In North America, EIFS is pretty much a single type of design, namely expanded polystyrene insulation adhesively attached to the supporting wall, and a thin, synthetic, two-layer, glass fiber mesh-reinforced coating system. 

The two organisations employ a total of more than 450 people

Dame Julia Cleverdon spent 17 years as the chief executive of Business in the Community as part of a long career in the voluntary sector

World Wide Security, Garden City, N.Y., launched its “Go Green!” program promoting energy conservation to its customers. As energy prices rise throughout the United States, the Long Island region is often impacted more dramatically because it is an island with logistics and energy challenges.

As a subsidiary of ASSA ABLOY, HID Global follows its policy on minimizing its carbon footprint and helping to stimulate renewable energy markets. HID Global is dedicated to reducing the environmental impact of its operations through continuous concentration on Genuine HID™ products; how they are designed, how they are built, and how they are used.

Sensitive to environmental considerations in the security and video surveillance industry, Panasonic System Networks Company of America, Secaucus, N.J., is taking leadership by offering products manufactured in energy-efficient facilities, using fewer hazardous materials and emitting less CO2, and which also consume less power than previous Panasonic comparable models.

Arlington, VA — Mine operators should train miners on recognizing highwall hazards and following procedures for their safe control, the Mine Safety and Health Administration advises in a recent safety alert.

The new Urban Roots is dedicated to delivering plant-forward products with bold, globally inspired flavors. The rebrand comes with two line expansions: the launch of Fruit+, and Cantina-Style Salsa.

Metallika from Surfaces brings “the beauty of pure aluminum, transformed in sophisticated patterns and color combinations with stone and glass.”

Karndean Design flooring has expanded its premium Art Select Woods collection by adding eleven new skillfully-crafted designs that replicate the beauty of natural timber.

The inherent beauty of stone is timeless, and Daltile brings that beauty to life with its new Natural Stone and Manufactured Stone collections and line extensions. 

The Carpet and Rug Institute's (CRI) annual meeting in Dalton, Georgia, highlighted an industry balancing success with new challenges, from global growth to mounting regulations.

Electrolit's planned 600,000-sq.-ft. greenfield project is slated to open in early 2026.

by Taylor Griggs

The Mercury provides news and fun every single day—but your help is essential. If you believe Portland benefits from smart, local journalism and arts coverage, please consider making a small monthly contribution, because without you, there is no us. Thanks for your support! 

Good morning, Portland! There's rain on the menu for today, but you probably didn't need me to tell you that. Hopefully you know how to layer for November in Portland by now. Anddddd that's all the small talk we have time for this morning, so chop chop. It's news time. 

IN LOCAL NEWS: 

• Portland City Council is set to vote today on a five-year contract renewal for the Downtown Portland Clean & Safe district, as well as a major expansion of the service area it covers and a fee hike. A couple weeks ago, when this item was first brought to the council, many Portlanders testified against the contract renewal. Now, four incoming city councilors (Mitch Green, Sameer Kanal, Tiffany Koyama Lane and Angelita Morillo)—along with community organizations and dozens of residents, have penned a letter to the current City Council asking them to postpone the contract renewal. 

Why the negativity for Clean & Safe? Well, as an excellent new article from our Courtney Vaughn details, the Clean & Safe district is overseen by an organization that has significant overlap in its management with the Portland Metro Chamber, AKA the Portland Business Alliance. The new contract would funnel a good portion of the $58 million contract to the Metro Chamber, which they will spend on lobbying efforts for private business interests. The program is also convoluted and lacks oversight, and it contributes majorly to the criminalization of homeless people in downtown Portland. So there's a lot wrong with it. Read the article for more of the details, and stay tuned for City Council's decision today. 

• The Portland Auditor's Office has released a much-anticipated (by me, at least) report on the Portland Bureau of Transportation's (PBOT) Vision Zero Action Plan, which the city adopted in 2016 in an effort to eliminate traffic crash fatalities and serious injuries. But in the eight years since the Vision Zero plan was adopted (and been updated twice), traffic crash deaths have increased in Portland, especially in the last four years. In 2023, 69 people were killed in traffic crashes on Portland streets. Given the current reality, it's understandable that people are questioning how effective the Vision Zero program is. 

While the Auditor's Office isn't seeking an overhaul of the program, the report recommends PBOT makes several key changes to improve Vision Zero outcomes. The audit report says PBOT should create a better project evaluation system, install more speed cameras, and use more qualitative data to determine the most equitable safety projects. According to PBOT, most of the concerns expressed in the audit report have already been addressed in the most recent Vision Zero update.

PBOT leaders did say they are hopeful more traffic safety improvements will be possible when Portland finally (fully) transitions to its new, less-siloed form of government in January. The report just came out this morning, so there hasn't been much in the way of community response yet, but I'm sure it will spark some Thoughts, capital "T." 

•  On a related note, the World Day of Remembrance of Road Traffic Victims is this Sunday, an annual day to honor the many lives lost prematurely to traffic violence. Community organizations Families for Safe Streets, BikeLoud PDX, and Oregon Walks will join PBOT, elected leaders, and community members for a gathering at Portland City Hall. Find out more about the event here. 

          View this post on Instagram                      

A post shared by Families for Safe Streets PDX (@fss_pdx)

• Here's a painful fact, courtesy of a new investigation from OPB and ProPublica: Despite President Biden's repeated promises to save old growth forests in the Pacific Northwest, the Bureau of Land Management is allowing timber companies to log such forests now more than in the last 10 years. Biden's BLM is on track to log 47,000 acres of public lands during his four years in office— about the same amount that Trump oversaw during his first term in office. And, get this: This is after Biden made an executive order to protect mature and old-growth forests in 2022! Considering the rare beauty of these forests—and, more importantly, their importance to ecosystems and ability to mitigate carbon emission—this is very unfortunate. The Biden administration hasn't answered for the BLM's actions, or if they're planning to take steps to further protect old growth forests in preparation for the next Trump administration. Let's hope he makes some changes while he still can, because we all know Trump will be a lot worse. 

• Rene Gonzalez, after losing his bid for mayor, is seeking donations of up to $579 because his campaign is in debt. I wonder if anyone will pay him. 

Stealing this from the other site because y’all need to see it. Anyone gonna donate $579 to Rene Gonzalez’s failed campaign for mayor??? @pradapdx.bsky.social

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— Taylor Griggs (@taylorgriggs.bsky.social) November 12, 2024 at 5:11 PM

IN NATIONAL/WORLD NEWS: 

• President-elect Donald Trump (ouch) has asked Vivek Ramaswamy (ouch again) and Elon Musk (commentary unnecessary here) to lead a new government agency that he plans to create in order to regulate federal spending. The new agency will be called the Department of Government Efficiency, which just happens to create the acronym DOGE, a reference to the Shiba Inu meme of the mid-2010s and the joke cryptocurrency by the same name that Musk promoted. Apparently, a Department of Government Efficiency needs to be run by two people. I hope I am adequately conveying my tone of contempt here. 

As ridiculous as this all is, it's also extremely bad. Trump, Musk, and Ramaswamy's plan is to fire thousands of federal employees, cut necessary regulations, and ultimately destroy many of the most crucial components of the federal government. All we can do is hope that SOME Republicans in Congress (we don't need all of them!) will realize how idiotic this is and block Trump's attempt to create a new government agency, which he can't do without congressional approval. Or can he? The limit to this idiocy knows no bounds.

However, given these men's volatility—which is replicated in many others in Trump's sphere—it does seem pretty likely that they'll all be in a huge fight by the time Trump takes office. I do think there are some major catfights on the horizon, if that gives you any comfort in these trying times. 

fundamentally this is what Trump administrations are all about: the guys. there will be new guys every week. they will startle you, you'll be astounded by them, and then as quickly as they appeared they will fade into an indistinguishable mass, leaves on the forest floor.

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— Peter (@notalawyer.bsky.social) November 12, 2024 at 4:39 PM

• Here's something that will NOT give you comfort in these trying times: Despite the hope last year would mark a global carbon dioxide emissions peak, humans are burning more fossil fuels this year than we did last year. The world is on track to put 0.8 percent more carbon into the atmosphere than in 2023. Though this is not surprising, it IS actually crazy behavior from humanity (and let me be clear, it's a tiny minority of humans leading the charge on this, though a substantially larger minority are eagerly/mindlessly participating in burning fossil fuels at a rate incompatible with the future of life on this planet). Good thing we will have strong climate leadership in the White House come January. NOT!!!! 

• One way people are attempting to #resist Elon Musk after he helped Trump get into office and will now seemingly play a key role in his administration? Leaving Twitter, AKA X, the social media site he bought and ruined. Bluesky may be the place to be now. (I am finding it much more pleasant.) 

In the week since the U.S. presidential election, Elon Musk has used X, the social media platform he owns, to reiterate his support for President-elect Donald Trump. Some of X’s users have decided they want to post elsewhere. Among the largest beneficiaries of that desire is Bluesky. nyti.ms/48JtYAt

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— The New York Times (@nytimes.com) November 12, 2024 at 10:46 PM

• Okay, here's some actual good news: The U.S. House voted down a bill that would've helped Trump censor and persecute his political opponents. The Stop Terror-Financing and Tax Penalties on American Hostages Act had previously received bipartisan support, but after Trump was elected, some Democratic lawmakers (and The Intercept) raised alarm bells. The bill would give the U.S. Treasury Department complete authority to revoke the tax-exempt status of nonprofits it deems are "terrorist supporting organizations," which Trump could use to enable the destruction of nonprofits that the future president doesn't politically align with. WHEW. 

• Finally, please watch this video of a little boy and his crow friend. ???????? Bye bye! 

          View this post on Instagram                      

A post shared by Dogs | Puppies | Family (@yourpaws.global)

The Friday bout pits the 58-year-old former heavyweight champ against a much younger opponent whose fame is rooted in social media.

NPR's Michel Martin speaks with Penn State labor and employment relations professor Paul Clark about blue-collar voters and their decision to back President-elect Trump in this election.

Robert F. Kennedy Jr. says President-elect Trump wants "measurable impacts" toward ending chronic disease within two years. About 60% of Americans suffer from at least one chronic disease.

House Minority Leader Hakeem Jeffries speaks with NPR's Michel Martin about his new book "The ABCs of Democracy," and Democrats' outlook following the 2024 election.

Fresh out of the boxed crate ex Birmingham factory, UK, the BSA badge stood out distinctively. In bright White it was pure English,. Especially when it contrasted with the British Racing Green petrol tank. One could already smell the oil and grease that housed the engine and transmission assembly. I did. After the straw packaging had settled, Gino, my Italian mechanic and friend, emerged fresh from the clutter. At that moment, his countenance shone. His voice cracked with joy. “You makka good choice. But not a Moto Guzzi.” Fair enough. He, like all Italians, had a distinct preference for Ferrari Red. That color predilection even extended to their motorcycles. Gino was not finished. He continued his soliloquy. Gino had more to wisdom to convey. “Bruh... Stay off the main highway. You like to race. Take the first country road exit. There’s a good one. About a mile east.”

The American Association of Nurse Anesthesiology (AANA) calls on Department of Veterans Affairs (VA) Undersecretary for Health, Shereef Elnahal, to correct his inaccurate statement made under oath about Certified Registered Nurse Anesthetist (CRNA) practice during a House Committee on Veterans' Affairs hearing.

In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

Community partnerships led to a specialized clinic delivering COVID and flu shots to individuals with neurodevelopmental conditions like autism at the MIND Institute.

Private equity is more likely to look at public firms for acquisition when the target aggressively manages its earnings to meet analyst expectations, because those firms are often so cut to the bone there's more room to add value with investment.

Argonne scientist, Maria Chan, has been elected as a Fellow of the American Physical Society for her contributions to energy research.

University of Central Florida's A Team with A Dream wins the 2024 CyberForce Competition(r). The mission of the competition is to equip the next generation of cybersecurity professionals with hands-on experience defending critical infrastructure.

In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

Community partnerships led to a specialized clinic delivering COVID and flu shots to individuals with neurodevelopmental conditions like autism at the MIND Institute.

Discover the unique Gemini and Libra compatibility! Dive into how these air signs balance each other in love, friendship, and communication. Are they the perfect match?

Discover Taurus and Aquarius compatibility in love, friendship, and more. Uncover their unique strengths, challenges, and potential for a balanced relationship

[International] :
China has named Dai Bing, deputy chief of its permanent mission to the United Nations, as the new ambassador to South Korea. According to diplomatic sources on Thursday, Beijing nominated the UN mission deputy to succeed former Ambassador Xing Haiming, who left the post vacant in July.  Dai’s career ...

[more...]

[Inter-Korea] :
The government reiterated that it will take “effective and phased” steps, in line with the principles of composure and restraint, in response to the battlefield deployment of North Korean troops in support of Russia in its war against Ukraine. Speaking to local reporters on Thursday, an official at ...

[more...]

[Politics] :
The ruling People Power Party has decided to take steps to ensure that the National Assembly recommends candidates for the post of special inspector to look at allegations against members of the president’s family. The ruling camp adopted the party policy during a general meeting for its lawmakers on ...

[more...]

[Economy] :
Finance Minister Choi Sang-mok said Thursday that the government will take “active measures” in the event of excessive volatility in the foreign exchange market, as the South Korean won weakened past the psychological threshold of 14-hundred won against the U.S. dollar. The minister made the “verbal ...

[more...]

FIS has announced a partnership with

Volt Lithium Corp. (VLT:TSV; VLTLF:US; I2D:FSE) says it has significantly improved the operating capacity of its next-generation Direct Lithium Extraction (DLE) technology for processing oilfield brines in Texas' Delaware Basin. Read why one analyst predicts more steady increases.

Mary Ann de Lares Norris is Chief Operating Officer of Oblong Industries. She brings her dog LouLou to Oblong's downtown LA headquarters.; Credit: Brian Watt/KPCC

KPCC recently reported on the tech world’s diversity problem. Technology firms face challenges in hiring diverse staffs of its coders, web developers and software engineers.

It’s also a challenge at nonprofits such as Southern California Public Radio,  parent of 89.3 KPCC, which has always sought to build a staff that reflects the region it serves. The section of that staff that develops the KPCC app and makes its website run is all white and mostly male.

But a small talent pool means the diversity challenge is even greater for nonprofits and even smaller tech firms.

“The first problem is that all of the people working for me are male,” says Alex Schaffert, the one female on KPCC’s tech team.  “I’m kind of focusing on maybe getting another girl into the mix.”

Schaffert can use the term “girl” because she happens to be the leader of the tech team:  KPCC’s Managing Director of Digital Strategy and Innovation. 

Why diversity is important

Schaffert recently launched the topic of diversity – or lack thereof – at a weekly meeting of her team. She expected a “stilted and awkward” discussion from the five white men on her team, but a few of them didn’t hold back.  

“Not having diversity represented on the team leaves us more susceptible to circular thinking and everyone sort of verifying each other's assumptions,” said Joel Withrow,  who was serving at the time as KPCC’s Product Manager. “It impacts the work. It limits what you’re able to build.”

Sean Dillingham, KPCC’s Design and Development Manager, said living in a diverse community is what attracted him to Los Angeles, and he wants diversity in his immediate work team, too.

“When I look at other tech companies, I will often go to their ‘about us’ page, where they’ll have a page of photos of everyone, and I am immediately turned off when I just see just a sea of white dudes, or even just a sea of dudes,” Dillingham said.

Big competition, small talent pool

Dillingham and Schaffert are currently recruiting heavily to fill two tech-savvy positions. When a reporter or editor job opens up at KPCC, Schaffert says close to 100 resumes come in.

"But if you post a programmer job, and you get three or four resumes, you may not get lucky among those resumes," she says. "There may not be a woman in there. There may not be a person of color in there."

In other words, the talent pool is already small, and the diversity challenge makes it even smaller. KPCC is competing for talent with Google and Yahoo and all the start-ups on L.A.’s Silicon Beach. 

Schaffert’s being proactive, mining LinkedIn and staging networking events to attract potential candidates. She’s also trying to make sure KPCC’s job descriptions don’t sound like some she's seen in the tech world.

"If you read between the lines, they’re really looking for someone who is male and is somewhere between 25-30 years old and likes foosball tables and free energy drinks in the refrigerator," Schaffert says. “So you read between lines, and you know that they’re not talking about me, a mother of two kids who also has a demanding career. They're talking about someone different.”

Pay vs. passion

Schaffert's challenges and approaches to dealing with them are similar to those of Mary Ann de Lares Norris, the Chief Operating Officer at Oblong Industries. Based in downtown Los Angeles and founded in 2006, the company designs operating platforms for businesses that allow teams to collaborate in real time on digital parts of a project.

“I think technology and diversity is tough,” Norris told KPCC.  She’s proud her company’s management ranks are diverse, but says only 12 percent of its engineers are female. “Pretty standard in the tech industry, but it’s not great,” Norris says. “We really strive to increase that number, and all of the other companies are also, and it's really hard.”

Like Schaffert at KPCC, Norris works hard fine-tuning job descriptions and communicating that her company values diversity and work-life balance. But sometimes, it just boils down to money.

"We have to put out offers that have competitive salaries,” Norris says, adding that she can’t compete with the major tech firms. "The Googles and the Facebooks of the world can always pay more than we can. So we attract people who are passionate about coming to work for Oblong.  And, of course, we also offer stock options."

KPCC doesn’t have the  stock options, but we’ve got plenty of passion. Could that be the secret recruiting weapon for both small tech companies and nonprofits?  

LinkedIn recently surveyed engineers about what they look for in an employer. Good pay and work-life balance were the two top draws. Slightly more women prioritized work-life balance and slightly more men chose the big bucks. 

Clinical Entrepreneurship professor Adlai Wertman says that, historically, nonprofits and small businesses actually had the upper hand over big companies in recruiting minorities and women.

"There’s a feeling that they’re safer, more caring environments, less killer environments, and we know that corporate America has been the bastion of white males," said Wertman. 

But Wertman says that advantage disappears in the tech world because of the "supply-and-demand" problem with talent. When big firms decide to focus on diversity – as some have recently — they have plenty of resources.

"They’re always going to be able to pay more, and in truth they’re getting access to students coming out of these schools in ways that we as nonprofits and small companies never will," said Wertman. 

Wertman worked 18 years as an investment banker on Wall Street, then left to head a nonprofit on L.A.’s skid row. Now he heads the Brittingham Social Enterprise Lab Enterprise Lab at USC’s Marshall School of Business. He believes that, early on, the big companies have the best shot attracting diverse tech talent. But in the long run, much of that talent will turn back to smaller firms and nonprofits.

"I think ultimately people vote with where they’re most comfortable, where 'my values align with my employer's values, and if I don’t feel those values align, then I’m going to leave,'" Wertman said. "Ultimately, I think, for a lot of women and minorities, there’s a lot of value alignment within communities that are doing good in the world." 

This content is from Southern California Public Radio. View the original story at SCPR.org.

Walter Flores was unemployed for 8 months in 2014 but is now working in sales for Workforce Solutions in Compton; Credit: Brian Watt/KPCC

California's unemployment rate continued its decline in December, ending the year at 7 percent, according to figures released Friday by the state Employment Development Department.

But in Compton, Willowbrook and the Florence-Graham section of Los Angeles County, it remains about double that, data show.

“You might have work this week. But next week, you won’t have work,” said James Hicks, 36, 0f Compton. He's worked in warehouses through staffing agencies, but said the jobs have always been temporary.

Statewide, California has added jobs at a faster rate than the United States for three straight years, according to Robert Kleinhenz, Chief Economist with the Los Angeles County Economic Development Corporation. He pointed out the statewide unemployment rate is now where it was June 2008. 

"All in all, with the recession now five years back in our rearview mirror, we’re finally at the point where we can say that we have shrugged off quite a bit of the pain that occurred back during those times," Kleinhenz said.

The Los Angeles County metro area saw a net gain of almost 71,000 jobs in 2014.  The County's overall unemployment rate has fallen to 7.9 percent from 9.2 percent a year ago.

But Compton's unemployment rate was 13 percent in December.

“I’d rather have a  full-time type of gig, working 40 hours a week, but right now, even if you get 25 hours, it’s a blessing,” said Hicks, the warehouse worker in Compton.

On Thursday, he interviewed to be a guard with a security firm, but was told there weren’t any positions available. He had another security guard job six months ago that he thought might become full time and permanent. 

"It was going all right for about two to three months, until they cut my hours and days," Hicks said. 

Walter Flores lives in La Mirada but currently works as an account executive in the Compton office of Workforce Solutions. He was unemployed for about eight months last year after a car accident.

"Losing what you love to do is a tough one, but I'm back," he said. "2015 is going to be a great year."

Flores said most major warehouse and logistics companies prefer to hire temporary workers through industrial staffing firms like the one where he's working because their needs are sporadic.  

But he said it's still a potential opportunity.

"It doesn't matter that it's a temporary position, as long as you put your foot in the door, and then you let the employer know how much value you are for the company," Flores said.  

Hicks, who's earned a GED, wants to find a program to study physical therapy. But first, he’d like to find a job. 

He said you can't judge Compton’s residents by its unemployment rate.

"Some of us out here who [are] looking for jobs, but sometimes it’s the luck of the draw," he said. "It’s kind of scarce out there.” 

This content is from Southern California Public Radio. View the original story at SCPR.org.

Source: Dr. Douglas Loe 11/12/2024

Sernova Corp. (SVA:TSX.V; SEOVF:OTCQB; PSH:XERTA) should benefit from Sana Biotechnology's recent prioritization of its diabetes-targeted cell therapy programs, reported Leede Financial Inc. analyst Dr. Douglas Loe in a Nov. 6 research note. Now Sana's clinical programs in oncology and Huntington's disease are a secondary focus.

"Our model assumes that Sernova's cell reservoir device Cell Pouch will itself remain focused on Type 1 diabetes, and we are thus encouraged to see a U.S. peer prioritize its pipeline in ways that are consistent with our own views on how priorities in regenerative medicine will evolve in coming years," Loe wrote.

500% Potential Return

Leede has a CA$1.50 per share target price on Sernova, trading at the time of the report at about CA$0.25 per share, noted Loe.

"At current price levels, our price target corresponds to a one-year return of 500%, a return that we believe is imminently achievable by 2025E but likely with a milestone-driven, and not a linear, trajectory," the analyst wrote.

The company is a Speculative Buy.

Synergistic Potential Exists

Loe highlighted that Sernova and Sana could benefit from aligning their programs, on a timeline providing synergies to both.

"We are encouraged to see a leading regenerative firm choose to expedite its diabetes cell therapy program in preference to other initiatives that it could fund if it chose to," Loe wrote. "This is consistent with our own view that the most attractive medical market for regenerative firms, and for Sernova, to target is the large and growing diabetes market both for economic and technical reasons."

Sana's Diabetes Programs

Sana's primary focus is its program to treat Type 1 diabetes with its Phase 1-stage, hypo-immune platform (HIP)-modified primary pancreatic islet cell therapy UP421 and its preclinical HIP-modified, stem cell-derived pancreatic islet platform SC451.

Through this platform, regenerative cell therapies can be modified genetically to evade immune detection post implantation. This is achieved by reducing expression of major histocompatibility-complex, classes one and two human leukocyte antigens while increasing expression of CD24. This is a surface protein found on stem cells in the pancreas.

Sernova's Cell Reservoir Platform

As for Sernova, it has a well-vascularized, sustainably functioning cell reservoir platform, Cell Pouch, proven for some time. Development of regenerative islet platform technology is now catching up. Sernova has a clinical trial underway that combines the two technologies. This Phase 1 trial in diabetes, in partnership with the University of Chicago, already has shown "impressive long-term insulin independence data" up to five years in some study participants.

This is "well beyond what we believe is a reasonable threshold for the U.S. Food and Drug Administration to require for future Cell Pouch approval, at least for Type 1 diabetes," Loe wrote.

Currently, with regard to this program, Sernova optimizing background immunosuppression in Cell Pouch patients. Details of its new immunosuppressive regimen are expected in the biotech's next Phase 1 study update, likely in early H1/25.

"Future enrollees could be subjected to novel immunosuppressive therapies that conceivably could extend islet survival and perhaps even reduce the immunosuppressive burden that transplant patients must endure at present," Loe commented.

Further, Sernova is considering conducting a Phase 1 study using its Cell Pouch and Evotec AG's stem-cell-derived iBeta platform to treat diabetes. Before this can happen, though, Evotec needs to be able to produce iBeta at a clinical scale, which Loe expects can happen by H2/25.

"We see no reason why Sana and its UP421/SC451 modified islet platforms could not be incorporated into a Cell Pouch environment as a way to sustain their therapeutic half-life in the body post-implantation," wrote Loe.

Possible Stock Price Movers

Loe provided a handful of potential catalysts for Sernova's share price. They are:

1) Sernova's conclusion of its ongoing Phase 1 study in Type 1 diabetes with the University of Chicago, which Loe asserted should happen a quickly as possible given available capital. Also, the biotech should incorporate into this trial or a separate one to commence soon after, regeneratively produced pancreatic islets.

2) Sernova, in partnership with Sana, launching a Phase 1 iBeta/Cell Pouch trial late next year, which could boost Sernova's share price.

3) Sernova identifying additional developers of regenerative cell therapies with which it could combine Cell Pouch in mutually beneficial ways.

4) Sernova starting clinical programs in hemophilia A and in thyroid disease, expected to happen in the coming quarters.

5) Sernova incorporating its confocal cell coating technology into one or more future protocols for stem cell-derived pancreatic islet production, even its current Phase 1 diabetes trial with the University of Chicago. Before this can happen, however, coating polymer composition and manufacturing methodologies must be honed to meet good manufacturing practices specifications.

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Important Disclosures:

1. Sernova Corp. has a consulting relationship with Street Smart an affiliate of Streetwise Reports. Street Smart Clients pay a monthly consulting fee between US$8,000 and US$20,000.
2. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Sernova Corp.
3. Doresa Banning wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor.
4. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.
5. This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

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Disclosures for Leede Financial Inc., Sernova Corp., November 6, 2024

Important Information and Legal Disclaimers Leede Financial Inc. (Leede) is a member of the Canadian Investment Regulatory Organization (CIRO) and a member of the Canadian Investor Protection Fund (CIPF). This document is not an offer to buy or sell or a solicitation of an offer to buy or sell any security or instrument or to participate in any particular investing strategy. Data from various sources were used in the preparation of these documents; the information is believed but in no way warranted to be reliable, accurate and appropriate. All information is as of the date of publication and is subject to change without notice. Any opinions or recommendations expressed herein do not necessarily reflect those of Leede. Leede cannot accept any trading instructions via e-mail as the timely receipt of e-mail messages, or their integrity over the Internet, cannot be guaranteed. Dividend yields change as stock prices change, and companies may change or cancel dividend payments in the future. All securities involve varying amounts of risk, and their values will fluctuate, and the fluctuation of foreign currency exchange rates will also impact your investment returns if measured in Canadian Dollars. Past performance does not guarantee future returns, investments may increase or decrease in value, and you may lose money. Leede employees may buy and sell shares of the companies that are recommended for their own accounts and for the accounts of other clients. Disclosure codes are used in accordance with Policy 3600 of CIRO.

The analyst or any associate of the analyst responsible for the report or public comment hold shares or is short any of the company's securities directly or through derivatives.

Leede provided investment banking services for the company during the 12 months preceding the publication of the research report.

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His expression said it all.  KPCC Director of On-Air Fundraising Rob Risko walked into my studio about 10:45 a.m. to update me on where we stood with our Fall member drive.  I knew we had a $10,000 challenge that had started first thing in the morning, but didn't have any idea how far behind we had fallen in reaching the required 1,000 member threshold.

 Rob gave it to me straight -- we had to attract well over 500 members during "AirTalk" to meet the challenge.  I knew that was nearly impossible during a full two-hour show, let alone one that would be significantly pre-empted by the President's news conference.  Regardless, I knew we had to do our best and hope our listeners would contribute in a record-setting way.  Boy, did they.

We didn't start our show until 11:25 a.m., following the news conference.  Right off the bat the phones started ringing and the KPCC website starting humming.  The volume of member contributions stayed high with only a few exceptions.  There were times we could barely keep track of how many members were coming in.  It was one of the most exciting and rewarding experiences I've had in all my years hosting "AirTalk."

I've been on a high all afternoon thinking about how commited our listeners are to the mission of KPCC.  You've made me very happy, and very proud of our audience.  Thank you for a wonderful show of support.  I will long remember this day.

By the way, we set a fundraising record for "AirTalk" with today's show.  We're still tallying it all up.  I'll have the totals for you tomorrow morning at 11.

This content is from Southern California Public Radio. View the original story at SCPR.org.

The Getty spent $65m (and change) for this late Manet masterpiece, "Spring."

A  132-year-old vision of springtime has landed permanently at the Getty Museum, smack in the middle of this California autumn: "Spring (Jeanne Demarsy)," one of Impressionist painter Edouard Manet’s  last completed pictures.

Here's what Getty Director Timothy Potts had to say about the artist:

Manet was the ultimate painter’s painter: totally committed to his craft, solidly grounded in the history of painting and yet determined to carve out a new path for himself and for modern art. ... Alone of his contemporaries (the only one who comes near is Degas), Manet achieved this almost impossible balancing act, absorbing and channeling the achievements of the past into a radically new vision of what painting could be.

"Spring" somehow manages to be the evocation of youth itself and all its hopes. The subject is 16-year-old actress Jeanne Demarsy, just then seeing her stage career ascend at the same time Manet neared the end of his own career. (He died at age 51 in 1883,  soon after the painting went on display.) 

For most of the years since its creation, the picture has been in private hands. It was recently on loan to the National Gallery.

Getty Assistant Curator Scott Allan said that the Getty worked hard to acquire "Spring" and was lucky to get her. According to news reports, the Christie's auction price paid was an eyebrow-lifting $65 million — about double the top previous sale price for a Manet. "We don’t discuss the price," Potts said.

At the Getty, "Spring (Jeanne Demarsy)" hangs next to an early Manet in the museum's Impressionist-Post Impressionist gallery. It was intended to be one of the "Four Seasons" by the late-19th century French master. The series was never completed (although "Autumn" hangs in a museum in France).

(More seasoning: Manet's "Autumn." Museum of Fine Arts of Nancy, France)

Allan said that, unlike many of Manet's early works, "Spring" was intended to hang in the Salon, the French art establishment’s showplace of traditional painting, which had rejected innovators like the Impressionists for decades. That led most of the Impressionists to disdain the Salon. But Allan said Manet was extremely pleased that his late work was accepted there. 

Here's Potts again:

So popular was it that "Spring" became the subject of one of the first color photographs of a work of art. Its acquisition by the Getty brings to Los Angeles the most important — and beautiful! — painting by this artist left in private hands and one of the great masterpieces of late-19th-century art. 

The painting depicts a lovely teenager, dressed in the peak of 1880s fashion in a blue-on-white printed dress; a flowered, fringed hat; and a parasol balanced on her left shoulder. The background features white rhododendrons, barely in blossom.

Mlle. Demarsy stares off to the left, the demure image of a confident young woman at the earliest spring of her adulthood, with an entire creative life before her, already immortalized before the world by one of the century’s greatest artists.

But Manet was himself at the peak of his accomplishments,  just before his sudden demise.
 
"Spring" became one of Manet’s most popular works, deeply appreciated by art lovers young and old and by critics of both the old guard and the avant garde. It was his last picture to hang in the Salon. Manet’s powers would soon decline, and he devoted much of his last few months to watercolors, said Allan.

(Getty director Timothy Potts looks at the Getty's new painting, Manet's "Spring." Getty Museum)

This content is from Southern California Public Radio. View the original story at SCPR.org.

Actors Benedict Cumberbatch and Sophie Hunter arrive at the 26th Annual Palm Springs International Film Festival Film Festival Awards Gala at Palm Springs Convention Center on January 3, 2015 in Palm Springs, California.; Credit: Frazer Harrison/Getty Images

The 26th Annual Palm Springs International Film Festival opened this weekend, distinguished by robust audience turnouts, megawatt celebrity visitations and constant reminders of the unique space PSIFF occupies and the specialized services it provides to Hollywood.

Falling as it does just before Sundance and just after the Golden Globes nominations, Palm Springs is as much a part of the awards season calendar as it is the festival circuit. Big ticket screenings are presented with all the photo op pomp that would greet a major world premiere at, say, the Los Angeles Film Festival, but in many cases this is to build buzz for (or to re-energize) films that are already in theaters.

At Sundance or Tribeca, the suspense is usually about whether the films in competition will get good reviews and/or find distribution. At Palm Springs, especially on opening weekend, it's more about whether you'll run into Brad Pitt in the guest and industry suite at the Renaissance Hotel.

At the PSIFF awards gala, Golden Globe nominee Reese Witherspoon took home the oddly gender specific Chairman's Award for her performance in "Wild."

J.K. Simmons received something called a Spotlight Award for his superb turn as the menacing music instructor in "Whiplash."

David Oyelowo grabbed the "Breakthrough Performance Award (Male)" for depicting Martin Luther King Jr. in "Selma." Brad Pitt's sing-along presentation of Oyelowo's award became the meme for much of the post-event press coverage.

Sing-a-long with Brad Pitt

Rosamund Pike got the "Breakthrough Performance Award (Female)" for "Gone Girl."

Michael Keaton presented the Director of the Year award to his "Birdman" collaborator Alejandro G. Iñárritu.

And the Palm Spring Convention Center stage was home to two young British heartthrobs who are in Oscar contention this year for period biopics about scientific genius: Eddie Redmayne, who grabbed the Desert Palm Achievement Award (Male) for portraying ALS sufferer Stephen Hawking in "The Theory of Everything," and Benedict Cumberbatch, who split glory with the cast of the Alan Turing biography "The Imitation Game" as co-winner of the Ensemble Performance Award.

The Desert Palm Achievement Award (Female) went to Julianne Moore in the Alzheimer's drama "Still Alice."

Every single one of the movies honored is in theaters now, almost all of them in the midst of slowly expanding release patterns as they mount their long slow march toward the Academy Awards.

The generous "one award per movie" policy and the care with which PSIFF avoids alienating celebrity affections by giving out trophies with such blunt and unequivocal titles as "Best Actress" or "Best Actor" mark the PSIFF awards gala as a psuedo-event: a kind of open-armed Hollywood team huddle before things get grim and serious with the Oscar announcements at the end of the month.

Even an Oscar-worthy oddity like Richard Linklater's "Boyhood" managed to find a place in the parade, with Linklater, who directed Shirley MacLaine in the 2010 black comedy "Bernie," presenting the 80-year-old actress with the Sonny Bono Visionary Award, essentially for career achievement.

Meanwhile, the festival's generous supply of indie, studio and foreign movies churned away in various local movie theaters, a really quite remarkable cluster of buzzworthy pictures, almost all of which have played elsewhere, including at Sundance and Toronto and Tribeca, and in many cases at your local multiplex.

This programming approach can be a double-edged sword. Director Ava DuVernay, whose civil rights-era epic "Selma" opened the festival, was unable to stay for her full run of Palm Springs personal appearances because her movie has been out long enough to spark a rather bitter controversy over its depiction of President Lyndon Johnson. DuVernay abandoned a Palm Springs Q and A in order to defend her film on Charlie Rose. 

While some audience members were bitterly disappointed at missing the chance to hear one of this year's golden ones, I'm sure the PSIFF Board of Governors understood completely. This time of year, you have to play the long game, and, in the words of the civil rights anthem, "keep your eyes on the prize."

Off-Ramp contributor R.H. Greene, former editor of Boxoffice Magazine, is in Palm Spring this week to cover the 26th Annual Palm Springs International Film Festival. Look for his missives here, and listen Saturday to Off-Ramp for his report on the festival.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Albert Rad, a mobile phone wholesaler who fled religious persecution in Iran decades ago, said that he fully backs President Trump's decision to assassinate Iran's top military commander. ; Credit: Josie Huang/LAist

Los Angeles is home to the largest Iranian population outside of Iran. The killing of top Iranian commander Qassem Suleimani is generating some strong emotions here. KPPC’s Josie Huang reports from Persian Square in Westwood. 

This content is from Southern California Public Radio. View the original story at SCPR.org.

US-based identity platform Persona has partnered with Okta to deliver an automated identity verification solution and support organisations to safeguard against phishing and deepfakes. 

Volt Lithium Corp. (VLT:TSV; VLTLF:US; I2D:FSE) says it has significantly improved the operating capacity of its next-generation Direct Lithium Extraction (DLE) technology for processing oilfield brines in Texas' Delaware Basin. Read why one analyst predicts more steady increases.

This is proposed with the aim of ensuring data privacy, security, and integrity, especially with sensitive investor information. In its consultation paper, Sebi said that the market infra institutions should also be accountable for any actions taken based on AI outputs.

Bima Sugam India Federation is working to create a digital insurance marketplace in India.