Title: Playing Football, Hockey in High School Ups Odds for Stimulant Abuse
Category: Health News
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM

Title: Smoking Rates Drop for Americans Battling Depression, Substance Abuse
Category: Health News
Created: 4/27/2022 12:00:00 AM
Last Editorial Review: 4/27/2022 12:00:00 AM

Title: How Childhood Abuse Can Haunt the Senior Years
Category: Health News
Created: 7/8/2022 12:00:00 AM
Last Editorial Review: 7/8/2022 12:00:00 AM

Endocannabinoids, which are present throughout the central nervous system (CNS), can activate cannabinoid receptors 1 and 2 (CB1 and CB2). CB1 and CB2 agonists exhibit broad anti-inflammatory properties, suggesting their potential to treat inflammatory diseases. However, careful evaluation of abuse potential is necessary. This study evaluated the abuse potential of lenabasum, a selective CB2 receptor agonist in participants (n = 56) endorsing recreational cannabis use. Three doses of lenabasum (20, 60, and 120 mg) were compared with placebo and nabilone (3 and 6 mg). The primary endpoint was the peak effect (E_max) on a bipolar Drug Liking visual analog scale (VAS). Secondary VAS and pharmacokinetic (PK) endpoints and adverse events were assessed. Lenabasum was safe and well tolerated. Compared with placebo, a 20-mg dose of lenabasum did not increase ratings of Drug Liking and had no distinguishable effect on other VAS endpoints. Dose-dependent increases in ratings of Drug Liking were observed with 60 and 120 mg lenabasum. Drug Liking and all other VAS outcomes were greatest for nabilone 3 mg and 6 mg, a medication currently approved by the US Food and Drug Administration (FDA). At a target therapeutic dose (20 mg), lenabasum did not elicit subjective ratings of Drug Liking. However, supratherapeutic doses of lenabasum (60 and 120 mg) did elicit subjective ratings of Drug Liking compared with placebo. Although both doses of lenabasum were associated with lower ratings of Drug Liking compared with 3 mg and 6 mg nabilone, lenabasum does have abuse potential and should be used cautiously in clinical settings.

Danielle Smith says she is “100 per cent committed” to a leaked plan to replace Alberta Health Services with new health boards, agencies, bureaucracy, all directed out of her office.

The post UCP set to announce plan to bust up AHS appeared first on rabble.ca.

RADIO shock jock fan Alan Jones unleashed on both sides of politics on Q&A last night — and came out in defence of Brexit.

Emergency services were called to the Glebe Place area of the town

Relatives of Lyle and Erik Menendez spoke in an interview Wednesday about their long-running fears that the brothers had been abused for years before they killed their parents.

After a press conference in which they’d called for the imprisoned siblings’ freedom, the family members told Chris Cuomo on NewsNation about how their suspicions only deepened as time passed.

“Over the years we really did know that there was abuse at gut-level. But as time goes on and we all talked to each other more and more, it validates the fears and the gut-level reactions that we had,” the brothers’ cousin Karen VanderMolen-Copley told Cuomo. “That solidified the knowledge that the sexual abuse actually did occur, because that’s not something you want to believe, and then once you talk to each other it becomes more and more obvious.”

Read more at The Daily Beast.

Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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JUDY WOODRUFF: Firefighters say they are making some progress battling the wildfires in Northern California. In all, the fires have consumed more than 220,000 acres, an area larger than New York City.

More than 5,700 structures have been destroyed. And at least 41 people have died, making it the deadliest wildfire in the state’s history.

The wine industry and the tourism business connected with it are trying to take stock. More than $50 billion in California’s economy comes from the wine business. And nearly 24 million people visit the region for that reason every year.

Special correspondent Joanne Jennings reports from Napa County.

JOANNE JENNINGS, Special Correspondent: The Mayacamas mountain range creates a natural barrier between Sonoma and Napa Counties. And it is here where the massive Nuns fire is posing a tough challenge for some 11,000 firefighters who are taming the blaze with aircraft and units on the ground.

CAPT. MARK BRENNERMAN, Viejas fire Department: We’re going around and making sure none of these fires that are still smoldering and smoking, we’re not going to get another big fire out of them.

JOANNE JENNINGS: Even as firefighters are battling shifting winds, owners and workers in Wine Country are trying to determine just how much damage has been done.

The tony Highlands gated community was among the first to be consumed by flames when the Atlas fire raced through this canyon, leaving several mansions in rubble. Down the hill, at the Silverado resort, charred remnants of the Safeway PGA Tour remain. The major golf event had just wrapped up last Sunday afternoon, a few hours before flames engulfed tents and grandstands, forcing spectators and athletes to evacuate.

MAN: Do you see how it burned right up to the retaining wall here?

JOANNE JENNINGS: Silverado resident Steve Messina stayed behind and shot video of fire crews containing the flames, which consumed some condos. Within minutes, flames raced three miles down Silverado Trail, home to several storied hillside vineyards.

Most wineries in the region have been spared the worst. But hundreds suffered some damage. And at least eight vineyards have been significantly damaged or destroyed.

Pierre Birebent, who has been making wines for the family-owned Signorello estate for 20 years, rushed to his winery as quickly as he could.

PIERRE BIREBENT, Signorello Estate Vineyards: I jumped right in my truck, came down, and then when I was riding down, I saw the hill all flaming.

JOANNE JENNINGS: Two vineyard workers joined him to help save the estate’s tasting room.

PIERRE BIREBENT: But the smoke was getting very thick, and the wind was very strong. And after an hour, we couldn’t breathe anymore. At the moment, I was so upset. It was rage to see that I couldn’t do anything. But it was like fighting a giant.

JOANNE JENNINGS: The tasting room, which also housed the winery’s office and a dining room, burned to the ground. But Birebent says he wants to focused on what survived.

Fortunately, he said, the fire stopped short of reaching the vineyard, the crush pad, or any of the barrels of wine stored on site; 95 percent of this year’s grapes were already picked.

But, to be on the safe side, Birebent is taking these samples to a lab to make sure the juice is not too acidic for winemaking. If the crops are OK, a staff of 25 employees will have jobs to return to.

As the fires begin to recede and the smoke clears, people here are beginning to wonder when the tourists, who fuel much of the economy, will return.

It’s a serious concern for Andrew and Jeni (ph) Schluter, who are self-employed and are raising a young family.

ANDREW SCHLUTER, Andrew’s Tours and Transportation: I do wine tours and transportation for people. And my business started to do really, really well. I was on track to have the best month ever.

JOANNE JENNINGS: Andrew just bought this new SUV, which has been idle in his driveway collecting ash. Jeni is a personal trainer and has family who lost their homes in the fires. She’s just not sure how they’re going to make ends meet.

WOMAN: I think we’re just overwhelmed, you know? And uncertainty is kind of scary.

ANDREW SCHLUTER: We will hopefully get by for awhile, but we might make — have to make some hard decisions shortly.

JOANNE JENNINGS: While fires burn nearby, some vineyards are already open to tourists. At the Raymond Vineyard, workers are crushing grapes at a feverish pitch. The tasting room is open for the first time since the fires started.

Jeremy and Erika Moore arrived from Tennessee yesterday. They considered canceling their trip, but decided the best way they could help people here is to give them their business.

JEREMY MOORE, Tourist: On the one hand, a few hundred yards from here, you can see them shuttling up with the helicopters fighting fires, but then here it’s beautiful. They are doing some great tastings, and they are working outside on the crops. So, it’s a weird combination of tragedy, but then at the same time business must go on, too.

JOANNE JENNINGS: Proprietor Jean-Charles Boisset owns several wineries in California, France and Canada, but like many other people here, he and his family had to evacuate their home when the flames came dangerously close.

Still, he is bullish about the future of the wine industry in this region.

JEAN-CHARLES BOISSET, Boisset Collection: Napa has been one of the most amazing agricultural places in California for a long time, so it will survive those fires. What I love, as a Frenchman here in California, is that amazing American positive attitude.

We will recover. We will walk again, run again, and we will welcome all our guests and give them the dreams of fine wine.

JOANNE JENNINGS: For the PBS NewsHour, I’m Joanne Jennings in Napa Valley, California.

The post California wine country tries to get back to business despite wildfire destruction appeared first on PBS NewsHour.

‘Battle of Technologies’ sees electric vehicles and combustion cars compete at the highest level. Who will win?

Myah Saakwa-Mante, a 20-year-old British university student, was caught at Los Angeles International Airport and arrested after allegedly attempting to smuggle T-shirts soaked with methamphetamine.

The Archbishop of Canterbury's position is now untenable, according to the Bishop of Newcastle who joined the growing calls for Justin Welby to resign.

The business secretary Jonathan Reynolds has called for a change of culture at the Post Office, as he gave evidence to the inquiry into the Horizon scandal.

Justin Welby's resignation as the Archbishop of Canterbury came after days of mounting pressure following a damning report into the cover-up of horrific abuse.

Dry ice is becoming an essential resource for various industries in Lakeland, Florida. Made from carbon dioxide in its solid form, dry ice sublimates directly into gas without leaving any liquid residue. This characteristic makes it a highly effective cooling solution, ideal for transporting perishable goods, supporting medical needs, and industrial cleaning. With the right […]

The post Essential Guide to Choosing the Best Lakeland Dry Ice Supplier for Your Business Needs appeared first on Chart Attack.

Organizing business events can be a challenge. There’s always the concern that guests will lose interest or become disengaged. When organizing team-building activities and office parties, it becomes essential to add something extra that keeps everyone active and involved. That way, the event not only meets expectations but exceeds them, leaving people excited and talking […]

The post 4 Creative Ways to Keep Guests Engaged at Your Next Business Event appeared first on Chart Attack.

Imagine walking into your yard with a coffee in one hand, no lawn mower in sight, and the kind of lush greenery that looks effortlessly perfect. No frantic trimming or sweating under the summer sun. Sounds too good to be true? It’s possible when you pick the right low-maintenance grass. Let’s walk through some game-changing […]

The post Looking for Low-Maintenance Grasses? Discover the Best Choices for Busy Gardeners appeared first on Chart Attack.

They pose no risk to human health, and they're living their best lives.

Donald Trump and the Republicans have a mandate for new economic policy.

The post Breitbart Business Digest: The Trump Economic Mandate appeared first on Breitbart.

President-elect Donald Trump announced that he has picked businessman and real estate investor Steven Witkoff to serve as Special Envoy to the Middle East.

The post President-Elect Donald Trump Picks Businessman Steven Witkoff to Be Special Envoy to Middle East appeared first on Breitbart.

Industry Minister François-Philippe Champagne said the decision to dissolve TikTok of its Canadian business is meant to address risks perceived to be related to TikTok's Chinese parent company.

The film looks to deliver an exploration of samurai culture in a tumultuous era that aligns with a renewed global interest in samurai narratives, spurred by FX’s ‘Shōgun’

Netflix recently announced more games coming to its service in the coming months, but an unannounced (as far as I’m …

Continue reading "‘SpongeBob: Bubble Pop’ Is a New Bust-a-Move-Like Coming to iOS and Android Through Tic Toc Games, Nickelodeon, and Netflix"

It’s that time again: eShop sale time! Nintendo’s calling this one the Blockbuster Sale, so I’m sure we can expect …

Continue reading "The Best Nintendo Switch eShop Sales From The ‘Blockbuster Sale’"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for September 2nd, 2024. I think it’s a holiday today in …

Continue reading "SwitchArcade Round-Up: Reviews Featuring ‘Bakeru’ & ‘Peglin’, Plus Highlights From Nintendo’s Blockbuster Sale"

Cloud-based business management software (CRM, ERP) can revolutionise an SME.

But the streaming gaming revolution "is not going to happen overnight."

A new battery plant under construction in South Carolina will supply BMW factories.

Archbishop of Canterbury Justin Welby has resigned over accusations that he failed to report physical and sexual abuse to the police.

The jury also decided to hold a Virginia-based military contractor responsible for contributing to the torture and mistreatment of detainees at the notorious Iraqi prison two decades ago.

An inquiry found abuse, torture and neglect of some 200,000 people in state care over 70 years. People with disabilities or from Maori and Pacific Islander communities were especially vulnerable.

The 2024 election made clear a fact with which both Right and Left must reckon. 

Deputy PM admits former Soviet state was until recently a 'highly corrupt country' - but insists things are changing fast.

At this moment in time the pre-pandemic cardiology research agenda needs to be completely reprioritized. There are two broad areas that now take precedence over all existing research concerns. On the one hand, researchers need to achieve a better understanding of the staggering incidence of deferred or delayed treatment of cardiovascular events and conditions as...

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TAIPEI — Taiwanese businessman Robert Tsao said on Nov 11 that he would sue in a Taiwan court senior Chinese officials over sanctions they had placed on him, saying he was seeking to counter China's intimidation of lawful activity. China, which claims Taiwan as its own territory, said in October it would punish and sanction Tsao, the retired founder of chipmaker United Microelectronics Corp (UMC), for alleged criminal and pro-Taiwan independence activities. China's Taiwan Affairs Office said the "Black Bear Academy" that Tsao has helped fund was seeking to incite separatism that would endanger cross-strait ties. Tsao, one of Taiwan's richest men who has pledged to provide millions to two civilian defence training programmes, told a press conference that China was threatening the lawful holding of political views in Taiwan and his personal safety. The lawsuit will be lodged in a Taipei court against Song Tao, head of China's Taiwan Affairs Office, and also the office's spokesman Chen Binhua. Taiwan courts have no jurisdiction in China and senior Chinese officials do not visit the island.

ISLAMABAD — A bus carrying 27 passengers fell into the Indus river in northern Pakistan on Nov 12, killing 14 people, according to a statement from the Gilgit Baltistan authorities. Twelve of the remaining passengers are missing, and one passenger has survived the accident with injuries, the statement from the authorities said. The accident occurred due to speeding, and the driver losing control of the vehicle, according to the authorities. According to local broadcaster Geo, the bus was part of a wedding procession headed towards Pakistan's Chakwal district when it fell into the river from Telchi bridge at the limits of Diamer district. Fatal road accidents are common in Pakistan, where traffic rules are rarely followed and roads in many rural areas are in poor condition. Earlier in August, two bus accidents in north-east and south-west Pakistan killed at least 34 people.

Aug 31, 2015

There is growing evidence that the Chinese economic miracle is a consequence of the rural entrepreneurship which started in the 1980s. This contradicts classical interpretations that focus on state-led enterprises and receptiveness to foreign direct investment....The lesson from China's experience is that development must be viewed as an expression of human potentialities, not as a product of external interventions.

Mar 19, 2024

Africa is home to approximately 1.4 billion people[1], about 16 percent of the world’s population, yet its continental share in global trade remains below 3 percent[2], according to the World Trade Organization (WTO). This suboptimal proportion of world trade is compounded by Africa's limited intra-continental trade. During the 26th Africa Business Conference (ABC) held at Harvard Business School (HBS) on the 17^th of February 20, 2024, industry experts, policymakers, students, faculty members, and entrepreneurs converged to interrogate these concerns and explore opportunities for improving intra-African trade. 

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John Sculley introduces his new multimedia business learning series �How to Build a Successful Business�

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European Business Award Teaser 2015

SDA Bocconi - 1-year Full-Time MBA - Master of Business Administration

Alongside new �British Businessman� digital spot, belVita debuts its latest tool to help you fake it �til you make it.