatching will continue for the next few weeks, this causes concern for businesses, residents, and the agriculture industry because this notorious hitchhiker will be on the move. “From the time we enacted […]

The Delaware Department of Agriculture has partnered with the Delaware Electric Cooperative to launch a new irrigation grant program to help Delaware farmers install environmentally friendly irrigation systems.

Agency: HSS Closing Date: 5/27/2020

DOVER – La División de Salud Pública de Delaware (DPH, por sus siglas en inglés) ha confirmado once casos de paperas asociados a un brote entre las personas que asistieron a dos diferentes bailes mexicanos en el condado de New Castle. Siete de los casos confirmados asistieron, o viven con personas que asistieron, al evento […]

As many Delawareans head outside for Fourth of July festivities, the Division of Public Health (DPH) encourages Delaware residents to prepare for extreme heat early this week and prevent heat-related illness as temperatures rise. Temperatures are expected to reach the mid-90s through Tuesday, with the heat index values as high as 105 degrees.

NEW CASTLE (Jan. 30, 2019) With Delaware facing the coldest temperatures of the winter from Wednesday night through Thursday, Code Purple is being declared across the state by the nonprofit and volunteer organizations that operate the shelters to keep people who are homeless safe during dangerous winter weather. When severe snowstorms or sub-zero temperatures are […]

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind. To that end, all public facing buildings that deliver various services will be going cashless across the State, including toll plazas and all Division of Motor Vehicle locations, effective Tuesday, March 17, 2020.

At DelDOT's four DMV locations, only credit or debit cards will be accepted, and the Department continues to urge all customers to utilize mydmv.delaware.gov which offers more than 20 services online, including renewal of Delaware Driver License/ID, renewing vehicle registration, and changing your home address. [More]

Wilmington --

Due to the presence of Coronavirus (COVID-19) in Delaware, business closures, reductions in staffing and lower ridership levels, effective Wednesday, March 18, DART public transit services will operate on the following reduced service schedule until further notice. On weekdays, regular fixed route services will operate on a Saturday service schedule statewide, with additional service on Routes 15, 18, 43 and 301. DART's regularly scheduled weekend service will operate normal service levels. [More]

Dover --

The Delaware Department of Transportation (DelDOT) continues to review operational needs while keeping the health and safety of our employees and customers in mind.

Effective Tuesday, March 17, 2020 at 6:00pm, the Biden Welcome Center on I-95 in Newark will temporarily close to the public as efforts continue to limit crowds from gathering in response to the Coronavirus. Fuel will still be available at the gas station located on the north side of the property and bathroom facilities in the convenience store will also be available to motorists. [More]

Wilmington --

UPDATE - In addition to the service outlined below, starting Thursday, March 19, Route 301 will add the weekday roundtrip leaving Wilmington at 4:20 AM, arriving in Dover at 5:42 AM; and then leaving Dover at 6:00 AM, arriving in Wilmington at 7:41 AM. Route 303 will be operating the weekday schedule. In Sussex County, Route 206 will operate on the normal weekday schedule. [More]