Redox reactions control fundamental biochemical processes, including energy production, metabolism, respiration, detoxification, and signal transduction. Cancer cells, due to their generally active metabolism for sustained proliferation, produce high levels of reactive oxygen species (ROS) compared to normal cells and are equipped with antioxidant defense systems to counteract the detrimental effects of ROS to maintain redox homeostasis. The KEAP1-NRF2 system plays a major role in sensing and regulating endogenous antioxidant defenses in both normal and cancer cells, creating a bivalent contribution of NRF2 to cancer prevention and therapy. Cancer cells hijack the NRF2-dependent antioxidant program and exploit a very unique metabolism as a trade-off for enhanced antioxidant capacity. This work provides an overview of redox metabolism in cancer cells, highlighting the role of the KEAP1-NRF2 system, selenoproteins, sulfur metabolism, heme/iron metabolism, and antioxidants. Finally, we describe therapeutic approaches that can be leveraged to target redox metabolism in cancer.

The broad application of noninvasive imaging has transformed preclinical cancer research, providing a powerful means to measure dynamic processes in living animals. While imaging technologies are routinely used to monitor tumor growth in model systems, their greatest potential lies in their ability to answer fundamental biological questions. Here we present the broad range of potential imaging applications according to the needs of a cancer biologist with a focus on some of the common biological processes that can be used to visualize and measure. Topics include imaging metastasis; biophysical properties such as perfusion, diffusion, oxygenation, and stiffness; imaging the immune system and tumor microenvironment; and imaging tumor metabolism. We also discuss the general ability of each approach and the level of training needed to both acquire and analyze images. The overall goal is to provide a practical guide for cancer biologists interested in answering biological questions with preclinical imaging technologies.

Advancements in immunotherapy in the perioperative setting have revolutionised the treatment of resectable nonsmall cell lung cancer (NSCLC). Here we present the methodology and results of the clinical trial CheckMate 816 demonstrating the benefit of neoadjuvant therapy with nivolumab plus chemotherapy compared with chemotherapy alone. Furthermore, this article discusses the implications for future practice in resectable NSCLC and the need for future research.

Lung cancer is one of the leading causes of death worldwide. It can broadly be divided into small cell lung cancer (SCLC) and nonsmall cell lung cancer. There have been many advances over the recent years in both fields. The purpose of this review is to provide a concise summary of SCLC for the general respiratory readership.

Palliative care pertains to the holistic multidimensional concept of "patient-centred" care. It is an interprofessional specialty, primarily aiming to improve quality of care for cancer patients and their families, from the time of diagnosis of malignant disease, over the continuum of cancer care, and extending after the patient's death to the period of bereavement to support the patient's family. There are various complex and frequently unmet needs of lung cancer patients and their families/caregivers, not only physical but also psychological, social, spiritual and cultural. Systematic monitoring of patients’ symptoms using validated questionnaires and patient-reported outcomes (PROs), on a regular basis, is highly encouraged and recommended in recent guidelines on the role of PRO measures in the continuum of cancer clinical care. It improves patient–physician communication, physician awareness of symptoms, symptom control, patient satisfaction, health-related quality of life and cost-effectiveness. This implies that all treating physicians should improve their skills in communication with lung cancer patients/relatives and become more familiar with this multidimensional assessment, repeatedly screening patients for palliative care needs. Therefore, they should receive education and training to develop palliative care knowledge, skills and attitudes. This review is dedicated to lung cancer palliative care essentials that should be within the competences of treating physicians, i.e. pneumologists/thoracic oncologists.

The City of Vancouver council has reneged on a previous commitment to a living wage for its employees.

The post City of Vancouver to lowest paid workers: Let them eat cuts! appeared first on rabble.ca.

HUNDREDS of travellers’ holiday plans are in disarray after all Tigerair flights in and out of Bali were cancelled again today and early tomorrow.

Ministers must follow the UK Government and extend rates relief for businesses in Scotland, Anas Sarwar has said.

The accountancy firm has opened a new office in the Scottish town

The plane is hailed as 'one of the most advanced aircraft available on the market'

Emergency services were called to the Glebe Place area of the town

A baroque fiddle believed to have been played by Robert Burns will be performed live on stage in the United States for the first time.

The best way to predict the review score of a game is to play a demo of it. So never trouble another for what you can do yourself. For every minute you are playing you lose sixty seconds of ignorance. And without Pokémon tooth brushing games, life would be a mistake.

The post RPG Cast – Episode 547: “Cancer Inducing External Hardrive” appeared first on RPGamer.

Josh is having an Ys-y time. Anna Marie ranks all the slime families. Robert gets notified every time google kills a product. And Chris tells everyone to blink on cue.

The post RPG Cast – Episode 572: “Partly Cloudy Souls With a Chance of Roguelike” appeared first on RPGamer.

Chris gets caught up on Columbo while queueing for FFXIV. Eclipse steals the show from Kelley by opening the Chrome dev tools. And Josh sells all his Spoony Bard NFTs.

The post RPG Cast – Episode 613: “Nancy New Year” appeared first on RPGamer.

Robert wants to be Tuxedo Mask, but with food and goggles. Kelley plays Find the Smell every day. Chris longs for freedom from his loot torture.

The post RPG Cast – Episode 707: “Pictomancers Working for Exposure” appeared first on RPGamer.

Take-Two CEO Strauss Zelnick in the company's latest earnings report said he isn't worried about Rockstar getting Grand Theft Auto VI to run on the Xbox Series S.

"Look, we support the platforms where the consumers are for as long as they’re there, and we find a way to support platforms despite different levels of tech," said Zelnick (via VideoGamesChronicle) when asked about the Xbox Series S.

Zelnick added, "Our labels are really good at that. I’m not really worried. I’ve never worried about where hardware was going. And I’ve said this many times over the years because, first of all, I don’t worry about things over which I have zero control.

"Secondly, I believe in the audience. The audience is going to show up if you have great properties, and so we just have to make sure to be on an array of platforms."

Zelnick added PC is an important platform to release games on, despite the fact Grand Theft Auto VI has not been announced for PC.

"If one platform diminishes in value, there’s always another one," he said. "So we’re seeing great growth in PC right now, for example. And I have been able to view that open formats would continue to grow. PC is an open format.

"I do think PC will continue to be a more and more important part of the console business going forward, and that isn’t complicated for us to support at all. So the bottom line is we are selective about which platforms we support. We make the tech work when we can make it work as long as the audience is big enough to make that worthwhile."

Grand Theft Auto VI will launch for the PlayStation 5 and Xbox Series X|S in Fall 2025.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463023/take-two-ceo-is-not-worried-about-grand-theft-auto-vi-performance-on-xbox-series-s/

Republican vice presidential candidate JD Vance boldly said “no,” Donald Trump did not lose the 2020 election, when pressed on the issue at a campaign event Wednesday in Williamsport, Pennsylvania.

The Ohio senator has avoided directly denying the results over the past few weeks.

When quizzed by The New York Times about the results over the weekend, for example, he refused multiple times to answer the question, on one occasion claiming he was “focused on the future”—echoing an answer he gave to Democratic opponent Tim Walz at the vice presidential debate.

Read more at The Daily Beast.

Donald Trump pulled out of another mainstream interview Thursday–this time nixing a sit-down with NBC News.

The interview, CNN reported, would be in Philadelphia with NBC News' senior business correspondent, Christine Romans. CNN’s Brian Stelter said one source suggested that it had only been “postponed.”

It was the second time in a week that he had canceled a scheduled appearance outside the conservative news sphere, CNN’s Reliable Sources reported Thursday. He had canceled an in-studio appearance on the CNBC flagship show, Squawk Box, which was due on Friday.

Read more at The Daily Beast.

Remedy's Alan Wake 2 has now "recouped most of its development and marketing expenses", CEO Tero Virtala has announced in a business review for January-September 2024. Speaking as somebody who would quite like there to be more Alan Wake games - or at least, moderately weird and pretty decent blockbuster singleplayer horror games - I am both pleased by this news and a little troubled that Remedy's eldritch forest fable (which came out in October 2023) has yet to break even.

Read more

I have zero archaeology experience or knowledge, but I bet archaeologists really love their jobs (for the most part). They get to analyse and discover cool artefacts and educate us on the histories of forgotten civilisations. That's dreamy stuff, that is. But I do wonder what it's like for archaeologists to discover and study something they shouldn't have; something with a disturbing secret - a curse, maybe. Bite-sized horror game The Children Of Clay explores this idea and I'd like more of it, please.

Read more

A DWP employee who has been working in the welfare system for 42 years has shared some key advice for new claims for the likes of PIP and Attendance Allowance

Benefit increases, new investment opportunities, and several tax changes are due to come into effect in April.

Data collected by the Zhurong rover and orbiting satellites suggests the existence of an ancient shoreline in the Utopia Planitia region of Mars

Dangerous radiation reaches Mars at levels we aren't exposed to on Earth, which makes the Red Planet a particularly dangerous place to be during pregnancy

Devices that let people with paralysis walk and talk are rapidly improving. Some see a future in which we alter memories and download skills – but major challenges remain

Archaeologists are using AI and US spy satellite imagery from the cold war to find ancient underground aqueducts that helped humans survive in the desert

Who built this ripped, anatomically graphic snowman? Is there a world of snowmen offscreen waiting to be turned into sex objects for widows?

Is Jessie available to babysit again?

Krasinski scores the title of People’s Sexiest Man Alive 2024.

Emma Raducanu struck a deal to return to one of her favourite tournaments.

Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

ICRA@40: 23–26 September 2024, ROTTERDAM, NETHERLANDS

IROS 2024: 14–18 October 2024, ABU DHABI, UAE

ICSR 2024: 23–26 October 2024, ODENSE, DENMARK

Cybathlon 2024: 25–27 October 2024, ZURICH

Enjoy today’s videos!

I think it’s time for us all to admit that some of the most interesting bipedal and humanoid research is being done by Disney.

[ Research Paper from ETH Zurich and Disney Research]

Over the past few months, Unitree G1 robot has been upgraded into a mass production version, with stronger performance, ultimate appearance, and being more in line with mass production requirements.

[ Unitree ]

This robot is from Kinisi Robotics, which was founded by Brennand Pierce, who also founded Bear Robotics. You can’t really tell from this video, but check out the website because the reach this robot has is bonkers.

Kinisi Robotics is on a mission to democratize access to advanced robotics with our latest innovation—a low-cost, dual-arm robot designed for warehouses, factories, and supermarkets. What sets our robot apart is its integration of LLM technology, enabling it to learn from demonstrations and perform complex tasks with minimal setup. Leveraging Brennand’s extensive experience in scaling robotic solutions, we’re able to produce this robot for under $20k, making it a game-changer in the industry.

[ Kinisi Robotics ]

Thanks Bren!

Finally, something that Atlas does that I am also physically capable of doing. In theory.

Okay, never mind. I don’t have those hips.

[ Boston Dynamics ]

Researchers in the Department of Mechanical Engineering at Carnegie Mellon University have created the first legged robot of its size to run, turn, push loads, and climb miniature stairs.

They say it can “run,” but I’m skeptical that there’s a flight phase unless someone sneezes nearby.

[ Carnegie Mellon University ]

The lights are cool and all, but it’s the pulsing soft skin that’s squigging me out.

[ Paper, Robotics Reports Vol.2 ]

Roofing is a difficult and dangerous enough job that it would be great if robots could take it over. It’ll be a challenge though.

[ Renovate Robotics ] via [ TechCrunch ]

Kento Kawaharazuka from JSK Robotics Laboratory at the University of Tokyo wrote in to share this paper, just accepted at RA-L, which (among other things) shows a robot using its flexible hands to identify objects through random finger motion.

[ Paper accepted by IEEE Robotics and Automation Letters ]

Thanks Kento!

It’s one thing to make robots that are reliable, and it’s another to make robots that are reliable and repairable by the end user. I don’t think iRobot gets enough credit for this.

[ iRobot ]

I like competitions where they say, “just relax and forget about the competition and show us what you can do.”

[ MBZIRC Maritime Grand Challenge ]

I kid you not, this used to be my job.

[ RoboHike ]

A virtual private network is a service that encrypts your internet connection, ensuring your online activity remains private and secure.

The Portuguese midfielder is settling into life in east London well after his loan move.

The Italian is reportedly set to leave Stamford Bridge at the end of his contract..

ALEXIS SANCHEZ returns to former club Arsenal tonight - and Manchester United fans are desperate to see him celebrate if he scores at the Emirates..

… level with France in the Davis Cup quarterfinals Friday. The 20th-ranked Fognini … all five of his previous Davis Cup matches and beat Fognini recently ….

Apple Music gives a whole new meaning to the phrase the hits just keep on coming.  It’s not the opposing candidates, it’s public AI systems that are spreading election disinformation, and LockBit, the cybercriminal gang may be back from the dead and saying so long to the ChatGPT plugins, which went from innovation to legacy […]

As many as 115 Post Office Branches and hundreds of jobs could be at risk following a strategic review held by Post Office Chairman Nigel Railton.

A mum-of-four was tragically found dead at her home following a fire.

Ryzen and Epyc chips have two main issues; L3 cache latency, and 'preferred core' tech.

Administrative innovations in south-west Asia during the 4th millennium BCE, including the cylinder seals that were rolled on the earliest clay tablets, laid the foundations for proto-cuneiform script.

The post Study: Cylinder Seals and Sealing Practices Stimulated Invention of Writing in Ancient South-West Asia appeared first on Sci.News: Breaking Science News.

Sedimentary mineral deposits found on the surface of Mars may have been left by an ancient sea 3.5 billion years ago.

The post Ancient Coastline Spotted in Martian Utopia Region appeared first on Sci.News: Breaking Science News.

Wastewater is a major reservoir for antibiotic resistance genes, but modified bacteria can chop up this DNA before the dangerous microbes reach people

Stem cells made in the lab may one day aid cancer treatment by reducing our reliance on donors

Narratives around addiction often reduce it to a series of poor choices, lack of values and weakness. This has real-world consequences, warns Anna Wolfe