Microchip Releases Version 2.1 of TimeProvider 4100 Timing Grandmaster

ADB has released the 13th annual performance report of its corporate results framework, the Development Effectiveness Review, a management tool that monitors performance and progress during 2019.

Access new product features and offerings through releases twice a year. Learn more about the benefits of upgrading MATLAB® and Simulink® products.

ADB has released the 13th annual performance report of its corporate results framework, the Development Effectiveness Review, a management tool that monitors performance and progress during 2019.

Genetically modified diamondback moths designed to replace pesticides by wiping out female moths have been released in New York state

Title: Pediatricians Issue New Guidelines for Hospital Release of Newborns
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM

PMC released a new and improved journal list on March 31, 2009, after a comprehensive redesign for greater clarity and organization.

The new design not only combines the full-list and tabbed-list views of the previous version but also includes some new or updated features to provide users with a greater overview of the total PMC archive. Looking at this new list, you will find:

1. An Expanded View of PMC journals that includes NIH Portfolio
2. Special Collections
3. A New “Participation Level” Journal Category
4. Hide/Show Display Option for Predecessor Titles
5. Article and Journal Search Feature

For more information, see the complete article in the May-June issue of the NLM Technical Bulletin: https://www.nlm.nih.gov/pubs/techbull/mj09/mj09_pmc_redesign.html

You can now find embargoed articles and their corresponding PMCIDs through a recently released search option in the PMC Entrez database. Using the “Limits” tab, click in the field, “Show both free and embargoed articles” and refine your search by journal, author, date, article type, and/or tag term, as needed. Once you’re on the summary page, click on the “embargoed” tab at the top to find the articles in this category. You can then find the PMCID and date of availability at the bottom of the article citation, as indicated in the example below. Note: The PMC search option only includes articles with an initial embargo of up to 12 months. Articles with an embargo greater than 12 months are not compliant with the NIH Public Access Policy and will appear in search results only when the full text is free in PMC. For more information, see the article in the September-October issue of the NLM Technical Bulletin.

The PMC user's guide, PMC Help has been updated to include new and improved information on navigating the site as well as descriptions and instructions on using the new search functions, such as Limits and Advanced Search Builder. Further updates will also be forthcoming.

PMC has recently released an updated version of its PubReader view. The new version (1.2) includes a "search this page" feature that allows you to find specific terms within the article. The latest source code is also available from the GitHub repository.

PMC has just released an upgrade to our ID converter, now dubbed the PMCID - PMID -Manuscript ID - DOI Converter. This utility allows you to start with the unique identifier for an article that is in PMC, and find additional unique identifiers that may apply to the article. Improvements include support for DOIs, auto-detection of the ID type based on its format, and enhanced output. It also provides output in any of several different formats: HTML, XML, JSON, or CSV. This tool uses an underlying web service, that is also publicly available for those needing programmatic access to this data. See the ID Converter API documentation.

PMC has released expanded information about its selection process for journals that apply for participation. The current review process has been in place since November 2014 and focuses on the scientific rigor and editorial quality of each journal that applies to participate in PMC. Some of the attributes taken into account as part of this process include the article content, journal policies, language quality, and presentation of content. The same assessment considerations are used for reevaluation of currently participating journals. We encourage you to visit the Journal Selection for PMC page to learn more.

Publishers and journals interested in submitting an application to PMC are also encouraged to review our updated policies on agreement types. These policies provide the eligibility criteria for each type of participation agreement and should be considered alongside the pre-application requirements.

We hope these updates are informative and look forward to hearing your feedback.

Title: Sublocade (buprenorphine extended release)
Category: Medications
Created: 4/17/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM

The way genes contribute to behavior is complicated. Although there are some single genes with large contributions, most behavioral differences are due to small effects from many interacting genes. This makes it hard to identify the genes that cause behavioral differences. Mutagenesis screens in model organisms, selective breeding experiments in animals, comparisons between related populations with different behaviors, and genome-wide association studies in humans are promising and complementary approaches to understanding the heritable aspects of complex behaviors. To connect genes to behaviors requires measuring behavioral differences, locating correlated genetic changes, determining when, where, and how these candidate genes act, and designing causative confirmatory experiments. This area of research has implications from basic discovery science to human mental health.

Cellular starvation is typically a consequence of tissue injury that disrupts the local blood supply but can also occur where cell populations outgrow the local vasculature, as observed in solid tumors. Cells react to nutrient deprivation by adapting their metabolism, or, if starvation is prolonged, it can result in cell...

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.

Publisher Sony Interactive Entertainment and developer Naughty Dog have released the story trailer for The Last of Us Part II ahead of the game's release next month.

View the trailer below:

Here is an overview of the game:

Five years after their dangerous journey across the post-pandemic United States, Ellie and Joel have settled down in Jackson, Wyoming. Living amongst a thriving community of survivors has allowed them peace and stability, despite the constant threat of the infected and other, more desperate survivors. When a violent event disrupts that peace, Ellie embarks on a relentless journey to carry out justice and find closure. As she hunts those responsible one by one, she is confronted with the devastating physical and emotional repercussions of her actions.

Key Features:

• A Complex and Emotional Story – Experience the escalating moral conflicts created by Ellie’s relentless pursuit of vengeance. The cycle of violence left in her wake will challenge your notions of right versus wrong, good versus evil, and hero versus villain.

  A Beautiful Yet Dangerous World – Set out on Ellie’s journey, taking her from the peaceful mountains and forests of Jackson to the lush, overgrown ruins of greater Seattle. Encounter new survivor groups, unfamiliar and treacherous environments, and terrifying evolutions of the infected. Brought to life by the latest iteration of the Naughty Dog engine, the deadly characters and world are more realistic and meticulously detailed than ever before.

• Tense and Desperate Action-Survival Gameplay – New and evolved gameplay systems deliver upon the life-or-death stakes of Ellie’s journey through the hostile world. Feel her desperate struggle for survival through improved features such as high-intensity melee combat, fluid movement, and dynamic stealth. A broad variety of weapons, crafting items, skills, and upgrades allows you to personalize Ellie’s capabilities to your play style.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443406/the-last-of-us-part-ii-story-trailer-released/

ebb software has released a new trailer for the Xbox Series X version of the atmospheric first-person horror adventure, Scorn. The game is in development for the Xbox Series X and Windows PC via Steam and Windows Store.

View the Xbox Series X trailer below:

Here is an overview of the game:

Scorn is set in a nightmarish universe of odd forms and somber tapestry. It is designed around the idea of "being thrown into the world". Isolated and lost inside this dream-like world, you will explore different interconnected regions in a non-linear fashion. Every location contains its own theme, puzzles and characters that are integral in creating a cohesive world.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443422/horror-adventure-game-scorn-xbox-series-x-trailer-released/

The makers of Blair Witch, Observer and Layers of Fear today announced a new psychological horror game - The Medium.

Codemasters next racing game, DIRT 5 has been announced.

Chorus: Rise as One is a new space-combat shooter, revealed during Inside Xbox. Here's everything you need to know.

A public disagreement between a trusted games journalist and the GTA community is showing Rockstar just how eager people are for a GTA 6 announcement

FIFA 20 Team Of The Season So Far continues this week, hopefully with the release of the Bundesliga FUT Squad. Here some predictions on who might be included, plus when they'll be announced.

Bailey Williams reflects on the final Beatles album.

"ARK: Survival Evolved" Crystal Isles is coming to PC soon, alongside a huge anniversary event on all platforms. Get the full details here.

The newly-remastered images show the icy surface of Europa, the sixth of Jupiter’s moons and the fourth largest, in enhanced color. All three high-resolution images were captured along the same longitude of Europa as NASA’s Galileo spacecraft flew by on September 26, 1998, in the eighth of the spacecraft’s 11 targeted flybys of the icy [...]

The 36th edition of the European Athletics Indoor Championships is scheduled to take place from March 5 to 7 next year in Torun, Poland.

Five prominent labour activists have returned to their homes more than a year after they were arrested in coordinated raids in the southern Chinese city of Shenzhen, according to people close to them and a Hong Kong-based rights group.

Strong as ever

And confirms its plans for Zen 3 and RDNA 2

Required for Comet Lake processors

Blackpink, BIllie Eilish, Ariana Grande and other artists from the...

The post Billie Eilish, Blackpink, Ariana Grande And More Release Branded Face Masks For Charity appeared first on Man's World India.

Amazon Prime Video today announced the trailer launch of its...

The post Watch: Amazon Prime Video Releases Paatal Lok Trailer appeared first on Man's World India.

The Trump campaign released a new ad in Spanish targeting Democrats for their response to the allegations Tara Reade made against presumptive Democratic nominee Joe Biden.

After teasing it for seven months, President Donald Trump’s re-election campaign finally launched a new phone application to rally supporters on Thursday that has been re-imagined for the virtual political age.

Data leaks of this magnitude are virtually unheard of in Canada

Maryland police released body camera footage of an officer shooting and killing a man who rushed towards him with a knife.

Will a modern design and more cameras keep customers from the iPhone SE?

Read our live updates on coronavirus HERE Coronavirus: The symptoms

Coronavirus: the symptoms Follow our live updates HERE

Nazanin Zaghari-Ratcliffe and her family must continue their excruciating wait to find out if her temporary release from prison in Iran has been extended.

Nazanin Zaghari-Ratcliffe's temporary release from prison in Iran has been extended during the coronavirus pandemic, her MP has said.

Ministers have come under renewed pressure to release thousands more prisoners after it was revealed that more than 500 jail staff and inmates have contracted Covid-19.

Previously leaked videos of US Navy pilots encountering "unexplained aerial phenomena" have been released by the Pentagon.

The full impact of coronavirus on the UK is set to be revealed as the Government prepares to publish the country's death toll for care homes on a daily basis.