pr Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00472H, CommunicationWen-Jie Li, Jun-You Chen, Hui-Xia Zhu, Yi-Ming Li, Yang XuA diaminodiacid (DADA) containing an amide bond can be used in Fmoc solid-phase peptide synthesis (SPPS) of an Asp-based lactam cyclic peptide with no aspartimide formation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Synthesis of alkenylphosphine oxides via Tf2O promoted addition–elimination of ketones and secondary phosphine oxides By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00318G, CommunicationJiangkai Ma, Lianjie Wang, Anjiang Qiao, Zhongxian Li, Fengqian Zhao, Junliang WuAn efficient method for the synthesis of alkenylphosphine oxides via the addition-elimination of SPOs to ketones has been developed. The reaction exhibits good yields and compatibility. Several conversions have also proven the value of this method.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00442F, CommunicationFuxin Li, Hui Liu, Wanyu Xing, Qingju Zhang, Liming WangHere we report an efficient electrochemical nickel-catalyzed cross-coupling reaction for the synthesis of S-glycosides from preactivated phenols and ketones.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Stereoselective Synthesis of gem-Dihalopiperidines via Halo-Aza-Prins Cyclization Reaction: Access to Piperidin-4-ones and Pyridines By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00338A, PaperAnil Kumar Saikia, Surjya Kumar Bora, Subhamoy Biswas, Bipin Kumar BeheraAn efficient methodology for the synthesis of 4,4-dihalopiperidine derivatives has been developed from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide and aldehyde catalyzed by In(OTf)3 in excellent yields. The reaction involves an initial formation of six...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Hydrosilylation of nitriles and tertiary amides using a zinc precursor By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3053-3058DOI: 10.1039/D4OB00161C, PaperRavi Kumar, Rohan Kumar Meher, Himadri Karmakar, Tarun K. PandaA competent and selective hydrosilylation of nitriles and tertiary amides catalyzed by zinc bis(hexamethyldisilazide) [Zn(HMDS)2] under solvent-free and mild conditions are reported, as a sustainable and desirable alternative to existing methods.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3019-3024DOI: 10.1039/D4OB00334A, PaperMan Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong LiSix unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Synthesis of alkynyl sulfides via base-promoted nucleophilic ring-opening of α-bromostyrene sulfonium salt By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2953-2957DOI: 10.1039/D4OB00203B, CommunicationJunqi Zhou, Ziyu Wang, Hanmiao Xu, Mengke Su, Jian WenAn effective method for synthesizing various alkynyl sulfides has been developed using tetramethylene sulfoxide as a sulfur source through base-promoted nucleophilic ring-opening reactions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3025-3034DOI: 10.1039/D4OB00279B, PaperJouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale ClivioEvidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Photochromism of phenazine-2,3-diol derivatives through excited state intermolecular proton transfer based on keto–enol tautomerization By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00387J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kazuki Ohira, Kumpei Kozuka, Naoki Kaneda, Masahiro Yamamoto, Keiichi Imato, Yousuke OoyamaIt was found that phenazine-2,3-diol derivatives exhibit photochromism through excited state intermolecular proton transfer (ESInterPT) processes based on keto–enol tautomerization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Charge-transfer inclusion complex formation of the tropylium cation with prism[6]arenes By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00423J, CommunicationGuojiao Zhang, Channi Cheng, Zhengxiang Li, Dezhi Zhao, Chengyou HanWe report that charge-transfer (CT) inclusion complexes were formed between prism[6]arenes and tropylium cation. Additionally, the CT complex showed Cl−/Ag+ responsiveness which can be easily monitored by the naked eye.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00380B, CommunicationShigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi NishidaThis work discloses the origin of regio- and stereoselectivity of hydrocyanation of alkynoates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Exploring the mechanism of the reductive amination of acetophenones via Borch approach: the role of the acid catalyst By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00160E, PaperJoão Pedro Albuquerque Souza, Amanda Krauskopf Jacobs, Leandro Piovan, Renan Borsoi CamposThe energetic viability of several mechanistic variations of the reductive amination of acetophenones via the Borch approach was reexamined through density functional theory calculations. The crucial involvement of the acid...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00240G, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. FalconerHerein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess–Martin periodinane oxidising agent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00397G, PaperAngel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. MöllerHerein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00236A, Review ArticleGoverdhan Mehta, Saumitra Sengupta, Srihari PabbarajaOften referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00302K, CommunicationQiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo ZhaoThe aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00167B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. SmirnovaEPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00315B, PaperShoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang HuangA series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00479E, CommunicationCao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh NguyenA cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pr As the price of aviation turbine fuel soars, airlines’ finances spin out of control By www.thehindubusinessline.com Published On :: Sun, 25 Jul 2021 16:35:44 +0530 Full Article Flight Plan
pr Omicron: Airlines on a wing and prayer By www.thehindubusinessline.com Published On :: Sun, 26 Dec 2021 18:03:30 +0530 Over 3,000 flights were cancelled on the eve of Christmas and cancellations are expected to double as New Year approaches Full Article Flight Plan
pr 2022 holds promise for the airline sector By www.thehindubusinessline.com Published On :: Sun, 09 Jan 2022 17:48:23 +0530 Omicron might dent growth, but the long-term outlook seems promising Full Article Flight Plan
pr As India builds its newest airports, it needs robust, fail-proof SOPs By www.thehindubusinessline.com Published On :: Mon, 24 Jan 2022 10:23:59 +0530 A near air mishap on Bengaluru skies that put the lives of 430 people in danger shows safety risk norms require constant refresh Full Article Flight Plan
pr Profits offer hope of soft landing to Spicejet By www.thehindubusinessline.com Published On :: Sun, 20 Feb 2022 22:00:00 +0530 Apart from swift settlement with former owners, the airline urgently needs an immediate infusion of cash Full Article Flight Plan
pr Corporate travel is unlikely to reach pre-Covid levels By www.thehindubusinessline.com Published On :: Sun, 03 Apr 2022 18:42:20 +0530 However, with offices opening up, many airlines are seeing increased demand with an uptick for premium cabins Full Article Flight Plan
pr First-ever gravity-defying plane swap set for April 24 By www.thehindubusinessline.com Published On :: Sun, 17 Apr 2022 20:02:19 +0530 Two pilots will swap planes mid-air Full Article Flight Plan
pr How cabin pressure plays a key role By www.thehindubusinessline.com Published On :: Sun, 15 May 2022 16:31:02 +0530 Ensures adequate levels of oxygen in the air Full Article Logistics
pr Air infrastructure plans should be future-proof By www.thehindubusinessline.com Published On :: Sun, 04 Sep 2022 22:00:00 +0530 India’s aviation story is full of delayed, untapped and under-utilised potential Full Article Flight Plan
pr Why has private capital not been taken to Indian aviation By www.thehindubusinessline.com Published On :: Sun, 30 Oct 2022 21:00:00 +0530 With banks becoming increasingly cautious and credit flows tightening, private capital must be explored and enticed Full Article Flight Plan
pr Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra By www.thehindu.com Published On :: Fri, 25 Oct 2024 12:38:20 +0530 As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India Full Article Technology
pr Apple AirPods Pro’s new hearing aid feature could help people face a problem they’d rather ignore By www.thehindu.com Published On :: Tue, 29 Oct 2024 08:47:33 +0530 Millions who could benefit from hearing aids have never tried them, but the Apple AirPods could change this Full Article Technology
pr Jio’s Diwali Dhamaka plan offers year-long prepaid plan for ₹3,599 By www.thehindu.com Published On :: Tue, 29 Oct 2024 13:14:07 +0530 Jio is offering a prepaid plan of 2.5 GB of data per day for an entire year, priced at₹3,599, as part of a Diwali offer Full Article Technology
pr Google’s moneymaking machine still pumping out massive profits despite multiple threats By www.thehindu.com Published On :: Wed, 30 Oct 2024 08:18:51 +0530 Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire Full Article Technology
pr Amazon's improving retail sales boost third-quarter profit, revenue beats estimates By www.thehindu.com Published On :: Fri, 01 Nov 2024 10:16:16 +0530 Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software Full Article Technology
pr Perplexity AI CEO says “still haven’t gotten” a green card amid immigration debate ahead of U.S. Presidential Election 2024 By www.thehindu.com Published On :: Fri, 01 Nov 2024 16:12:23 +0530 Srinivas went on to work with OpenAI for a year before co-founding Perplexity AI in 2022 Full Article Technology
pr Centre eyes ‘presumed consent’ for cornea retrieval in hospital deaths By www.thehindu.com Published On :: Tue, 22 Oct 2024 23:24:42 +0530 THOTA may be amended to facilitate retrieval of cornea from all Indians who die in hospitals, without family consent. Full Article India
pr Why did the Centre sanction a 50% hike in prices of commonly-used drugs? By www.thehindu.com Published On :: Fri, 25 Oct 2024 06:00:00 +0530 According to the government the recent 50% hike in prices of eight drugs was sanctioned keeping in mind the larger public interest and to ensure continued availability of drugs Full Article Health
pr Trachoma eliminated as a public health problem in India; what next? By www.thehindu.com Published On :: Fri, 25 Oct 2024 06:00:00 +0530 The achievement marks a significant public health victory and has profound economic implications. Trachoma’s impact, through blindness and visual impairment, results in an estimated economic loss of $2.9 to 5.3 billion annually due to reduced productivity Full Article Health
pr Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products By www.thehindu.com Published On :: Sat, 26 Oct 2024 03:00:00 +0530 Four spurious drugs were also found and action has been initiated against the makers, the DCGI said Full Article Health
pr What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments? By www.thehindu.com Published On :: Mon, 28 Oct 2024 17:06:09 +0530 Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams Full Article Health
pr Roll back approval to import used medical devices, med-tech industry urges PM By www.thehindu.com Published On :: Mon, 28 Oct 2024 20:20:33 +0530 The group said the move puts at risk patient safety and undermines the domestic med-tech sector. It said that refurbished machines are not subject to stringent quality checks applicable to new devices. Full Article India
pr Doctors stress healthy lifestyle, regular check-up to prevent strokes in young adults By www.thehindu.com Published On :: Mon, 28 Oct 2024 21:27:43 +0530 The webinar was held as part of The Hindu’s Wellness Series Full Article Tamil Nadu
pr National Pharmaceutical Pricing Authority directs firms to cut prices of three anti-cancer drugs By www.thehindu.com Published On :: Tue, 29 Oct 2024 20:03:20 +0530 Govt. had earlier scrapped customs duty on Trastuzumab, Osimertinib and Durvalumab and also reduced GST rates on them Full Article India
pr ICMR invites expression of interest from firms for making anaemia detection device By www.thehindu.com Published On :: Wed, 30 Oct 2024 19:45:56 +0530 The council wants to expand the effective screening network of anaemia among different age populations across India Full Article India
pr Following WHO guidelines for sodium content in packaged food could prevent 3 lakh deaths in India in 10 years: study By www.thehindu.com Published On :: Fri, 01 Nov 2024 16:35:02 +0530 Additionally, about 1.7 million new cardiovascular disease cases and 7,00,000 new chronic kidney disease cases could be prevented compared to current practices, the study said Full Article Health
pr Doctors urge National Medical Commission to simplify centralised registration process By www.thehindu.com Published On :: Sat, 02 Nov 2024 21:24:48 +0530 The register is a centralised repository that contains the name, address, and qualifications of licensed medical practitioners; however the registration process is complex and cumbersome, say doctors Full Article India
pr Stop abuse of patent monopolies in rare diseases, say patient representatives and treatment activists By www.thehindu.com Published On :: Tue, 05 Nov 2024 19:17:18 +0530 They seek urgent intervention by government, courts, and lawmakers into the issue Full Article Health
pr Bengaluru start-up strives to bridge India’s genomics data gap to aid precision oncology By www.thehindu.com Published On :: Thu, 07 Nov 2024 09:00:00 +0530 The company, 4baseCare, has come up with a gene panel for the Indian population after extensive research. This, according to the founders, will allow doctors to provide more evidence-based and data-backed treatment for cancer patients in the country Full Article Bengaluru
pr Osteoporosis can shorten your life − here’s how to prevent fractures and keep bones healthy By www.thehindu.com Published On :: Thu, 07 Nov 2024 09:30:00 +0530 The key to having healthy bones for a lifetime is to take some simple preventive measures – and the earlier, the better Full Article Health
pr Can mid-level healthcare providers compensate for physician shortages in rural India? By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:30:00 +0530 To make up for doctor shortages, several countries around the world have introduced a cadre of MLHPs into their health systems; however, in India, mainstreaming of MLHPs has time and again been met with resistance from organised medicine Full Article Health