Our beautiful 23 year old long haired tabby Sophie died peacefully in my husband's arms this week on 19 June 2013 - my birthday. The pain is unbearable

I was wondering if you might give my little women’s (boomers) some guidance as to a beginning graphic novel for...

The physical integrity of endothelial cells (ECs) lining the blood vessels regulates the inflammatory response. Both innate immunity and inflammatory disorders hinge on the EC-neutrophil interaction. Neutrophil binding, rolling, and migrating along and between ECs is associated with vascular permeability. In this issue of the JCI, Owen-Woods et al. tracked neutrophils in vivo in venules of mouse striated muscle and revealed how endothelial permeability can affect neutrophil trafficking. Strikingly, many neutrophils that migrated between EC junctions were able to rejoin the blood circulation. Further, the chemokine and neutrophil chemoattractant, CXCL1, drove this reverse transendothelial migration (rTEM). This paradigm-shifting study provides a mechanism for distal organ damage as well as an explanation for sepsis-associated acute respiratory distress syndrome.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

IBM annonce aujourd’hui que son nouveau cloud pour les fabricants d’appareils électroniques fournira à la TV connectée de Philips de nouveaux services internet, afin de proposer une gamme de services plus interactifs à des millions de téléspectateurs dans plus de 30 pays en Europe, mais aussi au Brésil et en Argentine.

To develop a successful marketing plan, you must know your target customers. With this knowledge, you can increase sales and improve profits.  One way to ...

The post How to Segment Your Customer Demographics in a Marketing Plan appeared first on Saleschase Stories.

Dressed as "Star Wars" characters, local officials in the Philippines are out and about to enforce strict quarantine measures while also handing out relief packages.

If there has been a constant concern throughout the coronavirus, it has been the issue of infection control. While the medical community works tirelessly to save lives and straighten the COVID-19 curve, first responders play an equally vital role on the

In the last few months, multiple groups of attackers successfully compromised corporate email accounts of at least 156 high-ranking officers at various firms based in Germany, the UK, Netherlands, Hong Kong, and Singapore. Dubbed 'PerSwaysion,' the newly spotted cyberattack campaign leveraged Microsoft file-sharing services—including Sway, SharePoint, and OneNote—to launch highly targeted

My department manager was looking for an intern:

Boss: It doesn’t have to be a graphic designer, just someone that can use Adobe Illustrator efficiently and has an eye for detail and composition.

Me: So… a designer?

This book contains essays from the 2016 postings of A Philosopher’s Blog. Subjects range from the metaphysics of guardian angels to the complicated ethics of guns. There are numerous journeys into the realm of political philosophy and some forays into …

Embed from Getty Images Scottie Nell Hughes, a Trump surrogate, presented her view of truth on The Diane Rehm Show. As she sees it: Well, I think it’s also an idea of an opinion. And that’s—on one hand, I hear …

If only you knew how to make your employees care as much as you do. If only you knew how to motivate them. Then, they'd be more productive, more enthusiastic. Here's the simple and direct great leaders motivate a team member.

PHILADELPHIA (May 7, 2020) – The U.S. Environmental Protection Agency (EPA) announced the 2019 winners of the National WasteWise Awards this month. Peace Dining Corporation of Philadelphia, Pennsylvania, received an honorable mention in the Large Business Category.

When I arrived in Krabi ofcourse they didn't bring us to the pier. Instead they offered a mototaxi for a high price so I decided to walk. Along the way I put up my thumb and yes a crazy German guy stopped and brought me to the pier. There I bought my ti

Estimating the returns to education remains an active area of research amongst applied economists. Most studies that estimate the causal return to education exploit changes in schooling and/or labor laws to generate exogenous differences in education. An implicit assumption is that more time in school may translate into greater earnings potential. None of these studies, however, explicitly consider the quality of schooling to which impacted students are exposed. To extend this literature, we examine the interaction between school quality and policy-induced returns to schooling, using temporally-available school quality measures from Card and Krueger (1992). We find that additional compulsory schooling, via either schooling or labor laws, increases earnings only if educational inputs are of sufficiently high quality. In particular, we find a consistent role for teacher quality, as measured by relative teacher pay across states, in generating consistently positive returns to compulsory schooling.

Traveling beyond the immediate surroundings of one’s residence can lead to greater exposure to new ideas and information, jobs, and greater transmission of disease. In this paper, we document the geographic mobility of individuals in the U.S., and how this mobility varies across U.S. cities, regions, and income classes. Using geolocation data for ~1.7 million smartphone users over a 10-month period, we compute different measures of mobility, including the total distance traveled, the median daily distance traveled, the maximum distance traveled from one’s home, and the number of unique haunts visited. We find large differences across cities and income groups. For example, people in New York travel 38% fewer total kilometers and visit 14% fewer block-sized areas than people in Atlanta. And, individuals in the bottom income quartile travel 12% less overall and visit 13% fewer total locations than the top income quartile.

The lack of reliable electricity in the developing world is widely viewed by policymakers as a major constraint on firm productivity. Yet most empirical studies find modest short-run effects of power outages on firm performance. This paper builds a dynamic macroeconomic model to study the long-run general equilibrium effects of power outages on productivity. The model captures the key features of how firms acquire electricity in the developing world, in particular the rationing of grid electricity and the possibility of self-generated electricity at higher cost. Power outages lower productivity in the model by creating idle resources, by depressing the scale of incumbent firms and by reducing entry of new firms. Consistent with the empirical literature, the model predicts that the short-run partial-equilibrium effects of eliminating outages are small. However, the long-run general-equilibrium effects are many times larger, supporting the view that eliminating outages is an important development objective.

Repeat Software are delighted to welcome Optima Digital Inc., as a reseller partner in the Philippines. Optima Digital has more than 60 PLDT stores in the Philippines using Repeat Signage Media Wall software.

Rugby Football Union chief executive Bill Sweeney has described the prospect of the sport being postponed into 2021 as "catastrophic".

Anna Phillips has joined the Los Angeles Times as a member of the Metro education team.

New Indianapolis Colts quarterback Philip Rivers has his post-NFL life figured out already.

Retailing for $2,070 and $3,150, respectively, the Philipp Plein tank top and hoodie are being sold to support the Mamba & Mambacita Sports Foundation, which was started by Lakers legend Kobe Bryant.

The L.A. Phil's Martin Chalifour performs a violin recital at home, a highlight of cultural events you can stream while in quarantine.

Ticket sales were supposed to help theater and opera companies pay the costs of turning freelancers into staff members under AB 5. What now?

The L.A. Phil deadline arrives for subscribers to renew for next season, but fans — even loyal ones — say there's too much uncertainty about fall.

Former Chargers quarterback Philip Rivers, who signed with the Indianapolis Colts this offseason, has listed his longtime home in San Diego for sale at $4.199 million.

Longtime Chargers QB Philip Rivers has put his San Diego home up for sale. Kylie Jenner buys in Bel-Air. OneRepublic's Brent Kutzle lists in Topanga.

Deborah Borda, now head of the New York Philharmonic, talks leadership in the coronavirus crisis. Her strategy: Invest in a future that people want.

Kalvin Phillips is destined to play in the Premier League but that may not be with Leeds United after all.

THE QUEEN has one of the most extensive jewellery collections in the world, and is particularly noted for her tiaras. The Belgian Sapphire is a particular favourite of Her Majesty's - and it has a scandalous former royal owner.

QUEEN ELIZABETH II, 94, is the world's best-travelled monarch and has visited countries all over the world. Prince Philip, 98, often joins her on her many travels - but there's one thing he hates.

Leeds manager Marcelo Bielsa has claimed that he's hopeful that both Kiko Casilla and Kalvin Phillips will be fit to play against Middlesbrough on Wednesday night. Casilla had taken a kick in the hand against Reading, while Phillips limped off in the 37th minute during the Championship clash.

Leeds face Middlesbrough in the Championship on Wednesday evening, with Marcelo Bielsa hoping to continue the Whites' good form after back-to-back wins. Express Sport brings you the latest team news and injury updates, with concerns over the inclusion of Kalvin Phillips and Kiko Casilla in the manager's starting XI.

PHILLIP SCHOFIELD - a host on This Morning alongside Holly Willoughby - has addressed claims that he "moved out of his family home" he shared with wife Steph Lowe following the announcement he is gay.

Phil Taylor will take on women's darts superstar Mikuru Suzuki in a special virtual darts match on Thursday evening.

KATE, DUCHESS of Cambridge and Prince William have been married for nine years, but how did the Cambridge's wedding day echo the Queen and Prince Philip's romance?

Buộc cắt giảm hầu hết các chuyến bay do virus corona, các hàng hãng không phải thuê chỗ đỗ phi cơ và bỏ chi phí tốn kém để bảo dưỡng.