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Heterobimetallic Ru(II)/Fe(II) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

Metallomics, 2020, 12,547-561
DOI: 10.1039/C9MT00272C, Paper
Adriana Pereira Mundim Guedes, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Maria Alice Montes de Sousa, Paula Francinete Faustino da Silva, Mariana S. de Camargo, Hendryk Gemeiner, Menegário A. Amauri, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Elisângela de Paula Silveira-Lacerda, Alzir A. Batista
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A Companion to the Harlem Renaissance


 

A Companion to the Harlem Renaissance presents a comprehensive collection of original essays that address the literature and culture of the Harlem Renaissance from the end of World War I to the middle of the 1930s.



Read More...




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IRCS State branch: observes World Red cross Day

IRCS State branch: observes World Red cross Day




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[ASAP] Optimized Multimetal Sensitized Phosphor for Enhanced Red Up-Conversion Luminescence by Machine Learning

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00035




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Annual Report to the Nation: Overall cancer mortality continues to decline; Special section on adults ages 20 to 49 shows higher cancer incidence and mortality for women than men

The 2019 Annual Report to the Nation on the Status of Cancer finds overall cancer death rates continue to decline and cancer incidence dropped in men and remained stable in women. A special section reports on recent cancer trends in younger adults.




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NCI study finds long-term increased risk of cancer death following common treatment for hyperthyroidism

Findings from a new NCI study of patients who received radioactive iodine (RAI) treatment for hyperthyroidism show an association between the dose of treatment and long-term risk of death from solid cancers, including breast cancer.




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Study quantifies impact of NCI-sponsored trials on clinical cancer care

Nearly half of phase 3 cancer clinical trials carried out by the NCI-sponsored SWOG Cancer Research Network were associated with clinical care guidelines or new drug approvals, a study in JAMA Network Open shows.




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Testing with combined biopsy method improves prostate cancer diagnosis in NCI study

Testing for prostate cancer with a combined biopsy method led to more accurate diagnosis and prediction of the course of the disease in an NCI study. The method is poised to reduce the risk of prostate cancer overtreatment and undertreatment.




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Annual Report to the Nation: Cancer death rates continue to decline

The 2020 Annual Report to the Nation on the Status of Cancer finds overall cancer death rates continue to decline in the United States for all cancer sites combined. A companion study looked at Healthy People 2020 targets for four common cancers.




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Manyjilyjarra - English pictorial dictionary of landscape terms / [prepared for Kanyirninpa Jukurrpa by Clair Hill and Andrew Turk with assistance from Martu language speakers: Gladys Bidu; Jakayu Biljabu; Nancy Chapman; Mulyatingki Marney; Minyawu Miller




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Da Tang tai zi Li Jiancheng / Long Erdong zhu

Long, Erdong




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Zhan lüe xing xin xing chan ye xin cai liao bao gao = Report on advanced materials of strategic emerging industries / Zhong Yongheng zhu bian




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Zhongguo di fang zheng fu ji xiao guan li yan jiu : yi Shenzhen de shi jian wei li = Research on performance management of local government in China : a case of Shenzhen practice / Zhu Yanqiang zhu

Zhu, Yanqiang




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Zhongguo Cheng Zhen zhi gong shi ye bao xian wen ti yan jiu = The research for the problem of Chinese city officers and workers unemployment insurance / Shen Shuigen zhu

Shen, Shuigen




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[ASAP] Tuning the Metal–Support Interaction and Enhancing the Stability of Titania-Supported Cobalt Fischer–Tropsch Catalysts via Carbon Nitride Coating

ACS Catalysis
DOI: 10.1021/acscatal.0c01121




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[ASAP] Modulating Location of Single Copper Atoms in Polymeric Carbon Nitride for Enhanced Photoredox Catalysis

ACS Catalysis
DOI: 10.1021/acscatal.0c01099




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[ASAP] Enhancing the Electrocatalytic Activity of Pd/M (M = Ni, Mn) Nanoparticles for the Oxygen Reduction Reaction in Alkaline Media through Electrochemical Dealloying

ACS Catalysis
DOI: 10.1021/acscatal.9b05499




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Antibody kits arrive from China, but only for surveillance

These kits, also known as serological testing kits, are not meant for early diagnosis or detection of the disease, said Raman Gangakhedkar, head of the department of epidemiology at the Indian Council of Medical Research.




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Wasserstadt: Träume, Geld und Wirklichkeit / Franco Supino

Hayden Library - PT2681.U65 W37 2013




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The hundred days / Joseph Roth ; translated Richard Panchyk

Hayden Library - PT2635.O84 H813 2014




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Verlangen und Melancholie: Roman / Bodo Kirchhoff

Hayden Library - PT2671.I69 V45 2014




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Born under Auschwitz: melancholy traditions in postwar German literature / Mary Cosgrove

Hayden Library - PT405.C693 2014




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Superabundance / Heinz Helle ; translated by Kári Driscoll

Hayden Library - PT2708.E4855 B4713 2016




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The business affairs of Mr Julius Caesar / Bertolt Brecht ; translated by Charles Osborne ; edited by Anthony Phelan and Tom Kuhn with assistance from Charlotte Ryland

Hayden Library - PT2603.R397 G4713 2016




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Arthur Schnitzler et la France, 1894-1938: enquête sur une réception / Karl Zieger

Online Resource




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Modern drama and German classicism: renaissance from Lessing to Brecht / Benjamin Bennett

Online Resource




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Science Podcast - Fear-enhanced odor detection, the latest from the Curiosity mission, and more (13 Dec 2013)

Fear-enhanced odor detection with John McGann; the latest from Curiosity’s hunt for traces of ancient life on Mars with Richard Kerr; and more.




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Science Podcast - The genome of a transmissible dog cancer, the 10-year anniversary of Opportunity on Mars, and a rundown of stories from our daily news site (24 Jan 2014)

The genome from a cancerous cell line that's been living for millenia, Opportinty's first 10 years on Mars, and a daily news roundup.




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Science Podcast - A BRCA1 and breast cancer retrospective and a news roundup (28 Mar 2014)

BRCA1 turns 20; roundup of daily news with David Grimm.




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The spread of an ancient technology and a daily news roundup (26 September 2014)

New evidence reveals the complicated history of stone tool use 400,000 - 200,000 years ago.




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Antimicrobial resistance and a news roundup

Stephen Baker discusses the challenges faced by lower-income countries when fighting antimicrobial resistant infections. Emily Conover discusses daily news stories. Hosted by Susanne Bard. [Img: Merton Wilton/flickr/CC BY-NC 2.0]




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Ancient DNA and a news roundup

Elizabeth Culotta discusses the ancient DNA revolution and David Grimm brings online news stories about rising autism numbers, shark safety, and tiny cloudmakers. Hosted by Sarah Crespi. [Img: Alexander Maklakov]




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Podcast: Dancing dinosaurs, naked black holes, and more

What stripped an unusual black hole of its stars? Can a bipolar drug change ant behavior? And did dinosaurs dance to woo mates? Science's Online News Editor David Grimm chats about these stories and more with Science's Multimedia Producer Sarah Crespi. Plus,Science's Emily Underwood wades into the muddled world of migraine research, and Jessica Metcalf talks about using modern microbial means to track mammalian decomposition.




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Podcast: Combatting malnutrition with gut microbes, fighting art forgers with science, and killing cancer with gold

Online News Editor David Grimm shares stories on how our abilities shape our minds, killing cancer cells with gold nanoparticles, and catching art forgery with cat hair.   Laura Blanton joins host Sarah Crespi to discuss how nourishing our gut microbes may prevent malnutrition. Read the related research in Science.   [Image: D. S. Wagner et al., Biomaterials, 31 (2010)]   Authors: Sarah Crespi; David Grimm




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Podcast: Spreading cancer, sacrificing humans, and transplanting organs

Online news editor David Grimm shares stories on evidence for the earth being hit by supernovae, record-breaking xenotransplantation, and winning friends and influencing people with human sacrifice.   Staff news writer Jocelyn Kaiser joins host Sarah Crespi to discuss how small membrane-bound packets called “exosomes” might pave the way for cancer cells to move into new territory in the body.     [Image: Val Altounian/Science]    




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Podcast: Why animal personalities matter, killer whale sanctuaries, and the key to making fraternal twins

Online News Editor David Grimm shares stories on a proposal for an orca sanctuary in the sea, the genes behind conceiving fraternal twins, and why CRISPR won’t be fixing the sick anytime soon.   Elizabeth Pennisi joins host Sarah Crespi to discuss bold birds, shy spiders, and the importance of animal personality.   [Image: Judy Gallagher]




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Podcast: Saving wolves that aren’t really wolves, bird-human partnership, and our oldest common ancestor

Stories on birds that guide people to honey, genes left over from the last universal common ancestor, and what the nose knows about antibiotics, with Devi Shastri.  The Endangered Species Act—a 1973 U.S. law designed to protect animals in the country from extinction—may need a fresh look. The focus on “species” is the problem. This has become especially clear when it comes to wolves—recent genetic information has led to government agencies moving to delist the grey wolf. Robert Wayne helps untangle the wolf family tree and talks us through how a better understanding of wolf genetics may trouble their protected status.  [Image: Claire N. Spottiswoode/Music: Jeffrey Cook]




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Podcast: Explaining menopause in killer whales, triggering killer mice, and the role of chromosome number in cancer immunotherapy

This week, we chat about a surprising reason why killer whales undergo menopause, flipping a kill switch in mice with lasers, and Fukushima residents who measured their own radiation exposure[link tk], with Online News Editor Catherine Matacic. Plus, Science’s Alexa Billow talks to Stephen Elledge about the relationship between chromosomal abnormalities in tumors and immunotherapy for cancer.   Listen to previous podcasts.   [Image: Copyright Kenneth Balcomb Center for Whale Research; Music: Jeffrey Cook]




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Podcast: Where dog breeds come from, bots that build buildings, and gathering ancient human DNA from cave sediments

This week, a new family tree of dog breeds, advances in artificial wombs, and an autonomous robot that can print a building with Online News Editor David Grimm.   Viviane Slon joins Sarah Crespi to discuss a new way to seek out ancient humans—without finding fossils or bones—by screening sediments for ancient DNA.   Jen Golbeck interviews Andrew Shtulman, author of Scienceblind: Why Our Intuitive Theories About the World Are So Often Wrong for this month’s book segment.    Listen to previous podcasts.   See more book segments.     Download the show transcript. Transcripts courtesy of Scribie.com. [Image: nimis69/iStockphoto; Music: Jeffrey Cook]  




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A new taste for the tongue, ancient DNA from Egyptian mummies, and early evidence for dog breeding

This week we have stories on how we taste water, extracting ancient DNA from mummy heads, and the earliest evidence for dog breeding with Online News Editor David Grimm. Sarah Crespi talks to John Travis about postsurgical cognitive dysfunction—does surgery sap your brain power? Listen to previous podcasts. [Music: Jeffrey Cook]




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DNA and proteins from ancient books, music made from data, and the keys to poverty traps

This week we hear stories on turning data sets into symphonies for business and pleasure, why so much of the world is stuck in the poverty trap, and calls for stiffening statistical significance with Online News Editor David Grimm. Sarah Crespi talks to news writer Ann Gibbons about the biology of ancient books—what can we learn from DNA, proteins, and book worm trails about a book, its scribes, and its readers? Listen to previous podcasts. [Music: Jeffrey Cook]




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Coddled puppies don’t do as well in school, some trees make their own rain, and the Americas were probably first populated by ancient mariners

This week we hear stories on new satellite measurements that suggest the Amazon makes its own rain for part of the year, puppies raised with less smothering moms do better in guide dog school, and what DNA can tell us about ancient Greeks’ near mythical origins with Online News Editor David Grimm. Sarah Crespi talks to Lizzie Wade about coastal and underwater evidence of a watery route for the Americas’ first people. Listen to previous podcasts. [Image: Lizzie Wade; Music: Jeffrey Cook] 




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Putting rescue robots to the test, an ancient Scottish village buried in sand, and why costly drugs may have more side effects

This week we hear stories about putting rescue bots to the test after the Mexico earthquake, why a Scottish village was buried in sand during the Little Ice Age, and efforts by the U.S. military to predict posttraumatic stress disorder with Online News Editor David Grimm. Andrew Wagner interviews Alexandra Tinnermann of the University Medical Center of Hamburg, Germany, about the nocebo effect. Unlike the placebo effect, in which you get positive side effects with no treatment, in the nocebo effect you get negative side effects with no treatment. It turns out both nocebo and placebo effects get stronger with a drug perceived as more expensive. Read the research. Listen to previous podcasts. [Image: Chris Burns/Science; Music: Jeffrey Cook]




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Who visits raccoon latrines, and boosting cancer therapy with gut microbes

David Grimm—online news editor for Science—talks with Sarah Crespi about a long-term project monitoring raccoon latrines in California. What influence do these wild bathrooms have on the ecosystem? Sarah also interviews Christian Jobin of the University of Florida in Gainesville about his Perspective on three papers linking the success of cancer immunotherapy with microbes in the gut—it turns out which bacteria live in a cancer patient’s intestines can predict their response to this cutting-edge cancer treatment. Read the related papers: Routy et al., Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors, Science 2018 Gopalakrishnan et al., Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018 Matson et al., The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients, Science 2018 aan4236 Listen to previous podcasts. [Image: cuatrok77/Flickr; Music: Jeffrey Cook]




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The dangers of dismantling a geoengineered sun shield and the importance of genes we don’t inherit

Catherine Matacic—online news editor for Science—talks with Sarah Crespi about how geoengineering could reduce the harshest impacts of climate change, but make them even worse if it were ever turned off. Sarah also interviews Augustine Kong of the Big Data Institute at the University of Oxford in the United Kingdom about his Science paper on the role of noninherited “nurturing genes.” For example, educational attainment has a genetic component that may or may not be inherited. But having a parent with a predisposition for attainment still influences the child—even if those genes aren’t passed down. This shift to thinking about other people (and their genes) as the environment we live in complicates the age-old debate on nature versus nurture. Listen to previous podcasts. [Image: Collection of Dr. Pablo Clemente-Colon, Chief Scientist National Ice Center; Music: Jeffrey Cook]




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How humans survived an ancient volcanic winter and how disgust shapes ecosystems

When Indonesia’s Mount Toba blew its top some 74,000 years ago, an apocalyptic scenario ensued: Tons of ash and debris entered the atmosphere, coating the planet in ash for 2 weeks straight and sending global temperatures plummeting. Despite the worldwide destruction, humans survived. Sarah Crespi talks with Online News Editor Catherine Matacic about how life after Toba was even possible—were humans decimated, or did they rally in the face of a suddenly extra hostile planet? Next, Julia Buck of the University of California, Santa Barbara, joins Sarah to discuss her Science commentary piece on landscapes of disgust. You may have heard of a landscape of fear—how a predator can influence an ecosystem not just by eating its prey, but also by introducing fear into the system, changing the behavior of many organisms. Buck and colleagues write about how disgust can operate in a similar way: Animals protect themselves from parasites and infection by avoiding disgusting things such as dead animals of the same species or those with disease. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Emma Forsber/Flickr; Music: Jeffrey Cook]




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Drug use in the ancient world, and what will happen to plants as carbon dioxide levels increase

Armed with new data, archaeologists are revealing that mind-altering drugs were present at the dawn of the first complex societies some 5000 years ago in the ancient Middle East. Contributing writer Andrew Lawler joins Sarah Crespi to discuss the evidence for these drugs and how they might have impacted early societies and beliefs. Sarah also interviews Sarah Hobbie of the University of Minnesota about the fate of plants under climate change. Will all that extra carbon dioxide in the air be good for certain types of flora? A 20-year long study published this week in Science suggests theoretical predictions have been off the mark. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Public domain Music: Jeffrey Cook]




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Ancient DNA is helping find the first horse tamers, and a single gene is spawning a fierce debate in salmon conservation

Who were the first horse tamers? Online News Editor Catherine Matacic talks to Sarah Crespi about a new study that brings genomics to bear on the question. The hunt for the original equine domesticators has focused on Bronze Age people living on the Eurasian steppe. Now, an ancient DNA analysis bolsters the idea that a small group of hunter-gatherers, called the Botai, were likely the first to harness horses, not the famous Yamnaya pastoralists often thought to be the originators of the Indo-European language family. Sarah also talks with News Intern Katie Langin about her feature story on a single salmon gene that may separate spring- and fall-run salmon. Conservationists, regulators, and citizens are fiercely debating the role such a small bit of DNA plays in defining distinct populations. Is the spring run distinct enough to warrant protection? This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Jessica Piispanen/USFWS; Music: Jeffrey Cook] 




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Tracking ancient Rome’s rise using Greenland’s ice, and fighting fungicide resistance

Two thousand years ago, ancient Romans were pumping lead into the air as they smelted ores to make the silvery coin of the realm. Online News Editor David Grimm talks to Sarah Crespi about how the pollution of ice in Greenland from this process provides a detailed 1900-year record of Roman history. This week is also resistance week at Science—where researchers explore the global challenges of antibiotic resistance, pesticide resistance, herbicide resistance, and fungicide resistance. Sarah talks with Sarah Gurr of the University of Exeter in the United Kingdom about her group’s work on the spread of antifungal resistance and what it means for crops and in the clinic. And in a bonus books segment, staff writer Jennifer Couzin-Frankel talks about medicine and fraud in her review of Bad Blood: Secrets and Lies in a Silicon Valley Startup by John Carreyrou. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Wheat rust/Oregon State University; Music: Jeffrey Cook]




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Liquid water on Mars, athletic performance in transgender women, and the lost colony of Roanoke

Billions of years ago, Mars probably hosted many water features: streams, rivers, gullies, etc. But until recently, water detected on the Red Planet was either locked up in ice or flitting about as a gas in the atmosphere. Now, researchers analyzing radar data from the Mars Express mission have found evidence for an enormous salty lake under the southern polar ice cap of Mars. Daniel Clery joins host Sarah Crespi to discuss how the water was found and how it can still be liquid—despite temperatures and pressures typically inhospitable to water in its liquid form. Read the research. Sarah also talks with science journalist Katherine Kornei about her story on changing athletic performance after gender transition. The feature profiles researcher Joanna Harper on the work she has done to understand the impacts of hormone replacement therapy and testosterone levels in transgender women involved in running and other sports. It turns out within a year of beginning hormone replacement therapy, transgender women plateau at their new performance level and stay in a similar rank with respect to the top performers in the sport. Her work has influenced sports oversight bodies like the International Olympic Committee. In this month’s book segment, Jen Golbeck interviews Andrew Lawler about his book The Secret Token: Myth, Obsession, and the Search for the Lost Colony of Roanoke. Next month’s book will be The Book of Why: The New Science of Cause and Effect by Judea Pearl and Dana Mackenzie. Write us at sciencepodcast@aaas.org or tweet to us @sciencemagazine with your questions for the authors. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. [Image: Henry Howe; Music: Jeffrey Cook]