Davide Gabrielli, Ida Germana Minelli.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 558--585.

Abstract:
Stochastic monotonicity is a well-known partial order relation between probability measures defined on the same partially ordered set. Strassen theorem establishes equivalence between stochastic monotonicity and the existence of a coupling compatible with respect to the partial order. We consider the case of a countable set and introduce the class of finitely decomposable flows on a directed acyclic graph associated to the partial order. We show that a probability measure stochastically dominates another probability measure if and only if there exists a finitely decomposable flow having divergence given by the difference of the two measures. We illustrate the result with some examples.

Christian Rau.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 549--557.

Abstract:
We revisit a shape inversion formula derived by Panaretos in the context of a particle density estimation problem with unknown rotation of the particle. A distribution is presented which imitates, or “fakes”, the uniformity or Haar distribution that is part of that formula.

Christian Olivera, Ciprian Tudor.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 520--531.

Abstract:
Via a special transform and by using the techniques of the Malliavin calculus, we analyze the density of the solution to a stochastic differential equation with unbounded drift.

Rosineide F. da Paz, Narayanaswamy Balakrishnan, Jorge Luis Bazán.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 455--479.

Abstract:
Tadikamalla and Johnson [ Biometrika 69 (1982) 461–465] developed the $L_{B}$ distribution to variables with bounded support by considering a transformation of the standard Logistic distribution. In this manuscript, a convenient parametrization of this distribution is proposed in order to develop regression models. This distribution, referred to here as L-Logistic distribution, provides great flexibility and includes the uniform distribution as a particular case. Several properties of this distribution are studied, and a Bayesian approach is adopted for the parameter estimation. Simulation studies, considering prior sensitivity analysis, recovery of parameters and comparison of algorithms, and robustness to outliers are all discussed showing that the results are insensitive to the choice of priors, efficiency of the algorithm MCMC adopted, and robustness of the model when compared with the beta distribution. Applications to estimate the vulnerability to poverty and to explain the anxiety are performed. The results to applications show that the L-Logistic regression models provide a better fit than the corresponding beta regression models.

Jamye Curry, Xin Dang, Hailin Sang.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 425--454.

Abstract:
We study a rank based univariate two-sample distribution-free test. The test statistic is the difference between the average of between-group rank distances and the average of within-group rank distances. This test statistic is closely related to the two-sample Cramér–von Mises criterion. They are different empirical versions of a same quantity for testing the equality of two population distributions. Although they may be different for finite samples, they share the same expected value, variance and asymptotic properties. The advantage of the new rank based test over the classical one is its ease to generalize to the multivariate case. Rather than using the empirical process approach, we provide a different easier proof, bringing in a different perspective and insight. In particular, we apply the Hájek projection and orthogonal decomposition technique in deriving the asymptotics of the proposed rank based statistic. A numerical study compares power performance of the rank formulation test with other commonly-used nonparametric tests and recommendations on those tests are provided. Lastly, we propose a multivariate extension of the test based on the spatial rank.

Yong-Chao Zhang, Na Zhang.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 1, 184--191.

Abstract:
We investigate the equivalence of dynamic and static asset allocations in the case where the price process of a risky asset is driven by a Poisson process. Under some mild conditions, we obtain a necessary and sufficient condition for the equivalence of dynamic and static asset allocations. In addition, we provide a simple sufficient condition for the equivalence.

John J. Dziak, Donna L. Coffman, Matthew Reimherr, Justin Petrovich, Runze Li, Saul Shiffman, Mariya P. Shiyko.

Source: Statistics Surveys, Volume 13, 150--180.

Abstract:
Researchers are sometimes interested in predicting a distal or external outcome (such as smoking cessation at follow-up) from the trajectory of an intensively recorded longitudinal variable (such as urge to smoke). This can be done in a semiparametric way via scalar-on-function regression. However, the resulting fitted coefficient regression function requires special care for correct interpretation, as it represents the joint relationship of time points to the outcome, rather than a marginal or cross-sectional relationship. We provide practical guidelines, based on experience with scientific applications, for helping practitioners interpret their results and illustrate these ideas using data from a smoking cessation study.

Norbert Hirschauer, Sven Grüner, Oliver Mußhoff, Claudia Becker.

Source: Statistics Surveys, Volume 12, 136--172.

Abstract:
Data on how many scientific findings are reproducible are generally bleak and a wealth of papers have warned against misuses of the $p$-value and resulting false findings in recent years. This paper discusses the question of what we can(not) learn from the $p$-value, which is still widely considered as the gold standard of statistical validity. We aim to provide a non-technical and easily accessible resource for statistical practitioners who wish to spot and avoid misinterpretations and misuses of statistical significance tests. For this purpose, we first classify and describe the most widely discussed (“classical”) pitfalls of significance testing, and review published work on these misuses with a focus on regression-based “confirmatory” study. This includes a description of the single-study bias and a simulation-based illustration of how proper meta-analysis compares to misleading significance counts (“vote counting”). Going beyond the classical pitfalls, we also use simulation to provide intuition that relying on the statistical estimate “$p$-value” as a measure of evidence without considering its sample-to-sample variability falls short of the mark even within an otherwise appropriate interpretation. We conclude with a discussion of the exigencies of informed approaches to statistical inference and corresponding institutional reforms.

Adrien Saumard, Jon A. Wellner.

Source: Statistics Surveys, Volume 8, 45--114.

Abstract:
We review and formulate results concerning log-concavity and strong-log-concavity in both discrete and continuous settings. We show how preservation of log-concavity and strong log-concavity on $mathbb{R}$ under convolution follows from a fundamental monotonicity result of Efron (1965). We provide a new proof of Efron’s theorem using the recent asymmetric Brascamp-Lieb inequality due to Otto and Menz (2013). Along the way we review connections between log-concavity and other areas of mathematics and statistics, including concentration of measure, log-Sobolev inequalities, convex geometry, MCMC algorithms, Laplace approximations, and machine learning.

Gery Geenens

Source: Statist. Surv., Volume 5, 30--43.

Abstract:
Recently, some nonparametric regression ideas have been extended to the case of functional regression. Within that framework, the main concern arises from the infinite dimensional nature of the explanatory objects. Specifically, in the classical multivariate regression context, it is well-known that any nonparametric method is affected by the so-called “curse of dimensionality”, caused by the sparsity of data in high-dimensional spaces, resulting in a decrease in fastest achievable rates of convergence of regression function estimators toward their target curve as the dimension of the regressor vector increases. Therefore, it is not surprising to find dramatically bad theoretical properties for the nonparametric functional regression estimators, leading many authors to condemn the methodology. Nevertheless, a closer look at the meaning of the functional data under study and on the conclusions that the statistician would like to draw from it allows to consider the problem from another point-of-view, and to justify the use of slightly modified estimators. In most cases, it can be entirely legitimate to measure the proximity between two elements of the infinite dimensional functional space via a semi-metric, which could prevent those estimators suffering from what we will call the “curse of infinite dimensionality”.

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Gregory J. Matthews, Ofer Harel

Source: Statist. Surv., Volume 5, 1--29.

Abstract:
There is an ever increasing demand from researchers for access to useful microdata files. However, there are also growing concerns regarding the privacy of the individuals contained in the microdata. Ideally, microdata could be released in such a way that a balance between usefulness of the data and privacy is struck. This paper presents a review of proposed methods of statistical disclosure control and techniques for assessing the privacy of such methods under different definitions of disclosure.

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Building a scalable machine learning system for unsupervised anomaly detection via representation learning is highly desirable. One of the prevalent methods is using a reconstruction error from variational autoencoder (VAE) via maximizing the evidence lower bound. We revisit VAE from the perspective of information theory to provide some theoretical foundations on using the reconstruction error, and finally arrive at a simpler and more effective model for anomaly detection. In addition, to enhance the effectiveness of detecting anomalies, we incorporate a practical model uncertainty measure into the metric. We show empirically the competitive performance of our approach on benchmark datasets.

Beginning from a basic neural-network architecture, we test the potential benefits offered by a range of advanced techniques for machine learning, in particular deep learning, in the context of a typical classification problem encountered in the domain of high-energy physics, using a well-studied dataset: the 2014 Higgs ML Kaggle dataset. The advantages are evaluated in terms of both performance metrics and the time required to train and apply the resulting models. Techniques examined include domain-specific data-augmentation, learning rate and momentum scheduling, (advanced) ensembling in both model-space and weight-space, and alternative architectures and connection methods.

Following the investigation, we arrive at a model which achieves equal performance to the winning solution of the original Kaggle challenge, whilst being significantly quicker to train and apply, and being suitable for use with both GPU and CPU hardware setups. These reductions in timing and hardware requirements potentially allow the use of more powerful algorithms in HEP analyses, where models must be retrained frequently, sometimes at short notice, by small groups of researchers with limited hardware resources. Additionally, a new wrapper library for PyTorch called LUMINis presented, which incorporates all of the techniques studied.

We study the problem of parameter estimation for a non-ergodic Gaussian Vasicek-type model defined as $dX_t=(mu+ heta X_t)dt+dG_t, tgeq0$ with unknown parameters $ heta>0$ and $muinR$, where $G$ is a Gaussian process. We provide least square-type estimators $widetilde{ heta}_T$ and $widetilde{mu}_T$ respectively for the drift parameters $ heta$ and $mu$ based on continuous-time observations ${X_t, tin[0,T]}$ as $T ightarrowinfty$.

Our aim is to derive some sufficient conditions on the driving Gaussian process $G$ in order to ensure that $widetilde{ heta}_T$ and $widetilde{mu}_T$ are strongly consistent, the limit distribution of $widetilde{ heta}_T$ is a Cauchy-type distribution and $widetilde{mu}_T$ is asymptotically normal. We apply our result to fractional Vasicek, subfractional Vasicek and bifractional Vasicek processes. In addition, this work extends the result of cite{EEO} studied in the case where $mu=0$.

This paper revisits the problem of computing empirical cumulative distribution functions (ECDF) efficiently on large, multivariate datasets. Computing an ECDF at one evaluation point requires $mathcal{O}(N)$ operations on a dataset composed of $N$ data points. Therefore, a direct evaluation of ECDFs at $N$ evaluation points requires a quadratic $mathcal{O}(N^2)$ operations, which is prohibitive for large-scale problems. Two fast and exact methods are proposed and compared. The first one is based on fast summation in lexicographical order, with a $mathcal{O}(N{log}N)$ complexity and requires the evaluation points to lie on a regular grid. The second one is based on the divide-and-conquer principle, with a $mathcal{O}(Nlog(N)^{(d-1){vee}1})$ complexity and requires the evaluation points to coincide with the input points. The two fast algorithms are described and detailed in the general $d$-dimensional case, and numerical experiments validate their speed and accuracy. Secondly, the paper establishes a direct connection between cumulative distribution functions and kernel density estimation (KDE) for a large class of kernels. This connection paves the way for fast exact algorithms for multivariate kernel density estimation and kernel regression. Numerical tests with the Laplacian kernel validate the speed and accuracy of the proposed algorithms. A broad range of large-scale multivariate density estimation, cumulative distribution estimation, survival function estimation and regression problems can benefit from the proposed numerical methods.

Uncertainties in a structure is inevitable, which generally lead to variation in dynamic response predictions. For a complex structure, brute force Monte Carlo simulation for response variation analysis is infeasible since one single run may already be computationally costly. Data driven meta-modeling approaches have thus been explored to facilitate efficient emulation and statistical inference. The performance of a meta-model hinges upon both the quality and quantity of training dataset. In actual practice, however, high-fidelity data acquired from high-dimensional finite element simulation or experiment are generally scarce, which poses significant challenge to meta-model establishment. In this research, we take advantage of the multi-level response prediction opportunity in structural dynamic analysis, i.e., acquiring rapidly a large amount of low-fidelity data from reduced-order modeling, and acquiring accurately a small amount of high-fidelity data from full-scale finite element analysis. Specifically, we formulate a composite neural network fusion approach that can fully utilize the multi-level, heterogeneous datasets obtained. It implicitly identifies the correlation of the low- and high-fidelity datasets, which yields improved accuracy when compared with the state-of-the-art. Comprehensive investigations using frequency response variation characterization as case example are carried out to demonstrate the performance.

I study the minimax-optimal design for a two-arm controlled experiment where conditional mean outcomes may vary in a given set. When this set is permutation symmetric, the optimal design is complete randomization, and using a single partition (i.e., the design that only randomizes the treatment labels for each side of the partition) has minimax risk larger by a factor of $n-1$. More generally, the optimal design is shown to be the mixed-strategy optimal design (MSOD) of Kallus (2018). Notably, even when the set of conditional mean outcomes has structure (i.e., is not permutation symmetric), being minimax-optimal for variance still requires randomization beyond a single partition. Nonetheless, since this targets precision, it may still not ensure sufficient uniformity in randomization to enable randomization (i.e., design-based) inference by Fisher's exact test to appropriately detect violations of null. I therefore propose the inference-constrained MSOD, which is minimax-optimal among all designs subject to such uniformity constraints. On the way, I discuss Johansson et al. (2020) who recently compared rerandomization of Morgan and Rubin (2012) and the pure-strategy optimal design (PSOD) of Kallus (2018). I point out some errors therein and set straight that randomization is minimax-optimal and that the "no free lunch" theorem and example in Kallus (2018) are correct.

Effective property prediction methods can help accelerate the search for COVID-19 antivirals either through accurate in-silico screens or by effectively guiding on-going at-scale experimental efforts. However, existing prediction tools have limited ability to accommodate scarce or fragmented training data currently available. In this paper, we introduce a novel approach to learn predictors that can generalize or extrapolate beyond the heterogeneous data. Our method builds on and extends recently proposed invariant risk minimization, adaptively forcing the predictor to avoid nuisance variation. We achieve this by continually exercising and manipulating latent representations of molecules to highlight undesirable variation to the predictor. To test the method we use a combination of three data sources: SARS-CoV-2 antiviral screening data, molecular fragments that bind to SARS-CoV-2 main protease and large screening data for SARS-CoV-1. Our predictor outperforms state-of-the-art transfer learning methods by significant margin. We also report the top 20 predictions of our model on Broad drug repurposing hub.

The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 7 November. Speaker: Dr Michael Brown (University of Roehampton), ‘Anxiety and compassion: emotions and the surgical encounter in early 19th-century Britain’ The historical study of the… Continue reading

The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 16 January. Speaker: Dr Catherine Rider (University of Exeter) Medieval Ideas about Infertility and Old Age Abstract: When they discussed fertility and reproductive disorders it was common… Continue reading